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Browse our Notch1 Proteins (NOTCH1)

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Notch 1 Proteins (NOTCH1)
On www.antibodies-online.com are 11 Notch 1 (NOTCH1) Proteins from 3 different suppliers available. Additionally we are shipping Notch1 Antibodies (381) and Notch1 Kits (20) and many more products for this protein. A total of 426 Notch1 products are currently listed.
Synonyms:
9930111A19Rik, hN1, lin-12, Mis6, N1, NOTCH, notch-1, NOTCH1, notch1-a, Tan1, xnotch, xnotch1, Xotch
list all proteins Gene Name GeneID UniProt
NOTCH1 4851 P46531
NOTCH1 18128 Q01705
Rat NOTCH1 NOTCH1 25496  

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Notch1 Proteins (NOTCH1) by Origin

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Top referenced Notch1 Proteins

  1. Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230 : Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

More Proteins for Notch1 Interaction Partners

Human Notch 1 (NOTCH1) interaction partners

  1. Notch1 expression is reduced and glu (show G6PC Proteins)cose-6-phosphata (show PLIN5 Proteins)se and (show G6PC Proteins) peril (show PLIN5 Proteins)ipin-5 (G6PC/PLIN5) are upregulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients.

  2. dependence of signaling on contact area can bias cellular differentiation in Notch-mediated lateral inhibition processes, such that smaller cells are more likely to differentiate into signal-producing cells.

  3. Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.

  4. sustained Notch1 activation in the vasculature occurs frequently in primary tumors and in the pre-metastatic niche.

  5. We performed multiplex immunohistochemistry to check for achaete-scute homolog 1 (show ASCL1 Proteins) and Notch homolog 1 expression in 139 pulmonary neuroendocrine tumor samples... we propose that ASCL1 (show ASCL1 Proteins) expression is not controlled by NOTCH1 in 50% of pulmonary neuroendocrine tumors cases

  6. elevated Notch1 expression is associated with poor prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Notch1 may be a critical regulator of stemness in HNSCC cells, and inactivation of this pathway could be a potential targeted approach for the treatment of HNSCC.

  7. co-expression of C-X-C chemokine receptor 4 and Notch1 is associated with tumor progression and lymphovascular invasion and is an independent indicator of poor survival in lung adenocarcinoma. In lung adenocarcinoma patients with high C-X-C chemokine receptor 4 and Notch1 expression, simultaneous inhibition of both factors might be an effective treatment strategy.

  8. MMP-9 (show MMP9 Proteins) plays an important role in TGF-beta1 (show TGFB1 Proteins)-induced epithelial-mesenchymal transition via upregulation of Notch signaling in human kidney glomerular endothelial cells.

  9. that NOTCH1 is a temporospatial controller of secretome composition

  10. Treatment with the gamma-secretase inhibitor LY3039478 led to inhibition of Clear Cell Renal Cancer cells in vitro and in vivo In summary, these data reveal the mechanistic basis of NOTCH pathway activation in Clear Cell Renal Cancer and demonstrate this pathway to a potential therapeutic target.

Mouse (Murine) Notch 1 (NOTCH1) interaction partners

  1. Notch ligand (show JAG2 Proteins) genes Jag1 (show JAG1 Proteins), Jag2 (show JAG2 Proteins), and Dll1 (show DLL1 Proteins) and target Hes1 became downregulated upon aging HIF-2alpha (show EPAS1 Proteins) dependently.

  2. Data show that glucose-6-phosphatase (show G6PC Proteins) and perilipin-5 (show PLIN5 Proteins) (G6PC (show G6PC Proteins)/PLIN5 (show PLIN5 Proteins)) are upregulated in notch1 knockout (KO) mice.

  3. These results implied that the Notch1/Jagged1 signaling-dependent M2 polarization of macrophages might play an important role in liver granuloma and fibrosis in schistosomiasis

  4. Notch signaling may play an important role in BMP9 (show GDF2 Proteins)-induced osteogenesis and angiogenesis. It's conceivable that simultaneous activation of the BMP9 (show GDF2 Proteins) and Notch pathways should efficiently couple osteogenesis and angiogenesis of MSCs for successful bone tissue engineering.

  5. Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.

  6. ligand-dependent non-canonical Notch signaling has a role in the proliferation and maintenance of the tumor stem cell niche in APC (show APC Proteins)-deficient intestinal adenomas

  7. that NOTCH1 is a temporospatial controller of secretome composition

  8. Absence of miR (show MLXIP Proteins)-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 (show ERBB4 Proteins) and Notch-1

  9. ARF4 (show ARF4 Proteins) is required for Presenilin basal body localization, Notch signaling, and subsequent epidermal differentiation.

  10. Treatment with the gamma-secretase inhibitor LY3039478 led to inhibition of Clear Cell Renal Cancer cells in vitro and in vivo In summary, these data reveal the mechanistic basis of NOTCH pathway activation in Clear Cell Renal Cancer and demonstrate this pathway to a potential therapeutic target.

Xenopus laevis Notch 1 (NOTCH1) interaction partners

  1. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3

  2. Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Proteins) expression in the midline.

  3. Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Proteins) gene or the constitutively active form of Notch (IC).

  4. ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Proteins) gene expression.

  5. results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Proteins)) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility

  6. the process of delimiting the three germ layers requires Notch signaling.

  7. BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Proteins)) from binding.

  8. the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis

  9. Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.

  10. Notch controls smad2 (show SMAD2 Proteins) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Proteins) in Xenopus embryos

Cow (Bovine) Notch 1 (NOTCH1) interaction partners

  1. the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height

  2. bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch.

  3. Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.

Notch1 (NOTCH1) Protein Profile

Protein Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

Alternative names and synonyms associated with Notch1 (NOTCH1)

  • notch 1 (notch1)
  • notch 1 (NOTCH1)
  • Notch homolog 1, translocation-associated (Drosophila) (NOTCH1)
  • Notch homolog 1, translocation-associated (NOTCH1)
  • notch 1 (Notch1)
  • 9930111A19Rik protein
  • hN1 protein
  • lin-12 protein
  • Mis6 protein
  • N1 protein
  • NOTCH protein
  • notch-1 protein
  • NOTCH1 protein
  • notch1-a protein
  • Tan1 protein
  • xnotch protein
  • xnotch1 protein
  • Xotch protein

Protein level used designations for Notch 1 Proteins (NOTCH1)

notch 1 , Notch homolog 1, translocation-associated (Drosophila) , Notch homolog 1, translocation-associated , neurogenic locus notch homolog protein 1 , translocation-associated notch protein TAN-1 , Motch A , Notch gene homolog 1 , mT14 , major type A protein , p300 , transmembrane receptor Notch1 , Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila) , neurogenic locus notch protein homolog , NOTCH-1

GENE ID SPECIES
100190917 Oncorhynchus mykiss
100631526 Amphimedon queenslandica
720888 Macaca mulatta
100037842 Xenopus (Silurana) tropicalis
100068764 Equus caballus
100144593 Sus scrofa
100224074 Taeniopygia guttata
4851 Homo sapiens
18128 Mus musculus
25496 Rattus norvegicus
394367 Xenopus laevis
395655 Gallus gallus
464865 Pan troglodytes
480676 Canis lupus familiaris
767866 Bos taurus
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