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anti-Human AATF Antibodies:
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Human Monoclonal AATF Primary Antibody for IF, WB - ABIN393641
Bruno, Desantis, Bossi, Di Agostino, Sorino, De Nicola, Iezzi, Franchitto, Benassi, Galanti, La Rosa, Floridi, Bellacosa, Passananti, Blandino, Fanciulli: Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation. in Cancer cell 2010
Show all 5 references for ABIN393641
Human Polyclonal AATF Primary Antibody for EIA, IHC (p) - ABIN499185
Page, Lödige, Kögel, Scheidtmann: AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis. in FEBS letters 2000
Show all 4 references for ABIN499185
Chicken Polyclonal AATF Primary Antibody for WB - ABIN2780860
Lehner, Sanderson: A protein interaction framework for human mRNA degradation. in Genome research 2004
Dog (Canine) Polyclonal AATF Primary Antibody for IHC, WB - ABIN2777467
Burgdorf, Leister, Scheidtmann: TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination. in The Journal of biological chemistry 2004
loss of Che-1 (show BCHE Antibodies) inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53 (show TP53 Antibodies)
It was concluded that PARP-1 (show PARP1 Antibodies) was involved in the DNA damage repair induced by HQ via increasing the accumulation of apoptosis antagonizing transcription factor through PARylation.
These results confirm Che-1 as an important regulator of p53 activity and suggest Che-1 to be a promising yet attractive drug target for cancer therapy.
In the face of high glucose threat, mitochondrial UCP2 (show UCP2 Antibodies) gene expression is regulated by miR (show MLXIP Antibodies)-2909 and AATF.
This mutant AATF along with its interactome consisting of SP1 (show PSG1 Antibodies), DNMT3B (show DNMT3B Antibodies) and Par-4 (show PAWR Antibodies) ensures cancer cell DNA methylation (show HELLS Antibodies) required for down-regulation of tumor suppressor genes.
HIPK2 depletion strongly decreases Che-1 ubiquitylation and degradation.
Che-1 (show BCHE Antibodies) expression correlates with the progression of multiple myeloma and is required for cell growth and survival.Che-1 controls mTOR (show FRAP1 Antibodies) through the induction of Redd1 (show DDIT4 Antibodies) and Deptor (show DEPTOR Antibodies), two important repressors of mTOR (show FRAP1 Antibodies).
Cell proliferation decreased by 41% which was accompanied by apoptosis induction in 30% MCF-7 cells after AATF gene knockdown.
Che-1 (show BCHE Antibodies) depletion abolishes the ability of Chk1 (show CHEK1 Antibodies) to bind pericentrin (show PCNT Antibodies) and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 (show CDK1 Antibodies) and advances entry into mitosis.
These results identify AATF as a nucleolar-confined c-Jun (show JUN Antibodies) cofactor whose expression levels and spatial distribution determine the stress-induced activity of c-Jun (show JUN Antibodies) and the levels of c-Jun (show JUN Antibodies)-mediated apoptosis.
AATF is an endogenous antagonist of Par-4 (show F2RL3 Antibodies) activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions.
Che-1 as a new Pin1 (show PIN1 Antibodies) and HDM2 target and confirm its important role in the cellular response to DNA damage.
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
apoptosis antagonizing transcription factor
, protein AATF
, Apoptosis antagonizing transcription factor
, protein AATF-like
, apoptosis-antagonizing transcription factor
, rb-binding protein Che-1
, traube protein