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Browse our anti-ATR (ATR) Antibodies

Full name:
anti-Ataxia Telangiectasia and Rad3 Related Antibodies (ATR)
On are 9 Ataxia Telangiectasia and Rad3 Related (ATR) Antibodies from 3 different suppliers available. A total of 9 ATR products are currently listed.
ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, Ataxia telangiectasia-mutated and RAD3-related, ATR, ATRAD3, FCTCS, frp1, mec1, MHK7.5, MHK7_5, sckl, sckl1, si:dkey-231j24.1, XATR
list all antibodies Gene Name GeneID UniProt
ATR 300942  
ATR 545 Q13535
ATR 245000  

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Top referenced anti-ATR Antibodies

  1. Dog (Canine) Polyclonal ATR Primary Antibody for EIA, WB - ABIN401401 : Olson, Nievera, Klimovich, Fanning, Wu: RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. in The Journal of biological chemistry 2006 (PubMed)
    Show all 5 references for ABIN401401

  2. Human Polyclonal ATR Primary Antibody for IHC (p) - ABIN319379 : Vostal, Shafer, Mondoro, Fratantoni: Endogenous ADP prevents PGE1-induced tyrosine dephosphorylation of focal adhesion kinase in thrombin-activated platelets. in Biochimica et biophysica acta 1997 (PubMed)
    Show all 4 references for ABIN319379

  3. Human Monoclonal ATR Primary Antibody for WB - ABIN1449281 : Cimprich, Shin, Keith, Schreiber: cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

More Antibodies against ATR Interaction Partners

Pig (Porcine) Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. Ataxia telangiectasia and Rad3 related protein (ATR) plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Human Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. ATR inhibition rewires cellular signaling networks induced by replication stress.

  2. RAD9 (show RAD9A Antibodies) has a prominent role in the ATR (show ANTXR1 Antibodies)-Chk1 (show CHEK1 Antibodies) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  3. ATM and ATR depletion reduced assembly of the telomerase complex.

  4. the role of both ATM and ATR in DNA repair, cell cycle regulation and apoptosis

  5. Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.

  6. The innate immune regulator STAT-5 is shown to regulate transcription of the ATR binding factor TopBP1, and this is critical for the induction of the ATR pathway in human papillomavirus-infected keratinocytes.

  7. ATR (show ANTXR1 Antibodies) is down-regulated by STAT3 (show STAT3 Antibodies)-regulated microRNA-383 in A431 cells.

  8. We suggest that MNNG-stimulated ATR (show ANTXR1 Antibodies)/CHK1 (show CHEK1 Antibodies) signaling stabilizes E2F3 by S124 phosphorylation, and then E2F3 together with NFY co-transactivate RRM2 (show RRM2 Antibodies) expression for DNA repair.

  9. ATR (show ANTXR1 Antibodies) controls basal deoxycytidine kinase (show DCK Antibodies) activity in response to replication stress.

  10. AZD6738, a novel ATR (show ANTXR1 Antibodies) kinase inhibitor sensitized TP53 (show TP53 Antibodies)- or ATM (show ATM Antibodies)-defective primary chronic lymphocytic leukemia cells to chemotherapy and ibrutinib.

Xenopus laevis Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  2. APE2 (show APEX2 Antibodies) associates with Chk1 (show CHEK1 Antibodies); a serine residue (S86) in the Chk1 (show CHEK1 Antibodies)-binding motif of APE2 (show APEX2 Antibodies) is essential for Chk1 (show CHEK1 Antibodies) phosphorylation, indicating a Claspin (show CLSPN Antibodies)-like but distinct role for APE2 (show APEX2 Antibodies) in ATR-Chk1 (show CHEK1 Antibodies) signaling.

  3. MRN (MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 (show NLRP2 Antibodies)) complex has role in ATR activation via TOPBP1 (show TOPBP1 Antibodies) recruitment.

  4. ATM (show ATM Antibodies) activity is required for an early step in resection, leading to ATR activation, CtIP (show RBBP8 Antibodies)-T818 phosphorylation, and accumulation of CtIP (show RBBP8 Antibodies) on chromatin.

  5. ATM (show ATM Antibodies) and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies)/Nbs1 (show NLRP2 Antibodies) dependent recovery of collapsed replication forks.

  6. Human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk and the CDC6-ATR interaction is conserved in Xenopus.

  7. ATM (show ATM Antibodies) and ATR phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Antibodies) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  8. ATRIP (show ATRIP Antibodies) must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 (show CHEK1 Antibodies) effectively

  9. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  10. Data show that recombinant TopBP1 (show TOPBP1 Antibodies) induces a large increase in the kinase activity of both Xenopus and human ATR-ATRIP (show ATRIP Antibodies).

Mouse (Murine) Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. RAD9 (show RAD9A Antibodies) has a prominent role in the ATR-Chk1 (show CHEK1 Antibodies) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  2. telomeres are protected from hyper-resection through the repression of the ATM (show ATM Antibodies) and ATR kinases by TRF2 (show TERF2 Antibodies) and TPP1 (show TPP1 Antibodies)-bound POT1a (show POT1 Antibodies)/b, respectively.

  3. DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

  4. ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair

  5. Observations suggest that ATR mediates a mechanical response to membrane stress that could be caused by chromatin dynamics and is important for genome integrity.

  6. These results suggest that minute virus of mice infection disables the ATR cellular signaling pathway.

  7. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development.

  8. A new localization of ATR in the cilia of photoreceptors and the fact that mutant mice have shorter cilia suggests that the photoreceptor degeneration here described results from a ciliary defect.

  9. a role for ATR in the epigenetic regulation of gene expression

  10. A HORMAD2-dependent quality control mechanism that recognizes unsynapsis and recruits ATR activity during mammalian meiosis.

Arabidopsis thaliana Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. ATR function together with SOG1 and ALT2 (show GPT2 Antibodies) to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.

  2. Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation.

  3. ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other.

  4. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis

  5. TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.

  6. Short telomeres in tert mutant plants activate both ATM and ATR. Absence of telomerase elicits and ATM and ATR-dependent DNA damage response at telomeres.

  7. cooperation among DNA translesion synthesis (TLS (show FUS Antibodies)) polymerases (Poleta, Polzeta) and DNA-damage-activated protein kinases (ATR, ATM (show ATM Antibodies))

  8. Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction.

  9. The MRN complex is essential for activation of the ATM and ATR kinases in response to irradiation.

  10. Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR]

ATR Antigen Profile

Antigen Summary

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Alternative names and synonyms associated with ATR

  • ataxia telangiectasia and Rad3 related (Atr) antibody
  • ataxia telangiectasia and Rad3 related (ATR) antibody
  • ataxia telangiectasia and Rad3 related (atr) antibody
  • serine/threonine-protein kinase ATR (ATR) antibody
  • ATATR antibody
  • Ataxia telangiectasia-mutated and RAD3-related antibody
  • ATR antibody
  • ATRAD3 antibody
  • FCTCS antibody
  • frp1 antibody
  • mec1 antibody
  • MHK7.5 antibody
  • MHK7_5 antibody
  • sckl antibody
  • sckl1 antibody
  • si:dkey-231j24.1 antibody
  • XATR antibody

Protein level used designations for ATR

ataxia telangiectasia and Rad3 related , ataxia telangiectasia and Rad3 related protein , serine/threonine-protein kinase ATR-like , FRAP-related protein 1 , FRAP-related protein-1 , MEC1, mitosis entry checkpoint 1, homolog , Rad3 related protein , ataxia telangiectasia and Rad3-related protein , protein kinase ATR , serine/threonine-protein kinase ATR , checkpoint kinase , protein kinase , serine/threonine-protein kinase atr

300942 Rattus norvegicus
460745 Pan troglodytes
477101 Canis lupus familiaris
504869 Bos taurus
567770 Danio rerio
714443 Macaca mulatta
100062529 Equus caballus
100127459 Sus scrofa
100412321 Callithrix jacchus
100454403 Pongo abelii
100464897 Ailuropoda melanoleuca
100561948 Anolis carolinensis
545 Homo sapiens
398197 Xenopus laevis
245000 Mus musculus
834082 Arabidopsis thaliana
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