AATF antibody (AA 451-560)
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- Target See all AATF Antibodies
- AATF (Apoptosis Antagonizing Transcription Factor (AATF))
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Binding Specificity
- AA 451-560
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AATF antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Cow,Pig,Horse,Rabbit,Guinea Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human AATF
- Isotype
- IgG
- Top Product
- Discover our top product AATF Primary Antibody
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anti-Apoptosis Antagonizing Transcription Factor (AATF) (AA 151-250) antibody
AATF Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 3C7 unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (N-Term) antibodyAATF Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (AA 1-39) antibodyAATF Reactivity: Human, Mouse WB, IF Host: Rat Monoclonal 1B2D8 unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (AA 240-438) antibodyAATF Reactivity: Mouse WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (AA 237-523) antibodyAATF Reactivity: Rat WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (N-Term) antibodyAATF Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Saccharomyces cerevisiae WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (N-Term) antibodyAATF Reactivity: Human, Monkey WB, IHC, IP, IF, IC Host: Rabbit Polyclonal unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (N-Term) antibodyAATF Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (N-Term) antibodyAATF Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Apoptosis Antagonizing Transcription Factor (AATF) (AA 6-294) antibodyAATF Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- AATF (Apoptosis Antagonizing Transcription Factor (AATF))
- Alternative Name
- AATF (AATF Products)
- Background
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Synonyms: DED, BFR2, CHE1, CHE-1, Protein AATF, Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, AATF, HSPC277
Background: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
- Gene ID
- 26574
- UniProt
- Q9NY61
- Pathways
- Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome
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