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Browse our EGFR Proteins (EGFR)

Full name:
Epidermal Growth Factor Receptor Proteins (EGFR)
On www.antibodies-online.com are 105 Epidermal Growth Factor Receptor (EGFR) Proteins from 18 different suppliers available. Additionally we are shipping EGFR Antibodies (1724) and EGFR Kits (136) and many more products for this protein. A total of 2039 EGFR products are currently listed.
Synonyms:
9030024J15Rik, AI552599, C-erb, c-erbB, CG10079, D-Egf, d-egf-r, D-EGFR, dEgfr, dEGFR1, der, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DER1, DER flb, Dmel\\CG10079, DmHD-33, EFG-R, Egf, Egf-r, egfr, egfr1, EGFR12, EGFR15, EK2-6, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, Erbb, ErbB-1, ERBB1, Erbb2, Errb1, Errp, flb, HD-33, HER1, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57Ea, l(2)57EFa, mENA, mor1, PIG61, top, top/DER, top/flb, Torpedo/DER, torpedo/egfr, wa-2, wa2, Wa5
list all proteins Gene Name GeneID UniProt
EGFR 1956 P00533
EGFR 24329  
EGFR 13649 Q01279

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EGFR Proteins (EGFR) by Origin

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Top referenced EGFR Proteins

  1. Rat (Rattus) EGFR Protein expressed in Human Cells - ABIN2009151 : Schlessinger: Cell signaling by receptor tyrosine kinases. in Cell 2000 (PubMed)
    Show all 2 references for ABIN2009151

  2. Human EGFR Protein expressed in Human Cells - ABIN2001839 : Yarden, Sliwkowski: Untangling the ErbB signalling network. in Nature reviews. Molecular cell biology 2001 (PubMed)
    Show all 2 references for ABIN2001839

  3. Human EGFR Protein expressed in Wheat germ - ABIN1352437 : Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. in Nature 2013 (PubMed)

  4. Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000 : Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. in Molecular cancer therapeutics 2014 (PubMed)

More Proteins for EGFR Interaction Partners

Horse (Equine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (show ERBB2 Proteins)).

Fruit Fly (Drosophila melanogaster) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.

  2. Data suggest that OSCP1 (organic solute carrier partner 1 (show OSCP1 Proteins)) plays multiple roles during eye development in D. melanogaster; OSCP1 (show OSCP1 Proteins) regulates developmental gene expression and epidermal growth factor receptor signaling pathway in imaginal discs of eye.

  3. The vector of cell movement is regulated by localised epidermal growth factor (EGF (show EGF Proteins)) signalling from the distally placed tip cell lineage and the acquisition of planar polarity leads to asymmetric pulsatile Myosin II accumulation.

  4. Our findings provide in vivo evidence for the role of adult neurons in the maintenance of glia and a novel role for EGFR signaling in the autophagic flux.

  5. Gro inhibits rho expression in undifferentiated cells and represses the expression of both ato and rho in non-R8 precursors during initiation of photoreceptor differentiation in an E(spl (show SGPL1 Proteins))-dependent manner.

  6. strategy for producing ordered square cell packing configurations in epithelia and reveal a molecular mechanism by which organized tissue structure is generated through spatiotemporally regulated responses to EGF receptor activation.

  7. the findings indicate that Vps4 (show VPS4A Proteins) can promote EGFR activity through an endocytosis-independent mechanism.

  8. Drosophila compound eye development is a good model for studying the Egfr signaling pathway.

  9. Mechanistically, miR (show MYLIP Proteins)-998 operates by repressing dCbl, a negative regulator of EGFR signaling. Significantly, dCbl is a critical target of miR (show MYLIP Proteins)-998 since dCbl phenocopies the effects of miR (show MYLIP Proteins)-998 on dE2f1 (show E2F1 Proteins)-dependent apoptosis in rbf (show ATP5I Proteins) mutants

  10. FGFR (show FGFR2 Proteins) signaling most likely affects ethanol-induced behavior through a different mechanism, possibly through acute action in adult neurons.

Zebrafish Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Study demonstrated that IGF-I (show IGF1 Proteins) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.

  2. These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.

  3. EGFR signaling in vertebrate oocytes can prevent meiotic progression.

  4. the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes

Human Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Chromogenic Assay for Lung Cancer-Related EGFR Exon 19 Hotspot Deletion Mutations.

  2. four cases harbored the BRAF (show BRAF Proteins)-V600E mutation, one case harbored the BRAF (show BRAF Proteins)-G606R mutation, and three cases harbored deletions in exon 19 of EGFR

  3. in non-small cell lung carcinoma patients, EGFR mutations were detected in exon 19 in 32 patients, exon 20 in 16, and exon 21 in 15; no mutations were observed in exon 18

  4. EGFR is transcriptionally activated by G protein-coupled receptors. (Review)

  5. these data indicate that activation of EGFR enhanced the expression of P2X7R (show P2RX7 Proteins) in neuroblastoma (show ARHGEF16 Proteins) cells lacking trophic support, being PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/PKC (show PRRT2 Proteins) signaling pathway and Sp1 (show PSG1 Proteins) mediating this pro-survival outcome

  6. Our results suggested that smoking status could influence not only the frequency but also the spectrum of EGFR mutations. These findings provide a clue for further investigation of EGFR mutagenesis.

  7. mRNA expression of BIM (show BCL2L11 Proteins) and MTOR (show FRAP1 Proteins) in 57 patients with EGFR-mutant non-small-cell lung cancer.

  8. CD24 (show CD24 Proteins) regulates EGFR signaling by inhibiting EGFR internalization and degradation in a RhoA (show RHOA Proteins)-dependent manner in gastric cancer cells.

  9. Compared with other predominant subtypes with EGFR mutations, the microenvironment of SPA (show FASL Proteins) with EGFR mutations is characterized by cancer cells with higher invasive and immune evasion potential and more abundant stromal cells with tumor-promoting functions, which would contribute to the more aggressive behavior of SPA (show FASL Proteins).

  10. Mucin (show SLC13A2 Proteins) production via the TLR3 (show TLR3 Proteins)-epidermal growth factor receptor (EGFR) pathway in airway epithelial cells, which is the pathogenesis of COPD (show ARCN1 Proteins).

Mouse (Murine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. The afatinib plus cetuximab combination does not suppress the emergence of EGFR(T790M).

  2. Results provided a new insight of how EGFR regulation the production of TNF-alpha (show TNF Proteins) in cardiomyocytes

  3. Data indicate that Sonic hedgehog (Shh (show SHH Proteins)) stimulate branching morphogenesis (BrM (show SMARCA2 Proteins)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 Proteins) protein, epidermal growth factor (EGF (show EGF Proteins)) and receptors of the ErbB receptors ErbB1, ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins).

  4. EGFR ligands play a substance-dependent role in controlling vascular smooth muscle cell migration.

  5. strategies contributing to promote either endogenous production of tPA (show PLAT Proteins) or its associated EGFR-linked signaling pathway may have beneficial effects following brain injuries such as stroke.

  6. Results demonstrate a selective regulation of TLR4 (show TLR4 Proteins) signaling by EGFR and highlight the potential use of EGFR inhibitors to treat septic shock syndrome.

  7. MIG6 (show ERRFI1 Proteins) is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma.

  8. Results suggest that EGFR signaling upregulates NMDA receptors through modification of the GluN2B (show GRIN2B Proteins) subunit, and is required for high-frequency stimulation-induced long-term potentiation in the hippocampus

  9. GPCR (show GPBAR1 Proteins)-mediated EGF receptor transactivation regulates TRPV4 (show TRPV4 Proteins) action in the vasculature

  10. Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr signaling.

Pig (Porcine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.

  2. patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation

  3. Report EGFR expression in the normal pancreas.

  4. Injury and activation of purinergic receptors and direct activation of EGFR via EGF (show EGF Proteins) induce distinct downstream pathways.

  5. Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (show NOS1 Proteins)-derived nitric oxide.

  6. EGFR, VEGFR (show KDR Proteins) and FGFR (show FGFR2 Proteins) are expressed in porcine oviduct and endometrium during the time of implantation [review]

  7. the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct

  8. The phase-related expression of EGF (show EGF Proteins) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (show EGF Proteins) and its receptor on the uterine artery and the region supplying these vessels.

  9. This result suggests that ubiquitination of the kinase-impaired receptor can mediate its internalization by the clathrin pathway.

  10. A linear relationship of EGF/EGFR, PI3-kinase (show PIK3CA Proteins), MAPK (show MAPK1 Proteins) and geminal vesicle breakdown, presents a relatively definitive mechanism of EGF (show EGF Proteins)-induced meiotic resumption of porcine oocyte.

Cow (Bovine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Stimulation of bovine oviduct epithelial cell EGFR with EGF (show EGF Proteins) (human recombinant EGF (show EGF Proteins)) alone or with EGF (show EGF Proteins) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (show EGF Proteins) on phosphorylation of MAPKs.

  2. Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.

  3. Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.

  4. EGFR may simultaneously activate c-Src (show SRC Proteins) and PI3K to amplify the oxytocin signaling to increase the output of PGF (show PGF Proteins)(2 alpha) in endometrial epithelial cells.

  5. results indicate that arginase induction depends in part on epidermal growth factor (EGF (show EGF Proteins)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release

  6. Data suggest that epidermal growth factor (EGF (show EGF Proteins)) and EGF (show EGF Proteins) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.

  7. MT1-MMP (show MMP14 Proteins) has a role in signaling events mediating EGFR transactivation

  8. possible cooperative role of the EGF (show EGF Proteins) and HGF (show HGF Proteins) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow

  9. EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.

EGFR Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Alternative names and synonyms associated with EGFR

  • epidermal growth factor receptor (EGFR)
  • Epidermal growth factor receptor (Egfr)
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (egfra)
  • epidermal growth factor receptor (egfr1)
  • epidermal growth factor receptor (AaeL_AAEL004319)
  • epidermal growth factor receptor (Egfr)
  • epidermal growth factor receptor (LOC100008806)
  • 9030024J15Rik protein
  • AI552599 protein
  • C-erb protein
  • c-erbB protein
  • CG10079 protein
  • D-Egf protein
  • d-egf-r protein
  • D-EGFR protein
  • dEgfr protein
  • dEGFR1 protein
  • der protein
  • DER/EGFR protein
  • DER/faint little ball protein
  • DER/top protein
  • DER/torpedo protein
  • DER1 protein
  • DER flb protein
  • Dmel\\CG10079 protein
  • DmHD-33 protein
  • EFG-R protein
  • Egf protein
  • Egf-r protein
  • egfr protein
  • egfr1 protein
  • EGFR12 protein
  • EGFR15 protein
  • EK2-6 protein
  • El protein
  • Elp protein
  • Elp-1 protein
  • Elp-B1 protein
  • Elp-B1RB1 protein
  • Erbb protein
  • ErbB-1 protein
  • ERBB1 protein
  • Erbb2 protein
  • Errb1 protein
  • Errp protein
  • flb protein
  • HD-33 protein
  • HER1 protein
  • l(2)05351 protein
  • l(2)09261 protein
  • l(2)57DEFa protein
  • l(2)57Ea protein
  • l(2)57EFa protein
  • mENA protein
  • mor1 protein
  • PIG61 protein
  • top protein
  • top/DER protein
  • top/flb protein
  • Torpedo/DER protein
  • torpedo/egfr protein
  • wa-2 protein
  • wa2 protein
  • Wa5 protein

Protein level used designations for EGFR

CG10079-PA , CG10079-PB , DER-Ellipse , EGF-receptor , EGFR , Egf receptor , Egfr-PA , Egfr-PB , drosophila epidermal growth factor receptor homologue , ellipse , ellipse torpedo , epidermal growth factor receptor , faint little ball , morphological defects 1 , torpedo , torpedo/DER , erbb1a , avian erythroblastic leukemia viral (v-erb-b) oncogene homolog , cell growth inhibiting protein 40 , cell proliferation-inducing protein 61 , proto-oncogene c-ErbB-1 , receptor tyrosine-protein kinase erbB-1 , EGFR-related peptide , Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) , avian erythroblastic leukemia viral (v-erbB) oncogene homolog , epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) , waved 2 , CER , epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) , egf receptor , receptor tyrosine kinase ErbB1

GENE ID SPECIES
100067755 Equus caballus
37455 Drosophila melanogaster
378478 Danio rerio
778955 Ciona intestinalis
5564544 Aedes aegypti
1956 Homo sapiens
24329 Rattus norvegicus
13649 Mus musculus
396494 Gallus gallus
397070 Sus scrofa
404306 Canis lupus familiaris
407217 Bos taurus
100008806 Oryctolagus cuniculus
100725363 Cavia porcellus
780479 Ovis aries
613027 Macaca mulatta
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