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Browse our CD40 Ligand Proteins (CD40LG)

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CD40 Ligand Proteins (CD40LG)
On are 121 CD40 Ligand (CD40LG) Proteins from 24 different suppliers available. Additionally we are shipping CD40 Ligand Antibodies (654) and CD40 Ligand Kits (96) and many more products for this protein. A total of 894 CD40 Ligand products are currently listed.
CD40-L, Cd40l, CD154, gp39, hCD40L, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, Tnfsf5, TRAP
list all proteins Gene Name GeneID UniProt
CD40LG 959 P29965
CD40LG 21947 P27548
CD40LG 84349 Q9Z2V2

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CD40 Ligand Proteins (CD40LG) by Origin

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Top referenced CD40 Ligand Proteins

  1. Human CD40 Ligand Protein expressed in HEK-293 - ABIN2666789 : Davidson, Hirschman, Sun, Singh, Kasischke, Maggirwar: Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders. in PLoS ONE 2012 (PubMed)
    Show all 7 references for ABIN2666789

  2. Human CD40 Ligand Protein expressed in Human Cells - ABIN2002415 : Korthäuer, Graf, Mages, Brière, Padayachee, Malcolm, Ugazio, Notarangelo, Levinsky, Kroczek: Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. in Nature 1993 (PubMed)
    Show all 4 references for ABIN2002415

  3. Mouse (Murine) CD40 Ligand Protein expressed in Human Cells - ABIN2007673 : Seyama, Nonoyama, Gangsaas, Hollenbaugh, Pabst, Aruffo, Ochs: Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome. in Blood 1998 (PubMed)
    Show all 4 references for ABIN2007673

  4. Rat (Rattus) CD40 Ligand Protein expressed in Human Cells - ABIN2009254 : Lin, Rohrer, Allen, Larché, Greene, Shigeoka, Gatti, Derauf, Belmont, Conley: A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome. in The Journal of clinical investigation 1996 (PubMed)
    Show all 4 references for ABIN2009254

  5. Dog (Canine) CD40 Ligand Protein expressed in Human Cells - ABIN2008913 : Khandekar, Silverman, Wells-Marani, Bacon, Birrell, Brigham-Burke, DeMarini, Jonak, Camilleri, Fishman-Lobell: Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells. in Protein expression and purification 2001 (PubMed)
    Show all 4 references for ABIN2008913

  6. Human CD40 Ligand Protein expressed in Escherichia coli (E. coli) - ABIN666635 : Gordon: CD40 and its ligand: central players in B lymphocyte survival, growth, and differentiation. in Blood reviews 1995 (PubMed)
    Show all 2 references for ABIN666635

More Proteins for CD40 Ligand Interaction Partners

Chimpanzee CD40 Ligand (CD40LG) interaction partners

  1. specific cross-linking with trimeric recombinant HIV-1 gp140 revealed reduced sensitivity for inhibition of CD154 up-regulation in chimpanzees, requiring fourfold higher concentrations of viral protein

Atlantic Salmon (Salmo salar) CD40 Ligand (CD40LG) interaction partners

  1. identification and functional characterization of CD40L and CD40 (show CD40 Proteins) from Atlantic salmon (Salmo salar); results provide evidence for the existence of a functional CD40L mediated costimulatory pathway in Atlantic salmon

Human CD40 Ligand (CD40LG) interaction partners

  1. These results suggest soluble CD40L could have a prognostic value in ST-elevation myocardial infarction patients.

  2. persistence of helper T-cell-derived CD40L on or in B cells could permit sustained CD40 (show CD40 Proteins) signaling enabling survival and proliferation of antigen-presenting B cells following brief interactions with helper T cells in vivo in germinal centers.

  3. These results demonstrate the feasibility of engineered nuclease (show DCLRE1C Proteins)-directed gene repair to restore endogenously regulated CD40L, and the potential for its use in T-cell therapy for X-HIGM syndrome.

  4. Increased CD40 (show CD40 Proteins) ligation and reduced B-cell receptor signalling leads to higher IL-10 (show IL10 Proteins) production in B Cells from tolerant kidney transplant recipients.

  5. Hypertensives showed significantly enhanced soluble CD40L levels compared to normotensive controls

  6. CD40L gene polymorphism was found to be associated with severe falciparum malaria in Indian population especially in severe malarial anaemia.

  7. While CD40 (show CD40 Proteins) expression tends to be relatively high in the peritumoral dermis of epithelial carcinomas, the expression of CD40L in mast cells is low in the same peritumoral area, compared with the opposite findings in psoriasis and actinic keratosis.

  8. Primary Aldosteronism is related to platelet activation, expressed as higher plasma values of soluble CD40L and soluble P-selectin (show SELP Proteins) values.

  9. Overexpression of CD154 on CD4 (show CD4 Proteins)(+)T cells is unlikely to be central to the pathogenesis of idopathic thrombocytopenic purpura, and other immune dysfunctions should be targeted for therapy purposes.

  10. the serum levels of the soluble factors sCD40L and CXCL1 (show CXCL1 Proteins) are not associated with endometriosis and are not suitable as biomarkers for disease diagnosis.

Mouse (Murine) CD40 Ligand (CD40LG) interaction partners

  1. Platelets promote allergic asthma through the expression of CD154.

  2. CD40L does not play a functional role in experimental acute pancreatitis

  3. The tissue-specific, activation-dependent and reversible expression of CD40L fully mimics the physiological induction and disappearance of the molecule from the surface of murine T lymphocytes.

  4. there is a major involvement of the CD40 (show CD40 Proteins)-CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis.

  5. Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases.

  6. although treated CD40 (show CD40 Proteins) knockout mice remained healed, developed long-term immunity, and were resistant to secondary Leishmania major challenge, treated CD40L knockout reactivated their lesion after cessation of rIL (show PDLIM4 Proteins)-12 treatment.

  7. PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development.

  8. Anti-OX40L (show TNFSF4 Proteins) mAb could prolong secondary heart allograft survival based on CD40 (show CD40 Proteins)/CD40L and LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) blockade.

  9. CD40 (show CD40 Proteins) on lymph node fibroblasts facilitated bidirectional communication with CD4 (show CD4 Proteins)(+) T cells via CD40 (show CD40 Proteins)-CD40L, thereby altering fibroblast gene expression of immune regulatory molecules.

  10. CD40L mediates neointima formation via its classic receptor CD40 (show CD40 Proteins) rather than via its recently described novel interaction with Mac-1 (show ITGAM Proteins).

Pig (Porcine) CD40 Ligand (CD40LG) interaction partners

  1. CD40 ligand has a role in inducing endothelial dysfunction in human and porcine coronary artery endothelial cells

Cow (Bovine) CD40 Ligand (CD40LG) interaction partners

  1. Results demonstrated greater CD40 (show CD40 Proteins) and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.

Rhesus Monkey CD40 Ligand (CD40LG) interaction partners

  1. Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells.

CD40 Ligand (CD40LG) Protein Profile

Protein Summary

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.

Alternative names and synonyms associated with CD40 Ligand (CD40LG)

  • CD40 ligand (CD40LG)
  • CD40 ligand (cd40l)
  • TNF superfamily member 5 (cd40l)
  • CD40 ligand (Cd40lg)
  • CD40 ligand (LOC100358388)
  • CD40 ligand (CD154)
  • CD40-L protein
  • Cd40l protein
  • CD154 protein
  • gp39 protein
  • hCD40L protein
  • HIGM1 protein
  • IGM protein
  • IMD3 protein
  • Ly-62 protein
  • Ly62 protein
  • T-BAM protein
  • Tnfsf5 protein
  • TRAP protein

Protein level used designations for CD40 Ligand Proteins (CD40LG)

CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) , CD40 ligand , TNF superfamily member 5 , CD40 antigen ligand , CD40-L , T-B cell-activating molecule , T-cell antigen Gp39 , TNF-related activation protein , tumor necrosis factor (ligand) superfamily member 5 , tumor necrosis factor ligand superfamily member 5 , CD40 ligand CD154 , tumor necrosis factor (ligand) superfamily, member 5 , human : hyper-IgM syndrome , uncharacterized protein LOC100358388 , putative CD154 (CD40 ligand) , CD154 protein

473802 Pan troglodytes
100286596 Salmo salar
100136698 Oncorhynchus mykiss
959 Homo sapiens
21947 Mus musculus
84349 Rattus norvegicus
397231 Sus scrofa
403468 Canis lupus familiaris
282387 Bos taurus
100358388 Oryctolagus cuniculus
100733664 Cavia porcellus
493850 Felis catus
395485 Gallus gallus
767628 Ovis aries
574160 Macaca mulatta
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