Browse our EGFR Proteins (EGFR)

On www.antibodies-online.com are 136 Epidermal Growth Factor Receptor (EGFR) Proteins from 18 different suppliers available. Additionally we are shipping EGFR Antibodies (2360) and EGFR Kits (145) and many more products for this protein. A total of 2714 EGFR products are currently listed.
Synonyms:
9030024J15Rik, AI552599, C-erb, c-erbB, CG10079, D-Egf, d-egf-r, D-EGFR, dEgfr, dEGFR1, der, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DER1, DER flb, Dmel\\CG10079, DmHD-33, EFG-R, Egf, Egf-r, egfr, egfr1, EGFR12, EGFR15, EK2-6, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, Erbb, ErbB-1, ERBB1, Erbb2, Errb1, Errp, flb, HD-33, HER1, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57Ea, l(2)57EFa, mENA, mor1, PIG61, top, top/DER, top/flb, Torpedo/DER, torpedo/egfr, wa-2, wa2, Wa5
list all proteins Gene Name GeneID UniProt
EGFR 1956 P00533
EGFR 24329  
EGFR 13649 Q01279

EGFR Proteins (EGFR) by Origin

More Proteins for EGFR Interaction Partners

Horse (Equine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (show ERBB2 Proteins)).

Fruit Fly (Drosophila melanogaster) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. The activity of Gro (show CXCL1 Proteins) is antagonized by EGFR signaling, which inhibits Gro (show CXCL1 Proteins)-dependent repression via p-ERK (show MAPK1 Proteins) mediated phosphorylation.

  2. These results reveal that ESCRT-0 (ESCRT-0 components stam (show STAM Proteins) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.

  3. we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded

  4. Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (show TGFb Proteins) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (show MAPK8 Proteins) signaling

  5. Loss of Usp5 (show USP5 Proteins) results in upregulation of Notch (show NOTCH1 Proteins) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.

  6. These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.

  7. Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (show AKT1 Proteins)/ERK (show MAPK1 Proteins) pathway.

  8. The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.

  9. Data suggest that OSCP1 (organic solute carrier partner 1 (show OSCP1 Proteins)) plays multiple roles during eye development in D. melanogaster; OSCP1 (show OSCP1 Proteins) regulates developmental gene expression and epidermal growth factor receptor signaling pathway in imaginal discs of eye.

  10. The vector of cell movement is regulated by localised epidermal growth factor (EGF (show EGF Proteins)) signalling from the distally placed tip cell lineage and the acquisition of planar polarity leads to asymmetric pulsatile Myosin II accumulation.

Zebrafish Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Study demonstrated that IGF-I (show IGF1 Proteins) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.

  2. These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.

  3. EGFR signaling in vertebrate oocytes can prevent meiotic progression.

  4. the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes

Human Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. EGFR and C/EBP-beta (show CEBPB Proteins) oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-beta (show CEBPB Proteins) isoform

  2. Studies indicate that positive PD-L1 (show CD274 Proteins) expression was significantly correlated with KRAS mutation and EGFR mutation.

  3. Piccolo contributes to tumor aggressiveness in esophageal squamous cell carcinoma, likely by stabilizing EGFR and promoting EGFR-dependent signaling.

  4. Finally, the authors show that EGFR-ERK1/2 and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 (show EGR1 Proteins) upregulation.

  5. Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2 (show BTNL2 Proteins)) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1 (show ROS1 Proteins)/DCBLD1) and rs2179920 (HLA-DPB1 (show HLA-DPB1 Proteins)) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases

  6. Study shows that EGFR negatively regulates POPDC1 (show BVES Proteins) expression in breast cancer cell lines and that overexpression of POPDC1 (show BVES Proteins) can reduce EGFR-mediated cell migration and proliferation in breast cancer cells.

  7. The present findings indicate that genetic variation in EGFR may contribute to the attainment of extreme old age in Japanese.

  8. developed a simulator to accurately calculate the dynamic sensitivity of extracellular-signal-regulated kinase (ERK (show EPHB2 Proteins)) activity (ERK (show EPHB2 Proteins)*) and Akt (show AKT1 Proteins) activity (Akt (show AKT1 Proteins)*), downstream of the ErbB receptors stimulated with epidermal growth factor (EGF (show EGF Proteins)) and heregulin (HRG (show NRG1 Proteins))

  9. EGFR amplification/EGFRvIII mutation can repress the expression of Pri-miR (show MLXIP Proteins)-524 by histone modification. MiR (show MLXIP Proteins)-524-3p and miR (show MLXIP Proteins)-524-5p inhibited TGF/beta (show TGFB1 Proteins), Notch (show NOTCH1 Proteins) and the Hippo pathway by targeting Smad2 (show SMAD2 Proteins), Hes1 and Tead1 (show TEAD1 Proteins), respectively; these pathways repressed their common downstream transcription factor, C-myc (show MYC Proteins).

  10. The searched for functional interactions between EGFR and D2-like receptors, focusing on the molecular mechanisms involved in the EGFR-mediated regulation of dopamine receptor signaling.

Mouse (Murine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. EGFR signaling in macrophages, but not in colonic epithelial cells, has a significant role in colitis-associated carcinogenesis.

  2. KrasG12D-driven proliferation of pancreatic ductal epithelial cells (PDECs) depends on an EGFR signaling loop engaging the oncogenic transcription factor c-MYC (show MYC Proteins).

  3. Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor

  4. High expression of EGFR is associated with lung carcinogenesis.

  5. our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore.

  6. In FGF9-overexpressing colorectal cancer cell lines, FGF9 overexpression induced strong resistance to anti-EGFR therapies via the enforced FGFR (show FGFR2 Proteins) signal, and this resistance was cancelled by the application of an FGFR (show FGFR2 Proteins) inhibitor.

  7. Although EGFR activation promotes wound healing, released exosomes may antagonize EGFR activation and wound healing.

  8. opposing signals generated by different ErbB dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.

  9. Combined targeting of TGF-beta (show TGFB1 Proteins), EGFR and HER2 (show ERBB2 Proteins) signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.

  10. The conjugation of benzylguanine-modified auristatin F to EGFR-specific 425(scFv)-SNAP and HER2 (show ERBB2 Proteins)-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.

Pig (Porcine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways

  2. Syndecan-4 (show SDC4 Proteins) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.

  3. These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.

  4. patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation

  5. Report EGFR expression in the normal pancreas.

  6. Injury and activation of purinergic receptors and direct activation of EGFR via EGF (show EGF Proteins) induce distinct downstream pathways.

  7. Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (show NOS1 Proteins)-derived nitric oxide.

  8. EGFR, VEGFR (show KDR Proteins) and FGFR (show FGFR2 Proteins) are expressed in porcine oviduct and endometrium during the time of implantation [review]

  9. the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct

  10. The phase-related expression of EGF (show EGF Proteins) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (show EGF Proteins) and its receptor on the uterine artery and the region supplying these vessels.

Cow (Bovine) Epidermal Growth Factor Receptor (EGFR) interaction partners

  1. Stimulation of bovine oviduct epithelial cell EGFR with EGF (show EGF Proteins) (human recombinant EGF (show EGF Proteins)) alone or with EGF (show EGF Proteins) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (show EGF Proteins) on phosphorylation of MAPKs.

  2. Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.

  3. Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.

  4. EGFR may simultaneously activate c-Src (show SRC Proteins) and PI3K to amplify the oxytocin signaling to increase the output of PGF (show PGF Proteins)(2 alpha) in endometrial epithelial cells.

  5. results indicate that arginase induction depends in part on epidermal growth factor (EGF (show EGF Proteins)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release

  6. Data suggest that epidermal growth factor (EGF (show EGF Proteins)) and EGF (show EGF Proteins) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.

  7. MT1-MMP (show MMP14 Proteins) has a role in signaling events mediating EGFR transactivation

  8. possible cooperative role of the EGF (show EGF Proteins) and HGF (show HGF Proteins) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow

  9. EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.

EGFR Protein Profile

Protein Summary

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Alternative names and synonyms associated with EGFR

  • epidermal growth factor receptor (EGFR)
  • Epidermal growth factor receptor (Egfr)
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (egfra)
  • epidermal growth factor receptor (egfr1)
  • epidermal growth factor receptor (AaeL_AAEL004319)
  • epidermal growth factor receptor (Egfr)
  • epidermal growth factor receptor (LOC100008806)
  • 9030024J15Rik protein
  • AI552599 protein
  • C-erb protein
  • c-erbB protein
  • CG10079 protein
  • D-Egf protein
  • d-egf-r protein
  • D-EGFR protein
  • dEgfr protein
  • dEGFR1 protein
  • der protein
  • DER/EGFR protein
  • DER/faint little ball protein
  • DER/top protein
  • DER/torpedo protein
  • DER1 protein
  • DER flb protein
  • Dmel\\CG10079 protein
  • DmHD-33 protein
  • EFG-R protein
  • Egf protein
  • Egf-r protein
  • egfr protein
  • egfr1 protein
  • EGFR12 protein
  • EGFR15 protein
  • EK2-6 protein
  • El protein
  • Elp protein
  • Elp-1 protein
  • Elp-B1 protein
  • Elp-B1RB1 protein
  • Erbb protein
  • ErbB-1 protein
  • ERBB1 protein
  • Erbb2 protein
  • Errb1 protein
  • Errp protein
  • flb protein
  • HD-33 protein
  • HER1 protein
  • l(2)05351 protein
  • l(2)09261 protein
  • l(2)57DEFa protein
  • l(2)57Ea protein
  • l(2)57EFa protein
  • mENA protein
  • mor1 protein
  • PIG61 protein
  • top protein
  • top/DER protein
  • top/flb protein
  • Torpedo/DER protein
  • torpedo/egfr protein
  • wa-2 protein
  • wa2 protein
  • Wa5 protein

Protein level used designations for EGFR

CG10079-PA , CG10079-PB , DER-Ellipse , EGF-receptor , EGFR , Egf receptor , Egfr-PA , Egfr-PB , drosophila epidermal growth factor receptor homologue , ellipse , ellipse torpedo , epidermal growth factor receptor , faint little ball , morphological defects 1 , torpedo , torpedo/DER , erbb1a , avian erythroblastic leukemia viral (v-erb-b) oncogene homolog , cell growth inhibiting protein 40 , cell proliferation-inducing protein 61 , proto-oncogene c-ErbB-1 , receptor tyrosine-protein kinase erbB-1 , EGFR-related peptide , Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) , avian erythroblastic leukemia viral (v-erbB) oncogene homolog , epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) , waved 2 , CER , epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) , egf receptor , receptor tyrosine kinase ErbB1

GENE ID SPECIES
100067755 Equus caballus
37455 Drosophila melanogaster
378478 Danio rerio
778955 Ciona intestinalis
5564544 Aedes aegypti
1956 Homo sapiens
24329 Rattus norvegicus
13649 Mus musculus
396494 Gallus gallus
397070 Sus scrofa
404306 Canis lupus familiaris
407217 Bos taurus
100008806 Oryctolagus cuniculus
100725363 Cavia porcellus
780479 Ovis aries
613027 Macaca mulatta
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