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ATR Products

(Ataxia Telangiectasia and Rad3 Related (ATR))

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The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008].

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Featured ATR Categories

ATR Antibodies

High quality antibodies with extensive validation data.

Recommended ATR Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC (p)
Validations
  • (1)
Cat. No. ABIN319379
Quantity 0.1 mL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN1449281
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Dog, Fish, Human, Monkey, Mouse, Rat, Xenopus laevis
Application EIA, WB
Validations
  • (1)
Cat. No. ABIN401401
Quantity 0.1 mg
Datasheet Datasheet

Recommended ATR ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6201396
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN6199496
Quantity 96 tests
Datasheet Datasheet

Recommended ATR Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7078705
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our ATR products

Shechter, Costanzo, Gautier: "Regulation of DNA replication by ATR: signaling in response to DNA intermediates." in: DNA repair, Vol. 3, Issue 8-9, pp. 901-8, (2004) (PubMed).

Zhou, Lu, Wulf, Lu: "Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism." in: Cellular and molecular life sciences : CMLS, Vol. 56, Issue 9-10, pp. 788-806, (2001) (PubMed).

Kastan, Lim: "The many substrates and functions of ATM." in: Nature reviews. Molecular cell biology, Vol. 1, Issue 3, pp. 179-86, (2001) (PubMed).

Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).

Jhiang: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).

Synonyms and alternative names related to ATR

ataxia telangiectasia and Rad3 related (Atr), ATR serine/threonine kinase (ATR), ataxia telangiectasia and Rad3 related (ATR), ATR serine/threonine kinase (atr), ATR serine/threonine kinase L homeolog (atr.L), Ataxia telangiectasia-mutated and RAD3-like protein (ATR), ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, Ataxia telangiectasia-mutated and RAD3-related, ATR, ATRAD3, FCTCS, FRP1, frp1, MEC1, mec1, MHK7.5, MHK7_5, SCKL, sckl, SCKL1, sckl1, si:dkey-231j24.1, XATR

Protein level used designations for ATR

  • ataxia telangiectasia and Rad3 related
  • ataxia telangiectasia and Rad3 related protein
  • serine/threonine-protein kinase ATR-like
  • FRAP-related protein 1
  • FRAP-related protein-1
  • MEC1, mitosis entry checkpoint 1, homolog
  • Rad3 related protein
  • ataxia telangiectasia and Rad3-related protein
  • protein kinase ATR
  • serine/threonine-protein kinase ATR
  • checkpoint kinase
  • protein kinase
  • serine/threonine-protein kinase atr
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