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Browse our Notch1 Proteins (NOTCH1)

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Notch 1 Proteins (NOTCH1)
On www.antibodies-online.com are 11 Notch 1 (NOTCH1) Proteins from 3 different suppliers available. Additionally we are shipping Notch1 Antibodies (350) and Notch1 Kits (11) and many more products for this protein. A total of 386 Notch1 products are currently listed.
Synonyms:
9930111A19Rik, hN1, lin-12, Mis6, N1, NOTCH, notch-1, NOTCH1, notch1-a, Tan1, xnotch, xnotch1, Xotch
list all proteins Gene Name GeneID UniProt
NOTCH1 4851 P46531
NOTCH1 18128 Q01705
Rat NOTCH1 NOTCH1 25496  

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Notch1 Proteins (NOTCH1) by Origin

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Top referenced Notch1 Proteins

  1. Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230 : Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

More Proteins for Notch1 Interaction Partners

Pig (Porcine) Notch 1 (NOTCH1) interaction partners

  1. Notch1 regulates the proliferation of porcine satellite cells through the activation of Hes5 (show HES5 Proteins).

Human Notch 1 (NOTCH1) interaction partners

  1. High Notch1 expression is associated with neoplasms.

  2. Evidence supporting a genetic basis includes the autosomal dominance of Bicuspid aortic valve inheritance patterns, and the identification of mutations in Notch homolog 1.

  3. Inhibition of WNT (show WNT2 Proteins) signaling by the PORCN (show PORCN Proteins) inhibitor WNT974 reduced metastatic spread of UM-SCC (show CYP11A1 Proteins) cells, especially in UM-SCCs with Notch1 deficiency.

  4. The role of CSL (show CSHL1 Proteins)-dependent and independent Notch signaling pathways in cell apoptosis is described in normal tissue homeostasis and in tumorigenesis. (Review)

  5. Data suggest that FAM84B protein and the NOTCH pathway are involved in the progression of esophageal squamous cell carcinoma (ESCC) and may be potential diagnostic targets for ESCC susceptibility.

  6. High Notch1 expression is associated with colorectal cancer.

  7. High Notch1 expression is associated with Prostatic Intraepithelial Neoplasia.

  8. findings provide evidence for a novel cell-autonomous pro-inflammatory Jagged1 (show JAG1 Proteins)-Notch1 pathway in endothelial cells

  9. Down-regulation of Notch1 by gamma-secretase inhibitors or siRNA combined with IL-24 (show IL24 Proteins) can sensitize apoptosis and decrease the invasion and migration capabilities of HepG2 cells.

  10. Findings of frequent mutations in CDKN2A, NOTCH1, PIK3CA (show PIK3CA Proteins), and EGFR (show EGFR Proteins) (all in excess (show RCC1 Proteins) of 20%) point to potential therapeutic avenues. Trials of targeted therapies directed toward these mutations should be explored.

Mouse (Murine) Notch 1 (NOTCH1) interaction partners

  1. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb (show ITPKB Proteins) restricts pre-T cell receptor (show PTCRA Proteins) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (show PTCRA Proteins) expression and Notch-engagement.

  2. Data suggest that expression of Notch-1 receptor in endothelial progenitor cells (EPC (show TCF21 Proteins)) in bone marrow is up-regulated in diabetic angiopathy (DA); signaling in EPC (show TCF21 Proteins) via Notch-1 receptor and VEGFA (show VEGFA Proteins)/VEGFR2 (show KDR Proteins) appears to be altered in DA.

  3. Data indicate that Notch receptors Notch1 and Notch3 (show NOTCH3 Proteins) deficiency compromises pericyte function and contributes to vascular pathologies.

  4. the cardioprotective effect of Notch1 against ischemic damage is mediated by AMPK (show PRKAA1 Proteins) signaling via an interaction with upstream LKB1 (show STK11 Proteins).

  5. Epidermal Notch1 recruits RORgamma(+) group 3 innate lymphoid cells to orchestrate normal skin repair.

  6. Jagged1 (show JAG1 Proteins) intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart.

  7. Data show that the proliferation of sustained expression of Notch1-induced choroid plexus (CP) tumours relies on Sonic Hedgehog (Shh (show SHH Proteins)) from the tumour microenvironment through their primary cilium.

  8. The physical interaction of NBEA with NOTCH1 is most relevant for autism spectrum disorders pathogenesis because NOTCH signaling is essential for neural development.

  9. LFNG (show LFNG Proteins) protein may have context-dependent effects on Notch activity

  10. A transgenic mouse model in which the Notch1 intracellular domain (NIC (show NCSTN Proteins)) is activated.

Xenopus laevis Notch 1 (NOTCH1) interaction partners

  1. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3

  2. Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Proteins) expression in the midline.

  3. Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Proteins) gene or the constitutively active form of Notch (IC).

  4. ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Proteins) gene expression.

  5. results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Proteins)) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility

  6. the process of delimiting the three germ layers requires Notch signaling.

  7. BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Proteins)) from binding.

  8. the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis

  9. Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.

  10. Notch controls smad2 (show SMAD2 Proteins) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Proteins) in Xenopus embryos

Cow (Bovine) Notch 1 (NOTCH1) interaction partners

  1. bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch.

  2. Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.

Notch1 (NOTCH1) Protein Profile

Protein Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

Alternative names and synonyms associated with Notch1 (NOTCH1)

  • notch 1 (notch1)
  • notch 1 (NOTCH1)
  • Notch homolog 1, translocation-associated (Drosophila) (NOTCH1)
  • Notch homolog 1, translocation-associated (NOTCH1)
  • notch 1 (Notch1)
  • 9930111A19Rik protein
  • hN1 protein
  • lin-12 protein
  • Mis6 protein
  • N1 protein
  • NOTCH protein
  • notch-1 protein
  • NOTCH1 protein
  • notch1-a protein
  • Tan1 protein
  • xnotch protein
  • xnotch1 protein
  • Xotch protein

Protein level used designations for Notch 1 Proteins (NOTCH1)

notch 1 , Notch homolog 1, translocation-associated (Drosophila) , Notch homolog 1, translocation-associated , neurogenic locus notch homolog protein 1 , translocation-associated notch protein TAN-1 , Motch A , Notch gene homolog 1 , mT14 , major type A protein , p300 , transmembrane receptor Notch1 , Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila) , neurogenic locus notch protein homolog , NOTCH-1

GENE ID SPECIES
100190917 Oncorhynchus mykiss
100631526 Amphimedon queenslandica
720888 Macaca mulatta
100037842 Xenopus (Silurana) tropicalis
100068764 Equus caballus
100144593 Sus scrofa
100224074 Taeniopygia guttata
4851 Homo sapiens
18128 Mus musculus
25496 Rattus norvegicus
394367 Xenopus laevis
395655 Gallus gallus
464865 Pan troglodytes
480676 Canis lupus familiaris
767866 Bos taurus
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