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Browse our EGFR Proteins (EGFR)

Full name:
Epidermal Growth Factor Receptor Proteins (EGFR)
On www.antibodies-online.com are 113 Epidermal Growth Factor Receptor (EGFR) Proteins from 18 different suppliers available. Additionally we are shipping EGFR Antibodies (2264) and EGFR Kits (141) and many more products for this protein. A total of 2591 EGFR products are currently listed.
Synonyms:
9030024J15Rik, AI552599, C-erb, c-erbB, CG10079, D-Egf, d-egf-r, D-EGFR, dEgfr, dEGFR1, der, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DER1, DER flb, Dmel\\CG10079, DmHD-33, EFG-R, Egf, Egf-r, egfr, egfr1, EGFR12, EGFR15, EK2-6, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, Erbb, ErbB-1, ERBB1, Erbb2, Errb1, Errp, flb, HD-33, HER1, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57Ea, l(2)57EFa, mENA, mor1, PIG61, top, top/DER, top/flb, Torpedo/DER, torpedo/egfr, wa-2, wa2, Wa5
list all proteins Gene Name GeneID UniProt
EGFR 1956 P00533
EGFR 24329  
EGFR 13649 Q01279

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EGFR Proteins (EGFR) by Origin

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Top referenced EGFR Proteins

  1. Rat (Rattus) EGFR Protein expressed in Human Cells - ABIN2009151 : Schlessinger: Cell signaling by receptor tyrosine kinases. in Cell 2000 (PubMed)
    Show all 2 references for ABIN2009151

  2. Human EGFR Protein expressed in Baculovirus infected Insect Cells - ABIN2001846 : Yarden, Sliwkowski: Untangling the ErbB signalling network. in Nature reviews. Molecular cell biology 2001 (PubMed)
    Show all 2 references for ABIN2001846

  3. Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000 : Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. in Molecular cancer therapeutics 2014 (PubMed)

  4. Human EGFR Protein expressed in Wheat germ - ABIN1352437 : Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. in Nature 2013 (PubMed)

More Proteins for EGFR Interaction Partners

Horse (Equine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (show ERBB2 Proteins)).

Fruit Fly (Drosophila melanogaster) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Loss of Usp5 (show USP5 Proteins) results in upregulation of Notch (show NOTCH1 Proteins) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.

  2. These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.

  3. Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (show AKT1 Proteins)/ERK (show MAPK1 Proteins) pathway.

  4. The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.

  5. Data suggest that OSCP1 (organic solute carrier partner 1 (show OSCP1 Proteins)) plays multiple roles during eye development in D. melanogaster; OSCP1 (show OSCP1 Proteins) regulates developmental gene expression and epidermal growth factor receptor signaling pathway in imaginal discs of eye.

  6. The vector of cell movement is regulated by localised epidermal growth factor (EGF (show EGF Proteins)) signalling from the distally placed tip cell lineage and the acquisition of planar polarity leads to asymmetric pulsatile Myosin II accumulation.

  7. Our findings provide in vivo evidence for the role of adult neurons in the maintenance of glia and a novel role for EGFR signaling in the autophagic flux.

  8. Gro (show CXCL1 Proteins) inhibits rho expression in undifferentiated cells and represses the expression of both ato and rho in non-R8 precursors during initiation of photoreceptor differentiation in an E(spl (show SGPL1 Proteins))-dependent manner.

  9. strategy for producing ordered square cell packing configurations in epithelia and reveal a molecular mechanism by which organized tissue structure is generated through spatiotemporally regulated responses to EGF receptor activation.

  10. the findings indicate that Vps4 (show VPS4A Proteins) can promote EGFR activity through an endocytosis-independent mechanism.

Zebrafish Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Study demonstrated that IGF-I (show IGF1 Proteins) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.

  2. These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.

  3. EGFR signaling in vertebrate oocytes can prevent meiotic progression.

  4. the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes

Human Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. EGFR TKI-sensitive mutations commonly occur in female, non-smoking and adenocarcinoma patients. The p-stage, TNM (show ODZ1 Proteins)-T stage, TNM (show ODZ1 Proteins)-N stage, EGFR and TTF-1 (show NKX2-1 Proteins) protein expression levels have close relationships with EGFR mutation status.

  2. EGFR expression was observed in 58% and c-KIT expression was seen in 30% of the cases [triple negative breast cancer]

  3. Cost analysis of a payment by results (PbR (show TSPO Proteins)) scheme in Catalonia for the introduction of gefitinib in the treatment of advanced EGFR-mutation positive non-small-cell lung cancer. The PbR (show TSPO Proteins) resulted in total savings of around 36,000 (880 per patient.

  4. tumors from stage IV NSCLC patients harbor characteristic gene alterations, of which EGFR L858R in particular appears to be a poor prognostic factor for overall survival.

  5. EGFR-mutated LADC may develop through a distinct carcinogenetic pathway, in which the mPAP element may play an important role in promoting progression.

  6. The presence of EGFR mutations is significantly associated with early stage disease at initial diagnosis in lung adenocarcinomas after adjusting for age, sex, smoking status, and screening. This finding implies that EGFR mutations may play a role as a positive prognostic marker.

  7. Aberrant expressionof Rb is frequently occurred in lung adenocarcinoma patients with EGFR mutations.

  8. EGFR, MEK1, MEK2 and ERK1/2 co-localize on endosomes.Role of chromatin-bound EGFR in RNA polymerase 2 transcription

  9. Report EGFR inhibitory activity of quinazolines/indoles for the treatment of ovarian cancer.

  10. C terminus of Hsc70-interacting protein (show ST13 Proteins) (CHIP) selectively interacted with epidermal growth factor receptor (EGFR) mutants and simultaneously induced their ubiquitination and proteasomal degradation.

Mouse (Murine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. genome-wide association study and network-based approach adds evidence for a role for Egfr in murine pulmonary hypertension.

  2. Our results support a role for the hepatocellular ERBB tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 (show ERBB3 Proteins) and EGFR-ERBB3 (show ERBB3 Proteins) DKO models, suggesting that EGFR-ERBB3 (show ERBB3 Proteins) heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR homodimeric signaling.

  3. Our results demonstrate that Respiratory syncytial virus F interacts with EGFR in a strain-specific manner, EGFR is a co-factor for infection, and EGFR plays a role in RSV-induced mucin (show SLC13A2 Proteins) expression

  4. These data highlight the importance of EGFR signaling and its downstream signaling cascade in postnatal beta cell growth.

  5. aldosterone induced the phosphorylation of EGFR through generation of reactive oxygen species.

  6. IL-4 (show IL4 Proteins)-stimulated HB-EGF (show HBEGF Proteins)-dependent transactivation of EGFR in macrophages may mediate inhibitory feedback for M2 polarization and HB-EGF (show HBEGF Proteins) production, thereby inhibiting gastrointestinal tumor growth.

  7. Inhibition of EGFR reduces p38 MAPK (show MAPK14 Proteins), resulting in decreased expression of hypoxia-inducible factor-1alpha, metalloproteinase 1, and VEGF (show VEGFA Proteins), leading to suppressions of angiogenesis and tumorigenesis.

  8. Data show that oligodendrocyte transcription factor 2 (Olig2 (show OLIG2 Proteins)) deletion causes platelet-derived growth factor receptor (PDGFR (show PDGFRB Proteins)) downregulation and reciprocal epidermal growth factor receptor (EGFR) upregulation.

  9. EGFR and Nestin (show NES Proteins) showed to have vital role during mice development, and considered to be suitable markers for the study of skin stem cells.

  10. EGFR suppression of mitotic regulators including Rcc2 (show RCC2 Proteins) and Stathmin 1 (show STMN1 Proteins) are a mechanism for catagen induction in mouse skin

Pig (Porcine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways

  2. Syndecan-4 (show SDC4 Proteins) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.

  3. These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.

  4. patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation

  5. Report EGFR expression in the normal pancreas.

  6. Injury and activation of purinergic receptors and direct activation of EGFR via EGF (show EGF Proteins) induce distinct downstream pathways.

  7. Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (show NOS1 Proteins)-derived nitric oxide.

  8. EGFR, VEGFR (show KDR Proteins) and FGFR (show FGFR2 Proteins) are expressed in porcine oviduct and endometrium during the time of implantation [review]

  9. the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct

  10. The phase-related expression of EGF (show EGF Proteins) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (show EGF Proteins) and its receptor on the uterine artery and the region supplying these vessels.

Cow (Bovine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Stimulation of bovine oviduct epithelial cell EGFR with EGF (show EGF Proteins) (human recombinant EGF (show EGF Proteins)) alone or with EGF (show EGF Proteins) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (show EGF Proteins) on phosphorylation of MAPKs.

  2. Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.

  3. Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.

  4. EGFR may simultaneously activate c-Src (show SRC Proteins) and PI3K to amplify the oxytocin signaling to increase the output of PGF (show PGF Proteins)(2 alpha) in endometrial epithelial cells.

  5. results indicate that arginase induction depends in part on epidermal growth factor (EGF (show EGF Proteins)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release

  6. Data suggest that epidermal growth factor (EGF (show EGF Proteins)) and EGF (show EGF Proteins) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.

  7. MT1-MMP (show MMP14 Proteins) has a role in signaling events mediating EGFR transactivation

  8. possible cooperative role of the EGF (show EGF Proteins) and HGF (show HGF Proteins) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow

  9. EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.

EGFR Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Alternative names and synonyms associated with EGFR

  • epidermal growth factor receptor (EGFR)
  • Epidermal growth factor receptor (Egfr)
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (egfra)
  • epidermal growth factor receptor (egfr1)
  • epidermal growth factor receptor (AaeL_AAEL004319)
  • epidermal growth factor receptor (Egfr)
  • epidermal growth factor receptor (LOC100008806)
  • 9030024J15Rik protein
  • AI552599 protein
  • C-erb protein
  • c-erbB protein
  • CG10079 protein
  • D-Egf protein
  • d-egf-r protein
  • D-EGFR protein
  • dEgfr protein
  • dEGFR1 protein
  • der protein
  • DER/EGFR protein
  • DER/faint little ball protein
  • DER/top protein
  • DER/torpedo protein
  • DER1 protein
  • DER flb protein
  • Dmel\\CG10079 protein
  • DmHD-33 protein
  • EFG-R protein
  • Egf protein
  • Egf-r protein
  • egfr protein
  • egfr1 protein
  • EGFR12 protein
  • EGFR15 protein
  • EK2-6 protein
  • El protein
  • Elp protein
  • Elp-1 protein
  • Elp-B1 protein
  • Elp-B1RB1 protein
  • Erbb protein
  • ErbB-1 protein
  • ERBB1 protein
  • Erbb2 protein
  • Errb1 protein
  • Errp protein
  • flb protein
  • HD-33 protein
  • HER1 protein
  • l(2)05351 protein
  • l(2)09261 protein
  • l(2)57DEFa protein
  • l(2)57Ea protein
  • l(2)57EFa protein
  • mENA protein
  • mor1 protein
  • PIG61 protein
  • top protein
  • top/DER protein
  • top/flb protein
  • Torpedo/DER protein
  • torpedo/egfr protein
  • wa-2 protein
  • wa2 protein
  • Wa5 protein

Protein level used designations for EGFR

CG10079-PA , CG10079-PB , DER-Ellipse , EGF-receptor , EGFR , Egf receptor , Egfr-PA , Egfr-PB , drosophila epidermal growth factor receptor homologue , ellipse , ellipse torpedo , epidermal growth factor receptor , faint little ball , morphological defects 1 , torpedo , torpedo/DER , erbb1a , avian erythroblastic leukemia viral (v-erb-b) oncogene homolog , cell growth inhibiting protein 40 , cell proliferation-inducing protein 61 , proto-oncogene c-ErbB-1 , receptor tyrosine-protein kinase erbB-1 , EGFR-related peptide , Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) , avian erythroblastic leukemia viral (v-erbB) oncogene homolog , epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) , waved 2 , CER , epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) , egf receptor , receptor tyrosine kinase ErbB1

GENE ID SPECIES
100067755 Equus caballus
37455 Drosophila melanogaster
378478 Danio rerio
778955 Ciona intestinalis
5564544 Aedes aegypti
1956 Homo sapiens
24329 Rattus norvegicus
13649 Mus musculus
396494 Gallus gallus
397070 Sus scrofa
404306 Canis lupus familiaris
407217 Bos taurus
100008806 Oryctolagus cuniculus
100725363 Cavia porcellus
780479 Ovis aries
613027 Macaca mulatta
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