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Mouse (Murine) DLL4 ELISA Kit for Sandwich ELISA - ABIN1889419
Noguera-Troise, Daly, Papadopoulos, Coetzee, Boland, Gale, Lin, Yancopoulos, Thurston: Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. in Nature 2006
Show all 3 references for ABIN1889419
Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma.
our data indicate that high DLL4 expression predicts pelvic lymph node metastasis and poor survival in cervical cancer. Therefore, DLL4 may be a potential clinical diagnostic marker for patients with early-stage cervical cancer.
Cyclic AMP Response Element Binding Protein (show CREB ELISA Kits) Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (show NOTCH1 ELISA Kits) Signaling
DLL4 and JAG1 (show JAG1 ELISA Kits) may have opposing effects on tumor angiogenesis in glioblastoma.
Data indicate the role for altered forkhead box C2 (FoxC2)-Delta-like (show DLK1 ELISA Kits) ligand 4 (Dll4)signaling in structural alterations of saphenous veins in patients with varicose veins.
Antagonism of the DLL4-Notch (show NOTCH1 ELISA Kits) signaling pathway might provide a potential therapeutic approach for breast cancer treatment by preventing angiogenesis.
Activation of Dll4/Notch (show NOTCH1 ELISA Kits) signaling led to increased expression of ephrin-B2 (show EFNB2 ELISA Kits) and subsequent inhibition of endothelial progenitor cells activity.
DLL4 is a unique functional molecule of human circulating dendritic cells critical for directing Th1 (show TH1L ELISA Kits) and Th17 differentiation
The expression of DLL4 was positively correlated with CD105-labeled MVD (show MVD ELISA Kits).
The detection of Notch1 (show NOTCH1 ELISA Kits) and Delta-like (show DLK1 ELISA Kits) 4 expression in peripheral blood lymphocytes of renal transplant recipients can serve as a positive indicator for evaluating the diagnosis and treatment efficacy of the AR reaction.
miRNA-30e targeted the 3'-UTR (show UTS2R ELISA Kits) of Dll4 and downregulated Dll4 expression
Dll4/Notch (show NOTCH1 ELISA Kits) signaling and HIF-1alpha (show HIF1A ELISA Kits) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.
Dll4-induced Notch1 (show NOTCH1 ELISA Kits) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.
Tumor promoting effect of low-dosage inhibition needs to be considered when implementing Delta-like (show DLK1 ELISA Kits) 4 targeting therapies.
The heart defects in Dll4-/- embryos are consistent with primary defects in vessel patterning.
DLL4 is an efficient cis (show CISH ELISA Kits)-inhibitor of Notch (show NOTCH1 ELISA Kits) signaling during embryogenesis.
Macrophage Dll4 promotes lesion development in vein grafts via macrophage activation and crosstalk between macrophages and smooth muscle cells.
work reveals how lymphatic vessel responses are shaped by tissue specialization and uncover a role for continuous DLL4 signaling in the function of adult lymphatic vasculature.
Delta-like (show DLK1 ELISA Kits) 4-mediated Notch (show NOTCH1 ELISA Kits) signaling is required for early T-cell development in a three-dimensional thymic structure.
Thsd7a (show THSD7A ELISA Kits) could regulate ISV angiogenesis via Notch (show NOTCH1 ELISA Kits)-dll4 signaling. Thus, Thsd7a (show THSD7A ELISA Kits) is a potent angioneurin involved in the development of both neural and vascular systems.
show that blood flow suppresses vascular Notch (show NOTCH1 ELISA Kits) signalling via down-regulation of dll4
Microinjection of miR (show MYLIP ELISA Kits)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.
Notch (show NOTCH1 ELISA Kits) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (show NOTCH1 ELISA Kits) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.
These studies imply critical roles for Dll4/Notch (show NOTCH1 ELISA Kits) signaling in the formation and wiring of the lymphatic network.
Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.
Vegfc (show VEGFC ELISA Kits)/Flt4 (show FLT4 ELISA Kits) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
delta-like protein 4
, delta 4
, delta ligand 4
, delta-like 4 homolog
, delta-like 4 protein
, drosophila Delta homolog 4
, notch ligand DLL4
, notch ligand delta-2