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Browse our anti-NOTCH4 (NOTCH4) Antibodies

Full name:
anti-Notch 4 Antibodies (NOTCH4)
On are 86 Notch 4 (NOTCH4) Antibodies from 21 different suppliers available. Additionally we are shipping NOTCH4 Proteins (11) and NOTCH4 Kits (4) and many more products for this protein. A total of 108 NOTCH4 products are currently listed.
Int-3, Int3, N4, NOTCH3, NOTCH4
list all antibodies Gene Name GeneID UniProt
NOTCH4 4855 Q99466
NOTCH4 18132 P31695
NOTCH4 406162  

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Most Popular Reactivities for anti-NOTCH4 (NOTCH4) Antibodies

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anti-Human NOTCH4 Antibodies:

anti-Mouse (Murine) NOTCH4 Antibodies:

anti-Rat (Rattus) NOTCH4 Antibodies:

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Top referenced anti-NOTCH4 Antibodies

  1. Mouse (Murine) Monoclonal NOTCH4 Primary Antibody for FACS - ABIN2660867 : Tanigaki, Honjo: Regulation of lymphocyte development by Notch signaling. in Nature immunology 2007 (PubMed)
    Show all 4 references for ABIN2660867

  2. Mouse (Murine) Monoclonal NOTCH4 Primary Antibody for FACS - ABIN2663863 : Shimizu, Chiba, Hosoya, Kumano, Saito, Kurokawa, Kanda, Hamada, Hirai: Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. in Molecular and cellular biology 2000 (PubMed)
    Show all 4 references for ABIN2663863

  3. Mouse (Murine) Monoclonal NOTCH4 Primary Antibody for FACS - ABIN2658818 : Riella, Ueno, Batal, De Serres, Bassil, Elyaman, Yagita, Medina-Pestana, Chandraker, Najafian: Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)
    Show all 4 references for ABIN2658818

  4. Mouse (Murine) Monoclonal NOTCH4 Primary Antibody for FACS - ABIN2657989 : Moriyama, Sekine, Koyanagi, Koyama, Ogata, Chiba, Hirose, Okumura, Yagita: Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. in International immunology 2008 (PubMed)
    Show all 3 references for ABIN2657989

  5. Human Polyclonal NOTCH4 Primary Antibody for ELISA, WB - ABIN1536151 : Sugaya, Sasanuma, Nohata, Kimura, Fukagawa, Nakamura, Ando, Inoko, Ikemura, Mita: Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3. in Gene 1997 (PubMed)
    Show all 2 references for ABIN1536151

  6. Human Polyclonal NOTCH4 Primary Antibody for IHC, WB - ABIN2779440 : Tang, Urs, Liaw: Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. in Circulation research 2008 (PubMed)

More Antibodies against NOTCH4 Interaction Partners

Human Notch 4 (NOTCH4) interaction partners

  1. findings indicate that Notch4+ melanoma cancer stem-like cells trigger epithelial-mesenchymal transition and promote the metastasis of melanoma cells

  2. the aberrant activation of Notch4 promotes oral squamous cell carcinoma metastasis.

  3. High Notch4 expression is associated with Prostatic Intraepithelial Neoplasia.

  4. The expression of cytoplasmic Notch1 (show NOTCH1 Antibodies) or nuclear Notch4 could also be upregulated by HBx in HepG2X cells. The upregulation of Notch1 (show NOTCH1 Antibodies) by HBx was through p38 MAPK (show MAPK14 Antibodies) pathway.

  5. Anti-estrogen resistance in human breast tumors is driven by JAG1 (show JAG1 Antibodies)-NOTCH4-dependent cancer stem cell activity.

  6. Notch 3 (show NOTCH3 Antibodies) and 4, and not Notch 1 (show NOTCH1 Antibodies), were highly increased in human arteriovenous malformations.

  7. NOTCH4 polymorphism can influence clinical symptoms in Slovenian patients with schizophrenia.

  8. Our findings provide a novel mechanism for Notch4-ICD (show GNPTAB Antibodies) regulation, suggesting a negative regulatory role for the PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) pathway in Notch4 nuclear signaling.

  9. This study failed to replicate the significant association between the NOTCH4 gene rs3131296 polymorphism and the risk for schizophrenia.

  10. BITC-mediated inhibition of bCSC was augmented by knockdown of Notch4 and Nicastrin (show NCSTN Antibodies), but not by RNA interference of Notch1 (show NOTCH1 Antibodies) or Notch2 (show NOTCH2 Antibodies).

Mouse (Murine) Notch 4 (NOTCH4) interaction partners

  1. Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4-/- compared with wild-type and Notch3 (show NOTCH3 Antibodies)-/- mice.

  2. Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.

  3. Notch (show NOTCH1 Antibodies) signaling is required for proper lymphatic valve formation and regulates integrin alpha9 and fibronectin (show FN1 Antibodies) EIIIA expression during valve morphogenesis

  4. Notch4-deficient mice exhibited slightly delayed vessel growth in the retina, consistent with the novel finding that NOTCH4 protein is expressed in the newly formed vasculature.

  5. Data indicate that expression of Dll4 (show DLL4 Antibodies) is specific to theca layer endothelial cells (ECs); Notch1 (show NOTCH1 Antibodies)/Notch4 in theca layer ECs and vascular smooth muscle cells (VSMCs), Notch3 (show NOTCH3 Antibodies) is restricted to VSMCs; Notch2 (show NOTCH2 Antibodies) in granulosa cells (GCs (show UGCG Antibodies)) of small follicles.

  6. In this study, we examined Notch (show NOTCH1 Antibodies) signaling in the well established Tg26 mouse model of HIV associated nephropathy.

  7. Notch4 normalization reduces blood vessel size in arteriovenous malformations

  8. results demonstrate that whey acidic protein promoter-Int3 has no oncogenic effect upon parity-identified mammary epithelial cells

  9. Trp53 (show TP53 Antibodies) regulates Notch 4 signaling through physical interactions with Mdm2 (show MDM2 Antibodies).

  10. Results indicate the importance of Notch (show NOTCH1 Antibodies) signaling in maintaining the lung vasculature and offer a new, reliable model with which to study the pathobiology of lung arteriovenous shunts and malformations.

NOTCH4 Antigen Profile

Antigen Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.

Alternative names and synonyms associated with NOTCH4

  • notch 4 (NOTCH4) antibody
  • Notch homolog 4 (Drosophila) (NOTCH4) antibody
  • notch 4 (Notch4) antibody
  • Int-3 antibody
  • Int3 antibody
  • N4 antibody
  • NOTCH3 antibody
  • NOTCH4 antibody

Protein level used designations for anti-Notch 4 (NOTCH4) Antibodies

notch 4 , neurogenic locus notch homolog protein 4-like , Notch homolog 4 , Notch homolog 4 (Drosophila) , neurogenic locus notch homolog protein 4 , Notch gene homolog 4

100477609 Ailuropoda melanoleuca
462587 Pan troglodytes
537814 Bos taurus
717323 Macaca mulatta
4855 Homo sapiens
100144522 Sus scrofa
481726 Canis lupus familiaris
536128 Bos taurus
18132 Mus musculus
406162 Rattus norvegicus
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