Browse our MTHFR Proteins (MTHFR)

Full name:
Methylenetetrahydrofolate Reductase (NAD(P)H) Proteins (MTHFR)
On www.antibodies-online.com are 4 Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) Proteins from 3 different suppliers available. Additionally we are shipping MTHFR Antibodies (98) and MTHFR Kits (19) and many more products for this protein. A total of 131 MTHFR products are currently listed.
Synonyms:
AI323986, DDBDRAFT_0204686, DDBDRAFT_0230137, DDB_0204686, DDB_0230137
list all proteins Gene Name GeneID UniProt
MTHFR 17769 Q9WU20
MTHFR 4524 P42898
Rat MTHFR MTHFR 362657  

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MTHFR Proteins (MTHFR) by Origin

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More Proteins for MTHFR Interaction Partners

Mouse (Murine) Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) interaction partners

  1. Ganglion cell loss and vasculopathy observed in Mthfr+/- and Cbs (show CBS Proteins)+/- mouse retinas may be milder than expected, not because of compensatory increases of enzymes in remethylation/transsulfuration pathways, but because downstream transsulfuration pathway products GSH, taurine, and H2S are maintained at robust levels.

  2. In summary, high folate intake during pregnancy leads to pseudo-MTHFR deficiency, disturbed choline/methyl metabolism, embryonic growth delay and memory impairment in offspring. These findings highlight the unintended negative consequences of supplemental folic acid.

  3. Study demonstrated that maternal MTHFR deficiency (i.e., in utero MTHFR deficiency) and early life exposure to vigabatrin separately and together alter the levels of proteins in the glutamatergic synapse

  4. Mildly hyperhomocysteinemic Mthfr+/- mice demonstrate reduced ganglion cell function, thinner NFL (show NEFL Proteins), and mild vasculopathy by 24 weeks.

  5. DNA methylation (show HELLS Proteins) patterns in undifferentiated spermatogonia are relatively stable in culture over time under conditions of altered methionine and MTHFR levels.

  6. Data from Mthfr knockout mice (in homozygous/heterozygous matings) suggest that maternal genotype contributes to sensitivity to arsenic as embryotoxin (i.e., genetic predisposition to fetal resorption/congenital malformation in arsenic poisoning).

  7. our results support an interaction between mild neonatal stress, the MTHFR genotype and sex

  8. investigation of Mthfr regulation in an in vivo mouse model revealed temporal- and tissue-specific regulation that supports important roles for MTHFR in the developing embryo, and in postnatal brain and male reproductive tissues

  9. A possible mechanism for the epigenetic involvement of Mthfr deficiency is proposed in the gender-dependent regulation of proteins associated with plasticity of the excitatory synapse.

  10. These results showed that methylenetetrahydrofolate reductase deficiency impairs endothelial progenitor cell formation and increases endothelial progenitor cell senescence by endothelial nitric oxide synthase (show NOS3 Proteins) uncoupling and downregulation of SIRT1 (show SIRT1 Proteins).

Human Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) interaction partners

  1. We did not find the association between C677T polymorphism of MTHRF gene and risk of ALS in Polish population, the results of meta-analysis suggest that the TT genotype can be a genetic risk factor for ALS in Caucasian population.

  2. MTHFR C677T polymorphism may be a good predictor for methotrexate toxicity in adult hematological malignancies--{REVIEW]

  3. significantly increased breast cancer risk was identified among Caucasians. MTHFR A1298C polymorphism might contribute to an increased risk of breast cancer and/or ovarian cancer susceptibility. In addition, MTHFR A1298C polymorphism had a significant association with breast cancer in Caucasians.

  4. Our findings suggest that individuals with the MTHFR 677TT or MTRR (show MTRR Proteins) 66AG/GG genotypes are more susceptible to the detrimental effect of being overweight/obesity on Type 2 Diabetes Mellitus

  5. Data suggest the potential association of methylenetetrahydrofolate reductase (MTHFR), thymidylate synthase (show TYMS Proteins) (TS) and TS enhancer region (TSER) polymorphisms with recurrent implantation failure (RIF) risk in Korean patients.

  6. The MTHFR 677T allele is associated with an increased risk of hypertension.

  7. meta-analyses of MTHFR 677 and 1298 genotype polymorphism-mutations and breast cancer risk; in this study, air pollution was notably the most significant contributing factor associated with MTHFR polymorphism-mutations and potential breast cancer susceptibility

  8. Meta-analysis of possible association between MTHFR C677T genetic variant and the risk of CHD (show CHDH Proteins) presented suggests that MTHFR C677T genetic variant is significantly associated with increased risk of congenital heart disease in Chinese paediatric population.

  9. This study suggests that Egyptian beta-TM patients with MTHFR 677TT genotype could be at increasing risk of developing Hhcy particularly with folate deficiency.

  10. In Chinese hypertensive patients, the effect of homocysteine on the first stroke was significantly modified by the methylenetetrahydrofolate reductase C677T genotype and folic acid supplementation.

MTHFR Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Alternative names and synonyms associated with MTHFR

  • methylenetetrahydrofolate reductase (NAD(P)H) (mthfr)
  • methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR)
  • methylenetetrahydrofolate reductase (metF)
  • methylenetetrahydrofolate reductase (DDB_G0279137)
  • 5,10-methylenetetrahydrofolate reductase (Mthfr)
  • methylenetetrahydrofolate reductase (NAD(P)H) (Mthfr)
  • AI323986 protein
  • DDBDRAFT_0204686 protein
  • DDBDRAFT_0230137 protein
  • DDB_0204686 protein
  • DDB_0230137 protein

Protein level used designations for MTHFR

5,10-methylenetetrahydrofolate reductase , 5,10-methylenetetrahydrofolate reductase (NADPH) , methylenetetrahydrofolate reductase (NAD(P)H) , methylenetetrahydrofolate reductase-like , methylenetetrahydrofolate reductase

GENE ID SPECIES
379784 Xenopus laevis
469800 Pan troglodytes
100125082 Xenopus (Silurana) tropicalis
100391000 Callithrix jacchus
1209960 Coxiella burnetii RSA 493
8621890 Dictyostelium discoideum AX4
17769 Mus musculus
4524 Homo sapiens
362657 Rattus norvegicus
478230 Canis lupus familiaris
397180 Sus scrofa
497032 Bos taurus
419489 Gallus gallus
100715703 Cavia porcellus
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