LGMN Protein (AA 18-433) (His tag)
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- Target See all LGMN Proteins
- LGMN (Legumain (LGMN))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 18-433
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LGMN protein is labelled with His tag.
- Purpose
- Human LGMN Protein
- Sequence
- Val18-Tyr433
- Characteristics
- Recombinant Human LGMN Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Val18-Tyr433.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product LGMN Protein
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Legumain (LGMN) (AA 18-435) protein (His tag)
LGMN Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Legumain (LGMN) (AA 18-325) protein (His-IF2DI Tag)LGMN Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Legumain (LGMN) (AA 1-433) protein (GST tag)LGMN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Legumain (LGMN) (Active) protein (His tag)LGMN Origin: Mouse Host: HEK-293 Cells Recombinant > 75 % as determined by SDS-PAGE Active
Legumain (LGMN) (AA 18-323) protein (His tag)Crystallography grade LGMN Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Legumain (LGMN) (AA 18-325) protein (His tag)Crystallography grade LGMN Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22μm filtered solution in PBS ( pH 7.4).
- Storage
- -80 °C
- Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- LGMN (Legumain (LGMN))
- Alternative Name
- LGMN (LGMN Products)
- Synonyms
- AEP Protein, LGMN1 Protein, PRSC1 Protein, AI746452 Protein, AU022324 Protein, Prsc1 Protein, MGC64351 Protein, cb173 Protein, cb460 Protein, sb:cb173 Protein, zgc:76953 Protein, wu:fa98g05 Protein, wu:fj92g08 Protein, lgmn Protein, MGC88980 Protein, DELTA VACUOLAR PROCESSING ENZYME Protein, DELTAVPE Protein, delta vacuolar processing enzyme Protein, legumain Protein, legumain L homeolog Protein, delta vacuolar processing enzyme Protein, Legumain Protein, LGMN Protein, Lgmn Protein, lgmn.L Protein, lgmn Protein, DELTA-VPE Protein, MBOO_RS07785 Protein, Odosp_3582 Protein, LOC569153 Protein
- Background
- Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.
- Molecular Weight
- 48.6 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades
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