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Browse our CD40 Ligand Proteins (CD40LG)

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CD40 Ligand Proteins (CD40LG)
On are 122 CD40 Ligand (CD40LG) Proteins from 24 different suppliers available. Additionally we are shipping CD40 Ligand Antibodies (653) and CD40 Ligand Kits (99) and many more products for this protein. A total of 897 CD40 Ligand products are currently listed.
CD40-L, Cd40l, CD154, gp39, hCD40L, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, Tnfsf5, TRAP
list all proteins Gene Name GeneID UniProt
CD40LG 959 P29965
CD40LG 21947 P27548
CD40LG 84349 Q9Z2V2

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CD40 Ligand Proteins (CD40LG) by Origin

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Top referenced CD40 Ligand Proteins

  1. Human CD40 Ligand Protein expressed in HEK-293 - ABIN2666789 : Davidson, Hirschman, Sun, Singh, Kasischke, Maggirwar: Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders. in PLoS ONE 2012 (PubMed)
    Show all 7 references for ABIN2666789

  2. Rat (Rattus) CD40 Ligand Protein expressed in Human Cells - ABIN2009254 : Korthäuer, Graf, Mages, Brière, Padayachee, Malcolm, Ugazio, Notarangelo, Levinsky, Kroczek: Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. in Nature 1993 (PubMed)
    Show all 4 references for ABIN2009254

  3. Mouse (Murine) CD40 Ligand Protein expressed in Human Cells - ABIN2007673 : Seyama, Nonoyama, Gangsaas, Hollenbaugh, Pabst, Aruffo, Ochs: Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome. in Blood 1998 (PubMed)
    Show all 4 references for ABIN2007673

  4. Dog (Canine) CD40 Ligand Protein expressed in Human Cells - ABIN2008913 : Lin, Rohrer, Allen, Larché, Greene, Shigeoka, Gatti, Derauf, Belmont, Conley: A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome. in The Journal of clinical investigation 1996 (PubMed)
    Show all 4 references for ABIN2008913

  5. Cynomolgus CD40 Ligand Protein expressed in Human Cells - ABIN2009828 : Khandekar, Silverman, Wells-Marani, Bacon, Birrell, Brigham-Burke, DeMarini, Jonak, Camilleri, Fishman-Lobell: Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells. in Protein expression and purification 2001 (PubMed)
    Show all 4 references for ABIN2009828

More Proteins for CD40 Ligand Interaction Partners

Chimpanzee CD40 Ligand (CD40LG) interaction partners

  1. specific cross-linking with trimeric recombinant HIV-1 gp140 revealed reduced sensitivity for inhibition of CD154 up-regulation in chimpanzees, requiring fourfold higher concentrations of viral protein

Atlantic Salmon (Salmo salar) CD40 Ligand (CD40LG) interaction partners

  1. identification and functional characterization of CD40L and CD40 (show CD40 Proteins) from Atlantic salmon (Salmo salar); results provide evidence for the existence of a functional CD40L mediated costimulatory pathway in Atlantic salmon

Human CD40 Ligand (CD40LG) interaction partners

  1. Primary Aldosteronism is related to platelet activation, expressed as higher plasma values of soluble CD40L and soluble P-selectin (show SELP Proteins) values.

  2. Overexpression of CD154 on CD4 (show CD4 Proteins)(+)T cells is unlikely to be central to the pathogenesis of idopathic thrombocytopenic purpura, and other immune dysfunctions should be targeted for therapy purposes.

  3. the serum levels of the soluble factors sCD40L and CXCL1 (show CXCL1 Proteins) are not associated with endometriosis and are not suitable as biomarkers for disease diagnosis.

  4. Increased sCD40L plasma levels are associated with the presence of insulin (show INS Proteins) resistance and not the state of glucose tolerance.

  5. It is likely that the CD40 (show CD40 Proteins)/CD40L interactions and TNF alpha (show TNF Proteins) are effective against cervical carcinomas by repressing transcriptional activity of human papilloma virus-18 promoter.

  6. we report that Kv1.3 (show KCNA3 Proteins)-NPs (show NPS Proteins) reduced NFAT (show NFATC1 Proteins) activation and CD40L expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3 (show KCNA3 Proteins)-NPs (show NPS Proteins) suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive.

  7. mCD40L-induced cell death mediated by NORE1A (show RASSF5 Proteins) expression appeared to be independent of mCD40L-induced cell death mediated by sustained JNK (show MAPK8 Proteins) activation since NORE1A (show RASSF5 Proteins) inhibition did not affect JNK (show MAPK8 Proteins) phosphorylation and vice versa

  8. CD40 (show CD40 Proteins)/CD40L system plays a role in regulating bone mineral density.

  9. diagnostic value of soluble CD40 ligand (sCD40L) and vascular endothelial growth factor (VEGF) for Alzheimer's disease

  10. Study allows identify significant different genetic heterogeneity between two investigated populations (France and Tunisia) and revealed discrepancies in the prevalence of CD40LG polymorphisms that may be explained by ethnic and geographic differences.

Mouse (Murine) CD40 Ligand (CD40LG) interaction partners

  1. Platelets promote allergic asthma through the expression of CD154.

  2. CD40L does not play a functional role in experimental acute pancreatitis

  3. The tissue-specific, activation-dependent and reversible expression of CD40L fully mimics the physiological induction and disappearance of the molecule from the surface of murine T lymphocytes.

  4. there is a major involvement of the CD40 (show CD40 Proteins)-CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis.

  5. Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases.

  6. although treated CD40 (show CD40 Proteins) knockout mice remained healed, developed long-term immunity, and were resistant to secondary Leishmania major challenge, treated CD40L knockout reactivated their lesion after cessation of rIL (show PDLIM4 Proteins)-12 treatment.

  7. PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development.

  8. Anti-OX40L (show TNFSF4 Proteins) mAb could prolong secondary heart allograft survival based on CD40 (show CD40 Proteins)/CD40L and LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) blockade.

  9. CD40 (show CD40 Proteins) on lymph node fibroblasts facilitated bidirectional communication with CD4 (show CD4 Proteins)(+) T cells via CD40 (show CD40 Proteins)-CD40L, thereby altering fibroblast gene expression of immune regulatory molecules.

  10. CD40L mediates neointima formation via its classic receptor CD40 (show CD40 Proteins) rather than via its recently described novel interaction with Mac-1 (show ITGAM Proteins).

Pig (Porcine) CD40 Ligand (CD40LG) interaction partners

  1. CD40 ligand has a role in inducing endothelial dysfunction in human and porcine coronary artery endothelial cells

Cow (Bovine) CD40 Ligand (CD40LG) interaction partners

  1. Results demonstrated greater CD40 (show CD40 Proteins) and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.

Rhesus Monkey CD40 Ligand (CD40LG) interaction partners

  1. Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells.

CD40 Ligand (CD40LG) Protein Profile

Protein Summary

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.

Alternative names and synonyms associated with CD40 Ligand (CD40LG)

  • CD40 ligand (CD40LG)
  • CD40 ligand (cd40l)
  • TNF superfamily member 5 (cd40l)
  • CD40 ligand (Cd40lg)
  • CD40 ligand (LOC100358388)
  • CD40 ligand (CD154)
  • CD40-L protein
  • Cd40l protein
  • CD154 protein
  • gp39 protein
  • hCD40L protein
  • HIGM1 protein
  • IGM protein
  • IMD3 protein
  • Ly-62 protein
  • Ly62 protein
  • T-BAM protein
  • Tnfsf5 protein
  • TRAP protein

Protein level used designations for CD40 Ligand Proteins (CD40LG)

CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) , CD40 ligand , TNF superfamily member 5 , CD40 antigen ligand , CD40-L , T-B cell-activating molecule , T-cell antigen Gp39 , TNF-related activation protein , tumor necrosis factor (ligand) superfamily member 5 , tumor necrosis factor ligand superfamily member 5 , CD40 ligand CD154 , tumor necrosis factor (ligand) superfamily, member 5 , human : hyper-IgM syndrome , uncharacterized protein LOC100358388 , putative CD154 (CD40 ligand) , CD154 protein

473802 Pan troglodytes
100286596 Salmo salar
100136698 Oncorhynchus mykiss
959 Homo sapiens
21947 Mus musculus
84349 Rattus norvegicus
397231 Sus scrofa
403468 Canis lupus familiaris
282387 Bos taurus
100358388 Oryctolagus cuniculus
100733664 Cavia porcellus
493850 Felis catus
395485 Gallus gallus
767628 Ovis aries
574160 Macaca mulatta
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