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Human HDAC3 Protein expressed in Wheat germ - ABIN1306448
Jiang, Ye, Guo, Lu, Gao: Inhibition of HDAC3 promotes ligand-independent PPAR? activation by protein acetylation. in Journal of molecular endocrinology 2014
Brm (show SMARCA2 Proteins)-HDAC3-Erm (show MSN Proteins) repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts.
Hdac3 served as an important regulator of the PI3K pathway and revealed a novel link between histone acetylation and growth control.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
) DHDAC1 (show HDAC1 Proteins) and -3 have distinct functions in the control of gene expression
Mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid.
The low expression of HDAC3 and overexpession of inflammatory cytokines (IL-18 (show IL18 Proteins), IL-12 (show IL12A Proteins) and TNF-alpha (show TNF Proteins)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
SNP rs14251 was found to be significant (and rs2530223 to be nominally significantly associated with the increasing risk of SCZ susceptibility in Han Chinese individuals, suggesting this gene as a potential genetic modifier for SCZ development.
Inhibition of HDAC3 with targeted therapy could benefit treatment of the diseases associated with sGCbeta1 down-regulation and/or deficiency such as cancer and several vascular-related diseases.
that histone deacetylase 3 interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (show FOXO3 Proteins) deacetylation, and disruption of HDAC3 contributes to cognitive and social impairment
provide evidence to show that CBX4 (show CBX4 Proteins) may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 to the Runx2 (show RUNX2 Proteins) promoter to impede Runx2 (show RUNX2 Proteins) expression
miRNA1236 regulates hypoxia-induced epithelial-mesenchymal transformation and metastasis by repressing HDAC3 and SENP1 (show SENP1 Proteins) expression.
class I HDACs (HDAC1 (show HDAC1 Proteins), 2, 3 and 8) play a major role in regulating extracellular matrix and Epithelial-mesenchymal transition, whereas class IIa HDACs (HDAC4 (show HDAC4 Proteins) and 5) are less effective.
Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.
Study demonstrated an association of elevated HDAC3 activity and HDAC3 mRNA expression in patients with type 2 diabetes (T2DM) which was positively correlated with proinflammation and insulin (show INS Proteins) resistance.
HDAC3 upregulation is associated with hepatocellular carcinoma.
Co-regulation of H3K9ac by HDAC1 (show HDAC1 Proteins) and HDAC3 is important to both embryonic brain development and neuro-differentiation.
depletion of the epigenome modifier histone deacetylase 3 (HDAC3) specifically in skeletal muscle causes severe systemic insulin (show INS Proteins) resistance in mice but markedly enhances endurance and resistance to muscle fatigue, despite reducing muscle force. This is due to lower glucose utilization and greater lipid oxidation in HDAC3-depleted muscles, a fuel switch caused by the activation of anaplerotic reactions driven by Ampd3 (show AMPD3 Proteins).
Mice lacking Hdac 3 specifically in the developing lung mesenchyme display lung hypoplasia including decreased mesenchymal proliferation and a severe impairment of AT1 (show SLC33A1 Proteins) cell differentiation. This is correlated with a decrease in Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in the lung epithelium.
we found that histone deacetylase (HDAC (show HDAC1 Proteins)) 3 is required for T cell development
Hdac3 controls the temporal and spatial expression of tissue-remodeling genes in chondrocytes to ensure proper endochondral ossification during development.
These results demonstrate that HDAC3 and SCAP control symbiotic pathways of liver lipid metabolism that are critical for suppression of lipotoxicity.
The study describes an interaction network of STAT5a (show STAT5A Proteins)/LSD1 (show KDM1A Proteins)/HDAC3 and a dual function of LSD1 (show KDM1A Proteins)/HDAC3 on STAT5a (show STAT5A Proteins)-dependent transcription, defined by protein-protein interactions, genomic binding localization/affinity and motifs.
Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.
The present study provides the first critical in vivo evidence showing a causal link between epigenetic modification of miR (show MLXIP Proteins)-10a mediated by HDAC3 and the development of diabetic nephropathy, and these results elucidate that HDAC3/miR (show MLXIP Proteins)-10a/CREB1 (show CREB1 Proteins) serves as a new mechanism underlying kidney injury, providing potential therapeutic targets in type 2 diabetes
These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 (show HDAC1 Proteins) and hdac3 in zebrafish embryonic development.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
, histone Deacetylase-3
, histone deacetylase 3
, HDAC3 splicing HDAC3alpha
, HDAC3 splicing HDAC3beta
, HDAC3 splicing HDAC3delta
, HDAC3 splicing HDAC3gamma
, histone deacetylase-3