Browse our anti-ATR (ATR) Antibodies

Full name:
anti-Ataxia Telangiectasia and Rad3 Related Antibodies (ATR)
On www.antibodies-online.com are 11 Ataxia Telangiectasia and Rad3 Related (ATR) Antibodies from 6 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 12 ATR products are currently listed.
Synonyms:
ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, Ataxia telangiectasia-mutated and RAD3-related, ATR, ATRAD3, FCTCS, frp1, mec1, MHK7.5, MHK7_5, sckl, sckl1, si:dkey-231j24.1, XATR
list all antibodies Gene Name GeneID UniProt
ATR 300942  
ATR 545 Q13535
ATR 245000  

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Top referenced anti-ATR Antibodies

  1. Human Polyclonal ATR Primary Antibody for IHC (p) - ABIN319379 : Vostal, Shafer, Mondoro, Fratantoni: Endogenous ADP prevents PGE1-induced tyrosine dephosphorylation of focal adhesion kinase in thrombin-activated platelets. in Biochimica et biophysica acta 1997 (PubMed)
    Show all 4 references for 319379

  2. Polyclonal ATR Primary Antibody for IHC (p) - ABIN4948298 : Zhou, Lu, Wulf, Lu: Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism. in Cellular and molecular life sciences : CMLS 2001 (PubMed)
    Show all 3 references for 4948298

  3. Human Monoclonal ATR Primary Antibody for WB - ABIN1449281 : Cimprich, Shin, Keith, Schreiber: cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

More Antibodies against ATR Interaction Partners

Zebrafish Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. Findings reveal a novel role for ATR in cilia signaling distinct from its canonical function during replication and strengthen emerging links between cilia function and development.

Human Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. Our data reveal that BETi can potentiate the cell stress and death caused by ATR inhibitors. This suggests that ATRi can be used in combination therapies of lymphomas without the use of genotoxic drugs

  2. Ultraviolet rays-induced ATR (show ANTXR1 Antibodies) and ATM (show ATM Antibodies) recruitment and activation differ in G1 and S phases due to the existence of distinct types of DNA lesions, which promote assembly of different proteins involved in the process of DNA repair and checkpoint activation.

  3. Small molecule ATR (show ANTXR1 Antibodies) and Chk1 (show CHEK1 Antibodies) inhibitors potently sensitize lymphoma cells to UVA radiation and induce a prominent apoptotic response

  4. ATR (show ANTXR1 Antibodies) inhibition potentiated Chk1 (show CHEK1 Antibodies) inhibitor induced replication stress and cytotoxicity via the abrogation of ATR (show ANTXR1 Antibodies)-dependent feedback activation of Chk1 (show CHEK1 Antibodies) induced by Chk1 (show CHEK1 Antibodies) inhibitor generated replication stress in tumor cell lines.

  5. Our data suggests that total cellular b-catenin levels decrease in the presence of secreted frizzled-related protein 1 (show SFRP1 Antibodies) and Wnt inhibitory factor 1 (show WIF1 Antibodies), and a significant increase in cell death after tyrosine kinase (show TXK Antibodies) inhibitor treatment is observed. On the contrary, when secreted frizzled-related protein 1 (show SFRP1 Antibodies) is suppressed, total b-catenin levels increase in the cell and the cells become resistant to tyrosine kinase (show TXK Antibodies) inhibitors.

  6. HPV31 regulates RRM2 (show RRM2 Antibodies) levels through expression of E7 and activation of the ATR (show ANTXR1 Antibodies)-Chk1 (show CHEK1 Antibodies)-E2F1 (show E2F1 Antibodies) DNA damage response, which is essential to combat replication stress upon entry into S-phase.

  7. disruption of IGF-1R signaling with small-molecule inhibitors or IGF-1 withdrawal partially abrogates both the phosphorylation and activation of CHK1 by ATR and the accompanying inhibition of chromosomal DNA synthesis in UVB-irradiated keratinocytes.

  8. that parallel TopBP1- and ETAA1-mediated pathways underlie ATR activation and that their combined action is essential for coping with replication stress

  9. The bocavirus large viral nonstructural protein NS1 (show PTPN11 Antibodies) is sufficient to induce the DNA damage response and the activation of the host ATM (show ATM Antibodies), ATR (show ANTXR1 Antibodies), and DNAPK (show PRKDC Antibodies).

  10. It is proposed that ATR functions control cell plasticity by sensing structural deformations of different cellular components, including DNA and initiating appropriate repair responses. (Review)

Xenopus laevis Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. The authors show, in live cells, that Ddx19 (show DDX19B Antibodies) transiently relocalizes from the nucleopore to the nucleus upon DNA damage, in an ATR/Chk1 (show CHEK1 Antibodies)-dependent manner, and that Ddx19 (show DDX19B Antibodies) nuclear relocalization is required to clear R-loops (DNA:RNA hybrids).

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. APE2 (show APEX2 Antibodies) associates with Chk1 (show CHEK1 Antibodies); a serine residue (S86) in the Chk1 (show CHEK1 Antibodies)-binding motif of APE2 (show APEX2 Antibodies) is essential for Chk1 (show CHEK1 Antibodies) phosphorylation, indicating a Claspin (show CLSPN Antibodies)-like but distinct role for APE2 (show APEX2 Antibodies) in ATR-Chk1 (show CHEK1 Antibodies) signaling.

  4. MRN (MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 (show NLRP2 Antibodies)) complex has role in ATR activation via TOPBP1 (show TOPBP1 Antibodies) recruitment.

  5. ATM (show ATM Antibodies) activity is required for an early step in resection, leading to ATR activation, CtIP (show RBBP8 Antibodies)-T818 phosphorylation, and accumulation of CtIP (show RBBP8 Antibodies) on chromatin.

  6. ATM (show ATM Antibodies) and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies)/Nbs1 (show NLRP2 Antibodies) dependent recovery of collapsed replication forks.

  7. Human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk and the CDC6-ATR interaction is conserved in Xenopus.

  8. ATM (show ATM Antibodies) and ATR phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Antibodies) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  9. ATRIP (show ATRIP Antibodies) must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 (show CHEK1 Antibodies) effectively

  10. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

Mouse (Murine) Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR-Chk1 (show CHEK1 Antibodies)/2-controlled DNA-damage response pathways.

  2. Atr deletion in cerebellar granule neuron progenitors (CGNPs) induced proliferation-associated DNA damage, p53 activation, apoptosis and cerebellar hypoplasia in mice. Genetic deletion of Atr blocked tumorigenesis in medulloblastoma-prone SmoM2 mice.

  3. ATR controls DNA damage-induced G2 checkpoint control and apoptosis in proliferating neurons.

  4. CDC25A-deficient embryonic stem cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs.

  5. These results therefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to induce an apoptotic form of cell death in non-cycling cells.

  6. RAD9 (show RAD9A Antibodies) has a prominent role in the ATR-Chk1 (show CHEK1 Antibodies) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  7. telomeres are protected from hyper-resection through the repression of the ATM (show ATM Antibodies) and ATR kinases by TRF2 (show TERF2 Antibodies) and TPP1 (show TPP1 Antibodies)-bound POT1a (show POT1 Antibodies)/b, respectively.

  8. DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

  9. ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair

  10. Observations suggest that ATR mediates a mechanical response to membrane stress that could be caused by chromatin dynamics and is important for genome integrity.

Arabidopsis thaliana Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. ATR function together with SOG1 and ALT2 (show GPT2 Antibodies) to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.

  2. Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation.

  3. ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other.

  4. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis

  5. TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.

  6. Short telomeres in tert mutant plants activate both ATM and ATR. Absence of telomerase elicits and ATM and ATR-dependent DNA damage response at telomeres.

  7. cooperation among DNA translesion synthesis (TLS (show FUS Antibodies)) polymerases (Poleta, Polzeta) and DNA-damage-activated protein kinases (ATR, ATM (show ATM Antibodies))

  8. Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction.

  9. The MRN complex is essential for activation of the ATM and ATR kinases in response to irradiation.

  10. Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR]

ATR Antigen Profile

Antigen Summary

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Alternative names and synonyms associated with ATR

  • ataxia telangiectasia and Rad3 related (Atr) antibody
  • ataxia telangiectasia and Rad3 related (ATR) antibody
  • ataxia telangiectasia and Rad3 related (atr) antibody
  • serine/threonine-protein kinase ATR (ATR) antibody
  • ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED antibody
  • ATATR antibody
  • Ataxia telangiectasia-mutated and RAD3-related antibody
  • ATR antibody
  • ATRAD3 antibody
  • FCTCS antibody
  • frp1 antibody
  • mec1 antibody
  • MHK7.5 antibody
  • MHK7_5 antibody
  • sckl antibody
  • sckl1 antibody
  • si:dkey-231j24.1 antibody
  • XATR antibody

Protein level used designations for ATR

ataxia telangiectasia and Rad3 related , ataxia telangiectasia and Rad3 related protein , serine/threonine-protein kinase ATR-like , FRAP-related protein 1 , FRAP-related protein-1 , MEC1, mitosis entry checkpoint 1, homolog , Rad3 related protein , ataxia telangiectasia and Rad3-related protein , protein kinase ATR , serine/threonine-protein kinase ATR , checkpoint kinase , protein kinase , serine/threonine-protein kinase atr

GENE ID SPECIES
300942 Rattus norvegicus
460745 Pan troglodytes
477101 Canis lupus familiaris
504869 Bos taurus
567770 Danio rerio
714443 Macaca mulatta
100062529 Equus caballus
100127459 Sus scrofa
100412321 Callithrix jacchus
100454403 Pongo abelii
100464897 Ailuropoda melanoleuca
100561948 Anolis carolinensis
545 Homo sapiens
398197 Xenopus laevis
245000 Mus musculus
834082 Arabidopsis thaliana
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