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Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.
These studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma.
Megalin mediates transepithelial albumin (show ALB ELISA Kits) clearance from the alveolar space of intact rabbit lungs
low-level LPS (show IRF6 ELISA Kits)-mediated TNF-alpha (show TNF ELISA Kits)-ERK1/2 (show MAPK1/3 ELISA Kits) signaling pathway is involved in downregulation of megalin expression in IRPTCs.
we discovered one novel locus (LRP2; most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).
miR (show MLXIP ELISA Kits)-148b directly down-regulates renal megalin expression.
Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules.
The studies suggest that impaired endocytosis of megalin/cubilin (show CUBN ELISA Kits) ligands, hemoglobin (show HBB ELISA Kits) and albumin (show ALB ELISA Kits), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.
VDR (show CYP27B1 ELISA Kits) and MEGALIN gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.
the main role for placental megalin is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin in the cytotrophoblasts.
specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2/Akt (show AKT1 ELISA Kits) pathway
abundances of megalin and Dab2 (show DAB2 ELISA Kits) (p = 0.046) were reduced in infected placentas from women with LBW deliveries
homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 (show TSPYL2 ELISA Kits) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability
The megalin expression appears to vary inversely with gestational age with the greatest expression noted in the most premature samples. Age-dependent differences in placental megalin may therefore influence fetal exposure.
Cell type-specific glycoforms of megalin exist in the proximal tubular cells and modulate ligand absorption capacity.
This study evaluated the role of transcobalamin (TC), the transcobalamin receptor (CD320 (show CD320 ELISA Kits)) , and megalin in various tissues during pregnancy.
miR (show MLXIP ELISA Kits)-148b negatively regulates megalin expression in unilateral ureteral obstruction-induced kidney injury.
study reveals a cross talk between ATR (show ATR ELISA Kits) signaling and DPP4 (show DPP4 ELISA Kits) activation in the regulation of megalin and underscores the significance of targeting DPP4 (show DPP4 ELISA Kits) in the prevention of obesity related kidney injury progression.
LRP2 plays a crucial role in cardiovascular development in mice.
Foxg1 (show FOXG1 ELISA Kits)-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia
megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology.
LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure.
we have identified hypothalamic clusterin (show CLU ELISA Kits) as a novel anorexigenic molecule that can potentiate central leptin (show LEP ELISA Kits) activity.
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
low density lipoprotein-related protein 2
, low-density lipoprotein receptor-related protein 2
, low density lipoprotein receptor-related protein 2
, low-density lipoprotein receptor-related protein 2-like
, Heymann nephritis antigen homolog
, calcium sensor protein
, glycoprotein 330