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Browse our Checkpoint Kinase 2 (CHEK2) ELISA Kits

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Checkpoint Kinase 2 ELISA Kits (CHEK2)
On www.antibodies-online.com are 15 Checkpoint Kinase 2 (CHEK2) ELISA Kits from 5 different suppliers available. Additionally we are shipping Checkpoint Kinase 2 Antibodies (468) and Checkpoint Kinase 2 Proteins (12) and many more products for this protein. A total of 518 Checkpoint Kinase 2 products are currently listed.
Synonyms:
Cds1, CHK-2, Chk2, fa66f08, hCds1, HUCDS1, LFS2, PP1425, Rad53, wu:fa66f08, zgc:55865
list all ELISA KIts Gene Name GeneID UniProt
CHEK2 11200 O96017
CHEK2 50883 Q9Z265
CHEK2 114212  

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Checkpoint Kinase 2 (CHEK2) ELISA Kits by Reactivity

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More ELISA Kits for Checkpoint Kinase 2 Interaction Partners

Human Checkpoint Kinase 2 (CHEK2) interaction partners

  1. the G2 damage checkpoint prevents stable recruitment of the chromosome-packaging-machinery components condensin complex (show SMC4 ELISA Kits) I and II onto the chromatin even in the presence of an active Cdk1 (show CDK1 ELISA Kits).

  2. data suggest that cancer risks reported for founder mutations may be generalizable to all CHEK2 + s, particularly for breast cancer

  3. K373E mutation of CHK2 in tumorigenesis

  4. Checkpoint kinase 1 (show CHEK1 ELISA Kits) and 2 signaling is important for apoptin regulation.

  5. High CHEK2 expression is associated with Lung Adenocarcinoma.

  6. Our study reports the first case of Li-Fraumeni syndrome (show TP53 ELISA Kits)-like in Chinese patients and demonstrates the important contribution of de novo mutations in this type of rare disease.

  7. hese findings confirmed that 53BP1 (show TP53BP1 ELISA Kits) loss might be a negative factor for chemotherapy efficacy, promoting cell proliferation and inhibiting apoptosis by suppressing ATM (show ATM ELISA Kits)-CHK2-P53 (show TP53 ELISA Kits) signaling, and finally inducing 5-FU resistance.

  8. All 14 exons of CHEK2 were amplified and sequenced.

  9. All 14 exons of CHEK2 were amplified.

  10. CHEK2 mutation is associated with Pancreatic Cancer.

Mouse (Murine) Checkpoint Kinase 2 (CHEK2) interaction partners

  1. We conclude that Chk2 regulates renal 25-hydroxyvitamin D 1alpha-hydroxylase expression thereby impacting on calcium and phosphate metabolism.

  2. TRIP13 (show TRIP13 ELISA Kits)-deficient spermatocytes also progress to an H1t (show HIST1H1T ELISA Kits)-positive stage if ATM (show ATM ELISA Kits) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A ELISA Kits) or Nbs1 (show NBN ELISA Kits) or by elimination of the ATM (show ATM ELISA Kits)-effector kinase CHK2

  3. Results represent the first demonstration of a role for CHK2 in the in vivo signaling of dysfunctional telomeres.

  4. DNA-PK/Chk2 signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

  5. Results demonstrate that Chk2 plays important roles in regulating cell cycle progression during female meiosis and early embryo development.

  6. These data establish CHK2 as essential for DNA damage surveillance in female meiosis and indicate that the oocyte DNA double-strand breaks damage response primarily involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, which then activates p53 and p63.

  7. Findings indicate that PIRH2 (show RCHY1 ELISA Kits) has central roles in the ubiquitylation of Chk2 and its turnover and in the regulation of its function.

  8. Chk2 deficiency in Myc (show MYC ELISA Kits) overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP (show PARP1 ELISA Kits) inhibition.

  9. Point mutation at the Nbs1 (show NBN ELISA Kits) Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 (show SMC1A ELISA Kits) phosphorylation after DNA damage.

  10. data indicate that an important role for Chk2 is maintaining lymphocyte development and that dual inactivation of Chk2 and Mus81 (show MUS81 ELISA Kits) remarkably inhibits cancer

Checkpoint Kinase 2 (CHEK2) Antigen Profile

Antigen Summary

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Checkpoint Kinase 2 (CHEK2)

  • serine/threonine-protein kinase chk2 (MCYG_07308) Elisa Kit
  • blue sensitive cone opsin (LOC396525) Elisa Kit
  • checkpoint kinase 2 (CHEK2) Elisa Kit
  • checkpoint kinase 2 (Chek2) Elisa Kit
  • CHK2 checkpoint homolog (S. pombe) (chek2) Elisa Kit
  • Cds1 Elisa Kit
  • CHK-2 Elisa Kit
  • Chk2 Elisa Kit
  • fa66f08 Elisa Kit
  • hCds1 Elisa Kit
  • HUCDS1 Elisa Kit
  • LFS2 Elisa Kit
  • PP1425 Elisa Kit
  • Rad53 Elisa Kit
  • wu:fa66f08 Elisa Kit
  • zgc:55865 Elisa Kit

Protein level used designations for Checkpoint Kinase 2 (CHEK2) ELISA Kits

serine/threonine-protein kinase chk2 , blue cone photoreceptor pigment , blue-sensitive opsin , opsin CHK-2 , CHK2 checkpoint homolog , cds1 homolog , checkpoint-like protein CHK2 , serine/threonine-protein kinase Chk2 , Cds1 homolog , Rad53 homolog , protein kinase Chk2

GENE ID SPECIES
9226831 Arthroderma otae CBS 113480
396525 Gallus gallus
11200 Homo sapiens
50883 Mus musculus
114212 Rattus norvegicus
486338 Canis lupus familiaris
336998 Danio rerio
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