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Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
Results indicate that Notch1 is significantly displaced and accumulated in fibrillary structures in the susceptible hippocampal and cortical regions of sporadic Alzheimer's disease (AD) patients. The dominant deposition of Notch1 in the brain parenchyma and its general signal reduction in neurons is consistent in all the AD patients analyzed and suggests that Notch1 may potentially be considered a novel hallmark of AD.
Diffuse NICD1 positivity in adenoid cystic carcinomas correlates with solid growth pattern, the presence of NOTCH1 gain-of-function mutations, and unfavorable outcome.
Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.
NOTCH pathway inhibition antagonizes the growth and invasion of transmembrane protease serine 2 (TMPRSS2 (show TMPRSS2 Proteins))-transforming protein ERG (ERG) (T2E) -positive prostate cancer cells.
ChIP-seq studies show a high concordance of functional NOTCH1 and NOTCH3 (show NOTCH3 Proteins) genomic binding sites that are enriched in binding motifs for RBPJ (show RBPJ Proteins), the transcription factor that recruits activated Notch to DNA. The interchangeability of NOTCH1 and NOTCH3 (show NOTCH3 Proteins) was confirmed by rescue of NOTCH1-dependent T-ALL cells with activated NOTCH3 (show NOTCH3 Proteins) and vice versa.
Dissection of the molecular mechanism revealed that the p38 (show CRK Proteins)-Notch1 axis was the main downstream signaling pathway in CD54 (show ICAM1 Proteins)-mediated regulation of cancer stem cells in prostate cancers.
MicroRNA-34a induces transdifferentiation of glioma stem cells into vascular endothelial cells by targeting Notch pathway
SASH1 (show SASH1 Proteins) acts through NOTCH1 and its inhibitor DLK1 (show DLK1 Proteins) in a three-dimensional model of lumenogenesis involving CEACAM1 (show CEACAM1 Proteins).
this study shows that Notch1 is an important signaling pathway in the differentiation of Lin-CD45RA-DC precursor cells to plasmcytoid dendritic cells
The data presented in this work suggest that a fine regulation of NOTCH signaling BY DLK1 (show DLK1 Proteins) plays an important role in the control of breast cancer cell proliferation and invasion.
pre-coated Notch1 protein promotes Notch1-knocked down B cells to produce antibody in LPS (show TLR4 Proteins)-stimulated B cells suggesting that Notch1 in other cells may promote antibody production by binding its ligands Dll1 (show DLL1 Proteins) and Jag1 (show JAG1 Proteins) in B cells.
behavioral and functional studies demonstrated that POMC (show POMC Proteins)-Notch1(-/-) mutant mice showed anxiety and depressive-like behavior with impaired synaptic transmission properties in the dentate gyrus
Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.
Notch1 haploinsufficiency decreased the expression of Ctgf (show CTGF Proteins) in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 intracellular domain (NICD) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1, not Notch3 (show NOTCH3 Proteins), directly modulates the expression of CTGF (show CTGF Proteins)
Notch signaling has roles in distinct aspects of prostate cancer biology, promoting metastasis in a prostate-specific Pten-null mouse model
Dll4 (show DLL4 Proteins)-Notch1 signalling couples sprouting angiogenesis and artery formation.
Genes that were dysregulated due to NOTCH1 haploinsufficiency in mice with shortened telomeres were concordant with proosteoblast and proinflammatory gene network alterations
this study shows that Notch signaling regulates basophils biological function, at least partially via the modulation of MAPK (show MAPK1 Proteins)
The PROX1 (show C16orf35 Proteins)/KLF2 (show KLF2 Proteins) complex upregulates the expression of DTX1 (show DTX1 Proteins) and DTX3L (show DTX3L Proteins). DTX1 (show DTX1 Proteins) and DTX3L (show DTX3L Proteins), functioning as a heterodimeric Notch E3 ligase, concertedly downregulate NOTCH1 activity and enhance lymphatic sprouting
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Proteins) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Proteins) gene or the constitutively active form of Notch (IC).
ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Proteins) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Proteins)) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Proteins)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (show SMAD2 Proteins) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Proteins) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog