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Human HDAC3 Protein expressed in Baculovirus infected Insect Cells - ABIN2004315
Pajerowski, Nguyen, Aghajanian, Shapiro, Shapiro: NKAP is a transcriptional repressor of notch signaling and is required for T cell development. in Immunity 2009
Show all 4 references for ABIN2004315
Human HDAC3 Protein expressed in Wheat germ - ABIN1306448
Jiang, Ye, Guo, Lu, Gao: Inhibition of HDAC3 promotes ligand-independent PPAR? activation by protein acetylation. in Journal of molecular endocrinology 2014
Brm (show SMARCA2 Proteins)-HDAC3-Erm (show MSN Proteins) repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.
Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X (show FMR1 Proteins) tremor ataxia (show USP14 Proteins) syndrome.
) DHDAC1 (show HDAC1 Proteins) and -3 have distinct functions in the control of gene expression
Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.
HDAC3 knockdown or HDAC3 inhibition was associated with simultaneous upregulation of the expression of miR130a and downregulation of the expression of TNF1alpha in peripheral blood mononuclear cells.
Data suggest that complexes of HDAC3-H1.3 with NCOR1 and NCOR2/SMRT accumulate on chromatin in synchronized HeLa cells in late G2 phase and mitosis; deacetylation activity of HDAC3 is activated via phosphorylation of Ser-424 by CK2 only in mitosis.
this is the first report on the regulation mechanism of SIRT7 (show SIRT7 Proteins) gene, in which, HDAC3 collaborated with C/EBPalpha (show CEBPA Proteins) to occupy its responding element in the upstream region of SIRT7 (show SIRT7 Proteins) gene and repressed its expression in human cells.
Among the class II HDACs, HDAC4 (show HDAC4 Proteins) interacted with both MR and HDAC3 after aldosterone stimulation. The nuclear translocation of HDAC4 (show HDAC4 Proteins) was mediated by protein kinase A (PKA) and protein phosphatases (PP)
miR (show MLXIP Proteins)-335 exerted apoptotic effects and inhibited ubiquitination of HDAC3 in anti-cancer drug-resistant cancer cell lines. miR (show MLXIP Proteins)-335 negatively regulated the invasion, migration, and growth rate of cancer cells.
ZBP-89 (show ZNF148 Proteins) attenuates HDAC3 by increasing IkappaB degradation, dependent on Pin1 (show PIN1 Proteins) but independent of NF-Kappab (show NFKB1 Proteins)
Data suggest, in chronic hepatitis C virus infection, HDAC9 (histone deacetylase 9 (show HDAC9 Proteins)) induction in liver regulates hepatic gluconeogenesis and systemic insulin (show INS Proteins) resistance via deacetylation of FoxO1 (show FOXO1 Proteins) (Forkhead box O 1) and HDAC3 (histone deacetylase 3).
These data suggest that HDAC3 indirectly modulates tubulin (show TUBB Proteins) acetylation
The inhibition of the transcriptional activity of BCL9-2 (show BCL9L Proteins) by WWOX (show WWOX Proteins) and HDAC3 constitutes a new molecular mechanism and provides new insight for a broad range of cancers.
These observations suggested that HDAC3 plays an important role in the pathological courses of spinal cord injury by regulating miR (show MLXIP Proteins)-130a expression
GC-induced direct repression, but not bindings of GR and of corepressors NCoR1 (show NCOR1 Proteins)/SMRT, was abolished, indicating that HDAC3 is instrumental in IR nGRE-mediated repression
GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1 (show NCOR1 Proteins)-HDAC3 repressing complex, which is indispensable for NF-kappaB (show NFKB1 Proteins)/AP1 (show JUN Proteins)-mediated GC-induced tethered indirect transrepression in vitro
studies reveal an intricate epigenetic pathway where Hdac3 is required to repress miR-17-92 expression to allow for proper TGF-beta (show TGFB1 Proteins) signaling during lung sacculation
Bach2 (show BACH2 Proteins) is suggested to cooperate with HDAC3-containing co-repressor complexes in B cells to regulate the stage-specific expression of Prdm1 (show PRDM1 Proteins) by writing epigenetic modifications at the Prdm1 (show PRDM1 Proteins) locus.
Hdac3 cooperates with p300 (show NOTCH1 Proteins) to prime and maintain oligodendrocyte identity
Wild-type HDAC3 or catalytically inactive HDAC3 expression rescues aberrant endothelial-to-mesenchymal transition and epigenetic silencing of Tgf-beta1 (show TGFB1 Proteins) in HDAC3-null outflow tracts and semilunar valves.
Study shows that conditional deletion of an epigenetic regulator, Hdac3, in osteoblast progenitor cells abrogates high fat diet-induced insulin (show INS Proteins) resistance and hepatic steatosis. These Hdac3-deficient mice have reduced bone formation and lower circulating levels of total and undercarboxylated osteocalcin (show BGLAP Proteins), coupled with decreased bone resorption activity.
These studies provide the first evidence for localization of HDAC3 at myofilaments and uncover a novel mechanism modulating the motor activity of cardiac MHC isoforms.
The study examined the physiological roles of Hdac3 by deletion of this gene during early thymocyte development using Lck (show LCK Proteins)-Cre.
Results showed that the expression levels of HDAC1 (show HDAC1 Proteins) and 3 are decreased gradually during embryonic stem cells (ESCs (show NR2E3 Proteins)) mesodermal differentiation and interact physically with Bry protein, which is critical for mesodermal lineage commitment.
These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 (show HDAC1 Proteins) and hdac3 in zebrafish embryonic development.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
, histone Deacetylase-3
, histone deacetylase 3
, HDAC3 splicing HDAC3alpha
, HDAC3 splicing HDAC3beta
, HDAC3 splicing HDAC3delta
, HDAC3 splicing HDAC3gamma
, histone deacetylase-3