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NOTCH4 Products

(Notch 4 (NOTCH4))
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008].

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Featured NOTCH4 Categories

NOTCH4 Antibodies

High quality antibodies with extensive validation data.

NOTCH4 ELISA Kits

Reliable ELISA kits for a wide range of species.

NOTCH4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NOTCH4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
  • (6)
Cat. No. ABIN7442495
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Guinea Pig, Horse, Human, Pig, Rat
Application WB, IHC
Validations
  • (3)
  • (4)
Cat. No. ABIN2777550
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7254322
Quantity 200 μL
Datasheet Datasheet

Recommended NOTCH4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968973
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958227
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6231564
Quantity 96 tests
Datasheet Datasheet

Recommended NOTCH4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275367
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7415095
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7415395
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our NOTCH4 products

Gelsomino, Panza, Giordano, Barone, Gu, Spina, Catalano, Fuqua, Andò: "Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines." in: Cancer letters, Vol. 428, pp. 12-20, (2018) (PubMed).

Bhat, Sun, Weger, Raouf: "Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells." in: Stem cells and development, Vol. 25, Issue 7, pp. 522-9, (2016) (PubMed).

Soylu, Acar, Ozbey, Unal, Koksal, Bassorgun, Ciftcioglu, Ustunel: "Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma." in: Pathology oncology research : POR, Vol. 22, Issue 1, pp. 87-94, (2015) (PubMed).

Sun, Klauzinska, Lake, Lee, Santopietro, Raafat, Salomon, Callahan, Artavanis-Tsakonas: "Trp53 regulates Notch 4 signaling through Mdm2." in: Journal of cell science, Vol. 124, Issue Pt 7, pp. 1067-76, (2011) (PubMed).

Sekine, Moriyama, Koyanagi, Koyama, Ogata, Okumura, Yagita: "Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands." in: International immunology, Vol. 21, Issue 3, pp. 295-301, (2009) (PubMed).

Tang, Urs, Liaw: "Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site." in: Circulation research, Vol. 102, Issue 6, pp. 661-8, (2008) (PubMed).

Murphy, Lam, Wu, Kim, Vartanian, Bollen, Carlson, Wang: "Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10901-6, (2008) (PubMed).

Moriyama, Sekine, Koyanagi, Koyama, Ogata, Chiba, Hirose, Okumura, Yagita: "Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice." in: International immunology, Vol. 20, Issue 6, pp. 763-73, (2008) (PubMed).

Bray: "Notch signalling: a simple pathway becomes complex." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 678-89, (2006) (PubMed).

Takahashi, Cui, Kojima, Han, Yu, Tanabe, Yara, Matsuura, Matsushima, Nakayama, Arinami, Shen, Faraone, Tsuang: "Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples." in: Biological psychiatry, Vol. 54, Issue 2, pp. 129-35, (2003) (PubMed).

Synonyms and alternative names related to NOTCH4

notch 4 (NOTCH4), notch 4 (Notch4), neurogenic locus notch homolog protein 4 (LOC100712850), Int-3, INT3, Int3, N4, NOTCH3, Notch4

Protein level used designations for NOTCH4

  • Notch homolog 4
  • neurogenic locus notch homolog protein 4
  • notch 4
  • neurogenic locus notch homolog protein 4-like
  • Notch gene homolog 4
  • putative Notch4 protein
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