Browse our anti-FBXW7 (FBXW7) Antibodies

Full name:
anti-F-Box and WD Repeat Domain Containing 7 Antibodies (FBXW7)
On www.antibodies-online.com are 138 F-Box and WD Repeat Domain Containing 7 (FBXW7) Antibodies from 20 different suppliers available. Additionally we are shipping FBXW7 Kits (12) and FBXW7 Proteins (4) and many more products for this protein. A total of 161 FBXW7 products are currently listed.
Synonyms:
1110001A17Rik, AGO, Cdc4, FBW6, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, hAgo, hCdc4, SEL-10, SEL10
list all antibodies Gene Name GeneID UniProt
FBXW7 100360914  
FBXW7 55294 Q969H0
FBXW7 50754 Q8VBV4

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Most Popular Reactivities for anti-FBXW7 (FBXW7) Antibodies

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Top referenced anti-FBXW7 Antibodies

  1. Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN393696 : Erbilgin, Sayitoglu, Hatirnaz, Dogru, Akcay, Tuysuz, Celkan, Aydogan, Salcioglu, Timur, Yuksel-Soycan, Ure, Anak, Agaoglu, Devecioglu, Yildiz, Ozbek: Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL. in Disease markers 2010 (PubMed)
    Show all 5 references for 393696

  2. Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN527479 : Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. in Cell reports 2012 (PubMed)
    Show all 5 references for 527479

  3. Human Polyclonal FBXW7 Primary Antibody for ICC, IF - ABIN4892424 : Lu, Pfeffer: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. in The Journal of cell biology 2013 (PubMed)
    Show all 4 references for 4892424

  4. Human Polyclonal FBXW7 Primary Antibody for IP - ABIN257813 : Bengoechea-Alonso, Ericsson: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 2 references for 257813

  5. Human Polyclonal FBXW7 Primary Antibody for WB - ABIN265230 : Strohmaier, Spruck, Kaiser, Won, Sangfelt, Reed: Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. in Nature 2001 (PubMed)
    Show all 2 references for 265230

  6. Human Polyclonal FBXW7 Primary Antibody for WB - ABIN4620357 : Moberg, Bell, Wahrer, Haber, Hariharan: Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. in Nature 2001 (PubMed)
    Show all 2 references for 4620357

  7. Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2782955 : Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. in Nature genetics 2014 (PubMed)

  8. Human Polyclonal FBXW7 Primary Antibody for IF (p), IHC (p) - ABIN1386103 : Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. in Biochemical and biophysical research communications 2015 (PubMed)

  9. Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2780093 : Huang, Ma, Li, Yu, Zhang, Wei, Jin, Xu, Gao, Huang: NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. in Oncotarget 2014 (PubMed)

More Antibodies against FBXW7 Interaction Partners

Human F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. C-MYC (show MYC Antibodies) and FBXW7 affect Adult T-cell Leukemia/Lymphoma proliferation and progression, and low FBXW7 may increase C-MYC (show MYC Antibodies) expression. C-MYC (show MYC Antibodies) was a critical prognostic factor in Adult T-cell Leukemia/Lymphoma patients.

  2. The findings reveal a PLK1 (show PLK1 Antibodies)-Fbw7-Myc (show MYC Antibodies) signaling circuit that underlies tumorigenesis and validate PLK1 (show PLK1 Antibodies) inhibitors, alone or with Bcl2 (show BCL2 Antibodies) antagonists, as potential effective therapeutics for MYC (show MYC Antibodies)-overexpressing cancers.

  3. Findings demonstrate that Fbw7 targets CDX2 (show CDX2 Antibodies) for ubiquitin-mediated proteasome degradation in a GSK3b (show GSK3b Antibodies)-dependent manner where GSK3b (show GSK3b Antibodies) presumably phosphorylates CDX2 (show CDX2 Antibodies) within the two potential phosphodegron motifs.

  4. Plk2 (show PLK2 Antibodies) represents an independent prognostic marker and regulates tumor growth and apoptosis by targeting Fbxw7/Cyclin E (show CCNE1 Antibodies) pathway in colorectal carcinoma.

  5. Here, we show that the SCFFBW7alpha ubiquitin ligase targets SOX9 (show SOX9 Antibodies) for proteasomal degradation and provide experimental evidence of a role for FBW7 in modulating medulloblastoma malignancy and cisplatin resistance by controlling SOX9 (show SOX9 Antibodies) proteolysis.

  6. The authors show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex.

  7. In colorectal cancers, mutations in the FBXW7 gene were more common in the younger cohort (27.5% vs 9.7%; P = .0022) as were mutations in the proofreading domain of polymerase epsilon catalytic subunit (POLE) (9.8% vs 1%; P = .0048).

  8. Study found that EYA1 (show EYA1 Antibodies) affects FBW7-Myc (show MYC Antibodies) binding to regulate the FBW7-mediated Myc (show MYC Antibodies) degradation machinery.

  9. Our findings reveal a novel regulatory mechanism for SOX9 (show SOX9 Antibodies) stability and uncover a unique function of SOX9 (show SOX9 Antibodies) in the cellular response to DNA damage. This new mechanism underlying a FBW7-SOX9 (show SOX9 Antibodies) axis in cancer could have implications in therapy resistance.

  10. Our results provide a novel mechanistic insight into the activation of Myc (show MYC Antibodies) by 27-HC via transcriptional repression of PP2A (show PPP2R4 Antibodies), SCP1 (show SYCP1 Antibodies) and FBW7 to increase Myc (show MYC Antibodies) protein stability in breast cancer cells.

Mouse (Murine) F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. The findings reveal a PLK1 (show PLK1 Antibodies)-Fbw7-Myc (show MYC Antibodies) signaling circuit that underlies tumorigenesis and validate PLK1 (show PLK1 Antibodies) inhibitors, alone or with Bcl2 (show BCL2 Antibodies) antagonists, as potential effective therapeutics for MYC (show MYC Antibodies)-overexpressing cancers.

  2. Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Antibodies)-dependent mechanism.

  3. Study identifies a REV-ERBalpha (show NR1D1 Antibodies) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Antibodies)) phosphorylation of REV-ERBalpha (show NR1D1 Antibodies) is recognized by the F-box protein (show FBXO30 Antibodies), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Antibodies) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Antibodies)-FBXW7-mediated REV-ERBalpha (show NR1D1 Antibodies) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...

  4. Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Antibodies) pathway in radiation-induced mouse thymic lymphomas.

  5. Prion (show PRNP Antibodies) infection induced the expression of FBXW7 in brain.

  6. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Antibodies) in tumor cells.

  7. data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 (show RUNX2 Antibodies) for ubiquitin-mediated degradation in a GSK3beta (show GSK3b Antibodies)-dependent manner

  8. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Antibodies), modulate intestinal homeostasis and cancer.

  9. These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.

  10. Dual regulation of Fbw7 activity by Usp28 (show USP28 Antibodies) is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28 (show USP28 Antibodies).

FBXW7 Antigen Profile

Antigen Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FBXW7

  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7) antibody
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7) antibody
  • F-box and WD repeat domain containing 7 (FBXW7) antibody
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (fbxw7) antibody
  • F-box and WD-40 domain protein 7 (Fbxw7) antibody
  • 1110001A17Rik antibody
  • AGO antibody
  • Cdc4 antibody
  • FBW6 antibody
  • Fbw7 antibody
  • Fbwd6 antibody
  • Fbx30 antibody
  • Fbxo30 antibody
  • Fbxw6 antibody
  • hAgo antibody
  • hCdc4 antibody
  • SEL-10 antibody
  • SEL10 antibody

Protein level used designations for FBXW7

F-box and WD-40 domain protein 7 , F-box/WD repeat-containing protein 7 , F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) , F-box protein FBW7 , F-box protein FBX30 , F-box protein SEL-10 , archipelago , homolog of C elegans sel-10 , F-box and WD-40 domain protein 7, archipelago homolog , F-box and WD-40 domain-containing protein 7 , F-box protein Fbxw6 , F-box-WD40 repeat protein 6 , f-box only protein 30

GENE ID SPECIES
100360914 Rattus norvegicus
475465 Canis lupus familiaris
100620112 Sus scrofa
540932 Bos taurus
100145670 Xenopus (Silurana) tropicalis
55294 Homo sapiens
101104688 Ovis aries
50754 Mus musculus
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