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The authors present novel structures of human ligands Jagged2 (show JAG2 ELISA Kits) and Delta-like4 and human Notch2 (show NOTCH2 ELISA Kits), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (show NOTCH1 ELISA Kits) binding is likely to be critical in establishing the optimal context for Notch (show NOTCH1 ELISA Kits) signalling.
Overexpression of DLL4 could significantly attenuate the cytotoxic effects of docetaxel in MCF-7 cells by increasing Bcl-2 (show BCL2 ELISA Kits) expression, while decreasing Bax (show BAX ELISA Kits) expression, apoptosis rate and DNA damage
In gastric epithelial cells co-cultured with Helicobacter pylori, the expression level of the ligand DLL4 was found to be significantly increased.
Low DLL4 abundance in tumour cells may predict the benefit from adjuvant gemcitabine therapy after PDAC resection.
Angiogenesis in Infantile haemangioma (IH) appears to be controlled by DLL4 within the endothelium in a VEGF-A (show VEGFA ELISA Kits) isoform-dependent manner, and in perivascular cells in a VEGF (show VEGFA ELISA Kits)-independent manner. The contribution of VEGF-A (show VEGFA ELISA Kits) isoforms to disease progression also indicates that IH may be associated with altered splicing.
Dll4 modulates liver inflammatory response by down-regulating chemokine (show CCL1 ELISA Kits) expression
Positive Jagged1 (show JAG1 ELISA Kits) and DLL4 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with pancreatic ductal carcinoma.
Data show that the IgA/delta-like protein 4 (Delta-4)/Notch (show NOTCH1 ELISA Kits) receptor (Notch (show NOTCH1 ELISA Kits)) axis is not observed in IgG-dendritic cells (DCs).
Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma.
our data indicate that high DLL4 expression predicts pelvic lymph node metastasis and poor survival in cervical cancer. Therefore, DLL4 may be a potential clinical diagnostic marker for patients with early-stage cervical cancer.
Dll4 seems to promote Apc (show APC ELISA Kits) (Min/+) tumorigenesis.
Dll4-Notch1 (show NOTCH1 ELISA Kits) signalling couples sprouting angiogenesis and artery formation.
Results suggest that Dll4 activation during differentiation sustained Treg cell phenotype and function to control respiratory syncytial virus infection.
DLL4 expression is not associated with the Pathogenesis of Non-Alcoholic Steatohepatitis.
The results demonstrate that the Vegf (show VEGFA ELISA Kits)-Dll4/Notch (show NOTCH1 ELISA Kits) feedback system normally operates to generate heterogeneity between endothelial cells driving blood vessel branching, whilst synchronization drives vessel expansion.
Cyclic AMP Response Element Binding Protein (show CREB ELISA Kits) Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (show NOTCH1 ELISA Kits) Signaling
miRNA-30e targeted the 3'-UTR (show UTS2R ELISA Kits) of Dll4 and downregulated Dll4 expression
Dll4/Notch (show NOTCH1 ELISA Kits) signaling and HIF-1alpha (show HIF1A ELISA Kits) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.
Dll4-induced Notch1 (show NOTCH1 ELISA Kits) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.
Thsd7a (show THSD7A ELISA Kits) could regulate ISV angiogenesis via Notch (show NOTCH1 ELISA Kits)-dll4 signaling. Thus, Thsd7a (show THSD7A ELISA Kits) is a potent angioneurin involved in the development of both neural and vascular systems.
show that blood flow suppresses vascular Notch (show NOTCH1 ELISA Kits) signalling via down-regulation of dll4
Microinjection of miR (show MYLIP ELISA Kits)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.
Notch (show NOTCH1 ELISA Kits) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (show NOTCH1 ELISA Kits) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.
These studies imply critical roles for Dll4/Notch (show NOTCH1 ELISA Kits) signaling in the formation and wiring of the lymphatic network.
Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.
Vegfc (show VEGFC ELISA Kits)/Flt4 (show FLT4 ELISA Kits) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
delta-like protein 4
, delta 4
, delta ligand 4
, delta-like 4 homolog
, delta-like 4 protein
, drosophila Delta homolog 4
, notch ligand DLL4
, notch ligand delta-2