Browse our HSD11B1 Proteins (HSD11B1)

Full name:
Hydroxysteroid (11-Beta) Dehydrogenase 1 Proteins (HSD11B1)
On www.antibodies-online.com are 14 Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) Proteins from 5 different suppliers available. Additionally we are shipping HSD11B1 Antibodies (112) and HSD11B1 Kits (34) and many more products for this protein. A total of 172 HSD11B1 products are currently listed.
Synonyms:
11-beta-HSD1, 11-DH, CORTRD2, HDL, hsd11, hsd11b, HSD11L, LRRGT00065, SDR26C1
list all proteins Gene Name GeneID UniProt
HSD11B1 3290 P28845
HSD11B1 15483 P50172
HSD11B1 25116 P16232

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HSD11B1 Proteins (HSD11B1) by Origin

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More Proteins for HSD11B1 Interaction Partners

Human Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) interaction partners

  1. The reduction of DHT obese homozygotic twins could be linked to its increased degradation by AKR1C2 (show AKR1C2 Proteins) and HSD11B1, and increased estrogen levels could be linked to increased adiposity-related expression of aromatase (show CYP19A1 Proteins) in adipose tissue.

  2. this study shows that the phenotypic switch of adipose tissue macrophages from M2 to mixed M1/M2 phenotype occurred through differentiation of adipocytes in obese individuals, and upregulation of intracellular 11beta-HSD1 might play a role in the process

  3. 11beta-HSD-2 (show HSD11B2 Proteins) plays an important role in the development of bone or osteoblast cell apoptosis, and the decreased expression of 11beta-HSD-2 (show HSD11B2 Proteins) may aggravate steroid induced bone/osteoblast cell apoptosis.

  4. 11beta-HSD1 may be an important enzyme in the pathogenesis of fatty liver and visceral obesity.

  5. In HSD11B1 gene of rs3753519-stratified analysis, carriers of the minor allele presented significantly increased BMI, fasting plasma glucose and HOMA-IR. The study provides support for plausible implication of the HSD11B1 polymorphisms in susceptibility to develop undesirable effects of glucocorticoid replacement in Addison's disease.

  6. Increased 11beta-HSD1 expression and its reductase activity in granulosa cells are the major causes of increased cortisol concentration in the follicular fluid of PCOS with insulin (show INS Proteins) resistance.

  7. Reciprocal regulation of the glucocorticoid metabolizing enzymes, 11beta-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-responsiveness and disease remission in childhood nephrotic syndrome.

  8. increased cortisol and 11beta-HSD1 abundance and decreased LOX (show LOX Proteins) abundance were observed in human amnion tissue after the labor-initiated spontaneous rupture of membranes

  9. These findings indicated that 11beta-HSD1 inhibition can give a potential benefit in reducing obesity and lowering insulin (show INS Proteins) resistance by modulating the insulin (show INS Proteins)-signaling pathway and adipocytokine production.

  10. Review of the role of HSD11B1 in pregnancy complications, fetal diseases, and later life morbidity.

Pig (Porcine) Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) interaction partners

  1. Results describe the cloning, sequence and expression of 11beta-hydroxysteroid dehydrogenase type 1 from pig testis.

  2. concluded that the 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 2) system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis

  3. Effects of age, weaning and/or social isolation on the expression of genes regulating HSD11B1.

Cow (Bovine) Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) interaction partners

  1. HSD11B1 was localized in mature adipocytes of early lactating cows, indicating that circulating glucocorticoids promote effects other than differentiation.

  2. investigation of gene expression for 11HSD1, 11HSD2 (show HSD11B2 Proteins), and glucocorticoid receptor (show NR3C1 Proteins) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of 11HSD1 is developmentally regulated in maturing follicles

  3. PGF2alpha but not PGE2 increases HSD11B1 bioactivity and protein expression by stimulating a posttranscriptional mechanism in stromal cells.

Mouse (Murine) Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) interaction partners

  1. These data identify suppression of CXCL2 (show CXCL2 Proteins) and CXCL5 (show CXCL5 Proteins) chemoattractant expression by 11beta-HSD1 as a novel mechanism with potential for regulation of neutrophil recruitment to the injured myocardium, and cardiac fibroblasts as a key site for intracellular glucocorticoid regeneration during acute inflammation following myocardial injury.

  2. Brown adipose tissue (BAT (show BAAT Proteins)) from aged 11beta-HSD1 KO mice showed elevated UCP1 (show UCP1 Proteins) protein and mitochondrial content, and a favorable profile of BAT (show BAAT Proteins) function.

  3. We envisage these data and models finding utility when investigating the muscle-specific functions of the 11beta-HSD1/G6PT/H6PDH triad.

  4. 11beta-HSD1-deficient mice are not protected from metabolic disease or hepatosteatosis in the face of a nonalcoholic fatty liver disease-inducing diet.

  5. 11beta-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation.

  6. these data suggest that corticosterone activation by 11beta-HSD1 in keratinocytes suppresses hapten-induced irritant dermatitis through suppression of expression of cytokines

  7. Nr3c2 (show NR3C2 Proteins) has a role in mouse skin development in a process that involves HSD11B1/HSD11B2 (show HSD11B2 Proteins)

  8. Loss of 11beta-HSD1 is associated with hepatocellular carcinoma.

  9. These findings suggest that 11beta-HSD1 may contribute to the decline in Npas4 (show NPAS4 Proteins) and Arc (show NOL3 Proteins) mRNA levels associated with memory impairment during ageing

  10. Our results demonstrate an inhibitory effect of IGF-I (show IGF1 Proteins) on 11beta-HSD1 expression and activity within the pancreatic islets, which may mediate part of the IGF-I (show IGF1 Proteins) effects on cell proliferation, survival and insulin (show INS Proteins) secretion

HSD11B1 Protein Profile

Protein Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with HSD11B1

  • hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1)
  • Corticosteroid 11-beta-dehydrogenase isozyme 1-like (LOC100342395)
  • hydroxysteroid (11-beta) dehydrogenase 1 (hsd11b1)
  • hydroxysteroid (11-beta) dehydrogenase 1 (Hsd11b1)
  • hydroxysteroid 11-beta dehydrogenase 1 (Hsd11b1)
  • 11-beta-HSD1 protein
  • 11-DH protein
  • CORTRD2 protein
  • HDL protein
  • hsd11 protein
  • hsd11b protein
  • HSD11L protein
  • LRRGT00065 protein
  • SDR26C1 protein

Protein level used designations for HSD11B1

11-beta-hydroxysteroid dehydrogenase 1 , hydroxysteroid 11-beta dehydrogenase 1 , hydroxysteroid (11-beta) dehydrogenase 1 , corticosteroid 11-beta-dehydrogenase isozyme 1 , short chain dehydrogenase/reductase family 26C, member 1 , 11-DH , 11-beta-HSD1 , 11-beta-hydroxysteroid dehydrogenase type 1 , 11-beta hydroxysteroid dehydrogenase , 11 beta-hydroxysteroid dehydrogenase type 1 , 7-alpha-HCD , 7-alpha-hydroxycholesterol dehydrogenase , 11beta-HSD-1 , 11beta-HSD1A , 11beta-hydroxysteroid dehydrogenase type 1 , Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A) , cortocosteroid 11-beta dehydrogenase , hydroxysteroid dehydrogenase, 11 beta type 1

GENE ID SPECIES
457698 Pan troglodytes
574322 Macaca mulatta
419861 Gallus gallus
100342395 Oryctolagus cuniculus
3290 Homo sapiens
443409 Ovis aries
379497 Xenopus laevis
449023 Canis lupus familiaris
397480 Sus scrofa
282589 Bos taurus
101835279 Mesocricetus auratus
15483 Mus musculus
25116 Rattus norvegicus
100135542 Cavia porcellus
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