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Browse our anti-FBXW7 (FBXW7) Antibodies

Full name:
anti-F-Box and WD Repeat Domain Containing 7 Antibodies (FBXW7)
On www.antibodies-online.com are 136 F-Box and WD Repeat Domain Containing 7 (FBXW7) Antibodies from 20 different suppliers available. Additionally we are shipping FBXW7 Kits (12) and FBXW7 Proteins (4) and many more products for this protein. A total of 159 FBXW7 products are currently listed.
Synonyms:
1110001A17Rik, AGO, Cdc4, FBW6, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, hAgo, hCdc4, SEL-10, SEL10
list all antibodies Gene Name GeneID UniProt
FBXW7 100360914  
FBXW7 55294 Q969H0
FBXW7 50754 Q8VBV4

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Most Popular Reactivities for anti-FBXW7 (FBXW7) Antibodies

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anti-Rat (Rattus) FBXW7 Antibodies:

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anti-Mouse (Murine) FBXW7 Antibodies:

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Top referenced anti-FBXW7 Antibodies

  1. Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN393696 : Erbilgin, Sayitoglu, Hatirnaz, Dogru, Akcay, Tuysuz, Celkan, Aydogan, Salcioglu, Timur, Yuksel-Soycan, Ure, Anak, Agaoglu, Devecioglu, Yildiz, Ozbek: Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL. in Disease markers 2010 (PubMed)
    Show all 5 references for ABIN393696

  2. Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN527479 : Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. in Cell reports 2012 (PubMed)
    Show all 4 references for ABIN527479

  3. Human Polyclonal FBXW7 Primary Antibody for WB - ABIN4620357 : Strohmaier, Spruck, Kaiser, Won, Sangfelt, Reed: Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. in Nature 2001 (PubMed)
    Show all 2 references for ABIN4620357

  4. Human Polyclonal FBXW7 Primary Antibody for IP - ABIN257813 : Bengoechea-Alonso, Ericsson: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 2 references for ABIN257813

  5. Human Polyclonal FBXW7 Primary Antibody for WB - ABIN265230 : Moberg, Bell, Wahrer, Haber, Hariharan: Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. in Nature 2001 (PubMed)
    Show all 2 references for ABIN265230

  6. Human Polyclonal FBXW7 Primary Antibody for IF (p), IHC (p) - ABIN1386103 : Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. in Biochemical and biophysical research communications 2015 (PubMed)

More Antibodies against FBXW7 Interaction Partners

Human F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. microRNA-770 was identified as an important downstream target of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling, to inhibit FBXW7 expression through targeting its 3'-untranslated region. Thus, our results suggest a previously unknown Wnt (show WNT2 Antibodies)/beta catenin (show CTNNB1 Antibodies)-miR (show MLXIP Antibodies)-770-FBXW7 molecular network in the HCC (show FAM126A Antibodies) development.

  2. The suppression of FBXW7 increased the proliferation.

  3. Low expression of FBXW7 is associated with hepatocellular carcinoma.

  4. FBXW7 is related to the susceptibility and prognosis of cervical squamous carcinoma, indicating FBXW7 may be a potentially important target for the prediction of prognosis

  5. Loss of FBXW7 expression is associated with pancreatic cancer.

  6. FBXW7 expression was downregulated in ovarian cancers, and was associated with p53 (show TP53 Antibodies) mutations and the DNA methylation (show HELLS Antibodies) status of the 5'-upstream regions of FBXW7.

  7. Study showed that overexpression of miR (show MLXIP Antibodies)-92a was identified in osteosarcoma specimens and cells compared to normal bone tissues; miR (show MLXIP Antibodies)-92a probably functions as a driver of tumor progression by targeting FBXW7.

  8. This study suggests that FBXW7, normally a tumor suppressor, can act as an oncogene (show RAB1A Antibodies) when mutated and may play an important role in the pathogenesis of adult T-cell leukemia.

  9. Notably, other mutations including MET, APC (show APC Antibodies), CDH1 (show CDH1 Antibodies), and FBXW7 were also identified in Taiwanese oral squamous cell carcinoma patients.

  10. Our observations sustain the role of FBXW7 as cancer predisposition gene and expand the spectrum of its possible associated diseases.

Mouse (Murine) F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. Study identifies a REV-ERBalpha (show NR1D1 Antibodies) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Antibodies)) phosphorylation of REV-ERBalpha (show NR1D1 Antibodies) is recognized by the F-box protein (show FBXO30 Antibodies), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Antibodies) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Antibodies)-FBXW7-mediated REV-ERBalpha (show NR1D1 Antibodies) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...

  2. Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Antibodies) pathway in radiation-induced mouse thymic lymphomas.

  3. Prion (show PRNP Antibodies) infection induced the expression of FBXW7 in brain.

  4. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Antibodies) in tumor cells.

  5. data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 (show RUNX2 Antibodies) for ubiquitin-mediated degradation in a GSK3beta (show GSK3b Antibodies)-dependent manner

  6. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Antibodies), modulate intestinal homeostasis and cancer.

  7. These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.

  8. Dual regulation of Fbw7 activity by Usp28 (show USP28 Antibodies) is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28 (show USP28 Antibodies).

  9. Ubiquitin-dependent degradation of GATA 2 (show GATA2 Antibodies) is promoted by Fbw7, is cyclin B-CDK1 (show CDK1 Antibodies)-mediated Thr176 phosphorylation-dependent, and influences hematopoietic cell differentiation.

  10. Fbw7 is a master regulator of cell fate decisions in the pancreas

FBXW7 Antigen Profile

Antigen Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FBXW7

  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7) antibody
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7) antibody
  • F-box and WD repeat domain containing 7 (FBXW7) antibody
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (fbxw7) antibody
  • F-box and WD-40 domain protein 7 (Fbxw7) antibody
  • 1110001A17Rik antibody
  • AGO antibody
  • Cdc4 antibody
  • FBW6 antibody
  • Fbw7 antibody
  • Fbwd6 antibody
  • Fbx30 antibody
  • Fbxo30 antibody
  • Fbxw6 antibody
  • hAgo antibody
  • hCdc4 antibody
  • SEL-10 antibody
  • SEL10 antibody

Protein level used designations for FBXW7

F-box and WD-40 domain protein 7 , F-box/WD repeat-containing protein 7 , F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) , F-box protein FBW7 , F-box protein FBX30 , F-box protein SEL-10 , archipelago , homolog of C elegans sel-10 , F-box and WD-40 domain protein 7, archipelago homolog , F-box and WD-40 domain-containing protein 7 , F-box protein Fbxw6 , F-box-WD40 repeat protein 6 , f-box only protein 30

GENE ID SPECIES
100360914 Rattus norvegicus
475465 Canis lupus familiaris
100620112 Sus scrofa
540932 Bos taurus
100145670 Xenopus (Silurana) tropicalis
55294 Homo sapiens
101104688 Ovis aries
50754 Mus musculus
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