Browse our CD40 Ligand Proteins (CD40LG)

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CD40 Ligand Proteins (CD40LG)
On are 135 CD40 Ligand (CD40LG) Proteins from 24 different suppliers available. Additionally we are shipping CD40 Ligand Antibodies (669) and CD40 Ligand Kits (95) and many more products for this protein. A total of 922 CD40 Ligand products are currently listed.
CD40-L, Cd40l, CD154, gp39, hCD40L, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, Tnfsf5, TRAP
list all proteins Gene Name GeneID UniProt
CD40LG 959 P29965
CD40LG 21947 P27548
CD40LG 84349 Q9Z2V2

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CD40 Ligand Proteins (CD40LG) by Origin

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Top referenced CD40 Ligand Proteins

  1. Human CD40 Ligand Protein expressed in HEK-293 - ABIN2666789 : Davidson, Hirschman, Sun, Singh, Kasischke, Maggirwar: Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders. in PLoS ONE 2012 (PubMed)
    Show all 7 references for 2666789

  2. Dog (Canine) CD40 Ligand Protein expressed in Human Cells - ABIN2008913 : Korthäuer, Graf, Mages, Brière, Padayachee, Malcolm, Ugazio, Notarangelo, Levinsky, Kroczek: Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. in Nature 1993 (PubMed)
    Show all 4 references for 2008913

  3. Human CD40 Ligand Protein expressed in Human Cells - ABIN2002415 : Seyama, Nonoyama, Gangsaas, Hollenbaugh, Pabst, Aruffo, Ochs: Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome. in Blood 1998 (PubMed)
    Show all 4 references for 2002415

  4. Human CD40 Ligand Protein expressed in Escherichia coli (E. coli) - ABIN2002417 : Lin, Rohrer, Allen, Larché, Greene, Shigeoka, Gatti, Derauf, Belmont, Conley: A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome. in The Journal of clinical investigation 1996 (PubMed)
    Show all 4 references for 2002417

  5. Mouse (Murine) CD40 Ligand Protein expressed in Human Cells - ABIN2007673 : Khandekar, Silverman, Wells-Marani, Bacon, Birrell, Brigham-Burke, DeMarini, Jonak, Camilleri, Fishman-Lobell: Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells. in Protein expression and purification 2001 (PubMed)
    Show all 4 references for 2007673

  6. Human CD40 Ligand Protein expressed in CHO Cells - ABIN1344289 : Holler, Tardivel, Kovacsovics-Bankowski, Hertig, Gaide, Martinon, Tinel, Deperthes, Calderara, Schulthess, Engel, Schneider, Tschopp: Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. in Molecular and cellular biology 2003 (PubMed)
    Show all 3 references for 1344289

  7. Human CD40 Ligand Protein expressed in CHO Cells - ABIN1344285 : Guarda, Dostert, Staehli, Cabalzar, Castillo, Tardivel, Schneider, Tschopp: T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. in Nature 2009 (PubMed)
    Show all 2 references for 1344285

More Proteins for CD40 Ligand Interaction Partners

Chimpanzee CD40 Ligand (CD40LG) interaction partners

  1. specific cross-linking with trimeric recombinant HIV-1 gp140 revealed reduced sensitivity for inhibition of CD154 up-regulation in chimpanzees, requiring fourfold higher concentrations of viral protein

Atlantic Salmon (Salmo salar) CD40 Ligand (CD40LG) interaction partners

  1. identification and functional characterization of CD40L and CD40 (show CD40 Proteins) from Atlantic salmon (Salmo salar); results provide evidence for the existence of a functional CD40L mediated costimulatory pathway in Atlantic salmon

Human CD40 Ligand (CD40LG) interaction partners

  1. studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (show CCR3 Proteins) signaling

  2. data suggest that therapeutic CD40 (show CD40 Proteins)-CD40L blocking agents may prove efficacious not only in early and established rheumatoid arthritis (RA), but also in inhibiting the progression of the disease from arthralgia or undifferentiated arthritis to RA

  3. CD40 (show CD40 Proteins) activation resulted in down-regulation of Thioredoxin (Trx)-1 (show TXN Proteins) to permit ASK1 (show MAP3K5 Proteins) activation and apoptosis. Although soluble receptor (show IFNAR1 Proteins) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 (show CD40 Proteins) agonist and pharmacological inhibition of Trx-1 (show MLL Proteins) was functionally equivalent to the signal triggered by mCD40L.

  4. CD4 (show CD4 Proteins)(+) T cells that coexpress CD57 (show B3GAT1 Proteins) and CD154, which are exclusively present in cytomegalovirus-positive individuals.

  5. Serum CD40L levels were elevated in both neuromyelitis optica and multiple sclerosis patients.

  6. plasma PGE2 is correlated with the prevention of IVIG resistance and CAL (show FBLIM1 Proteins) formation through CD40L in KD

  7. This study provides the first evidence that human circulating group 2 innate lymphoid cells can express CD154 and stimulate the production of IgE by B lymphocytes through IL-25 (show IL25 Proteins)/IL-33 (show IL33 Proteins) stimulation or TLR triggering

  8. data also demonstrated that the CD154-triggered inhibition of the Fas (show FAS Proteins)-mediated cell death response was dependent on a suppression of caspase-8 (show CASP8 Proteins) cleavage, but independent of de novo protein synthesis or alterations in Fas (show FAS Proteins) expression on cell surface.

  9. These results suggest soluble CD40L could have a prognostic value in ST-elevation myocardial infarction patients.

  10. persistence of helper T-cell-derived CD40L on or in B cells could permit sustained CD40 (show CD40 Proteins) signaling enabling survival and proliferation of antigen-presenting B cells following brief interactions with helper T cells in vivo in germinal centers.

Mouse (Murine) CD40 Ligand (CD40LG) interaction partners

  1. studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (show CCR3 Proteins) signaling

  2. our results unambiguously demonstrate that while CD40L is critical to generate effective primary CD8 (show CD8A Proteins)(+) T-cell responses also under inflammatory conditions, CD40L expression by CD8 (show CD8A Proteins)(+) T cells themselves is dispensable in acute lymphocytic choriomeningitis virus infection.

  3. Platelets promote allergic asthma through the expression of CD154.

  4. CD40L does not play a functional role in experimental acute pancreatitis

  5. The tissue-specific, activation-dependent and reversible expression of CD40L fully mimics the physiological induction and disappearance of the molecule from the surface of murine T lymphocytes.

  6. there is a major involvement of the CD40 (show CD40 Proteins)-CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis.

  7. Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases.

  8. although treated CD40 (show CD40 Proteins) knockout mice remained healed, developed long-term immunity, and were resistant to secondary Leishmania major challenge, treated CD40L knockout reactivated their lesion after cessation of rIL (show PDLIM4 Proteins)-12 treatment.

  9. PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development.

  10. Anti-OX40L (show TNFSF4 Proteins) mAb could prolong secondary heart allograft survival based on CD40 (show CD40 Proteins)/CD40L and LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) blockade.

Pig (Porcine) CD40 Ligand (CD40LG) interaction partners

  1. CD40 ligand has a role in inducing endothelial dysfunction in human and porcine coronary artery endothelial cells

Cow (Bovine) CD40 Ligand (CD40LG) interaction partners

  1. Results demonstrated greater CD40 (show CD40 Proteins) and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.

Rhesus Monkey CD40 Ligand (CD40LG) interaction partners

  1. Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells.

CD40 Ligand (CD40LG) Protein Profile

Protein Summary

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.

Alternative names and synonyms associated with CD40 Ligand (CD40LG)

  • CD40 ligand (CD40LG)
  • CD40 ligand (cd40l)
  • TNF superfamily member 5 (cd40l)
  • CD40 ligand (Cd40lg)
  • CD40 ligand (LOC100358388)
  • CD40 ligand (CD154)
  • CD40-L protein
  • Cd40l protein
  • CD154 protein
  • gp39 protein
  • hCD40L protein
  • HIGM1 protein
  • IGM protein
  • IMD3 protein
  • Ly-62 protein
  • Ly62 protein
  • T-BAM protein
  • Tnfsf5 protein
  • TRAP protein

Protein level used designations for CD40 Ligand Proteins (CD40LG)

CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) , CD40 ligand , TNF superfamily member 5 , CD40 antigen ligand , CD40-L , T-B cell-activating molecule , T-cell antigen Gp39 , TNF-related activation protein , tumor necrosis factor (ligand) superfamily member 5 , tumor necrosis factor ligand superfamily member 5 , CD40 ligand CD154 , tumor necrosis factor (ligand) superfamily, member 5 , human : hyper-IgM syndrome , uncharacterized protein LOC100358388 , putative CD154 (CD40 ligand) , CD154 protein

473802 Pan troglodytes
100286596 Salmo salar
100136698 Oncorhynchus mykiss
959 Homo sapiens
21947 Mus musculus
84349 Rattus norvegicus
397231 Sus scrofa
403468 Canis lupus familiaris
282387 Bos taurus
100358388 Oryctolagus cuniculus
100733664 Cavia porcellus
493850 Felis catus
395485 Gallus gallus
767628 Ovis aries
574160 Macaca mulatta
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