Browse our HDAC3 Proteins (HDAC3)

Full name:
Histone Deacetylase 3 Proteins (HDAC3)
On are 20 Histone Deacetylase 3 (HDAC3) Proteins from 8 different suppliers available. Additionally we are shipping HDAC3 Antibodies (253) and HDAC3 Kits (28) and many more products for this protein. A total of 325 HDAC3 products are currently listed.
AW537363, CG2128, dHDAC3, Dmel\\CG2128, dmHDA402, DmHDAC3, Dromel_CG2128_FBtr0078767_hdac3_mORF, HD3, HDAC, Hdac 3, hdac3, HDm, RPD3, RPD3-2, XRpd3, zgc:55927
list all proteins Gene Name GeneID UniProt
HDAC3 8841 O15379
HDAC3 84578 Q6P6W3
HDAC3 15183  

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HDAC3 Proteins (HDAC3) by Origin

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Top referenced HDAC3 Proteins

  1. Human HDAC3 Protein expressed in Baculovirus infected Insect Cells - ABIN2004315 : Pajerowski, Nguyen, Aghajanian, Shapiro, Shapiro: NKAP is a transcriptional repressor of notch signaling and is required for T cell development. in Immunity 2009 (PubMed)
    Show all 4 references for 2004315

  2. Human HDAC3 Protein expressed in Wheat germ - ABIN1306448 : Jiang, Ye, Guo, Lu, Gao: Inhibition of HDAC3 promotes ligand-independent PPAR? activation by protein acetylation. in Journal of molecular endocrinology 2014 (PubMed)

More Proteins for HDAC3 Interaction Partners

Fruit Fly (Drosophila melanogaster) Histone Deacetylase 3 (HDAC3) interaction partners

  1. Brm (show SMARCA2 Proteins)-HDAC3-Erm (show MSN Proteins) repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.

  2. Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.

  3. Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X (show FMR1 Proteins) tremor ataxia (show USP14 Proteins) syndrome.

  4. ) DHDAC1 (show HDAC1 Proteins) and -3 have distinct functions in the control of gene expression

  5. Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.

Human Histone Deacetylase 3 (HDAC3) interaction partners

  1. Inhibition of HDAC3 with targeted therapy could benefit treatment of the diseases associated with sGCbeta1 down-regulation and/or deficiency such as cancer and several vascular-related diseases.

  2. that histone deacetylase 3 interaction with MeCP2 (show MECP2 Proteins) positively regulates a subset of neuronal genes through FOXO (show FOXO3 Proteins) deacetylation, and disruption of HDAC3 contributes to cognitive and social impairment

  3. provide evidence to show that CBX4 (show CBX4 Proteins) may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 to the Runx2 (show RUNX2 Proteins) promoter to impede Runx2 (show RUNX2 Proteins) expression

  4. miRNA1236 regulates hypoxia-induced epithelial-mesenchymal transformation and metastasis by repressing HDAC3 and SENP1 (show SENP1 Proteins) expression.

  5. class I HDACs (HDAC1 (show HDAC1 Proteins), 2, 3 and 8) play a major role in regulating extracellular matrix and Epithelial-mesenchymal transition, whereas class IIa HDACs (HDAC4 (show HDAC4 Proteins) and 5) are less effective.

  6. Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.

  7. Study demonstrated an association of elevated HDAC3 activity and HDAC3 mRNA expression in patients with type 2 diabetes (T2DM) which was positively correlated with proinflammation and insulin (show INS Proteins) resistance.

  8. HDAC3 upregulation is associated with hepatocellular carcinoma.

  9. High HDAC3 expression is associated with pancreatic cancer.

  10. These findings pinpoint that TGF-beta (show TGFB1 Proteins) represses miR (show MLXIP Proteins)-30d through a Smad2 (show SMAD2 Proteins)/3-HDAC3-NCoR (show NCOR1 Proteins) repression complex and provide novel insights into a potential target for the treatment of podocyte injury-associated glomerulopathies.

Mouse (Murine) Histone Deacetylase 3 (HDAC3) interaction partners

  1. depletion of the epigenome modifier histone deacetylase 3 (HDAC3) specifically in skeletal muscle causes severe systemic insulin (show INS Proteins) resistance in mice but markedly enhances endurance and resistance to muscle fatigue, despite reducing muscle force. This is due to lower glucose utilization and greater lipid oxidation in HDAC3-depleted muscles, a fuel switch caused by the activation of anaplerotic reactions driven by Ampd3 (show AMPD3 Proteins).

  2. Mice lacking Hdac 3 specifically in the developing lung mesenchyme display lung hypoplasia including decreased mesenchymal proliferation and a severe impairment of AT1 (show SLC33A1 Proteins) cell differentiation. This is correlated with a decrease in Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in the lung epithelium.

  3. that histone deacetylase 3 interaction with MeCP2 (show MECP2 Proteins) positively regulates a subset of neuronal genes through FOXO (show FOXO3 Proteins) deacetylation, and disruption of HDAC3 contributes to cognitive and social impairment

  4. we found that histone deacetylase (HDAC (show HDAC1 Proteins)) 3 is required for T cell development

  5. Hdac3 controls the temporal and spatial expression of tissue-remodeling genes in chondrocytes to ensure proper endochondral ossification during development.

  6. These results demonstrate that HDAC3 and SCAP control symbiotic pathways of liver lipid metabolism that are critical for suppression of lipotoxicity.

  7. The study describes an interaction network of STAT5a (show STAT5A Proteins)/LSD1 (show KDM1A Proteins)/HDAC3 and a dual function of LSD1 (show KDM1A Proteins)/HDAC3 on STAT5a (show STAT5A Proteins)-dependent transcription, defined by protein-protein interactions, genomic binding localization/affinity and motifs.

  8. Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.

  9. The present study provides the first critical in vivo evidence showing a causal link between epigenetic modification of miR (show MLXIP Proteins)-10a mediated by HDAC3 and the development of diabetic nephropathy, and these results elucidate that HDAC3/miR (show MLXIP Proteins)-10a/CREB1 (show CREB1 Proteins) serves as a new mechanism underlying kidney injury, providing potential therapeutic targets in type 2 diabetes

  10. Hdac3 induces an medullary thymic epithelial cells-specific transcriptional program.

Zebrafish Histone Deacetylase 3 (HDAC3) interaction partners

  1. These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 (show HDAC1 Proteins) and hdac3 in zebrafish embryonic development.

Xenopus laevis Histone Deacetylase 3 (HDAC3) interaction partners

HDAC3 Protein Profile

Protein Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Alternative names and synonyms associated with HDAC3

  • Histone deacetylase 3 (Hdac3)
  • histone deacetylase 3 (hdac3)
  • histone deacetylase 3 (CNL05260)
  • histone deacetylase 3 (HDAC3)
  • histone deacetylase 3 (Hdac3)
  • histone deacetylase 3-like (LOC100354595)
  • AW537363 protein
  • CG2128 protein
  • dHDAC3 protein
  • Dmel\\CG2128 protein
  • dmHDA402 protein
  • DmHDAC3 protein
  • Dromel_CG2128_FBtr0078767_hdac3_mORF protein
  • HD3 protein
  • HDAC protein
  • Hdac 3 protein
  • hdac3 protein
  • HDm protein
  • RPD3 protein
  • RPD3-2 protein
  • XRpd3 protein
  • zgc:55927 protein

Protein level used designations for Histone Deacetylase 3 Proteins (HDAC3)

CG2128-PA , Hdac3-PA , histone Deacetylase-3 , histone deacetylase 3 , SMAP45 , HD3 , HDAC3 splicing HDAC3alpha , HDAC3 splicing HDAC3beta , HDAC3 splicing HDAC3delta , HDAC3 splicing HDAC3gamma , histone deacetylase-3

44446 Drosophila melanogaster
549637 Xenopus (Silurana) tropicalis
3254867 Cryptococcus neoformans var. neoformans JEC21
8841 Homo sapiens
478040 Canis lupus familiaris
84578 Rattus norvegicus
15183 Mus musculus
395506 Gallus gallus
393965 Danio rerio
404125 Bos taurus
100718985 Cavia porcellus
100511372 Sus scrofa
101107092 Ovis aries
100172482 Pongo abelii
432017 Xenopus laevis
100354595 Oryctolagus cuniculus
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