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Here, the authors unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 (show TP53 Proteins) inactivator. p53 (show TP53 Proteins) activates NGFR transcription, whereas NGFR inactivates p53 (show TP53 Proteins) by promoting its MDM2 (show MDM2 Proteins)-mediated ubiquitin-dependent proteolysis and by directly binding to its central DNA binding domain and preventing its DNA-binding activity.
Data suggest that p75NTR as a central regulator of glioma tumorigenesis, the tumor microenvironment, and tumor invasiveness; p75NTR may contribute to the drug resistance of glioma. [REVIEW]
These results demonstrated that EpCAM (show EPCAM Proteins) + p75NTR+ CTC count was a more accurate diagnostic marker than EpCAM (show EPCAM Proteins)+ CTC count, suggesting the highly metastatic potential of CTCs with p75NTR expression.
Co-immunoprecipitation and biochemical fractionation data suggested that p75 (show CUX1 Proteins) TM stimulates TrkB (show NTRK2 Proteins) phosphorylation at the cell membrane.
hese results suggest that LNGFR(+)THY-1 (show THY1 Proteins)(+) cells identified following NCLC induction from ESCs (show NR2E3 Proteins)/iPSCs shared similar potentials with multipotent MSCs.
a stage-related modulation of beta-NGF (show NGFB Proteins) and its receptors in the inflammatory process of OA
the results indicate that CD271 loss is critical for melanoma progression and metastasis.
For Fat3, the Kif5 (show KIF5A Proteins)-ID is regulated by alternative splicing, and the timecourse of splicing suggests that the distribution of Fat3 may switch between early and later stages of retinal development. In contrast, P75NTR binding to Kif5B (show KIF5B Proteins) is enhanced by tyrosine phosphorylation and thus has the potential to be dynamically regulated on a more rapid time scale
these data suggest a positive feedback loop through which NGF (show NGFB Proteins)-mediated upregulation of p75(NTR) can contribute to the chemo-resistance of Triple negative breast cancer cells.
Based on these current developments, the present review provides not only a broad overview of the biological effects of NGF-TrkA-p75NTR on cancer cells and their microenvironment, but also explains why NGF and its receptors are going to evoke major interest as promising therapeutic anti-cancer targets in the coming decade.
The carboxyl-terminal region of NRH is necessary and sufficient to rescue gastrulation defects and to induce filopodia formation in cells of the dorsal marginal zone.
NRH1 proteins play multiple roles in the proper expression of mesodermally expressed genes such as Xbra and Chordin (show CHRD Proteins), and to a lesser extent, of Xwnt11.
Here the authors demonstrate a novel function for p75(NTR) in regulating proper cell cycle exit of neuronal progenitors in the developing rat and mouse external granule layer, which is stimulated by proneurotrophin-3. In the absence of p75(NTR), cerebellar granule cell progenitors continue to proliferate beyond their normal period, resulting in a larger cerebellum that persists into adulthood, with consequent motor defici
75NTR is involved in downstream signaling events that mediate BMP7 (show BMP7 Proteins)-induced dendritic growth in sympathetic neurons.
Neurotoxic effect of gp120 (show ITIH4 Proteins) is mediated by p75NTR.
We show that myelin-associated glycoprotein (show MAG Proteins) or CNS myelin, in general, inhibit rodent Schwann cell migration and induce their death via cleavage of the neurotrophin (show BDNF Proteins) receptor p75.
Peri (show POSTN Proteins)-synaptic glia uses p75NTR to clear proBDNF secreted from neurons. Glial p75NTR is essential for long term potentiation maintenance.
Neuronal death induced by p75NTR requires Cys259.
NRADD deletion results in an increase in the proportion of dorsal root ganglion neurons expressing p75NTR
deletion of p75NTR in mice leads to physiological and morphological changes in the amygdala and altered behavior that is linked to the limbic system
Study showed that BDNF (show BDNF Proteins) signaling through its low-affinity receptor p75 is compromised in the forebrain of En2 (show EN2 Proteins)-/- mice; BDNF (show BDNF Proteins) signaling deficits might be involved in the neurodevelopmental alterations observed in the En2 (show EN2 Proteins)-/- forebrain
Results suggest a role for p75 in augmenting survival signaling in the striata of Hdh (show HTT Proteins)+/Q175 mice, and that the loss of this early pro-survival signaling leads to earlier onset of striatal dysfunction/degeneration
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
nerve growth factor receptor (TNFR superfamily, member 16)
, nerve growth factor receptor
, tumor necrosis factor receptor superfamily member 16-like
, NGF receptor
, TNFR superfamily, member 16
, low affinity nerve growth factor receptor
, low affinity neurotrophin receptor p75NTR
, low-affinity nerve growth factor receptor
, p75 ICD
, tumor necrosis factor receptor superfamily member 16
, nerve growth factor receptor, fast
, p75 neurotrophin receptor