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The studies performed did not confirm the ability of the SF1 insulator to protect expression of reporter gene white from the chromosome position effect in transgenic lines.
we found that KLF6 (show KLF6 Proteins) transcriptionally cooperates with NUR77 (show NR4A1 Proteins) and SF1
Data suggest that Ad4BP (show NR5A1 Proteins) plays role in regulation of intracellular NADPH (show FDXR Proteins) concentration via transcription of Me1 (show ME1 Proteins) and Mthfd2 (show MTHFD2 Proteins) genes in adrenocortical cells. (Ad4BP (show NR5A1 Proteins) = nuclear receptor subfamily 5 group A member 1 (show NR5A1 Proteins); Me1 (show ME1 Proteins) = malic enzyme 1 (show ME1 Proteins); Mthfd2 (show MTHFD2 Proteins) = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
WT1 (show WT1 Proteins) is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 expression. Without Wt1 (show WT1 Proteins), the expression of Sf1 was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
SF1 in the ventromedial nucleus of the hypothalamus regulates age-dependent obesity.
Data suggest that Sf1 and c-jun interact and cooperate to activate the Fdx1 promoter in MA-10 (tumorigenic cell line) and TM3 (non-tumorigenic cell line) Leydig cells; such activation requires different regulatory elements located between -124 and -306 bp of Fdx1 promoter and involves recruitment of Sf1 to this region. (Sf1 = splicing factor 1; c-jun = proto-oncogene c-jun; Fdx1 = ferredoxin 1)
Our data suggested that lipid accumulation in the Leydig cells of the 46,XY disorders of sex development phenotype with a steroidogenic factor 1 (show NR5A1 Proteins) mutation is due, at least in part, to the suppression of steroidogenic acute regulatory protein (show STAR Proteins) and CYP11A1 (show CYP11A1 Proteins), and a resulting increase in unmetabolized cholesterol.
The results of the current study show that EB treatment from P25 (show CDK5R1 Proteins) to P36 (show ANXA2 Proteins) could not restore the number of kisspeptin-ir cells in the AVPV in agonadal SF-1 KO mice to numbers found in gonadally intact WT or EB-treated WT/OVX females
the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 (show GATA4 Proteins) and SF-1 expression.
SF-1 is needed for proper development of fetal and adult Leydig cells but with distinct primary functions
Results clearly indicate that SF-1 is involved in the regulation of LIPE (show LIPE Proteins) expression after activation of protein kinase A in adrenocortical cells.
this study identified a novel regulatory circuit for ovarian AMH (show AMH Proteins) production; specifically, through the coordinated interplay between FOXL2 (show FOXL2 Proteins) and SF-1 (show NR5A1 Proteins) that could control ovarian follicle development.
SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA
SF1 (show NR5A1 Proteins) was the only specific marker of uterine tumour resembling ovarian sex cord-stromal tumour
rete ovarii were positive for PAX-8 (show PAX8 Proteins), weakly positive for SF-1 (show NR5A1 Proteins), and negative for PAX-2 (show PAX2 Proteins) and GATA-3 (show GATA3 Proteins)
A novel function of SF1 (show NR5A1 Proteins) in the initial recruitment of the U2 snRNP (show LSM2 Proteins) through direct interactions with two U2 snRNP (show LSM2 Proteins)-associated proteins.
Data suggest that post-translational processing of SF1 (show NR5A1 Proteins) (phosphorylation of Ser20) down-regulates nuclear import of SF1 (show NR5A1 Proteins) via alterations in kinetic interaction of SF1 (show NR5A1 Proteins) nuclear localization signal (NLS (show ALDH1A2 Proteins)) with NLS (show ALDH1A2 Proteins) receptor isoforms.
We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65
Gomafu indirectly modulates the function of the splicing factors SF1 (show NR5A1 Proteins) and Celf3 (show CELF3 Proteins) by sequestering these proteins into separate nuclear bodies.
The conserved SPSP motif phosphorylation and the SF1 (show NR5A1 Proteins)/U2AF interface are essential in vivo.
Findings suggest that Zinc finger motif-1 (ZFM1) is an important factor for the stabilization of a contractile SMC (show DYM Proteins) phenotype under basal or mildly activating conditions.
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants.
zinc finger protein 162
, splicing factor 1
, splicing factor 1, isoform 1
, adrenal 4-binding protein
, embryonal LTR-binding protein
, embryonal long terminal repeat-binding protein
, fushi tarazu 1 factor homolog
, fushi tarazu factor homolog 1
, steroid hormone receptor Ad4BP
, steroid hydroxylase positive regulator
, steroidogenic factor 1
, mammalian branch point-binding protein
, transcription factor ZFM1
, zinc finger gene in MEN1 locus