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Browse our Notch1 Proteins (NOTCH1)

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Notch 1 Proteins (NOTCH1)
On www.antibodies-online.com are 11 Notch 1 (NOTCH1) Proteins from 3 different suppliers available. Additionally we are shipping Notch1 Antibodies (358) and Notch1 Kits (12) and many more products for this protein. A total of 395 Notch1 products are currently listed.
Synonyms:
9930111A19Rik, hN1, lin-12, Mis6, N1, NOTCH, notch-1, NOTCH1, notch1-a, Tan1, xnotch, xnotch1, Xotch
list all proteins Gene Name GeneID UniProt
NOTCH1 4851 P46531
NOTCH1 18128 Q01705
Rat NOTCH1 NOTCH1 25496  

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Notch1 Proteins (NOTCH1) by Origin

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Top referenced Notch1 Proteins

  1. Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230 : Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

More Proteins for Notch1 Interaction Partners

Pig (Porcine) Notch 1 (NOTCH1) interaction partners

  1. Notch1 regulates the proliferation of porcine satellite cells through the activation of Hes5 (show HES5 Proteins).

Human Notch 1 (NOTCH1) interaction partners

  1. Notch 1 signaling was down-regulated in Notch 1 siRNA or Notch 1 plasmid after curcumin treatment in prostate cancer cells.

  2. OIP5 (show OIP5 Proteins) over-expression inhibited hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene (show RAB1A Proteins) in promoting breast cancer progression.

  3. restoration of Notch1 and PAX6 (show PAX6 Proteins) expression partially rescued the inhibition of cell proliferation and metastasis induced by miR (show MLXIP Proteins)-433 overexpression.

  4. The frequency of NOTCH1 mutations was 8.4% in the first cohort of 71 unselected CLL patients. We then evaluated a second cohort of 26 CLL patients with known cytogenetic abnormalities that were enriched for patients with trisomy 12. NOTCH1 mutations were detected in 43.7% of the patients with trisomy 12.

  5. FOXJ2 (show FOXJ2 Proteins) expression was down-regulated by transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins)) treated, and overexpression of FOXJ2 (show FOXJ2 Proteins) inhibited TGF-beta1 (show TGFB1 Proteins)-induced epithelial-mesenchymal transition.

  6. The overexpression of the intracellular domain of Notch1 repressed miR (show MLXIP Proteins)-124 expression.

  7. Notch1 and EZH2 (show EZH2 Proteins) coexpression contributes to the progression and prognosis of breast invasive ductal carcinoma.

  8. miR (show MLXIP Proteins)-342-5p acts as a multifunctional angiogenic repressor mediating the effects and interaction among angiogenic Notch1/VEGF (show VEGFA Proteins)/TGF-beta (show TGFB1 Proteins) signaling pathways.

  9. Notch1 was overexpressed in the epidermis of patients with hypertropic scar. Notch signalling contributes to HS by modulating keratinocyte phenotype.

  10. The clinical impact of small subclones harboring NOTCH1, SF3B1 (show SF3B2 Proteins), or BIRC3 (show BIRC3 Proteins) mutations in chronic lymphocytic leukemia patients appears to be less pronounced than that of small TP53 (show TP53 Proteins) mutated subclones.

Mouse (Murine) Notch 1 (NOTCH1) interaction partners

  1. Data show that liver progenitors differentiate into hepatocytes and cholangiocytes via transforming growth factor beta (TGFbeta (show TGFB1 Proteins)) treatment and Notch receptors.

  2. miR (show MLXIP Proteins)-342-5p acts as a multifunctional angiogenic repressor mediating the effects and interaction among angiogenic Notch1/VEGF (show VEGFA Proteins)/TGF-beta (show TGFB1 Proteins) signaling pathways.

  3. This study showed the effects of VEGF on excitatory synaptic transmission but also defines a role for the Notch1 receptor in mediating the response of synaptic activity to VEGF.

  4. we identified Notch1 signaling as a key determinant of triacylglycerol metabolism in response to a high fat diet, and we further revealed novel biological actions of Notch1 signaling pathways on the regulation of lipid oxidation.

  5. Interactions among the TGF-beta (show TGFB1 Proteins) signalling pathways, Jagged2 (show JAG2 Proteins)/Notch1 signalling pathways and epigenetic modifications regulate the expansion of lingual epithelial stem cells.

  6. polarizing macrophages toward a pro-inflammatory profile further increased their angiotrophic stimulation of vessel sprouting, and this increase was dependent on macrophage Notch signaling.

  7. Notch1 inhibition by siRNA or DAPT reduces low shear stress-induced plaque formation

  8. The consequences of Notch1 gain-of-function signaling on female reproductive tract development in mice with conditionally activated Notch1 is reported; mutant females demonstrated inflamed uteri with increased vascularization and an influx of inflammatory cells and older females developed ovarian, oviductal, and uterine cysts.

  9. Data show that the phenotype of Notch activation in osteocytes was prevented in matrix protein 1 (Dmp1 (show DMP1 Proteins))-Cre;Rosa(Notch) mice hemizygous for the Dmp1 (show DMP1 Proteins)-sclerostin (SOST (show SOST Proteins)) transgene.

  10. High Notch promoted stem-ness characteristics and metastasis potential in sphere-forming liver cancer stem cells.

Xenopus laevis Notch 1 (NOTCH1) interaction partners

  1. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3

  2. Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Proteins) expression in the midline.

  3. Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Proteins) gene or the constitutively active form of Notch (IC).

  4. ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Proteins) gene expression.

  5. results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Proteins)) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility

  6. the process of delimiting the three germ layers requires Notch signaling.

  7. BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Proteins)) from binding.

  8. the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis

  9. Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.

  10. Notch controls smad2 (show SMAD2 Proteins) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Proteins) in Xenopus embryos

Cow (Bovine) Notch 1 (NOTCH1) interaction partners

  1. bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch.

  2. Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.

Notch1 (NOTCH1) Protein Profile

Protein Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

Alternative names and synonyms associated with Notch1 (NOTCH1)

  • notch 1 (notch1)
  • notch 1 (NOTCH1)
  • Notch homolog 1, translocation-associated (Drosophila) (NOTCH1)
  • Notch homolog 1, translocation-associated (NOTCH1)
  • notch 1 (Notch1)
  • 9930111A19Rik protein
  • hN1 protein
  • lin-12 protein
  • Mis6 protein
  • N1 protein
  • NOTCH protein
  • notch-1 protein
  • NOTCH1 protein
  • notch1-a protein
  • Tan1 protein
  • xnotch protein
  • xnotch1 protein
  • Xotch protein

Protein level used designations for Notch 1 Proteins (NOTCH1)

notch 1 , Notch homolog 1, translocation-associated (Drosophila) , Notch homolog 1, translocation-associated , neurogenic locus notch homolog protein 1 , translocation-associated notch protein TAN-1 , Motch A , Notch gene homolog 1 , mT14 , major type A protein , p300 , transmembrane receptor Notch1 , Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila) , neurogenic locus notch protein homolog , NOTCH-1

GENE ID SPECIES
100190917 Oncorhynchus mykiss
100631526 Amphimedon queenslandica
720888 Macaca mulatta
100037842 Xenopus (Silurana) tropicalis
100068764 Equus caballus
100144593 Sus scrofa
100224074 Taeniopygia guttata
4851 Homo sapiens
18128 Mus musculus
25496 Rattus norvegicus
394367 Xenopus laevis
395655 Gallus gallus
464865 Pan troglodytes
480676 Canis lupus familiaris
767866 Bos taurus
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