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Browse our Notch1 Proteins (NOTCH1)

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Notch 1 Proteins (NOTCH1)
On www.antibodies-online.com are 11 Notch 1 (NOTCH1) Proteins from 3 different suppliers available. Additionally we are shipping Notch1 Antibodies (373) and Notch1 Kits (13) and many more products for this protein. A total of 411 Notch1 products are currently listed.
Synonyms:
9930111A19Rik, hN1, lin-12, Mis6, N1, NOTCH, notch-1, NOTCH1, notch1-a, Tan1, xnotch, xnotch1, Xotch
list all proteins Gene Name GeneID UniProt
NOTCH1 4851 P46531
NOTCH1 18128 Q01705
Rat NOTCH1 NOTCH1 25496  

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Notch1 Proteins (NOTCH1) by Origin

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Top referenced Notch1 Proteins

  1. Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230 : Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

More Proteins for Notch1 Interaction Partners

Pig (Porcine) Notch 1 (NOTCH1) interaction partners

  1. Notch1 regulates the proliferation of porcine satellite cells through the activation of Hes5 (show HES5 Proteins).

Human Notch 1 (NOTCH1) interaction partners

  1. our results show for the first time that miR (show MLXIP Proteins)-101 acts as a tumor suppressor in T-cell acute lymphoblastic leukaemia and it could enhance chemotherapeutic sensitivity. Furthermore, Notch1 was identified to be a novel target of miR (show MLXIP Proteins)-101. This study indicates that miR (show MLXIP Proteins)-101 may represent a potential therapeutic target for T-cell acute lymphoblastic leukemia intervention.

  2. This study provides novel evidences of the mechanisms integrating Notch and TNF-alpha (show TNF Proteins) signaling in the transcriptional induction of GATA3 (show GATA3 Proteins) and HOXB4 (show HOXB4 Proteins).

  3. Tbeta4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro and decreased tumor growth in vivo. Mechanistic investigations revealed a significant decrease in Notch1 activation in Tbeta4 gene-silenced cells.

  4. Downregulation of microRNA-429 protects cardiomyocytes against hypoxia-induced apoptosis by increasing Notch1 expression.

  5. High expression of Notch1 is associated with radiation resistance in pancreatic cancer.

  6. Notch signaling and ASCL1 (show ASCL1 Proteins) expression may determine the cell behaviors of SCLC partly through modifying EMT (show ITK Proteins) phenotypes.

  7. insertion expansion mutations in the NOTCH1 juxtamembrane region may be generated by complex mechanisms including tandem duplications, de novo insertions and partial intronic retention events in combination with alternative splicing.

  8. Notch and TGFbeta (show TGFB1 Proteins) form a reciprocal positive regulatory loop and cooperatively regulate Epithelial-mesenchymal transition and promote epithelial ovarian cancer cell motility and migration.

  9. TGFBR2 (show TGFBR2 Proteins) signaling can affect Notch1 glycosylation via regulation of glycosyltransferase (show GTDC2 Proteins) LFNG (show LFNG Proteins) expression and provide a first mechanistic example for altered glycosylation in microsatellite instability colorectal tumor cells.

  10. High Notch1 expression is associated with hepatocellular carcinoma.

Mouse (Murine) Notch 1 (NOTCH1) interaction partners

  1. Data show that liver progenitors differentiate into hepatocytes and cholangiocytes via transforming growth factor beta (TGFbeta (show TGFB1 Proteins)) treatment and Notch receptors.

  2. miR (show MLXIP Proteins)-342-5p acts as a multifunctional angiogenic repressor mediating the effects and interaction among angiogenic Notch1/VEGF (show VEGFA Proteins)/TGF-beta (show TGFB1 Proteins) signaling pathways.

  3. This study showed the effects of VEGF on excitatory synaptic transmission but also defines a role for the Notch1 receptor in mediating the response of synaptic activity to VEGF.

  4. we identified Notch1 signaling as a key determinant of triacylglycerol metabolism in response to a high fat diet, and we further revealed novel biological actions of Notch1 signaling pathways on the regulation of lipid oxidation.

  5. Interactions among the TGF-beta (show TGFB1 Proteins) signalling pathways, Jagged2 (show JAG2 Proteins)/Notch1 signalling pathways and epigenetic modifications regulate the expansion of lingual epithelial stem cells.

  6. polarizing macrophages toward a pro-inflammatory profile further increased their angiotrophic stimulation of vessel sprouting, and this increase was dependent on macrophage Notch signaling.

  7. Notch1 inhibition by siRNA or DAPT reduces low shear stress-induced plaque formation

  8. The consequences of Notch1 gain-of-function signaling on female reproductive tract development in mice with conditionally activated Notch1 is reported; mutant females demonstrated inflamed uteri with increased vascularization and an influx of inflammatory cells and older females developed ovarian, oviductal, and uterine cysts.

  9. Data show that the phenotype of Notch activation in osteocytes was prevented in matrix protein 1 (Dmp1 (show DMP1 Proteins))-Cre;Rosa(Notch) mice hemizygous for the Dmp1 (show DMP1 Proteins)-sclerostin (SOST (show SOST Proteins)) transgene.

  10. High Notch promoted stem-ness characteristics and metastasis potential in sphere-forming liver cancer stem cells.

Xenopus laevis Notch 1 (NOTCH1) interaction partners

  1. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3

  2. Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Proteins) expression in the midline.

  3. Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Proteins) gene or the constitutively active form of Notch (IC).

  4. ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Proteins) gene expression.

  5. results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Proteins)) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility

  6. the process of delimiting the three germ layers requires Notch signaling.

  7. BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Proteins)) from binding.

  8. the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis

  9. Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.

  10. Notch controls smad2 (show SMAD2 Proteins) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Proteins) in Xenopus embryos

Cow (Bovine) Notch 1 (NOTCH1) interaction partners

  1. bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch.

  2. Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.

Notch1 (NOTCH1) Protein Profile

Protein Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

Alternative names and synonyms associated with Notch1 (NOTCH1)

  • notch 1 (notch1)
  • notch 1 (NOTCH1)
  • Notch homolog 1, translocation-associated (Drosophila) (NOTCH1)
  • Notch homolog 1, translocation-associated (NOTCH1)
  • notch 1 (Notch1)
  • 9930111A19Rik protein
  • hN1 protein
  • lin-12 protein
  • Mis6 protein
  • N1 protein
  • NOTCH protein
  • notch-1 protein
  • NOTCH1 protein
  • notch1-a protein
  • Tan1 protein
  • xnotch protein
  • xnotch1 protein
  • Xotch protein

Protein level used designations for Notch 1 Proteins (NOTCH1)

notch 1 , Notch homolog 1, translocation-associated (Drosophila) , Notch homolog 1, translocation-associated , neurogenic locus notch homolog protein 1 , translocation-associated notch protein TAN-1 , Motch A , Notch gene homolog 1 , mT14 , major type A protein , p300 , transmembrane receptor Notch1 , Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila) , neurogenic locus notch protein homolog , NOTCH-1

GENE ID SPECIES
100190917 Oncorhynchus mykiss
100631526 Amphimedon queenslandica
720888 Macaca mulatta
100037842 Xenopus (Silurana) tropicalis
100068764 Equus caballus
100144593 Sus scrofa
100224074 Taeniopygia guttata
4851 Homo sapiens
18128 Mus musculus
25496 Rattus norvegicus
394367 Xenopus laevis
395655 Gallus gallus
464865 Pan troglodytes
480676 Canis lupus familiaris
767866 Bos taurus
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