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Browse our SQSTM1 Proteins (SQSTM1)

Full name:
Sequestosome 1 Proteins (SQSTM1)
On www.antibodies-online.com are 15 Sequestosome 1 (SQSTM1) Proteins from 9 different suppliers available. Additionally we are shipping SQSTM1 Antibodies (306) and SQSTM1 Kits (7) and many more products for this protein. A total of 342 SQSTM1 products are currently listed.
Synonyms:
A170, MGC79491, OSF-6, Osi, OSIL, p60, p62, p62B, PDB3, sb:cb621, sqstm1, STAP, zgc:85784, ZIP, ZIP3
list all proteins Gene Name GeneID UniProt
SQSTM1 8878 Q13501
SQSTM1 18412 Q64337
SQSTM1 113894 O08623

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SQSTM1 Proteins (SQSTM1) by Origin

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Top referenced SQSTM1 Proteins

  1. Human SQSTM1 Protein expressed in Escherichia coli (E. coli) - ABIN666979 : Falchetti, Di Stefano, Marini, Del Monte, Mavilia, Strigoli, De Feo, Isaia, Masi, Amedei, Cioppi, Ghinoi, Bongi, Di Fede, Sferrazza, Rini, Melchiorre, Matucci-Cerinic, Brandi: Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB). in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 (PubMed)

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Human Sequestosome 1 (SQSTM1) interaction partners

  1. siRNA-mediated knockdown of p62 clearly increased the efficiency of transfection of murine embryonic stem (mES) cells and human HeLa cells. These data indicate that p62 acts as a key regulator of gene delivery.

  2. These studies suggest that p62 is involved in the genesis of nuclear factor kappaB-induced proinflammatory and prolabor mediators.

  3. In this review, we discuss p62-mediated signaling pathways and their roles in liver pathophysiology, especially nonalcoholic steatohepatitis and hepatocellular carcinoma

  4. findings expand the SQSTM1-associated phenotypic spectrum and lend further support to the concept of disturbed selective autophagy pathways in neurodegenerative diseases

  5. Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubuleassociated protein 1A/1Blight chain 3 (LC3)I to LC3II, the increased expression levels of autophagyrelated gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation

  6. Results demonstrate that p62 (show GTF2H1 Proteins) facilitates activation of NRF2 (show GABPA Proteins) and mTORC1 and is essential for hepatocellular carcinomas (HCC (show FAM126A Proteins)) initiation. High levels of p62 accumulation in non-tumor liver tissue in early-stage HCC patients.

  7. Results show that Nrf2 (show GABPA Proteins) prevents TM-induced apoptotic cell death and that TM promotes p62 (show GTF2H1 Proteins)-dependent autophagic Keap1 (show KEAP1 Proteins) degradation, leading to Nrf2 (show GABPA Proteins) activation. In addition, we identified that p62 (show GTF2H1 Proteins) is essential to protect cells against TM-mediated oxidative damage through Nrf2 (show GABPA Proteins) activation.

  8. Spinal stenosis emerges as a prominent phenotype in SQSTM1 P392L-positive men with aging

  9. p62 is a crucial positive regulator of HIF1alpha, which is a facilitating factor in p62-enhanced tumorigenesis.

  10. SQSTM1 mutations were initially associated with Paget disease of bone (PDB), they have been also identified in FTD (show FTL Proteins)(familial frontotemporal dementia).

Mouse (Murine) Sequestosome 1 (SQSTM1) interaction partners

  1. Our results indicate that JEV replication is impaired in p62-deficient MEFs, suggesting that p62 positively regulates JEV replication in host cells.

  2. Results demonstrate that p62 (show GTF2H1 Proteins) facilitates activation of NRF2 (show NFE2L2 Proteins) and mTORC1 and is essential for hepatocellular carcinomas (HCC (show FAM126A Proteins)) initiation.

  3. p62 may be a crucial mediator for the mitochondrial apoptosis pathway in Monosodium Urate crystal-induced inflammation, which is linked to the acute inflammatory response during the early phase of gout.

  4. Results show that Nrf2 (show NFE2L2 Proteins) prevents TM-induced apoptotic cell death and that TM promotes p62 (show GTF2H1 Proteins)-dependent autophagic Keap1 (show KEAP1 Proteins) degradation, leading to Nrf2 (show NFE2L2 Proteins) activation. In addition, we identified that p62 (show GTF2H1 Proteins) is essential to protect cells against TM-mediated oxidative damage through Nrf2 (show NFE2L2 Proteins) activation.

  5. the molecular basis for the escape of TBC1D25 (show TBC1D25 Proteins) from autophagic degradation by performing a chimeric analysis between TBC1D25 (show TBC1D25 Proteins) and SQSTM1/p62, was investigated.

  6. p62 (show GTF2H1 Proteins) are subjected to parkin (show PARK2 Proteins) mediated proteasomal degradation

  7. Data show that sequestosome 1 protein p62 deficiency increased atherosclerotic plaque burden in mice with a macrophage-specific ablation of autophagy-related 5 protein ATG5.

  8. These results indicate that Sqstm1-GFP(KI/+) mice are a useful tool for analyzing Sqstm1 in living cells and intact animals.

  9. p62 (show GTF2H1 Proteins) is a novel binding partner for ARIP4 (show RAD54L2 Proteins), and that its binding regulates the cellular protein level of ARIP4 (show RAD54L2 Proteins) under conditions of metabolic stress.

  10. p62 (show GTF2H1 Proteins) is recruited together with ubiquitin to the T. gondii PVs (show PVRL2 Proteins), following IFN-gamma (show IFNG Proteins) stimulation, and plays a specific role in vacuolar-antigen-specific CD8 (show CD8A Proteins)+ T cell activation.

Zebrafish Sequestosome 1 (SQSTM1) interaction partners

  1. Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.

SQSTM1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with SQSTM1

  • sequestosome 1 (SQSTM1)
  • sequestosome 1 (LOC100342157)
  • sqstm1 protein (sqstm1)
  • sequestosome 1 (Sqstm1)
  • sequestosome 1 (sqstm1)
  • A170 protein
  • MGC79491 protein
  • OSF-6 protein
  • Osi protein
  • OSIL protein
  • p60 protein
  • p62 protein
  • p62B protein
  • PDB3 protein
  • sb:cb621 protein
  • sqstm1 protein
  • STAP protein
  • zgc:85784 protein
  • ZIP protein
  • ZIP3 protein

Protein level used designations for Sequestosome 1 Proteins (SQSTM1)

sequestosome 1 , sequestosome-1 , sequestosome-1-like , sqstm1 protein , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , ubiquitin-binding protein p62 , STONE14 , oxidative stress induced , PKC-zeta-interacting protein , protein kinase C-zeta-interacting protein

GENE ID SPECIES
462333 Pan troglodytes
705481 Macaca mulatta
770805 Gallus gallus
100135450 Ovis aries
100342157 Oryctolagus cuniculus
100385650 Callithrix jacchus
493277 Xenopus (Silurana) tropicalis
100067231 Equus caballus
8878 Homo sapiens
18412 Mus musculus
113894 Rattus norvegicus
406452 Danio rerio
379610 Xenopus laevis
338045 Bos taurus
481459 Canis lupus familiaris
100172461 Pongo abelii
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