Browse our anti-Legumain (LGMN) Antibodies

Full name:
anti-Legumain Antibodies (LGMN)
On www.antibodies-online.com are 69 Legumain (LGMN) Antibodies from 17 different suppliers available. Additionally we are shipping Legumain Kits (26) and Legumain Proteins (22) and many more products for this protein. A total of 129 Legumain products are currently listed.
Synonyms:
AEP, AI746452, AU022324, cb173, cb460, delta vacuolar processing enzyme, DELTAVPE, lgmn, LGMN1, MGC64351, MGC88980, PRSC1, sb:cb173, wu:fa98g05, wu:fj92g08, zgc:76953

Most Popular Reactivities for anti-Legumain (LGMN) Antibodies

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All available anti-Legumain Antibodies

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Top referenced anti-Legumain Antibodies

  1. Human Monoclonal LGMN Primary Antibody for ELISA - ABIN396827 : Sowa, Bennett, Gygi, Harper: Defining the human deubiquitinating enzyme interaction landscape. in Cell 2009 (PubMed)
    Show all 5 references for 396827

  2. Human Polyclonal LGMN Primary Antibody for WB - ABIN1881495 : Clerin, Shih, Deng, Hebert, Resmini, Shields, Feldman, Winkler, Albert, Maganti, Wong, Paulsen, Keith, Vlasuk, Pittman: Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis. in Atherosclerosis 2009 (PubMed)
    Show all 3 references for 1881495

  3. Human Polyclonal LGMN Primary Antibody for WB - ABIN519319 : Garcia-Cattaneo, Gobert, Müller, Toscano, Flores, Lescure, Del Nery, Benaroch: Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)

  4. Human Monoclonal LGMN Primary Antibody for ELISA - ABIN562455 : Liu, Bajjuri, Liu, Sinha: Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug. in Molecular pharmaceutics 2012 (PubMed)

More Antibodies against Legumain Interaction Partners

Arabidopsis thaliana Legumain (LGMN) interaction partners

  1. at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat

Human Legumain (LGMN) interaction partners

  1. AEP is activated and cleaves human alpha-synuclein (show SNCA Antibodies) at N103 in an age-dependent manner.

  2. AEP promotes activation of the PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signaling pathway in prostate cancer cells.

  3. upregulation of legumain is associated with malignant behavior of uveal melanoma.

  4. Studies indicate that legumain, usually in lysosomes, is also found extracellularly and even translocates to the cytosol and the nucleus.

  5. legumain might play an important role in cervical cancer cell migration and invasion.

  6. Legumain appears to be involved in tumor development and deterioration.

  7. AEP acts as a delta-secretase, cleaving APP (show APP Antibodies) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP Antibodies). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  8. High legumain expression is associated with breast cancer.

  9. This unique feature was confirmed by the crystal structure of AEPpH4.5 (AEP was matured at pH 4.5 and crystallized at pH 8.5), in which the broken peptide bonds were religated and the structure was transformed back to its proenzyme form.

  10. High legumain activity is associated with breast cancer.

Cow (Bovine) Legumain (LGMN) interaction partners

  1. legumain and TIMP-2 (show TIMP2 Antibodies) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy

Mouse (Murine) Legumain (LGMN) interaction partners

  1. This study showed that legumain may serve as a biomarker of disease, and that the occurrence of legumain-expressing macrophages in regions of acinar-to-ductal metaplasia suggests that this protease may influence reprogramming events that lead to inflammation-induced pancreatic cancer.

  2. AEP acts as a delta-secretase, cleaving APP (show APP Antibodies) at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP (show APP Antibodies). AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  3. results suggest that legumain expression and activation and cleavage of annexin A2 (show ANXA2 Antibodies) are regulated by DJ-1 (show PARK7 Antibodies) through p53 (show TP53 Antibodies)

  4. AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.

  5. TDP-43 (show TARDBP Antibodies) is cleaved by AEP in brain.

  6. TLR7 (show TLR7 Antibodies) requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling.

  7. We identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1 (show ICAM1 Antibodies)), and ras-related C3 botulinum toxin substrate 2 (RAC2 (show RAC2 Antibodies)), among others, in an invasive pre-B-cell line that produced leukemia in NOD-SCID (show PRKDC Antibodies) mice

  8. AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (show EGFR Antibodies)

  9. Immunohistochemical analyses revealed the expression of legumain in Iba1 (show AIF1 Antibodies)(+) microglial cells and glial fibrillary acidic protein (show GFAP Antibodies)-positive astrocytes of the peri (show POSTN Antibodies)-infarct area in mice after transient occlusion of the middle cerebral artery.

  10. AEP has a pivotal role in the endosomal/lysosomal degradation system

Legumain (LGMN) Antigen Profile

Antigen Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Alternative names and synonyms associated with Legumain (LGMN)

  • legumain-like (LOC100053265) antibody
  • legumain (lgmn) antibody
  • legumain (LGMN) antibody
  • delta vacuolar processing enzyme/legumain (DELTA-VPE) antibody
  • Legumain (Mboo_1489) antibody
  • Legumain (Odosp_3582) antibody
  • Legumain (lgmn) antibody
  • legumain (Lgmn) antibody
  • AEP antibody
  • AI746452 antibody
  • AU022324 antibody
  • cb173 antibody
  • cb460 antibody
  • delta vacuolar processing enzyme antibody
  • DELTAVPE antibody
  • lgmn antibody
  • LGMN1 antibody
  • MGC64351 antibody
  • MGC88980 antibody
  • PRSC1 antibody
  • sb:cb173 antibody
  • wu:fa98g05 antibody
  • wu:fj92g08 antibody
  • zgc:76953 antibody

Protein level used designations for anti-Legumain (LGMN) Antibodies

legumain , Legumain , asparaginyl endopeptidase , protease, cysteine 1 , protease, cysteine, 1 (legumain) , cysteine protease 1 , preprolegumain , protease, cysteine, 1

GENE ID SPECIES
100053265 Equus caballus
379601 Xenopus laevis
406625 Danio rerio
423418 Gallus gallus
448252 Xenopus (Silurana) tropicalis
821565 Arabidopsis thaliana
5410409 Methanoregula boonei 6A8
10255359 Odoribacter splanchnicus DSM 220712
100306856 Salmo salar
63865 Rattus norvegicus
5641 Homo sapiens
480232 Canis lupus familiaris
281281 Bos taurus
19141 Mus musculus
100173793 Pongo abelii
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