LGMN Products
(Legumain (LGMN))
Categories
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].
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Featured LGMN Categories
LGMN Antibodies
High quality antibodies with extensive validation data.
LGMN ELISA Kits
Reliable ELISA kits for a wide range of species.
LGMN Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LGMN Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7435007
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7440881
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IHC (p)
Validations
- (5)
Cat. No.
ABIN750958
Quantity
100 μL
Datasheet
Datasheet
Recommended LGMN ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968243
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957427
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957428
Quantity
96 tests
Datasheet
Datasheet
Recommended LGMN Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275145
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7275144
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123739
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our LGMN products
: "Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease." in: Nature communications, Vol. 6, pp. 8762, (2015) (PubMed).: "Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia." in: Molecular and cellular biology, Vol. 35, Issue 9, pp. 1491-505, (2015) (PubMed).
: "Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage." in: Cell research, Vol. 24, Issue 3, pp. 344-58, (2014) (PubMed).
: "Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment." in: Nature communications, Vol. 5, pp. 4280, (2014) (PubMed).
: "Degradation of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, by legumain in the mouse kidney." in: Biochemical and biophysical research communications, Vol. 453, Issue 3, pp. 631-5, (2014) (PubMed).
: "Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease." in: The Journal of biological chemistry, Vol. 288, Issue 24, pp. 17495-507, (2013) (PubMed).
: "Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 23, pp. 9053-8, (2012) (PubMed).
: "Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug." in: Molecular pharmaceutics, Vol. 9, Issue 1, pp. 168-75, (2012) (PubMed).
: "Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis." in: Atherosclerosis, Vol. 201, Issue 1, pp. 53-66, (2009) (PubMed).
: "Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase." in: Molecular cell, Vol. 29, Issue 6, pp. 665-78, (2008) (PubMed).
Synonyms and alternative names related to LGMN
legumain (LGMN), legumain (Lgmn), legumain L homeolog (lgmn.L), legumain (lgmn), delta vacuolar processing enzyme (DELTA-VPE), legumain (MBOO_RS07785), Legumain (Odosp_3582), legumain (LOC569153), AEP, AI746452, AU022324, cb173, cb460, DELTA VACUOLAR PROCESSING ENZYME, delta vacuolar processing enzyme, DELTAVPE, lgmn, LGMN1, MGC64351, MGC88980, PRSC1, Prsc1, sb:cb173, wu:fa98g05, wu:fj92g08, zgc:76953Protein level used designations for LGMN
- asparaginyl endopeptidase
- cysteine protease 1
- protease, cysteine 1
- protease, cysteine, 1 (legumain)
- preprolegumain
- protease, cysteine, 1
- legumain
- Legumain
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