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Browse our SQSTM1 Proteins (SQSTM1)

Full name:
Sequestosome 1 Proteins (SQSTM1)
On www.antibodies-online.com are 15 Sequestosome 1 (SQSTM1) Proteins from 9 different suppliers available. Additionally we are shipping SQSTM1 Antibodies (254) and SQSTM1 Kits (7) and many more products for this protein. A total of 290 SQSTM1 products are currently listed.
Synonyms:
A170, MGC79491, OSF-6, Osi, OSIL, p60, p62, p62B, PDB3, sb:cb621, sqstm1, STAP, zgc:85784, ZIP, ZIP3
list all proteins Gene Name GeneID UniProt
SQSTM1 8878 Q13501
SQSTM1 18412 Q64337
SQSTM1 113894 O08623

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SQSTM1 Proteins (SQSTM1) by Origin

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Top referenced SQSTM1 Proteins

  1. Human SQSTM1 Protein expressed in Escherichia coli (E. coli) - ABIN666979 : Falchetti, Di Stefano, Marini, Del Monte, Mavilia, Strigoli, De Feo, Isaia, Masi, Amedei, Cioppi, Ghinoi, Bongi, Di Fede, Sferrazza, Rini, Melchiorre, Matucci-Cerinic, Brandi: Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB). in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 (PubMed)

More Proteins for SQSTM1 Interaction Partners

Human Sequestosome 1 (SQSTM1) interaction partners

  1. Results show that Nrf2 (show GABPA Proteins) prevents TM-induced apoptotic cell death and that TM promotes p62 (show GTF2H1 Proteins)-dependent autophagic Keap1 (show KEAP1 Proteins) degradation, leading to Nrf2 (show GABPA Proteins) activation. In addition, we identified that p62 (show GTF2H1 Proteins) is essential to protect cells against TM-mediated oxidative damage through Nrf2 (show GABPA Proteins) activation.

  2. Spinal stenosis emerges as a prominent phenotype in SQSTM1 P392L-positive men with aging

  3. p62 is a crucial positive regulator of HIF1alpha, which is a facilitating factor in p62-enhanced tumorigenesis.

  4. SQSTM1 mutations were initially associated with Paget disease of bone (PDB), they have been also identified in FTD (show FTL Proteins)(familial frontotemporal dementia).

  5. new evidence supports an autophagy-independent key role of the adaptor p62 (show GTF2H1 Proteins) (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma. [Review]

  6. FRET-based translocation assays reveal that insulin (show INS Proteins) promotes the association of both p62 (show GTF2H1 Proteins) and aPKC with the insulin (show INS Proteins)-regulated scaffold IRS-1 (show IRS1 Proteins).

  7. p62 (show GTF2H1 Proteins) are subjected to parkin (show PARK2 Proteins) mediated proteasomal degradation

  8. The present study, for the first time, examined the expression of central autophagy proteins BAG3 and p62 in testicular cancer

  9. The present study supports previous observations on amyotrophic lateral sclerosis that SQSTM1 mutations consistently associate with TDP-43 (show TARDBP Proteins) pathology

  10. Suggest that Beclin 1 and p62 could serve as potential indicators for the prognosis of patients with non-small cell lung cancer.

Mouse (Murine) Sequestosome 1 (SQSTM1) interaction partners

  1. Results show that Nrf2 (show NFE2L2 Proteins) prevents TM-induced apoptotic cell death and that TM promotes p62 (show GTF2H1 Proteins)-dependent autophagic Keap1 (show KEAP1 Proteins) degradation, leading to Nrf2 (show NFE2L2 Proteins) activation. In addition, we identified that p62 (show GTF2H1 Proteins) is essential to protect cells against TM-mediated oxidative damage through Nrf2 (show NFE2L2 Proteins) activation.

  2. the molecular basis for the escape of TBC1D25 (show TBC1D25 Proteins) from autophagic degradation by performing a chimeric analysis between TBC1D25 (show TBC1D25 Proteins) and SQSTM1/p62, was investigated.

  3. p62 (show GTF2H1 Proteins) are subjected to parkin (show PARK2 Proteins) mediated proteasomal degradation

  4. Data show that sequestosome 1 protein p62 deficiency increased atherosclerotic plaque burden in mice with a macrophage-specific ablation of autophagy-related 5 protein ATG5.

  5. These results indicate that Sqstm1-GFP(KI/+) mice are a useful tool for analyzing Sqstm1 in living cells and intact animals.

  6. p62 (show GTF2H1 Proteins) is a novel binding partner for ARIP4 (show RAD54L2 Proteins), and that its binding regulates the cellular protein level of ARIP4 (show RAD54L2 Proteins) under conditions of metabolic stress.

  7. p62 (show GTF2H1 Proteins) is recruited together with ubiquitin to the T. gondii PVs (show PVRL2 Proteins), following IFN-gamma (show IFNG Proteins) stimulation, and plays a specific role in vacuolar-antigen-specific CD8 (show CD8A Proteins)+ T cell activation.

  8. Study shows that NF-kappaB (show NFKB1 Proteins) exerts its anti-inflammatory activity by inducing delayed accumulation of the autophagy receptor p62/SQSTM1.

  9. TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.

  10. The p62 (show GTF2H1 Proteins) double conditional knockout mice demonstrated that p62 (show GTF2H1 Proteins) aggregate formation triggers aberrant superoxide increases by impairing superoxide dismutase (show SOD1 Proteins) functions.

Zebrafish Sequestosome 1 (SQSTM1) interaction partners

  1. Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.

SQSTM1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with SQSTM1

  • sequestosome 1 (SQSTM1)
  • sequestosome 1 (LOC100342157)
  • sqstm1 protein (sqstm1)
  • sequestosome 1 (Sqstm1)
  • sequestosome 1 (sqstm1)
  • A170 protein
  • MGC79491 protein
  • OSF-6 protein
  • Osi protein
  • OSIL protein
  • p60 protein
  • p62 protein
  • p62B protein
  • PDB3 protein
  • sb:cb621 protein
  • sqstm1 protein
  • STAP protein
  • zgc:85784 protein
  • ZIP protein
  • ZIP3 protein

Protein level used designations for Sequestosome 1 Proteins (SQSTM1)

sequestosome 1 , sequestosome-1 , sequestosome-1-like , sqstm1 protein , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , ubiquitin-binding protein p62 , STONE14 , oxidative stress induced , PKC-zeta-interacting protein , protein kinase C-zeta-interacting protein

GENE ID SPECIES
462333 Pan troglodytes
705481 Macaca mulatta
770805 Gallus gallus
100135450 Ovis aries
100342157 Oryctolagus cuniculus
100385650 Callithrix jacchus
493277 Xenopus (Silurana) tropicalis
100067231 Equus caballus
8878 Homo sapiens
18412 Mus musculus
113894 Rattus norvegicus
406452 Danio rerio
379610 Xenopus laevis
338045 Bos taurus
481459 Canis lupus familiaris
100172461 Pongo abelii
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