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Browse our HDAC3 Proteins (HDAC3)

Full name:
Histone Deacetylase 3 Proteins (HDAC3)
On are 21 Histone Deacetylase 3 (HDAC3) Proteins from 9 different suppliers available. Additionally we are shipping HDAC3 Antibodies (238) and HDAC3 Kits (25) and many more products for this protein. A total of 306 HDAC3 products are currently listed.
AW537363, CG2128, dHDAC3, Dmel\\CG2128, dmHDA402, DmHDAC3, Dromel_CG2128_FBtr0078767_hdac3_mORF, HD3, HDAC, Hdac 3, hdac3, HDm, RPD3, RPD3-2, XRpd3, zgc:55927
list all proteins Gene Name GeneID UniProt
HDAC3 8841 O15379
HDAC3 84578 Q6P6W3
HDAC3 15183  

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HDAC3 Proteins (HDAC3) by Origin

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Top referenced HDAC3 Proteins

  1. Human HDAC3 Protein expressed in Baculovirus infected Insect Cells - ABIN2004315 : Pajerowski, Nguyen, Aghajanian, Shapiro, Shapiro: NKAP is a transcriptional repressor of notch signaling and is required for T cell development. in Immunity 2009 (PubMed)
    Show all 4 references for ABIN2004315

  2. Human HDAC3 Protein expressed in Wheat germ - ABIN1306448 : Jiang, Ye, Guo, Lu, Gao: Inhibition of HDAC3 promotes ligand-independent PPAR? activation by protein acetylation. in Journal of molecular endocrinology 2014 (PubMed)

More Proteins for HDAC3 Interaction Partners

Fruit Fly (Drosophila melanogaster) Histone Deacetylase 3 (HDAC3) interaction partners

  1. Brm (show SMARCA2 Proteins)-HDAC3-Erm (show MSN Proteins) repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.

  2. Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.

  3. Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X (show FMR1 Proteins) tremor ataxia (show USP14 Proteins) syndrome.

  4. ) DHDAC1 (show HDAC1 Proteins) and -3 have distinct functions in the control of gene expression

  5. Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.

Human Histone Deacetylase 3 (HDAC3) interaction partners

  1. HDAC3 upregulation is associated with hepatocellular carcinoma.

  2. High HDAC3 expression is associated with pancreatic cancer.

  3. These findings pinpoint that TGF-beta (show TGFB1 Proteins) represses miR (show MLXIP Proteins)-30d through a Smad2 (show SMAD2 Proteins)/3-HDAC3-NCoR (show NCOR1 Proteins) repression complex and provide novel insights into a potential target for the treatment of podocyte injury-associated glomerulopathies.

  4. Results show the direct regulation of CAGE expression by HDAC3 and that HDAC3-CAGE axis regulates the activation of EGFR (show EGFR Proteins). HDAC3 targets CAGE to regulate the tumorigenic potential and angiogenic potential of cancer cells.

  5. HDAC3 knockdown or HDAC3 inhibition was associated with simultaneous upregulation of the expression of miR130a and downregulation of the expression of TNF1alpha in peripheral blood mononuclear cells.

  6. Data suggest that complexes of HDAC3-H1.3 with NCOR1 and NCOR2/SMRT accumulate on chromatin in synchronized HeLa cells in late G2 phase and mitosis; deacetylation activity of HDAC3 is activated via phosphorylation of Ser-424 by CK2 only in mitosis.

  7. this is the first report on the regulation mechanism of SIRT7 (show SIRT7 Proteins) gene, in which, HDAC3 collaborated with C/EBPalpha (show CEBPA Proteins) to occupy its responding element in the upstream region of SIRT7 (show SIRT7 Proteins) gene and repressed its expression in human cells.

  8. Among the class II HDACs, HDAC4 (show HDAC4 Proteins) interacted with both MR and HDAC3 after aldosterone stimulation. The nuclear translocation of HDAC4 (show HDAC4 Proteins) was mediated by protein kinase A (PKA) and protein phosphatases (PP)

  9. miR (show MLXIP Proteins)-335 exerted apoptotic effects and inhibited ubiquitination of HDAC3 in anti-cancer drug-resistant cancer cell lines. miR (show MLXIP Proteins)-335 negatively regulated the invasion, migration, and growth rate of cancer cells.

  10. ZBP-89 (show ZNF148 Proteins) attenuates HDAC3 by increasing IkappaB degradation, dependent on Pin1 (show PIN1 Proteins) but independent of NF-Kappab (show NFKB1 Proteins)

Mouse (Murine) Histone Deacetylase 3 (HDAC3) interaction partners

  1. Hdac3 induces an medullary thymic epithelial cells-specific transcriptional program.

  2. concurrent declines in transcription and phosphorylation combine to suppress Hdac3 activity in aging bone, and reduced Hdac3 activity in osteochondroprogenitor cells contributes to increased marrow adiposity associated with aging.

  3. HDAC3 is required for efficient activation of E-box-driven gene expression, blocks CRY1 (show CRY1 Proteins) degradation and promotes BMAL1 (show ARNTL Proteins) and CRY1 (show CRY1 Proteins) association.

  4. GC-induced direct repression, but not bindings of GR and of corepressors NCoR1 (show NCOR1 Proteins)/SMRT, was abolished, indicating that HDAC3 is instrumental in IR nGRE-mediated repression

  5. GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1 (show NCOR1 Proteins)-HDAC3 repressing complex, which is indispensable for NF-kappaB (show NFKB1 Proteins)/AP1 (show JUN Proteins)-mediated GC-induced tethered indirect transrepression in vitro

  6. studies reveal an intricate epigenetic pathway where Hdac3 is required to repress miR-17-92 expression to allow for proper TGF-beta (show TGFB1 Proteins) signaling during lung sacculation

  7. Bach2 (show BACH2 Proteins) is suggested to cooperate with HDAC3-containing co-repressor complexes in B cells to regulate the stage-specific expression of Prdm1 (show PRDM1 Proteins) by writing epigenetic modifications at the Prdm1 (show PRDM1 Proteins) locus.

  8. Hdac3 cooperates with p300 (show NOTCH1 Proteins) to prime and maintain oligodendrocyte identity

  9. Wild-type HDAC3 or catalytically inactive HDAC3 expression rescues aberrant endothelial-to-mesenchymal transition and epigenetic silencing of Tgf-beta1 (show TGFB1 Proteins) in HDAC3-null outflow tracts and semilunar valves.

  10. Study shows that conditional deletion of an epigenetic regulator, Hdac3, in osteoblast progenitor cells abrogates high fat diet-induced insulin (show INS Proteins) resistance and hepatic steatosis. These Hdac3-deficient mice have reduced bone formation and lower circulating levels of total and undercarboxylated osteocalcin (show BGLAP Proteins), coupled with decreased bone resorption activity.

Zebrafish Histone Deacetylase 3 (HDAC3) interaction partners

  1. These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 (show HDAC1 Proteins) and hdac3 in zebrafish embryonic development.

Xenopus laevis Histone Deacetylase 3 (HDAC3) interaction partners

HDAC3 Protein Profile

Protein Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Alternative names and synonyms associated with HDAC3

  • Histone deacetylase 3 (Hdac3)
  • histone deacetylase 3 (hdac3)
  • histone deacetylase 3 (CNL05260)
  • histone deacetylase 3 (HDAC3)
  • histone deacetylase 3 (Hdac3)
  • histone deacetylase 3-like (LOC100354595)
  • AW537363 protein
  • CG2128 protein
  • dHDAC3 protein
  • Dmel\\CG2128 protein
  • dmHDA402 protein
  • DmHDAC3 protein
  • Dromel_CG2128_FBtr0078767_hdac3_mORF protein
  • HD3 protein
  • HDAC protein
  • Hdac 3 protein
  • hdac3 protein
  • HDm protein
  • RPD3 protein
  • RPD3-2 protein
  • XRpd3 protein
  • zgc:55927 protein

Protein level used designations for Histone Deacetylase 3 Proteins (HDAC3)

CG2128-PA , Hdac3-PA , histone Deacetylase-3 , histone deacetylase 3 , SMAP45 , HD3 , HDAC3 splicing HDAC3alpha , HDAC3 splicing HDAC3beta , HDAC3 splicing HDAC3delta , HDAC3 splicing HDAC3gamma , histone deacetylase-3

44446 Drosophila melanogaster
549637 Xenopus (Silurana) tropicalis
3254867 Cryptococcus neoformans var. neoformans JEC21
8841 Homo sapiens
478040 Canis lupus familiaris
84578 Rattus norvegicus
15183 Mus musculus
395506 Gallus gallus
393965 Danio rerio
404125 Bos taurus
100718985 Cavia porcellus
100511372 Sus scrofa
101107092 Ovis aries
100172482 Pongo abelii
432017 Xenopus laevis
100354595 Oryctolagus cuniculus
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