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anti-Human PKC zeta Antibodies:
anti-Mouse (Murine) PKC zeta Antibodies:
anti-Rat (Rattus) PKC zeta Antibodies:
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Human Polyclonal PKC zeta Primary Antibody for IHC (p), WB - ABIN391018
Lerner-Marmarosh, Miralem, Gibbs, Maines: Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007
Human Polyclonal PKC zeta Primary Antibody for IHC (p) - ABIN2476259
Hirai, Chida: Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. in Journal of biochemistry 2003
Human Polyclonal PKC zeta Primary Antibody for ICC, IF - ABIN4345863
Verbist, Guy, Milasta, Liedmann, Kamiński, Wang, Green: Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. in Nature 2016
Protein kinase c (show PKC Antibodies) activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
This study demonstrated that zinc upregulates PKCzeta by activating GPR39 (show GPR39 Antibodies) to enhance the abundance of ZO-1 (show TJP1 Antibodies), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 (show IL4 Antibodies) and interleukin-10 (show IL10 Antibodies)
Here we provide the first evidence that PKC-zeta is a potential target for the treatment of COPD (show ARCN1 Antibodies) by selective small molecules
Study provides evidence for a novel PKC-zeta to p47phox (show NCF1 Antibodies) interaction that is required for cell transformation from blebbishields and ROS (show ROS1 Antibodies) production in cancer cells.
FRET-based translocation assays reveal that insulin (show INS Antibodies) promotes the association of both p62 (show GTF2H1 Antibodies) and aPKC with the insulin (show INS Antibodies)-regulated scaffold IRS-1 (show IRS1 Antibodies).
data suggest that the interaction between this novel region in Galphaq (show GNAQ Antibodies) and the effector PKCzeta is a key event in Galphaq (show GNAQ Antibodies) signaling.
The PKC-zeta - induced phosphorylation of GSK-3 beta (show GSK3b Antibodies) stimulates GSK-3 beta (show GSK3b Antibodies) activity.
Over-expression of PRKCZ results in gene and/or protein expression alterations of insulin-like growth factor 1 receptor (IGF1R (show IGF1R Antibodies)) and integrin beta 3 (ITGB3 (show ITGB3 Antibodies)) in SKOV3 and OVCAR3 cells.
PKCzeta inhibition prevented alternative cleavage and release of TROP2 (show TACSTD2 Antibodies), suggesting that these events require endocytic uptake and exosomal release of the corresponding microvesicles.
Data show that aPKC scaffold protein (show HOMER1 Antibodies) p62 (show GTF2H1 Antibodies) tethers Atypical protein kinase C (aPKC) in an active conformation.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (show INS Antibodies) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (show FRAP1 Antibodies) protein) and Ccnd2 (cyclin-D2 (show CCND2 Antibodies)).
androstenedione administration increased Akt1 (show AKT1 Antibodies) and PKC zeta phosphorylation in the muscle tissue of C57BL6 mice.
studies support a model wherein an alternative mechanism regulates PKCzeta-mediated insulin (show INS Antibodies) signalling that does not utilize conventional activation via agonist-evoked phosphorylation at the activation loop
PKCzeta/p62 (show GTF2H1 Antibodies) activation stimulated inflammatory cytokine production and enhanced IGF-I (show IGF1 Antibodies)-stimulated VSMC proliferation
Neuronal NF1 (show NF1 Antibodies)/RAS regulation of cyclic AMP (show TMPRSS5 Antibodies) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (show NF1 Antibodies).
Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda.
Data indicate that pseudosubstrate arginine residues are key regulators of atypical protein kinase C-lambda (show PRKCI Antibodies) and atypical protein kinase C-zeta.
Lgl1 (show Klra7 Antibodies) forms two distinct complexes in vivo, Lgl1 (show Klra7 Antibodies)-NMIIA and Lgl1 (show Klra7 Antibodies)-Par6alpha (show PARD6A Antibodies)-aPKCzeta, and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (show Klra7 Antibodies).
Either depleting PKC-zeta or inhibiting NADPH oxidase (show NOX1 Antibodies).
KIBRA (show WWC1 Antibodies) levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (show ANGPT1 Antibodies), via phosphorylation of eNOS (show NOS3 Antibodies) on Thr (show TRH Antibodies)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (show VEGFA Antibodies)-stimulated endothelial permeability by Ang-1 (show ANGPT1 Antibodies).
ceramide as a potent physiological modulator of the Na(+)-ATPase (show DNAH8 Antibodies), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta