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The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (show PON1 Proteins), 2 and 3 in granulosa cells and PON1 (show PON1 Proteins) activity in follicular fluid and plasma of dairy cows.
Data suggest that paraoxonases (PON1 (show PON1 Proteins), PON2 (show PON2 Proteins), PON3) play roles in innate immunity, inflammatory response, and protection against oxidative stress; these factors are associated with the body's response to infectious diseases; low serum PON1 (show PON1 Proteins) activities are associated with poor survival in patients with severe sepsis. [REVIEW]
Data show that the mRNA levels of both paraoxonases PON2 (show PON2 Proteins) and PON3 were significantly upregulated whereas PON1 (show PON1 Proteins)'s mRNA was absent in transgenic mouse hearts.
Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4 (show ARHGEF4 Proteins), PON3, STAT5a (show STAT5A Proteins), and VAX2 (show VAX2 Proteins) gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation (show HELLS Proteins) analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumor
Low PON3 expression is associated with hepatocellular carcinoma progression.
This study showed that the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway is up-regulated by the expression of PON3 in oral squamous cell carcinoma by AP-1 (show FOSB Proteins).
Studies indicate that three paraoxonases PON1 (show PON1 Proteins), PON2 (show PON2 Proteins), and PON3 genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties.
PON3 SNP rs13226149 was associated with intracerebral hemorrhage in log-additive and dominant models. The A allele of rs13226149 contributed to the decreased risk of ICH (show COL4a2 Proteins). SNP rs1053275 was not associated with ICH (show COL4a2 Proteins).
Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1 (show PON1 Proteins), PON2 (show PON2 Proteins), PON3) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL (show HSD11B1 Proteins) level in blood. [REVIEW]
Interaction of PON-3 and PON-1 (show PON1 Proteins) and HDL (show HSD11B1 Proteins) are associated with the presence and severity of coronary artery disease in type 2 diabetes mellitus patients.
PON3 in HDL (show HSD11B1 Proteins) may be an important protein in preventing atherosclerosis.
study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality.
mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled
PON3 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.
The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1 (show PON1 Proteins)/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.
The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described.
Results show that PON3 mRNA and protein are ubiquitously expressed in pig tissues. Moreover, the relative abundance of PON3 mRNA, measured in perirenal and subcutaneous fat tissues, is higher in obese gilts compared with the leaner (show CACNA1A Proteins) gilts.
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described\; however, only one has been fully characterized.
, serum paraoxonase/lactonase 3-like
, serum paraoxonase/lactonase 3