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Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
in vitro modeling with Hypoplastic left heart syndrome -human induced pluripotent stem cells bearing NOTCH1 mutations facilitated the discovery of a nitric oxide-dependent signaling component essential for cardiovascular cell lineage specification.
Pathogenic mutations in NOTCH1 were identified in 7% of familial left-sided congenital heart disease (LS-CHD (show CHDH Proteins)) and in 1% of sporadic LS-CHD (show CHDH Proteins). The penetrance is high; a cardiovascular malformation was found in 75% of NOTCH1 mutation carriers
Eogt (show C3orf64 Proteins) resulted in defective retinal angiogenesis, with a mild phenotype similar to that caused by reduced Notch signaling in retina. Combined deficiency of different Notch1 mutant alleles exacerbated the abnormalities in Eogt (show C3orf64 Proteins)(-/-) retina, and Notch target gene expression was decreased in Eogt (show C3orf64 Proteins)(-/-)endothelial cells.
These data demonstrated fascin (show FSCN1 Proteins) as a critical regulator of breast cancer stem cell pool at least partially via activation of the Notch self-renewal signaling pathway.
Our overall findings provide preliminary evidence that NOTCH1 may be implicated in the susceptibility to anxiety and depression among sexual abuse victims. The study also underscores the potential importance of animal models for future studies on the health consequences of early-life stress and the mechanisms underlying increased risk for psychiatric disorders.
Results suggest that Notch signalling inhibition may represent a potential therapeutic target not only for lymphoid neoplasms, but also for acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)).
NOTCH1 mutations in CLL are associated with the overexpression of MYC (show MYC Proteins) and MYC (show MYC Proteins)-related genes involved in protein biosynthesis including NPM1 (show NPM1 Proteins), which are allegedly responsible for cell growth and/or proliferation advantages of NOTCH1-mut (show MUT Proteins) CLL
Jagged1 (JAG1) thymic medullary niche enriched for dendritic cells (DC)-lineage cells expressing Notch receptors indicate thymus as a DC-poietic organ, which provides selective microenvironments permissive for DC development.
miR (show MLXIP Proteins)-34a promotes the osteogenic differentiation of human adipose-derived stem cells via the RBP2 (show KDM5A Proteins)/NOTCH1/CYCLIN D1 (show CCND1 Proteins) coregulatory network.
The Sirt1 (show SIRT1 Proteins)-Notch interaction may constitute an important checkpoint that tunes noncanonical Notch1 signaling.
Results indicate a key role of the Notch1 receptor in myeloid cells for the initiation and progression of experimental autoimmune encephalomyelitis (EAE).
PrP(C (show PRNP Proteins)) controls the expression of the epidermal growth factor receptor (EGFR (show EGFR Proteins)) downstream from Notch.
data suggest that Notch signaling is an important regulator of DR and that in steatohepatitis, hepatocytes exposed to Jag1 (show JAG1 Proteins)-positive HSC (show FUT1 Proteins), contribute to pathologic DR by undergoing Notch-mediated differentiation towards an HPC-like phenotype
Specifically, constitutive Notch1 activation dedifferentiates myocytes into Pax7 (show PAX7 Proteins) quiescent satellite cells, leading to severe defects in muscle growth and regeneration, and postnatal lethality. By contrast, myotube-specific Notch1 activation improves the regeneration and exercise performance of aged and dystrophic muscles.
a critical role for PRL2 phosphatase in mediating Notch and c-Kit signals in early T cell progenitors, is reported.
Protein O-fucosyltransferase1 (Pofut1 (show POFUT1 Proteins)), which transfers O-fucose to the EGF (show EGF Proteins) domains of the Notch1 receptor, is indispensable for Notch signaling activation
plasticity of Group 3 innate lymphoid cells is regulated by the balance between the opposing effects of Notch and TGF-beta (show TGFB1 Proteins) signaling, maintaining homeostasis in the face of continual challenges
the cross-talk between SFRP4 (show SFRP4 Proteins), integrin alpha1beta1, and Notch1 suppresses the cardiac differentiation of P19CL6 cells.
we show that Ascl1 (show ASCL1 Proteins) induces the transcription factor MyT1 (show MYT1 Proteins) while promoting neuronal differentiation...It promotes neuronal differentiation by counteracting the inhibitory activity of Notch signaling at multiple levels, targeting the Notch1 receptor and many of its downstream targets
maternal decidual vascular endothelial cells are able to maintain decidual Regulatory T cells (Treg cell) identity and promote Treg cell differentiation through activation of Notch1 signal pathway.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Proteins) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Proteins) gene or the constitutively active form of Notch (IC).
ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Proteins) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Proteins)) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Proteins)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (show SMAD2 Proteins) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Proteins) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog