Browse our SQSTM1 Proteins (SQSTM1)

On are 14 Sequestosome 1 (SQSTM1) Proteins from 8 different suppliers available. Additionally we are shipping SQSTM1 Antibodies (307) and SQSTM1 Kits (8) and many more products for this protein. A total of 344 SQSTM1 products are currently listed.
A170, MGC79491, OSF-6, Osi, OSIL, p60, p62, p62B, PDB3, sb:cb621, sqstm1, STAP, zgc:85784, ZIP, ZIP3
list all proteins Gene Name GeneID UniProt
SQSTM1 8878 Q13501
SQSTM1 18412 Q64337
SQSTM1 113894 O08623

SQSTM1 Proteins (SQSTM1) by Origin

More Proteins for SQSTM1 Interaction Partners

Human Sequestosome 1 (SQSTM1) interaction partners

  1. The WDR81 coordinates p62 and LC3C to facilitate autophagic removal of Ub proteins, and provide important insights into CAMRQ2 syndrome, a WDR81-related developmental disorder.

  2. SQSTM1-Nup214, although mostly cytoplasmic, also forms nuclear bodies and inhibits nuclear protein but not poly(A)(+) RNA export.

  3. autophagy upregulation by Sequestosome 1 (p62/SQSM1) knockdown ameliorated this cell injury and relieved insulin (show INS Proteins) resistance

  4. This work suggests that UVA-induced p62 (show GTF2H1 Proteins) acts through COX-2 to promote skin tumor growth and progression.

  5. we provide evidence that p62 (show GTF2H1 Proteins) is implicated in the activation of NF-kappaB (show NFKB1 Proteins) signaling that is partly dependent on RIP1 (show UQCRFS1 Proteins)

  6. In this study, we first observed that p62-positive intranuclear aggregates also appeared in controls and were not specific for the Neuronal Intranuclear Hyaline Inclusion Disease cases.

  7. Data suggest that phosphorylation of SQSTM1 by AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) and translocation of SQSTM1 to mitochondria drives autophagic cell death in adult hippocampal neural stem cells; activation of AMPK (show PRKAA1 Proteins) promotes autophagic cell death; inhibition of AMPK (show PRKAA1 Proteins) (by enzyme inhibitor or RNA interference) suppresses autophagic cell death. (SQSTM1 = sequestosome 1)

  8. Authors found that p62/SQSTM1, a protein upregulated in liver parenchymal cells but downregulated in HCC (show FAM126A Proteins)-associated HSCs, negatively controls hepatic stellate cells activation.

  9. necessary for retinal pigmented epithelial cytoprotection under oxidative stress; NFkappaB p65 activity may be critical upstream initiator of p62 expression in retinal pigmented epithelial cells under oxidative stress

  10. p62/SQSTM1, which accumulates in autophagy-defective cells, directly binds to and inhibits nuclear RNF168 (show RNF168 Proteins), an E3 ligase essential for histone H2A ubiquitination and DNA damage responses. As a result, DNA repair proteins such as BRCA1, RAP80 (show UIMC1 Proteins), and Rad51 (show RAD51 Proteins) cannot be recruited to the sites of DNA double-strand breaks (DSBs), which impairs DSB repair.

Mouse (Murine) Sequestosome 1 (SQSTM1) interaction partners

  1. Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.

  2. Our findings show how p62 helps maintain intracellular pools of glutathione needed to limit mitochondrial dysfunction in tumor cells with elevated mTORC1

  3. TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses.

  4. Authors found that p62/SQSTM1, a protein upregulated in liver parenchymal cells but downregulated in HCC (show FAM126A Proteins)-associated HSCs, negatively controls hepatic stellate cells activation.

  5. SQSTM1 or damaged proteins may be transported from the nose to the brain. These findings strongly implicate widespread protein damage in the etiology of flavorings-related lung disease.

  6. Promoting amino acid sensitivity of the mTOR pathway is dependent on p62 accumulation by inhibition of autophagy and this process plays an important role in the hepatic differentiation of stem/progenitor cells.

  7. role of p62 (show GTF2H1 Proteins) in MDB (show ABR Proteins) maturation and stability

  8. two ALS-linked factors, SQSTM1 and ALS2, have distinct but additive protective roles against mutant SOD1 (show SOD1 Proteins)-mediated toxicity by modulating neuronal proteostasis possibly through the autophagy-endolysosomal system.

  9. These results demonstrated that p62-dependent mitophagy has an immunosuppressive role to innate immune response and might serve as a potential immunomodulatory target for inflammation-associated diseases.

  10. results indicate that autophagy is important for the removal of excess Endoplasmic Reticulum and hepatic CYP enzymes in mouse livers, a process associated with the autophagy receptor protein p62.

Zebrafish Sequestosome 1 (SQSTM1) interaction partners

  1. Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.

SQSTM1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with SQSTM1

  • sequestosome 1 (SQSTM1)
  • sequestosome 1 (LOC100342157)
  • sqstm1 protein (sqstm1)
  • sequestosome 1 (Sqstm1)
  • sequestosome 1 (sqstm1)
  • A170 protein
  • MGC79491 protein
  • OSF-6 protein
  • Osi protein
  • OSIL protein
  • p60 protein
  • p62 protein
  • p62B protein
  • PDB3 protein
  • sb:cb621 protein
  • sqstm1 protein
  • STAP protein
  • zgc:85784 protein
  • ZIP protein
  • ZIP3 protein

Protein level used designations for Sequestosome 1 Proteins (SQSTM1)

sequestosome 1 , sequestosome-1 , sequestosome-1-like , sqstm1 protein , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , ubiquitin-binding protein p62 , STONE14 , oxidative stress induced , PKC-zeta-interacting protein , protein kinase C-zeta-interacting protein

462333 Pan troglodytes
705481 Macaca mulatta
770805 Gallus gallus
100135450 Ovis aries
100342157 Oryctolagus cuniculus
100385650 Callithrix jacchus
493277 Xenopus (Silurana) tropicalis
100067231 Equus caballus
8878 Homo sapiens
18412 Mus musculus
113894 Rattus norvegicus
406452 Danio rerio
379610 Xenopus laevis
338045 Bos taurus
481459 Canis lupus familiaris
100172461 Pongo abelii
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