Notch1 Protein (AA 19-526) (His tag)
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- Target See all Notch1 (NOTCH1) Proteins
- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 19-526
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Notch1 protein is labelled with His tag.
- Characteristics
- Mouse NOTCH1 Protein, His Tag
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product NOTCH1 Protein
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Notch 1 (NOTCH1) (AA 19-526) protein (His-Avi Tag)
NOTCH1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Notch 1 (NOTCH1) protein (His-Avi Tag,Biotin)NOTCH1 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Notch 1 (NOTCH1) protein (His tag)NOTCH1 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Notch 1 (NOTCH1) (AA 2309-2555) protein (His tag)NOTCH1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Notch 1 (NOTCH1) (AA 23-132) protein (GST tag)NOTCH1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Notch 1 (NOTCH1) (Active) protein (His tag)NOTCH1 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 82 % as determined by SDS-PAGE Active
Notch 1 (NOTCH1) (AA 1757-2555) protein (His tag)Crystallography grade NOTCH1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Notch 1 (NOTCH1) (AA 1747-2531) protein (His tag)Crystallography grade NOTCH1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Notch 1 (NOTCH1) (AA 1721-2555) protein (rho-1D4 tag)Crystallography grade NOTCH1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
- Alternative Name
- NOTCH1 (NOTCH1 Products)
- Synonyms
- notch1 Protein, NOTCH1 Protein, hn1 Protein, tan1 Protein, notch Protein, xotch Protein, xnotch Protein, notch-1 Protein, xnotch1 Protein, TAN1 Protein, hN1 Protein, 9930111A19Rik Protein, Mis6 Protein, N1 Protein, Tan1 Protein, lin-12 Protein, NOTCH Protein, Xotch Protein, notch1-a Protein, notch 1 Protein, fibropellin-1 Protein, Notch homolog 1, translocation-associated (Drosophila) Protein, Notch homolog 1, translocation-associated Protein, notch 1 S homeolog Protein, notch1 Protein, LOC100631526 Protein, NOTCH1 Protein, Notch1 Protein, notch1.S Protein
- Background
- NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1, the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
- Molecular Weight
- 55.4 kDa
- NCBI Accession
- NP_032740
- Pathways
- Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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