LRP2 Products
(Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))
Categories
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].
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Featured LRP2 Categories
LRP2 Antibodies
High quality antibodies with extensive validation data.
LRP2 ELISA Kits
Reliable ELISA kits for a wide range of species.
LRP2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LRP2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
FACS, IF (cc), IF (p)
Validations
- (1)
Cat. No.
ABIN750991
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (2)
- (4)
Cat. No.
ABIN750988
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7158571
Quantity
100 μg
Datasheet
Datasheet
Recommended LRP2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968352
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968350
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6999575
Quantity
96 tests
Datasheet
Datasheet
Recommended LRP2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3083291
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3130822
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7397174
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our LRP2 products
: "Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension." in: Journal of the American Heart Association, Vol. 8, Issue 8, pp. e012395, (2019) (PubMed).: "IL-6/Smad2 signaling mediates acute kidney injury and regeneration in a murine model of neonatal hyperoxia." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 5, pp. 5887-5902, (2019) (PubMed).
: "Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule." in: International journal of molecular sciences, Vol. 20, Issue 10, (2019) (PubMed).
: "A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells." in: Stem cell reports, Vol. 11, Issue 2, pp. 470-484, (2018) (PubMed).
: "Combined Structural and Functional Imaging of the Kidney Reveals Major Axial Differences in Proximal Tubule Endocytosis." in: Journal of the American Society of Nephrology : JASN, Vol. 29, Issue 11, pp. 2696-2712, (2018) (PubMed).
: "Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism." in: Cellular and molecular life sciences : CMLS, Vol. 75, Issue 21, pp. 4021-4040, (2018) (PubMed).
: "Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies." in: Placenta, Vol. 42, pp. 9-16, (2016) (PubMed).
: "Role of serotonin in the regulation of renal proximal tubular epithelial cells." in: Renal failure, Vol. 38, Issue 7, pp. 1141-50, (2016) (PubMed).
: "Rho GAP myosin IXa is a regulator of kidney tubule function." in: American journal of physiology. Renal physiology, Vol. 309, Issue 6, pp. F501-13, (2015) (PubMed).
: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." in: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).
Synonyms and alternative names related to LRP2
LDL receptor related protein 2 (LRP2), low density lipoprotein receptor-related protein 2a (lrp2a), low density lipoprotein receptor-related protein 2 (LRP2), low-density lipoprotein receptor-related protein 2 (LRP2.3), LDL receptor related protein 2 L homeolog (lrp2.L), low-density lipoprotein receptor-related protein 2 (LOC100183506), LDL receptor related protein 2 (lrp2), low density lipoprotein receptor-related protein 2 (Lrp2), LDL receptor related protein 2 (Lrp2), AI315343, AW536255, D230004K18Rik, dbs, DBS, gp330, GP330, Gp330, im:680590, lrp2, megalin, MegalinProtein level used designations for LRP2
- low density lipoprotein-related protein 2
- gp330b
- low-density lipoprotein receptor-related protein 2
- megalin
- low density lipoprotein receptor-related protein 2
- low-density lipoprotein receptor-related protein 2-like
- Heymann nephritis antigen homolog
- LRP-2
- calcium sensor protein
- glycoprotein 330
- gp330
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