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Browse our Integrin beta 2 Proteins (ITGB2)

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Integrin beta 2 Proteins (ITGB2)
On are 16 Integrin beta 2 (ITGB2) Proteins from 5 different suppliers available. Additionally we are shipping Integrin beta 2 Antibodies (668) and Integrin beta 2 Kits (12) and many more products for this protein. A total of 703 Integrin beta 2 products are currently listed.
2E6, AI256028, AI528527, CD18, D12S370, ITGB2, LAD, LCAMB, LFA-1, Lfa1, LT-BETA-R, Ltar, LTbetaR, MAC-1, MF17, MFI7, TNF-R-III, Tnfbr, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRrp, TNFRSF3
list all proteins Gene Name GeneID UniProt
ITGB2 16414 P11835
ITGB2 309684  
ITGB2 3689 P05107

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Integrin beta 2 Proteins (ITGB2) by Origin

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Top referenced Integrin beta 2 Proteins

  1. Human Integrin beta 2 Protein expressed in HEK-293 Cells - ABIN2713476 : De Franceschi, Peuhu, Parsons, Rissanen, Vattulainen, Salmi, Ivaska, Pouwels: Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. in PLoS ONE 2015 (PubMed)

More Proteins for Integrin beta 2 Interaction Partners

Mouse (Murine) Integrin beta 2 (ITGB2) interaction partners

  1. Study suggest an important impact of NKT (show CTSL1 Proteins) cells and postulate a critical function for LFA-1 (show ITGAL Proteins) during processes of liver regeneration.

  2. NDR1 (show STK38 Proteins) kinase, activated by the Rap1 (show TERF2IP Proteins) signaling cascade through RAPL (show RASSF5 Proteins) and Mst1 (show MST1 Proteins)/Mst2 (show STK3 Proteins), associated with and recruited kindlin-3 (show FERMT3 Proteins) to the immunological synapses, which was required for high-affinity LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) binding.

  3. LTbetaR is essential for efficient liver regeneration and cooperates with TNFRp55 (show TNFRSF1A Proteins) in this process. Differences in survival kinetics strongly suggest distinct functions for these two cytokine receptors in liver regeneration.

  4. SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.

  5. Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 (show ITGAL Proteins) activation and neutrophil arrest in vivo

  6. report that beta2 and alpha4 integrins use different RIAM (show APBB1IP Proteins)-dependent and -independent pathways to undergo activation by talin

  7. Timely blockade of ICAM-1 (show ICAM1 Proteins).LFA-1 (show ITGAL Proteins) interaction prevents disease onset in a mouse model of emphysema.

  8. This study identified Mrp8 (show S100A8 Proteins)/14 and TLR4 (show TLR4 Proteins) as important modulators of the leukocyte recruitment cascade during inflammation via integrin beta2.

  9. Anti-OX40L (show TNFSF4 Proteins) mAb could prolong secondary heart allograft survival based on CD40 (show CD40 Proteins)/CD40L (show CD40LG Proteins) and LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) blockade.

  10. Alzheimer's disease model mice lacking LFA-1 (show ITGAL Proteins) were protected from cognitive decline

Human Integrin beta 2 (ITGB2) interaction partners

  1. K152 and D120 within the PH domain of SKAP55 (show SKAP1 Proteins) regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1 (show ITGAL Proteins).

  2. LIGHT and LTBR (show LTBR Proteins) interaction increases the survival and proliferation of human bone marrow-derived mesenchymal stem cells, and therefore, LIGHT might play an important role in stem cell therapy.

  3. Genetic inactivation and blockade studies revealed that homophilic interactions between intercellular adhesion molecule 1 (ICAM-1 (show ICAM1 Proteins)) expressed on tumor cells and MSCs, respectively, regulate the competition between tumor cells and HSPCs for binding to MSCs. Moreover, tumor cell-secreted soluble ICAM-1 (show ICAM1 Proteins)(sICAM-1) also impaired HSPC (show PSMA7 Proteins) adhesion via blocking CD18-ICAM-1 (show ICAM1 Proteins) binding between HSPCs and MSCs

  4. The ability of simvastatin to target CR3 (show ITGAM Proteins) in its ligand binding-activated conformation is a novel mechanism to explain the known anti-inflammatory effects of this compound, in particular because this CR3 (show ITGAM Proteins) conformation is found in pro-inflammatory environments.

  5. CD18 methylation and age greater than 65 years were independent prognostic factors of thrombosis complicated by primary myelofibrosis.

  6. We found that LTbetaR polymorphisms caused severe BPH (show GLI3 Proteins). Thus, LTbetaR may contribute to the risk of BPH (show GLI3 Proteins) development.

  7. our study highlights the difficulties with the sole use of CD18 for the diagnosis of LAD-1 (show COL17A1 Proteins).

  8. Critical role of the Mac1 (show ITGAM Proteins)/NOX2 (show CYBB Proteins) pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

  9. Contact-activated C3(H2O) is a novel ligand for CD11b/CD18 (show ITGAM Proteins) that mediates platelet-PMN (show TBCE Proteins) complex formation and the binding of platelet-derived microparticles to PMNs.

  10. The expression level of Mac-1 (show ITGAM Proteins) correlated with the number of neutrophils in patients with serous, endometrioid and undifferentiated epithelial ovarian cancer.

Cow (Bovine) Integrin beta 2 (ITGB2) interaction partners

  1. Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.

  2. intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (show SELL Proteins) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes

  3. A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (show CA2 Proteins)+]i, diminished annexin V (show ANXA5 Proteins) expression on the cell surface, and decreased caspase 3 (show CASP3 Proteins) activity in lysates

  4. The I-EGF (show EGF Proteins)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.

  5. These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]

  6. study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (show ORM1 Proteins) and inhibited the chemotaxis of monocytes

  7. Loss of CD18 is associated with bovine leukocyte adhesion deficiency.

  8. Intact signal peptide of CD18, the beta-subunit (show POLG Proteins) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.

Pig (Porcine) Integrin beta 2 (ITGB2) interaction partners

  1. CR3 (show ITGAM Proteins) plays a cardinal (show CARD8 Proteins) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.

  2. The expression of zona pellucida glycoprotein 3 (show ZP3 Proteins) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.

  3. early CD18 downregulation is profitable for the host in a situation with an intense LPS (show IRF6 Proteins) stimulus

  4. It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.

Goat Integrin beta 2 (ITGB2) interaction partners

  1. Integrin CD11c (show ITGAX Proteins)/CD18 alpha-chain (show FCGRT Proteins) phosphorylation is functionally important.

Integrin beta 2 (ITGB2) Protein Profile

Protein Summary

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Alternative names and synonyms associated with Integrin beta 2 (ITGB2)

  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2)
  • integrin, beta 2 (ITGB2)
  • integrin beta 2 (Itgb2)
  • integrin, beta 2 (Itgb2)
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (CD18)
  • lymphotoxin B receptor (Ltbr)
  • lymphotoxin beta receptor (TNFR superfamily, member 3) (LTBR)
  • 2E6 protein
  • AI256028 protein
  • AI528527 protein
  • CD18 protein
  • D12S370 protein
  • ITGB2 protein
  • LAD protein
  • LCAMB protein
  • LFA-1 protein
  • Lfa1 protein
  • LT-BETA-R protein
  • Ltar protein
  • LTbetaR protein
  • MAC-1 protein
  • MF17 protein
  • MFI7 protein
  • TNF-R-III protein
  • Tnfbr protein
  • TNFCR protein
  • TNFR-RP protein
  • TNFR2-RP protein
  • TNFR3 protein
  • TNFRrp protein
  • TNFRSF3 protein

Protein level used designations for Integrin beta 2 Proteins (ITGB2)

integrin beta-2 , Mac-1 beta , cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta , complement receptor C3 subunit beta , lymphocyte function associated antigen 1 , macrophage antigen-1 beta , CD18 leukocyte adhesion molecule , integrin beta 2 , integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1 , integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) , macrophage antigen 1 (mac-1) beta subunit) , cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor) , complement receptor C3 beta-subunit , integrin beta chain, beta 2 , leukocyte cell adhesion molecule CD18 , leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C , CD18 subunit , Leu-CAM receptor , integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2) , integrin beta 2 subunit , Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta , Complement receptor C3 subunit beta , Integrin beta-2 , antigen CD18 , integrin beta-2 chain , LT beta-R , LT-beta receptor , TNF receptor-related protein , lymphotoxin-beta receptor , tumor necrosis factor receptor superfamily member 3 , tumor necrosis factor receptor superfamily, member 3 , lymphotoxin B receptor , tumor necrosis factor C receptor , tumor necrosis factor receptor 2-related protein , tumor necrosis factor receptor type III

458607 Pan troglodytes
710577 Macaca mulatta
16414 Mus musculus
309684 Rattus norvegicus
3689 Homo sapiens
281877 Bos taurus
396943 Sus scrofa
396181 Gallus gallus
100861185 Capra hircus
494433 Ovis aries
17000 Mus musculus
4055 Homo sapiens
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