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Browse our anti-FBXW7 (FBXW7) Antibodies

Full name:
anti-F-Box and WD Repeat Domain Containing 7 Antibodies (FBXW7)
On are 127 F-Box and WD Repeat Domain Containing 7 (FBXW7) Antibodies from 19 different suppliers available. Additionally we are shipping FBXW7 Kits (15) and FBXW7 Proteins (4) and many more products for this protein. A total of 153 FBXW7 products are currently listed.
1110001A17Rik, AGO, Cdc4, FBW6, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, hAgo, hCdc4, SEL-10, SEL10
list all antibodies Gene Name GeneID UniProt
FBXW7 100360914  
FBXW7 55294 Q969H0
FBXW7 50754 Q8VBV4

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Top referenced anti-FBXW7 Antibodies

  1. Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN393696 : Erbilgin, Sayitoglu, Hatirnaz, Dogru, Akcay, Tuysuz, Celkan, Aydogan, Salcioglu, Timur, Yuksel-Soycan, Ure, Anak, Agaoglu, Devecioglu, Yildiz, Ozbek: Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL. in Disease markers 2010 (PubMed)
    Show all 5 references for ABIN393696

  2. Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN527479 : Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. in Cell reports 2012 (PubMed)
    Show all 4 references for ABIN527479

  3. Human Polyclonal FBXW7 Primary Antibody for WB - ABIN265230 : Strohmaier, Spruck, Kaiser, Won, Sangfelt, Reed: Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. in Nature 2001 (PubMed)
    Show all 2 references for ABIN265230

  4. Human Polyclonal FBXW7 Primary Antibody for IF (p), IHC (p) - ABIN1386103 : Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. in Biochemical and biophysical research communications 2015 (PubMed)

More Antibodies against FBXW7 Interaction Partners

Human F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. Our observations sustain the role of FBXW7 as cancer predisposition gene and expand the spectrum of its possible associated diseases.

  2. cells lacking FBW7 are sensitive to knockdown of the spindle assembly checkpoint (SAC (show ADCY10 Antibodies)) protein BUBR1 (show BUB1B Antibodies)

  3. miR (show MLXIP Antibodies)-25 is up-regulated in non-small cell lung cancer and promotes NSCLC cells proliferation and motility partially by targeting FBXW7.

  4. Results show that the expression of miR (show MLXIP Antibodies)-92a is up-regulated in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) tissues and cell lines and confirm it as an independent prognostic marker. MiR (show MLXIP Antibodies)-92a functions as a novel oncomiRNA by promoting tumor growth of HCC (show FAM126A Antibodies) by targeting.

  5. we observed an association of FBW7 with p105 (show CDH13 Antibodies) and p65 (show GORASP1 Antibodies), as well as p100 (show CUX1 Antibodies), and knockdown of FBW7 eliminated 1,25D-dependent subunit turnover

  6. Inhibition of proteasome, GSK3 (show GSK3b Antibodies) or the E3 ubiquitin ligase (show MUL1 Antibodies), FBXW7, prevented mSREBP1 reduction induced by mTORC2 (show CRTC2 Antibodies) inhibition.

  7. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Antibodies) in tumor cells.

  8. When endogenous Fbw7 was knocked down, both NS5B protein abundance and HCV replication were remarkably up-regulated.

  9. Fbxw7 induces apoptosis and growth arrest and inhibits theepithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) in part by down-regulating the RhoA (show RHOA Antibodies) signaling pathway.

  10. FBXW7 is a significant tumor suppressor gene in renal cancer.FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis.

Mouse (Murine) F-Box and WD Repeat Domain Containing 7 (FBXW7) interaction partners

  1. Prion (show PRNP Antibodies) infection induced the expression of FBXW7 in brain.

  2. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Antibodies) in tumor cells.

  3. data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 (show RUNX2 Antibodies) for ubiquitin-mediated degradation in a GSK3beta (show GSK3b Antibodies)-dependent manner

  4. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Antibodies), modulate intestinal homeostasis and cancer.

  5. These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.

  6. Dual regulation of Fbw7 activity by Usp28 (show USP28 Antibodies) is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28 (show USP28 Antibodies).

  7. Ubiquitin-dependent degradation of GATA 2 (show GATA2 Antibodies) is promoted by Fbw7, is cyclin B-CDK1 (show CDK1 Antibodies)-mediated Thr176 phosphorylation-dependent, and influences hematopoietic cell differentiation.

  8. Fbw7 is a master regulator of cell fate decisions in the pancreas

  9. FBXW7 modulates cellular stress response and metastatic potential through HSF1 (show HSF1 Antibodies) post-translational modification.

  10. these results suggest that FBXW7 antagonizes cancer development in not only a cell-autonomous manner, but also a non-cell-autonomous manner

FBXW7 Antigen Profile

Antigen Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FBXW7

  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7) antibody
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7) antibody
  • F-box and WD repeat domain containing 7 (FBXW7) antibody
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (fbxw7) antibody
  • F-box and WD-40 domain protein 7 (Fbxw7) antibody
  • 1110001A17Rik antibody
  • AGO antibody
  • Cdc4 antibody
  • FBW6 antibody
  • Fbw7 antibody
  • Fbwd6 antibody
  • Fbx30 antibody
  • Fbxo30 antibody
  • Fbxw6 antibody
  • hAgo antibody
  • hCdc4 antibody
  • SEL-10 antibody
  • SEL10 antibody

Protein level used designations for FBXW7

F-box and WD-40 domain protein 7 , F-box/WD repeat-containing protein 7 , F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) , F-box protein FBW7 , F-box protein FBX30 , F-box protein SEL-10 , archipelago , homolog of C elegans sel-10 , F-box and WD-40 domain protein 7, archipelago homolog , F-box and WD-40 domain-containing protein 7 , F-box protein Fbxw6 , F-box-WD40 repeat protein 6 , f-box only protein 30

100360914 Rattus norvegicus
475465 Canis lupus familiaris
100620112 Sus scrofa
540932 Bos taurus
100145670 Xenopus (Silurana) tropicalis
55294 Homo sapiens
101104688 Ovis aries
50754 Mus musculus
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