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atp2a3/serca3 expression is restricted to the ectoderm throughout development
SERCA3-dependent Ca(2+) stores control a specific ADP secretion pathway.
ANP (show NPPA ELISA Kits) counter-regulates cardiac MR activation in hypertensive heart disease. An imbalance in cardiac ANP (show NPPA ELISA Kits)/GC-A (show GUCA1A ELISA Kits) (inhibition) and aldosterone/MR signaling (augmentation) favors adverse cardiac remodeling in chronic pressure overload.
This study evaluated the role of SERCA2b (show ATP2A2 ELISA Kits) and SERCA3 in the control of the free calcium concentration in the endoplasmic reticulum and the role of SERCA3 in the control of insulin (show INS ELISA Kits) secretion.
identification of promoter region and binding site for Ets-1 (show ETS1 ELISA Kits) in mouse SERCA3
Ablation does not impair insulin (show INS ELISA Kits) secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2 (show CA2 ELISA Kits)+) pumps for Ca(2 (show CA2 ELISA Kits)+) homeostasis in pancreatic beta-cells
regulation in insulin (show INS ELISA Kits)-secreting beta-cells by insulin receptor substrate 1 (show IRS1 ELISA Kits)
IRS-1 (show IRS1 ELISA Kits) modulation of insulin (show INS ELISA Kits) secretion is associated with Ca(2 (show CA2 ELISA Kits)+) signaling and expression of SERCA-2b and -3 genes in pancreatic islets. Direct link between insulin (show INS ELISA Kits) resistance and defective insulin (show INS ELISA Kits) secretion.
Sp1 (show PSG1 ELISA Kits), Sp3 (show SP3 ELISA Kits), and Klf-4 (show KLF4 ELISA Kits) transcription factors bind to ATP2A3 proximal promoter elements and regulate basal gene expression. The study showed that these factors participated in the increase of ATP2A3 expression during cancer cell differentiation.
Together, these data provide evidence for the interaction of Bcl-2 (show BCL2 ELISA Kits) with SERCA3b in vitro and in cell culture, and for Bcl-2 (show BCL2 ELISA Kits)-dependent conformational and functional changes of SERCA3b.
ATP2A3 methylation was not altered between patients with type 2 diabetes and healthy men. Moreover, a glucose challenge did not alter ATP2A3 methylation.
we make a comprehensive analysis of the current knowledge of the role of the SERCA pumps in the pathophysiology of insulin (show INS ELISA Kits)-dependent diabetes mellitus type 1 (TIDM) and type 2 (T2DM) in the heart and beta-cells in the pancreas
Normal choroid plexus epithelial cells express SERCA3 abundantly, SERCA3 expression is strongly decreased in papillomas, and is absent in choroid plexus carcinoma, while expression in hyperplastic epithelium is high, similarly to normal epithelium.
aberrant SERCA3 expression is closely linked to the adenoma-adenocarcinoma sequence and progression of colorectal carcinomas.
Loss of SERCA3 expression is associated with lung cancer.
High SERCA3 expression is associated with pathogenesis, invasion, metastasis of gastric carcinomas.
SERCA2 (show ATP2A2 ELISA Kits) and SERCA3 isoforms have roles in the failing and failing human heart
Data show that low Ca2 (show CA2 ELISA Kits)+-affinity SERCA3, and the high Ca2 (show CA2 ELISA Kits)+-affinity SERCA2 (show ATP2A2 ELISA Kits) enzymes are simultaneously expressed in B cells, and decreased SERCA3 expression during EBV-infection.
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.
ATPase, Ca++ transporting, ubiquitous
, sarcoplasmic/endoplasmic reticulum calcium ATPase 3-like
, SR Ca(2+)-ATPase 3
, calcium pump 3
, sarcoendoplasmic reticulum Ca2+ ATPase type 3
, sarcoplasmic/endoplasmic reticulum calcium ATPase 3
, ATPase, Ca(2+)-transporting, ubiquitous
, adenosine triphosphatase, calcium
, calcium-translocating P-type ATPase
, sarco/endoplasmic reticulum Ca2+ -ATPase
, sarcoendoplasmic reticulum calcium ATPase