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Immunohistochemistry and histological and morphometric analyses revealed a twofold increase in proliferative endothelial cells and a 1.35-fold increase in proliferative alpha-smooth muscle actin (show ACTG2 ELISA Kits)-positive cells in the lungs of ITSN-deficient mice.
PRRT2 interacts with the Src (show SRC ELISA Kits) homology 3 domain-bearing protein Intersectin 1, an intracellular protein (show CKAP2 ELISA Kits) involved in synaptic vesicle cycling.
Endocytic deficiency caused by ITSN knock-down modified Alk5 (show TGFBR1 ELISA Kits) endocytic trafficking and enhances its degradation
It was concluded that miR (show MLXIP ELISA Kits)-194 regulates ROMK (show KCNJ1 ELISA Kits) channel activity by modulating ITSN1 expression thereby enhancing ITSN1/WNK-dependent endocytosis.
ITSN1 enhances Cbl (show CBL ELISA Kits) activity, in part, by modulating the interaction of Cbl (show CBL ELISA Kits) with Spry2 (show SPRY2 ELISA Kits) through recruitment of Shp2 (show PTPN11 ELISA Kits) phosphatase to the Cbl (show CBL ELISA Kits)-Spry2 (show SPRY2 ELISA Kits) complex.
This study demonistrated that Itsn1 mutant mice showed severe deficits in Morris water maze and contextual fear memory tasks.
ITSN1 binds Pro-rich regions in both Cbl (show CBL ELISA Kits) and Spry2 (show SPRY2 ELISA Kits), and interaction of ITSN1 with Spry2 (show SPRY2 ELISA Kits) disrupts Spry2 (show SPRY2 ELISA Kits)-Cbl (show CBL ELISA Kits) interaction, resulting in enhanced ubiquitylation of the EGFR (show EGFR ELISA Kits).
Data show that intersectin-SH3D interacts directly with a small region of CdGAP highly enriched in basic residues and comprising a novel conserved xKx(K/R)K motif.
Swapping of SH3 domain binding partners might act as a switch controlling the actin nucleation activity of intersectin 1L.
Cdc42 (show CDC42 ELISA Kits) and Ras cooperate to mediate cellular transformation by intersectin-L
Silencing ITSN1 in neuroblastoma (show ARHGEF16 ELISA Kits) cells led to decreased tumor growth in an orthotopic mouse model. Orthotopic animal models can provide insight into the role of ITSN1 pathways in neuroblastoma (show ARHGEF16 ELISA Kits) tumorigenesis.
These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.
Study suggests critical roles of ITSN1-S in malignant glioma proliferation, indicating a potential usage of ITSN1-S in the therapeutic intervention as a novel molecular target
Our observations suggest that ITSN1 is an important general regulator of Cdc42-, Nck- and N-WASP-dependent actin polymerisation
ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
Silencing ITSN1 significantly inhibits the anchorage independent growth of tumor cells in vitro.
the neuron-specific isoform of the stable tubule-only polypeptide (show MAP6 ELISA Kits) (STOP) interacts with SH3A domain of ITSN1.
ITSN-1s, via its SH3A domain has the unique ability to regulate dyn2 (show DNM2 ELISA Kits) assembly-disassembly and function during endocytosis
ITSN1 has two isoforms: ITSN1-long and ITSN1-short. siRNA-mediated down regulation of ITSN1-short inhibits migration and invasion of glioma cells.
study reveals a link between overexpression of specific ITSN1 isoforms and behavioral phenotypes
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
, intersectin 1
, intersectin 1, isoform 1
, EH and SH3 domains protein 1
, Eh domain, SH3 domain regulator of endocytosis 1
, intersectin (SH3 domain protein 1A)
, intersectin short form 2 variant 2
, SH3 domain-containing protein 1A
, Src homology 3 domain-containing protein
, human intersectin-SH3 domain-containing protein SH3P17
, intersectin 1 short form variant 3
, intersectin 1 short form variant, 11
, intersectin short variant 12
, EH domain and SH3 domain regulator of endocytosis 1
, intersectin 1 (SH3 domain protein 1A)