Browse our anti-SIRT4 (SIRT4) Antibodies

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anti-Sirtuin 4 Antibodies (SIRT4)
On are 115 Sirtuin 4 (SIRT4) Antibodies from 24 different suppliers available. Additionally we are shipping SIRT4 Kits (13) and SIRT4 Proteins (11) and many more products for this protein. A total of 150 SIRT4 products are currently listed.
4930596O17Rik, im:7139453, SIR2L4, SIRT4
list all antibodies Gene Name GeneID UniProt
SIRT4 23409 Q9Y6E7
SIRT4 75387 Q8R216
SIRT4 304539  

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anti-Human SIRT4 Antibodies:

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Top referenced anti-SIRT4 Antibodies

  1. Human Polyclonal SIRT4 Primary Antibody for IHC (p), IHC - ABIN250192 : Frye: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 4 references for 250192

  2. Human Polyclonal SIRT4 Primary Antibody for IHC (fro), IF (p) - ABIN872709 : Takumida, Takumida, Anniko: Localization of sirtuins in the mouse inner ear. in Acta oto-laryngologica 2014 (PubMed)
    Show all 2 references for 872709

  3. Human Polyclonal SIRT4 Primary Antibody for IHC, ELISA - ABIN185191 : do Amaral, Ueno, Oliveira, Borsonello, Vanzela, Ribeiro, Alves, Barbosa, Carneiro, Boschero: Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats. in The Journal of nutritional biochemistry 2011 (PubMed)
    Show all 2 references for 185191

  4. Cow (Bovine) Polyclonal SIRT4 Primary Antibody for IHC, WB - ABIN2779654 : Ahuja, Schwer, Carobbio, Waltregny, North, Castronovo, Maechler, Verdin: Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against SIRT4 Interaction Partners

Human Sirtuin 4 (SIRT4) interaction partners

  1. we found that knock-out of mitochondrial sirtuin (show SIRT1 Antibodies) sir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hyperactive channel induced necrosis. This work suggests a deleterious role of SIRT4 during ischemic processes in mammals that must be further investigated

  2. This is the first study to identify an association between SIRT4 expression and decreased mitochondrial fission, which was driven by Drp1. SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1.

  3. miR (show MLXIP Antibodies)-15b is a negative regulator of stress-induced SIRT4 expression, thereby counteracting senescence associated mitochondrial dysfunction and regulating the SASP (show ASPRV1 Antibodies) and possibly organ aging, such as photoaging of human skin.

  4. SIRT4 overexpression inhibits the proliferation of colorectal cancer cells in vitro and in vivo.

  5. Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Antibodies)), endometrial cancer (EC) showed SIRT7 (show SIRT7 Antibodies) mRNA overexpression, whereas SIRT1 (show SIRT1 Antibodies), SIRT2 (show SIRT2 Antibodies), SIRT4 and SIRT5 (show SIRT5 Antibodies) were underexpressed, and no significant differences were observed for SIRT3 (show SIRT3 Antibodies) and SIRT6 (show SIRT6 Antibodies).

  6. Thus, these results suggest that SIRT4 has essential roles in stress resistance and may be an important therapeutic target for cancer treatment.

  7. SIRT4 behaves as a tumor suppressor at the human tissue protein level.

  8. Overexpression of SIRT4 attenuated inflammation mediators in umbilical vein endothelial cells.

  9. Results show that mitochondrial sirtuins SIRT3 (show SIRT3 Antibodies), SIRT4, and SIRT5 (show SIRT5 Antibodies) can promote increased mitochondrial respiration and cellular metabolism and respond to excess glucose by inducing a coordinated increase of glycolysis and respiration.

  10. SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer.

Mouse (Murine) Sirtuin 4 (SIRT4) interaction partners

  1. These findings identify a robust enzymatic activity for SIRT4, uncover a mechanism controlling branched-chain amino acid flux, and position SIRT4 as a crucial player maintaining insulin (show INS Antibodies) secretion and glucose homeostasis during aging.

  2. miR (show MLXIP Antibodies)-497 modulates cardiac hypertrophy by targeting Sirt4 and may serve as a potential therapeutic substance in the course.

  3. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH (show PDP Antibodies) is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications.

  4. The results of this study indicated a critical and novel stress response role for SIRT4 in promoting proper glutamate (show GRIN1 Antibodies) transport capacity and protecting against excitotoxicity

  5. regulates ATP levels via ANT2 (show SLC25A5 Antibodies) and a feedback loop involving AMPK (show PRKAA1 Antibodies)

  6. these results highlight the tumor-suppressive role of SIRT4 in Myc (show MYC Antibodies)-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc (show MYC Antibodies)-induced and/or glutamine (show GFPT1 Antibodies)-dependent cancers.

  7. The enhanced fatty acid oxidation observed in SIRT4 knockout hepatocytes requires functional SIRT1 (show SIRT1 Antibodies), demonstrating a clear cross talk between mitochondrial and nuclear sirtuins.

  8. Data uncover SIRT4 as an important component of the DNA damage response pathway that orchestrates a metabolic block in glutamine (show GFPT1 Antibodies) metabolism, cell cycle arrest, and tumor suppression.

  9. SIRT4 represses fatty acid oxidation and stimulates lipogenesis. SIRT4 deacetylates and represses malonyl CoA decarboxylase, regulating malonyl coA levels.

  10. Data demonstrate that SIRT4 inhibition increases fat oxidative capacity in liver and mitochondrial function in muscle.

SIRT4 Antigen Profile

Antigen Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Alternative names and synonyms associated with SIRT4

  • sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) (SIRT4) antibody
  • zgc:103539 (zgc:103539) antibody
  • sirtuin 4 (SIRT4) antibody
  • sirtuin 4 (Sirt4) antibody
  • 4930596O17Rik antibody
  • im:7139453 antibody
  • SIR2L4 antibody
  • SIRT4 antibody

Protein level used designations for anti-Sirtuin 4 (SIRT4) Antibodies

sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , sirtuin 4 , NAD-dependent ADP-ribosyltransferase sirtuin-4 , NAD-dependent protein deacetylase sirtuin-4 , SIR2-like protein 4 , regulatory protein SIR2 homolog 4 , sir2-like 4 , sirtuin type 4 , NAD-dependent deacetylase sirtuin-4

742235 Pan troglodytes
791628 Danio rerio
100586803 Nomascus leucogenys
23409 Homo sapiens
75387 Mus musculus
304539 Rattus norvegicus
477507 Canis lupus familiaris
100125349 Sus scrofa
519328 Bos taurus
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