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Chicken Polyclonal KIF2A Primary Antibody for WB - ABIN2778182
Jang, Wong, Coppinger, Seki, Yates, Fang: DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. in The Journal of cell biology 2008
Human Monoclonal KIF2A Primary Antibody for IHC (p), ELISA - ABIN561592
Korolchuk, Saiki, Lichtenberg, Siddiqi, Roberts, Imarisio, Jahreiss, Sarkar, Futter, Menzies, OKane, Deretic, Rubinsztein: Lysosomal positioning coordinates cellular nutrient responses. in Nature cell biology 2011
Authors identified two different sets of KIF2A phosphorylation profiles that accelerate (A-type) and brake (B-type) the MT depolymerization activity of KIF2A.
Kif2a is a pruning factor that regulates target innervation by sensory axons.
This study provided evidence from live-cell analysis that the conserved heterotrimeric kinesin-2 is required for the normal transport of opsin (show RHO Antibodies) along the ciliary plasma membrane.
Kif2a functions in suppression of collateral extension.
This study demonstrated colorectal cancer (CRC (show CALR Antibodies)) tissue-preferred expression pattern of the KIF2A and suggested that high KIF2A expression might serve as an independent maker for poor prognosis in CRC (show CALR Antibodies) patients.
TTBK2 (show TTBK2 Antibodies) phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at microtubules plus ends for cell migration.
Ras regulates KIF2A to control cell migration pathways in transformed human bronchial epithelial cells.
KIF2A may play an important role in breast cancer progression and is potentially a novel predictive and prognostic marker for breast cancer.
up-regulation of KIF2C and KIF2A by ERK1/2 caused aberrant lysosomal positioning and mTORC1 activity in a mutant K-Ras-dependent cancer and cancer model.
Silencing Kif2a induces apoptosis and decreases the mRNA and protein level of PI3K (show PIK3CA Antibodies), Akt (show AKT1 Antibodies) and Bcell lymphoma 2 (Bcl2 (show BCL2 Antibodies)) in Tca8113 cells.
The distribution of Kif2A was limited to the distal ends of the central spindle through Aurora B (show AURKB Antibodies)-dependent phosphorylation and exclusion from the spindle midzone.
The kinesin-2 deficiency weakened intercellular adhesion, despite the maintenance of adherens junctions and other desmosome components at the plasma membrane.
Data show that 4-oxo-4-HPR (show HPR Antibodies) inhibited tubulin (show TUBB Antibodies) polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5 (show KIF11 Antibodies), Tara (show TRIOBP Antibodies), tankyrase-1 (show TNKS Antibodies), centractin (show ACTR1A Antibodies), and TOGp (show CKAP5 Antibodies).
Targeting of integrin beta1 and kinesin 2alpha by microRNA 183.
Interaction between kif2a and importin-alpha (show KPNA4 Antibodies) could be the mechanism by which spindle and cell sizes are coordinated early in development.
Kif2a is required for the epiboly (spreading) of animal cap. In animal caps (show CAPS Antibodies), Kif2a localizes to the spindle poles (centrosomes) and centromeres during mitosis and is required for spindle integrity and proper chromosome segregation.
These results reveal that kinesin-mediated transport of Smad2 (show SMAD2 Antibodies) along microtubules to the receptors is an essential step in ligand-induced Smad2 (show SMAD2 Antibodies) activation.
structural and physical properties of the carboxy-terminal stalk region of a kinesin-II
Studies conclude that the energy state of the Stage I oocyte regulates the rate of RNA localization to the Balbiani body and that this process, at least to some extent, involves kinesin II.
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene.
kinesin-like protein KIF2A
, kinesin heavy chain member 2
, Kinesin, heavy chain, 2
, kinesin family member 2A
, kinesin heavy chain family, member 2
, kinesin-related protein XKIF2
, KLC 1
, kinesin 2
, kinesin ii