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Human BBC3 Protein expressed in HEK-293 Cells - ABIN2730162
Carpenter, Han, Paw, Lo: HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells. in PLoS ONE 2013
Data show that targeting of synoviocytes by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.
In the mouse model of silicosis, Bbc3 knockout mice clearly exhibited decreased levels of autophagy and fibrosis progression. These results suggest that downregulation of BBC3 expression may become a novel therapeutic strategy for the treatment of silicosis.
Quantitative real-time PCR analysis indicated higher expression of PUM (show MYOD1 Proteins) in renal cell carcinoma (show MOK Proteins) tissues compared to that in para-carcinoma tissues.
we have demonstrated that miR (show MLXIP Proteins)-503-5p expression negatively correlates with PUMA expression in colorectal carcinoma cells.
data suggest that PUMA cooperates with p21 (show CDKN1A Proteins) to regulate normal acinus (show ACIN1 Proteins) formation and epithelial-to-mesenchymal transition.
Results show that in PUMA protein adenovirus-infected A2780s ovarian cancer cells, exogenous PUMA was partially accumulated in the cytosol and mainly located to the mitochondria.
Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 Proteins) phosphorylation leads to decreased expression of c-MYC (show MYC Proteins) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 Proteins) family member PUMA, whereas inhibition of mTORC2 (show CRTC2 Proteins) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (show EGR1 Proteins)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (show BCL2L11 Proteins) locus encoding BIM (show BCL2L11 Proteins).
These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1 (show HMGB1 Proteins)- and oxidative stress-mediated injury to islets.
miR (show MLXIP Proteins)-23a-3p, miR (show MLXIP Proteins)-23b-3p, and miR (show MLXIP Proteins)-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 (show BCL2 Proteins) proteins DP5 and PUMA and consequent human beta-cell apoptosis.
Our results revealed that Slug siRNA transfection in combination with radiation increased the expression of PUMA, which contributed to radiosensitivity of oral squamous cell carcinoma cells
This study has demonstrated that methamphetamine-mediated pericytes migration involves PUMA up-regulation.
Data show that Emu-Myc (show MYC Proteins) mice lacking both p21 and PUMA developed lymphoma at a rate considerably longer latency than Emu-Myc (show MYC Proteins);p53 (show TP53 Proteins)(+/-)mice.
Our data show a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic host cell death during Listeria infection.
Overexpression of miR (show MLXIP Proteins)-29 or miR (show MLXIP Proteins)-24 is sufficient to inhibit the induction of Bim (show BCL2L11 Proteins) and Puma in young sympathetic neurons.
loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL (show BCL2L1 Proteins). It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL (show BCL2L1 Proteins) with BAK (show BAK1 Proteins) and BAX (show BAX Proteins).
PUMA is dispensable for glucose homeostasis in lean and obese mice, but it can affect leptin (show LEP Proteins) levels and food intake during obesity.
MYSM1 (show MYSM1 Proteins) is a critical negative regulator of p53 (show TP53 Proteins) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cel function.
Therapeutic response to non-genotoxic activation of p53 (show TP53 Proteins) by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells.
Bim (show BCL2L11 Proteins) and Puma overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.
Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.
Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin (show TUBA4A Proteins) mutation
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
BCL2 binding component 3
, bcl-2-binding component 3
, p53 up-regulated modulator of apoptosis
, Bcl-2 binding component 3