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Mouse (Murine) DLL4 ELISA Kit for Sandwich ELISA - ABIN1889419
Noguera-Troise, Daly, Papadopoulos, Coetzee, Boland, Gale, Lin, Yancopoulos, Thurston: Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. in Nature 2006
Show all 3 references for ABIN1889419
DLL4 and JAG1 (show JAG1 ELISA Kits) may have opposing effects on tumor angiogenesis in glioblastoma.
Data indicate the role for altered forkhead box C2 (FoxC2)-Delta-like (show DLK1 ELISA Kits) ligand 4 (Dll4)signaling in structural alterations of saphenous veins in patients with varicose veins.
Antagonism of the DLL4-Notch (show NOTCH1 ELISA Kits) signaling pathway might provide a potential therapeutic approach for breast cancer treatment by preventing angiogenesis.
Activation of Dll4/Notch (show NOTCH1 ELISA Kits) signaling led to increased expression of ephrin-B2 (show EFNB2 ELISA Kits) and subsequent inhibition of endothelial progenitor cells activity.
DLL4 is a unique functional molecule of human circulating dendritic cells critical for directing Th1 (show TH1L ELISA Kits) and Th17 differentiation
The expression of DLL4 was positively correlated with CD105-labeled MVD (show MVD ELISA Kits).
The detection of Notch1 (show NOTCH1 ELISA Kits) and Delta-like (show DLK1 ELISA Kits) 4 expression in peripheral blood lymphocytes of renal transplant recipients can serve as a positive indicator for evaluating the diagnosis and treatment efficacy of the AR reaction.
Among all the Notch (show NOTCH1 ELISA Kits) ligands, Delta-like4 (Dll4) is specifically involved in angiogenesis. hD4R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay.
DLL4 and VEGFA (show VEGFA ELISA Kits) expression was closely related to tumour diameter, clinical stage, histological grade and lymph node metastasis.
DLL4/Notch1 (show NOTCH1 ELISA Kits) and BMP9 (show GDF2 ELISA Kits) interdependent signaling induces endothelial cell quiescence via P27KIP1 (show CDKN1B ELISA Kits)/thrombospondin pathway.
miRNA-30e targeted the 3'-UTR (show UTS2R ELISA Kits) of Dll4 and downregulated Dll4 expression
Dll4/Notch (show NOTCH1 ELISA Kits) signaling and HIF-1alpha (show HIF1A ELISA Kits) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.
Dll4-induced Notch1 (show NOTCH1 ELISA Kits) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.
Tumor promoting effect of low-dosage inhibition needs to be considered when implementing Delta-like (show DLK1 ELISA Kits) 4 targeting therapies.
The heart defects in Dll4-/- embryos are consistent with primary defects in vessel patterning.
DLL4 is an efficient cis (show CISH ELISA Kits)-inhibitor of Notch (show NOTCH1 ELISA Kits) signaling during embryogenesis.
Macrophage Dll4 promotes lesion development in vein grafts via macrophage activation and crosstalk between macrophages and smooth muscle cells.
work reveals how lymphatic vessel responses are shaped by tissue specialization and uncover a role for continuous DLL4 signaling in the function of adult lymphatic vasculature.
Delta-like (show DLK1 ELISA Kits) 4-mediated Notch (show NOTCH1 ELISA Kits) signaling is required for early T-cell development in a three-dimensional thymic structure.
Snail1 (show SNAI1 ELISA Kits) acts as a VEGF (show VEGFA ELISA Kits)-induced regulator of Notch1 (show NOTCH1 ELISA Kits) signalling and Dll4 expression. Results document a Snail1 (show SNAI1 ELISA Kits)-Dll4/Notch1 (show NOTCH1 ELISA Kits) axis that controls embryonic vascular development.
show that blood flow suppresses vascular Notch (show NOTCH1 ELISA Kits) signalling via down-regulation of dll4
Microinjection of miR (show MYLIP ELISA Kits)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.
Notch (show NOTCH1 ELISA Kits) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (show NOTCH1 ELISA Kits) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.
These studies imply critical roles for Dll4/Notch (show NOTCH1 ELISA Kits) signaling in the formation and wiring of the lymphatic network.
Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.
Vegfc (show VEGFC ELISA Kits)/Flt4 (show FLT4 ELISA Kits) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
delta-like protein 4
, delta 4
, delta ligand 4
, delta-like 4 homolog
, delta-like 4 protein
, drosophila Delta homolog 4
, notch ligand DLL4
, notch ligand delta-2