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Browse our Legumain Proteins (LGMN)

Full name:
Legumain Proteins (LGMN)
On www.antibodies-online.com are 22 Legumain (LGMN) Proteins from 7 different suppliers available. Additionally we are shipping Legumain Antibodies (63) and Legumain Kits (22) and many more products for this protein. A total of 118 Legumain products are currently listed.
Synonyms:
AEP, AI746452, AU022324, cb173, cb460, delta vacuolar processing enzyme, DELTAVPE, lgmn, LGMN1, MGC64351, MGC88980, PRSC1, sb:cb173, wu:fa98g05, wu:fj92g08, zgc:76953
list all proteins Gene Name GeneID UniProt
LGMN 63865 Q9R0J8
LGMN 5641 Q99538
LGMN 19141 O89017

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Legumain Proteins (LGMN) by Origin

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Top referenced Legumain Proteins

  1. Mouse (Murine) LGMN Protein expressed in Human Cells - ABIN2007233 : Dando, Fortunato, Smith, Knight, McKendrick, Barrett: Pig kidney legumain: an asparaginyl endopeptidase with restricted specificity. in The Biochemical journal 1999 (PubMed)
    Show all 4 references for ABIN2007233

More Proteins for Legumain Interaction Partners

Arabidopsis thaliana Legumain (LGMN) interaction partners

  1. at the early stage of seed development, deltaVPE is involved in cell death of limited cell layers, the purpose of which is to form a seed coat

Human Legumain (LGMN) interaction partners

  1. AEP promotes activation of the PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) signaling pathway in prostate cancer cells.

  2. upregulation of legumain is associated with malignant behavior of uveal melanoma.

  3. Studies indicate that legumain, usually in lysosomes, is also found extracellularly and even translocates to the cytosol and the nucleus.

  4. legumain might play an important role in cervical cancer cell migration and invasion.

  5. Legumain appears to be involved in tumor development and deterioration.

  6. AEP acts as a delta-secretase, cleaving APP at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP. AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  7. High legumain expression is associated with breast cancer.

  8. This unique feature was confirmed by the crystal structure of AEPpH4.5 (AEP was matured at pH 4.5 and crystallized at pH 8.5), in which the broken peptide bonds were religated and the structure was transformed back to its proenzyme form.

  9. High legumain activity is associated with breast cancer.

  10. AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.

Cow (Bovine) Legumain (LGMN) interaction partners

  1. legumain and TIMP-2 (show TIMP2 Proteins) mRNAs were up-regulated in the endometrium during the luteal phase of the oestrous cycle and during early pregnancy

Mouse (Murine) Legumain (LGMN) interaction partners

  1. AEP acts as a delta-secretase, cleaving APP at N373 and N585 residues, selectively influencing the amyloidogenic fragmentation of APP. AEP contributes to the age-dependent pathogenic mechanisms in Alzheimer disease.

  2. results suggest that legumain expression and activation and cleavage of annexin A2 (show ANXA2 Proteins) are regulated by DJ-1 (show PARK7 Proteins) through p53 (show TP53 Proteins)

  3. AEP acts as a crucial mediator of tau-related clinical and neuropathological changes.

  4. TDP-43 is cleaved by AEP in brain.

  5. TLR7 requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling.

  6. We identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1 (show ICAM1 Proteins)), and ras-related C3 botulinum toxin substrate 2 (RAC2 (show RAC2 Proteins)), among others, in an invasive pre-B-cell line that produced leukemia in NOD-SCID (show PRKDC Proteins) mice

  7. AEP is required for normal protein catabolism by PTCs, and its loss induces proliferative and other abnormalities in the murine kidney, at least in part through defective regulation of the EGF receptor (show EGFR Proteins)

  8. Immunohistochemical analyses revealed the expression of legumain in Iba1 (show AIF1 Proteins)(+) microglial cells and glial fibrillary acidic protein (show GFAP Proteins)-positive astrocytes of the peri (show POSTN Proteins)-infarct area in mice after transient occlusion of the middle cerebral artery.

  9. AEP has a pivotal role in the endosomal/lysosomal degradation system

  10. unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E (show CST6 Proteins) deficient mice.

Legumain (LGMN) Protein Profile

Protein Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Alternative names and synonyms associated with Legumain (LGMN)

  • legumain-like (LOC100053265)
  • legumain (lgmn)
  • legumain (LGMN)
  • delta vacuolar processing enzyme/legumain (DELTA-VPE)
  • Legumain (Mboo_1489)
  • Legumain (Odosp_3582)
  • Legumain (lgmn)
  • legumain (Lgmn)
  • AEP protein
  • AI746452 protein
  • AU022324 protein
  • cb173 protein
  • cb460 protein
  • delta vacuolar processing enzyme protein
  • DELTAVPE protein
  • lgmn protein
  • LGMN1 protein
  • MGC64351 protein
  • MGC88980 protein
  • PRSC1 protein
  • sb:cb173 protein
  • wu:fa98g05 protein
  • wu:fj92g08 protein
  • zgc:76953 protein

Protein level used designations for Legumain Proteins (LGMN)

legumain , Legumain , asparaginyl endopeptidase , protease, cysteine 1 , protease, cysteine, 1 (legumain) , cysteine protease 1 , preprolegumain , protease, cysteine, 1

GENE ID SPECIES
100053265 Equus caballus
379601 Xenopus laevis
406625 Danio rerio
423418 Gallus gallus
448252 Xenopus (Silurana) tropicalis
821565 Arabidopsis thaliana
5410409 Methanoregula boonei 6A8
10255359 Odoribacter splanchnicus DSM 220712
100306856 Salmo salar
63865 Rattus norvegicus
5641 Homo sapiens
480232 Canis lupus familiaris
281281 Bos taurus
19141 Mus musculus
100173793 Pongo abelii
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