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anti-Human PKC zeta Antibodies:
anti-Mouse (Murine) PKC zeta Antibodies:
anti-Rat (Rattus) PKC zeta Antibodies:
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Human Polyclonal PKC zeta Primary Antibody for IHC, WB - ABIN871617
Parmentier, Gandhi, Wiggins, Saeed, Bourgoin, Malik: Protein kinase Czeta regulates phospholipase D activity in rat-1 fibroblasts expressing the alpha1A adrenergic receptor. in BMC cell biology 2004
Show all 4 references for ABIN871617
Human Polyclonal PKC zeta Primary Antibody for IHC (p), WB - ABIN391018
Lerner-Marmarosh, Miralem, Gibbs, Maines: Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007
Cow (Bovine) Polyclonal PKC zeta Primary Antibody for WB - ABIN2775614
Xie, Dong, Zhang, Cui, Cohen, Riek, Neumann, Schlattner, Zou: Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. in The Journal of biological chemistry 2006
Protein kinase c (show PKC Antibodies) activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
The PKC-zeta - induced phosphorylation of GSK-3 beta (show GSK3b Antibodies) stimulates GSK-3 beta (show GSK3b Antibodies) activity.
Over-expression of PRKCZ results in gene and/or protein expression alterations of insulin-like growth factor 1 receptor (IGF1R (show IGF1R Antibodies)) and integrin beta 3 (ITGB3 (show ITGB3 Antibodies)) in SKOV3 and OVCAR3 cells.
PKCzeta inhibition prevented alternative cleavage and release of TROP2 (show TACSTD2 Antibodies), suggesting that these events require endocytic uptake and exosomal release of the corresponding microvesicles.
Data show that aPKC scaffold protein (show HOMER1 Antibodies) p62 (show GTF2H1 Antibodies) tethers Atypical protein kinase C (aPKC) in an active conformation.
PRKCZ methylation is associated with sunlight exposure
Neuronal NF1 (show NF1 Antibodies)/RAS regulation of cyclic AMP (show APRT Antibodies) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (show NF1 Antibodies).
The results indicate that induction and activation of PKCzeta promote TNBC growth, invasion and metastasis.
PKCzeta and PKMzeta are overexpressed in TCF3 (show TCF3 Antibodies)-rearranged paediatric acute lymphoblastic leukaemia and may have a role in thiopurine sensitivity
Results indicate that PKCzeta regulates survivin (show BIRC5 Antibodies) expression levels and inhibits apoptosis in colon cancer cells.
These data indicate for the first time that HIV-1 Gag phosphorylation on Ser487 is mediated by atypical PKC and that this kinase may regulate the incorporation of Vpr into HIV-1 virions and thereby supports virus infectivity.
androstenedione administration increased Akt1 (show AKT1 Antibodies) and PKC zeta phosphorylation in the muscle tissue of C57BL6 mice.
studies support a model wherein an alternative mechanism regulates PKCzeta-mediated insulin (show INS Antibodies) signalling that does not utilize conventional activation via agonist-evoked phosphorylation at the activation loop
PKCzeta/p62 (show GTF2H1 Antibodies) activation stimulated inflammatory cytokine production and enhanced IGF-I (show IGF1 Antibodies)-stimulated VSMC proliferation
Neuronal NF1 (show NF1 Antibodies)/RAS regulation of cyclic AMP (show TMPRSS5 Antibodies) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (show NF1 Antibodies).
Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda.
Data indicate that pseudosubstrate arginine residues are key regulators of atypical protein kinase C-lambda (show PRKCI Antibodies) and atypical protein kinase C-zeta.
Lgl1 (show Klra7 Antibodies) forms two distinct complexes in vivo, Lgl1 (show Klra7 Antibodies)-NMIIA and Lgl1 (show Klra7 Antibodies)-Par6alpha (show PARD6A Antibodies)-aPKCzeta, and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (show Klra7 Antibodies).
Either depleting PKC-zeta or inhibiting NADPH oxidase (show NOX1 Antibodies).
KIBRA (show WWC1 Antibodies) levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta
Phosphatidylinositol-3,4,5-triphosphate but not phosphatidylinositol-4,5-biphosphate plays an important role in GLUT4 (show SLC2A4 Antibodies) upregulation and glucose metabolism mediated by AKT (show AKT1 Antibodies)/PKCzeta/lambda phosphorylation.
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (show ANGPT1 Antibodies), via phosphorylation of eNOS (show NOS3 Antibodies) on Thr (show TRH Antibodies)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (show VEGFA Antibodies)-stimulated endothelial permeability by Ang-1 (show ANGPT1 Antibodies).
ceramide as a potent physiological modulator of the Na(+)-ATPase (show DNAH8 Antibodies), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta