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analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 (show MAP1LC3A Proteins) using a combination of fluorescence microscopy-based biophysical approaches in living cells
ENC1 (show ENC1 Proteins) interacts with the phosphorylated p62 (show GTF2H1 Proteins) to impair autophagic degradation of mutant huntingtin (show HTT Proteins) protein aggregates.
CAL (show FBLIM1 Proteins) suppresses the expression of pro-inflammatory cytokines via p62 (show GTF2H1 Proteins)/Nrf2 (show GABPA Proteins)-linked HO-1 (show HMOX1 Proteins) induction in RASFs.
Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.
casein kinase 1 (show CSNK1A1 Proteins) phosphorylates the SQSTM1 S349 residue when harmful proteins accumulate under HSF1 (show HSF1 Proteins) stress
SQSTM1 binds and inhibits E3 ligase RNF168s activity, which is essential for H2A ubiquitination
this study proved that SYVN1 (show SYVN1 Proteins) enhances SERPINA1 (show SERPINA1 Proteins)(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1 (show SERPINA1 Proteins)(E342K)/ATZ cytotoxicity.
The authors show that ufmylation regulates SQSTM1 by eliciting a cell type-specific endoplasmic reticulum stress response which induces SQSTM1 expression and results in its accumulation in the cytosol.
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
These data define that YOD1 (show YOD1 Proteins) antagonizes TRAF6 (show TRAF6 Proteins)/p62 (show GTF2H1 Proteins)-dependent IL-1 (show IL1A Proteins) signaling to NF-kappaB (show NFKB1 Proteins).
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3 (show MAP1LC3A Proteins)-II/Map1lc3 (show MAP1LC3B Proteins) in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (show GTF2H1 Proteins) and down-regulates Lc3 (show MAP1LC3A Proteins)-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3 (show MAP1LC3A Proteins)-II/Map1lc3 (show MAP1LC3B Proteins) = microtubule-associated protein (show SPAG5 Proteins) 1-light chain 3)
SQSTM1 dynamically associates with DNA damage foci (DDF) and regulates DNA repair.
Thyroid hormone (show PTH Proteins) promotes selective autophagy via induction of DAPK2 (show DAPK2 Proteins)-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
serine 351 phosphorylation of p62 (show GTF2H1 Proteins) did not enhance its binding to Keap1 (show KEAP1 Proteins) or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (show NFE2L2 Proteins)) transcription factor in this neuronal context. Nrf2 (show NFE2L2 Proteins) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (show NFE2L2 Proteins) gene
Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.
Our findings show how p62 helps maintain intracellular pools of glutathione needed to limit mitochondrial dysfunction in tumor cells with elevated mTORC1
Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
, sqstm1 protein
, EBI3-associated protein of 60 kDa
, EBI3-associated protein p60
, oxidative stress induced like
, phosphotyrosine independent ligand for the Lck SH2 domain p62
, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
, ubiquitin-binding protein p62
, oxidative stress induced
, PKC-zeta-interacting protein
, protein kinase C-zeta-interacting protein