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anti-Human NR0B2 Antibodies:
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Hamster Polyclonal NR0B2 Primary Antibody for IHC (p) - ABIN271164
He, Park, Zhang, Huang, Lu, Wang: Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. in Gastroenterology 2008
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This study was performed to test the hypothesis that the SHP (show LAMC1 Antibodies) gene is a target gene of DEC1 (show BHLHE40 Antibodies). Cotransfection demonstrated that DEC1 (show BHLHE40 Antibodies) repressed the SHP (show LAMC1 Antibodies) promoter and attenuated the transactivation of the classic circadian activator complex of Clock/Bmal1 (show ARNTL Antibodies).
The molecular dynamics and structural analysis of the small heterodimer partner in complex with glucocorticoid receptor (show NR3C1 Antibodies) is described.
The finding that overexpression of HIF-1alpha (show HIF1A Antibodies) increased the activity of the CYP7A1 (show CYP7A1 Antibodies) promoter suggested that hypoxia decreased the expression of CYP7A1 (show CYP7A1 Antibodies) in a HIF-1 (show HIF1A Antibodies)-independent manner.
Results demonstrated a detrimental effect of Bcl2 (show BCL2 Antibodies) and H19 (show NCKAP1 Antibodies) associated with cholestatic liver fibrosis and an indispensable role of Shp (show LAMC1 Antibodies) to maintain normal liver function.
These findings show that POD-1/TCF21 (show TCF21 Antibodies) regulates SF-1 (show NR5A1 Antibodies) and LRH-1 (show NR5A2 Antibodies) by distinct mechanisms, contributing to the understanding of POD-1 (show TCF21 Antibodies) involvement and its mechanisms of action in adrenal and liver tumorigenesis.
Overexpression of SHP (show LAMC1 Antibodies) and activation of AMPK (show PRKAA1 Antibodies) reverses profibrogenic features of HCV-infected cells by decreasing TGF-beta (show TGFB1 Antibodies) and fibrotic gene expression.
Data suggest that LRH1/NR5A2 (show NR5A2 Antibodies) (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 (show NCOA2 Antibodies) (co-activator; transcription intermediary factor 2) and SHP (show LAMC1 Antibodies).
At the molecular level, estrogen upregulated hepatic SHP (show LAMC1 Antibodies) expression through binding to its proximal promoter. In addition, the roles of estrogen were largely blunted in mice with SHP (show LAMC1 Antibodies) deficiency.
These data are suggestive of a role for SHP (show LAMC1 Antibodies) in controlling NLRP3 (show NLRP3 Antibodies) inflammasome activation through a mechanism involving interaction with NLRP3 (show NLRP3 Antibodies) and maintenance of mitochondrial homeostasis.
These results establish SHP (show LAMC1 Antibodies) as a novel antihypertrophic regulator that acts by interfering with GATA6 (show GATA6 Antibodies) signaling.
Six novel SNPs, five in ME1 (show ME1 Antibodies) and one in NR0B2, were identified as candidates that have effects on meat and carcass quality traits.
SHP (show LAMC1 Antibodies) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Antibodies) target genes Fgf15 and Shp (show LAMC1 Antibodies) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Antibodies) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
SHP (show LAMC1 Antibodies) and REV-ERBalpha (show NR1D1 Antibodies) play a critical role in controlling rhythmic CHOP (show DDIT3 Antibodies) expression in alcoholic fatty liver
our results suggest that SHP (show LAMC1 Antibodies) upregulation upon high-fat feeding leads to lipid accumulation, insulin (show INS Antibodies) resistance and inflammation in cardiomyocytes.
Mortality of SHP (show LAMC1 Antibodies)-/- mice after ethanol binge feeding was significantly reduced and Aldh2 (show ALDH2 Antibodies) mRNA level was higher. After an intoxicating dose of ethanol, SHP (show LAMC1 Antibodies)-/- mice exhibited faster blood ethanol clearance.
This study reveals SHP (show LAMC1 Antibodies) as a global transcriptional partner of SREBP-2 (show SREBF2 Antibodies) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Antibodies).
Our results suggest that SHP (show LAMC1 Antibodies) is required for both antidiabetic and hypolipidemic effects of TZDs in ob/ob mice through regulation of PPARgamma (show PPARG Antibodies) expression.
LSD1 (show KDM1A Antibodies) is a novel histone-modifying enzyme in the orchestrated regulation mediated by the farnesoid X receptor (show xpr1 Antibodies) and small heterodimer partner that reduces hepatic bile acid levels and protects the liver against bile acid toxicity.
SHP (show LAMC1 Antibodies) ablation creates a proinflammatory phenotype which is exacerbated after sleeve gastrectomy despite weight loss. These inflammatory alterations are possibly related to factors extrinsic to a direct manifestation of Non-alcoholic fatty liver.
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
short heterodimer partner
, nuclear receptor subfamily 0 group B member 2
, nuclear receptor SHP
, orphan nuclear receptor SHP
, small heterodimer partner
, small heterodimer partner homologue