AATF antibody (AA 1-39)

Catalog No. ABIN6971349

Product Details anti-AATF Antibody

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Binding Specificity: AA 1-39

Reactivity: Human, Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This AATF antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Characteristics: AATF/Che-1, or Apoptosis-antagonizing Transcription Factoris a key regulator of apoptosis through its interaction with MAP3K12 (DLK), as well as regulation of gene transcription and cell profileration through interaction with RNA polymerase II. AATF/Che-1 may promote cell proliferation by acting as a competitor of histone deacetylase 1 (HDAC1) interaction with the growth inhibiting protein pRb. AATF / Che-1 binding to pRb may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. AATF / Che-1 antibody (mAb) (Clone 1B2D8) was raised in a Rat host. It has been validated for use in Immunofluorescence and Western blot, it has been shown to react with Human and Mouse samples.

Purification: Protein A Chromatography

Immunogen: This antibody was raised against peptide comprising amino acids 1-39 of mouse AATF (Apoptosis-antagonizing transcription factor) (NP_062790).

Clone: 1B2D8

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for AATF

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Alternative Name: AATF / Che-1 (AATF Products)

NCBI Accession: NP_062790

Pathways: Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome