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There is evidence of cotranscription and intergenic splicing events between the PPARG (show PPARG Proteins) gene and the neighboring gene TSEN2 in cattle. Two types of chimeric transcripts are observed.
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.
tRNA-splicing endonuclease subunit Sen2
, tRNA spicing endonuclease 2-like protein
, tRNA splicing endonuclease 2 homolog (S. cerevisiae)
, tRNA-intron nuclease 2
, tRNA-splicing endonuclease subunit Sen2-like
, tRNA-intron endonuclease Sen2