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Browse our anti-NOTCH2 (NOTCH2) Antibodies

Full name:
anti-Notch 2 Antibodies (NOTCH2)
On are 194 Notch 2 (NOTCH2) Antibodies from 24 different suppliers available. Additionally we are shipping NOTCH2 Kits (13) and NOTCH2 Proteins (11) and many more products for this protein. A total of 227 NOTCH2 products are currently listed.
AGS2, AI853703, HJCYS, hN2, N2, notch6, sb:cb884
list all antibodies Gene Name GeneID UniProt
NOTCH2 4853 Q04721
NOTCH2 18129 O35516
NOTCH2 29492 Q9QW30

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Most Popular Reactivities for anti-NOTCH2 (NOTCH2) Antibodies

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anti-Human NOTCH2 Antibodies:

anti-Mouse (Murine) NOTCH2 Antibodies:

anti-Rat (Rattus) NOTCH2 Antibodies:

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Top referenced anti-NOTCH2 Antibodies

  1. Human Polyclonal NOTCH2 Primary Antibody for IHC (p), IHC - ABIN269894 : Chen, Oh, Hinman, Abraham: Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. in Journal of neurochemistry 2006 (PubMed)
    Show all 4 references for ABIN269894

  2. Human Polyclonal NOTCH2 Primary Antibody for EIA, IF - ABIN303122 : Siar, Ha, Aung, Nakano, Tsujigiwa, Nagatsuka, Ng, Kawakami: Immunolocalization of notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor. in European journal of medical research 2010 (PubMed)
    Show all 2 references for ABIN303122

  3. Chimpanzee Polyclonal NOTCH2 Primary Antibody for EIA, IHC (p) - ABIN117999 : Bertrand, Eckfeldt, Lysholm, LeBien: Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells. in Leukemia 2001 (PubMed)
    Show all 2 references for ABIN117999

  4. Human Monoclonal NOTCH2 Primary Antibody for FACS - ABIN1169006 : Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 2 references for ABIN1169006

  5. Human Polyclonal NOTCH2 Primary Antibody for ELISA - ABIN1043688 : Gridley: Notch signaling and inherited disease syndromes. in Human molecular genetics 2003 (PubMed)
    Show all 2 references for ABIN1043688

  6. Human Polyclonal NOTCH2 Primary Antibody for ELISA, WB - ABIN1536150 : Blaumueller, Qi, Zagouras, Artavanis-Tsakonas: Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. in Cell 1997 (PubMed)

  7. Human Polyclonal NOTCH2 Primary Antibody for WB - ABIN2777549 : Tilley, Harvey, Heguy, Hackett, Wang, OConnor, Crystal: Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. in American journal of respiratory and critical care medicine 2009 (PubMed)

More Antibodies against NOTCH2 Interaction Partners

Human Notch 2 (NOTCH2) interaction partners

  1. Findings indicate that niclosamide inhibits the progression of colon cancer by downregulating Notch1 (show NOTCH1 Antibodies), Notch2 and Notch3 (show NOTCH3 Antibodies) signaling and by upregulating the microRNA miR (show MLXIP Antibodies)-200 family members (miR200a, miR (show MLXIP Antibodies)-200b, miR (show MLXIP Antibodies)-200c).

  2. Notch2 may confer stemness properties in HCC (show FAM126A Antibodies).

  3. Macrophage notch1 (show NOTCH1 Antibodies) may play a more important role than notch2 and notch 3 (show NOTCH3 Antibodies) in the regulation of NF-kappaB (show NFKB1 Antibodies) signaling pathway in atherosclerosis.

  4. AGS (show JAG1 Antibodies) is caused by mutations in one of two genes, namely, JAG1 (show JAG1 Antibodies) or NOTCH2. These genes are part of the Notch (show NOTCH1 Antibodies) signaling pathway, which is involved in cell fate determination. JAG1 (show JAG1 Antibodies) mutations have been identified in 70-94% of individuals with clinically diagnosed AGS (show JAG1 Antibodies)

  5. This is supported by the depletion of CTCF (show CTCF Antibodies) in glioblastoma cells affecting the expression levels of NOTCH2 as a target of miR (show MLXIP Antibodies)-181c. CONCLUSION: Together, our results point to the epigenetic role of CTCF (show CTCF Antibodies) in the regulation of microRNAs implicated in tumorigenesis

  6. suggest that Notch2 has an essential role in the cell growth, invasion, and migration of SACC. Notch2 may therefore be a potential target gene for the treatment of SACC by interfering with cell growth and metastasis

  7. Notch2 and Notch3 (show NOTCH3 Antibodies) inhibited both cell proliferation and cell apoptosis in BeWo and JAR (show MYO6 Antibodies) trophoblast cell lines.

  8. A functional polymorphism in the premiR146a gene influences the prognosis of glioblastoma multiforme by interfering with the balance between Notch1 (show NOTCH1 Antibodies) and Notch2

  9. Results suggest that Notch2 pathway and miR (show MLXIP Antibodies)-23b interplay in a reciprocal regulation loop in gastric cancer cells and this axis plays an important role in gastric carcinogenesis.

  10. These findings suggested that the NOTCH2 signaling may confer aggressive behavior and immature morphology in human hepatocellular carcinoma cells.

Mouse (Murine) Notch 2 (NOTCH2) interaction partners

  1. In this study, authors use a smooth muscle-specific (show EIF3K Antibodies) deletion of Notch2 together with a global Notch3 (show NOTCH3 Antibodies) deletion to produce mice with combinations of mutant and wild-type Notch2/3 alleles in vascular smooth muscle cells

  2. 6955C-->T mutation in the Notch2 locus leading to cancellous and cortical bone osteopenia.

  3. Data (including data from studies in transgenic/knockout mice) suggest deletion of Notch1 (show NOTCH1 Antibodies) in podocytes prevents diabetic nephropathy development and up-regulates Notch2 expression; overexpression of Notch2 does not promote diabetic nephropathy.

  4. Expression of Notch1 and Notch2 was decreased in regenerated epidermis of wounds, where features of keratinocytes were altered. Notch1 and Notch2 down-regulation contributed to the induction of interleukin-36alpha expression.

  5. data indicate distinct effects of Notch (show NOTCH1 Antibodies) signaling on invariant natural killer T cells in the thymus and liver, which are at least partly independent of RBP-j (show RBPJ Antibodies) in the thymus.

  6. Notch1 (show NOTCH1 Antibodies) and Notch2 intracellular domains are functionally equivalent during development and carcinogenesis

  7. NOTCH2 inhibits PDGF-B (show PDGFB Antibodies)-dependent proliferation and its expression is decreased by PDGF-B (show PDGFB Antibodies).

  8. BTK (show BTK Antibodies) synergizes with Notch2 to govern marginal zone B cells in non-obese diabetic mice.

  9. Surface expression of NOTCH2 was seen in specified E11 (show PDPN Antibodies) AGM (show IGFBP7 Antibodies) (CD45 (show PTPRC Antibodies)+VE-cadherin (show CDH5 Antibodies)+) hematopoietic progenitors. NOTCH (show NOTCH1 Antibodies) activation by Delta1 can increase long-term engrafting HSC (show FUT1 Antibodies) numbers from these cells.

  10. Notch1 (show NOTCH1 Antibodies) is the primary receptor regulating intestinal stem cell function and Notch1 (show NOTCH1 Antibodies) and Notch2 together regulate epithelial cell proliferation, cell fate determination, and post-injury regeneration

Cow (Bovine) Notch 2 (NOTCH2) interaction partners

  1. bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 (show NOTCH1 Antibodies) and Notch3 (show NOTCH3 Antibodies), suggesting that ORF2 interfered with the trans-activation potential of Notch (show NOTCH1 Antibodies).

Zebrafish Notch 2 (NOTCH2) interaction partners

  1. DeltaC/Notch1a (show NOTCH1A Antibodies) and Notch2 signaling is responsible for a survival signal provided by xanthophores to melanophores.

NOTCH2 Antigen Profile

Antigen Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NOTCH2

  • notch 2 (NOTCH2) antibody
  • notch 2 (notch2) antibody
  • notch 2 (Notch2) antibody
  • notch homolog 2 (notch2) antibody
  • AGS2 antibody
  • AI853703 antibody
  • HJCYS antibody
  • hN2 antibody
  • N2 antibody
  • notch6 antibody
  • sb:cb884 antibody

Protein level used designations for anti-Notch 2 (NOTCH2) Antibodies

notch 2 , neurogenic locus notch homolog protein 2-like , Notch homolog 2 , neurogenic locus notch homolog protein 2 , Motch B , Notch gene homolog 2 , notch gene homolog 2 , notch receptor protein 6

581186 Strongylocentrotus purpuratus
100081510 Ornithorhynchus anatinus
100464781 Ailuropoda melanoleuca
100567900 Anolis carolinensis
100584613 Nomascus leucogenys
100224680 Taeniopygia guttata
4853 Homo sapiens
457173 Pan troglodytes
483148 Canis lupus familiaris
18129 Mus musculus
29492 Rattus norvegicus
100153369 Sus scrofa
513730 Bos taurus
58065 Danio rerio
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