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Browse our BBC3 Proteins (BBC3)

Full name:
BCL2 Binding Component 3 Proteins (BBC3)
On are 9 BCL2 Binding Component 3 (BBC3) Proteins from 5 different suppliers available. Additionally we are shipping BBC3 Antibodies (310) and BBC3 Kits (11) and many more products for this protein. A total of 348 BBC3 products are currently listed.
list all proteins Gene Name GeneID UniProt
BBC3 317673 Q80ZG6
BBC3 27113 Q96PG8 , Q9BXH1
BBC3 170770 Q99ML1

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BBC3 Proteins (BBC3) by Origin

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Top referenced BBC3 Proteins

  1. Human BBC3 Primary Antibody for - ABIN2730162 : Carpenter, Han, Paw, Lo: HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells. in PLoS ONE 2013 (PubMed)

More Proteins for BBC3 Interaction Partners

Human BCL2 Binding Component 3 (BBC3) interaction partners

  1. Our results revealed that Slug (show SNAI2 Proteins) siRNA transfection in combination with radiation increased the expression of PUMA, which contributed to radiosensitivity of oral squamous cell carcinoma cells

  2. p53 (show TP53 Proteins) and Bax (show BAX Proteins) might play an important role in microcystin-LR (MC-LR)-induced apoptosis in HepG2 cells in which PUMA and survivin (show BIRC5 Proteins) were involved.

  3. Therapeutic response to non-genotoxic activation of p53 (show TP53 Proteins) by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells.

  4. p53 (show TP53 Proteins)/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis

  5. Suggest that the accumulation of PUMA in the cytosol may be important for the participation of this protein in apoptosis without the need for prior transcription in Burkitt's lymphoma b cells.

  6. in vitro OGT (show OGT Proteins) knockdown induced more cell apoptosis through increasing PUMA and caspase-3 (show CASP3 Proteins) expression

  7. our data purport that p53 (show TP53 Proteins) not only increased Puma expression directly, but that it may also do so through miR (show MLXIP Proteins)-203. Additionally, functional studies revealed that miR (show MLXIP Proteins)-203 overexpression induced apoptosis and inhibited cell invasiveness.

  8. the selective degradation of BBC3 underlies the prosurvival role of chaperone-mediated autophagy.

  9. puma-mediated apoptosis is not induced in mucosal melanomas by cisplatin

  10. There-fore, stable transfection of PUMA can significantly enhance epirubicin-induced apoptosis sensitivity of MCF-7 breast cancer cells.

Mouse (Murine) BCL2 Binding Component 3 (BBC3) interaction partners

  1. PUMA is dispensable for glucose homeostasis in lean and obese mice, but it can affect leptin (show LEP Proteins) levels and food intake during obesity.

  2. MYSM1 (show MYSM1 Proteins) is a critical negative regulator of p53 (show TP53 Proteins) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cel function.

  3. Therapeutic response to non-genotoxic activation of p53 (show TP53 Proteins) by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells.

  4. Bim (show BCL2L11 Proteins) and Puma overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.

  5. Beta-arrestin 2 (show ARRB2 Proteins) promotes inflammation-induced intestinal epithelial apoptosis through endoplasmic reticulum stress/PUMA in colitis.

  6. Puma is the major mediator of virus-induced Bax (show BAX Proteins)/Bak (show BAK1 Proteins) activation and mitochondrial membrane permeabilization induction.

  7. Oxidative stress increases PUMA expression regulated by FoxO1 (show FOXO1 Proteins) in follicular granulosa cells.

  8. Results indicate that PUMA is involved in the apoptosis of cerebral astrocytes upon ischemia/reperfusion injury

  9. by preventing the consumption of IL-15 (show IL15 Proteins), Bim (show BCL2L11 Proteins) limits the role of Noxa (show PMAIP1 Proteins) and Puma in causing the death of effector cells with less memory potential.

  10. These results demonstrate that antagonism between PUMA and MCL-1 constitutes the major axis of control of hematopoietic stem cell survival.

Zebrafish BCL2 Binding Component 3 (BBC3) interaction partners

  1. Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.

  2. Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin (show TUBA4A Proteins) mutation

BBC3 Protein Profile

Protein Summary

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with BBC3

  • BCL2 binding component 3 (BBC3)
  • Bcl-2 binding component 3 (Bbc3)
  • BCL2 binding component 3 (Bbc3)
  • BCL2 binding component 3 (bbc3)
  • BBC3 protein
  • JFY-1 protein
  • JFY1 protein
  • PUMA protein
  • PUMA/JFY1 protein

Protein level used designations for BBC3

BCL2 binding component 3 , bcl-2-binding component 3 , p53 up-regulated modulator of apoptosis , BH3-only , Bcl-2 binding component 3 , Puma

612153 Canis lupus familiaris
746617 Pan troglodytes
317673 Rattus norvegicus
27113 Homo sapiens
170770 Mus musculus
751763 Danio rerio
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