Browse our Checkpoint Kinase 2 Proteins (CHEK2)

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Checkpoint Kinase 2 Proteins (CHEK2)
On are 12 Checkpoint Kinase 2 (CHEK2) Proteins from 8 different suppliers available. Additionally we are shipping Checkpoint Kinase 2 Antibodies (468) and Checkpoint Kinase 2 Kits (15) and many more products for this protein. A total of 518 Checkpoint Kinase 2 products are currently listed.
Cds1, CHK-2, Chk2, fa66f08, hCds1, HUCDS1, LFS2, PP1425, Rad53, wu:fa66f08, zgc:55865
list all proteins Gene Name GeneID UniProt
CHEK2 11200 O96017
CHEK2 50883 Q9Z265
Rat CHEK2 CHEK2 114212  

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Checkpoint Kinase 2 Proteins (CHEK2) by Origin

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Top referenced Checkpoint Kinase 2 Proteins

  1. Mouse (Murine) CHEK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2007792 : Matsuoka, Huang, Elledge: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 5 references for 2007792

  2. Human CHEK2 Protein expressed in Wheat germ - ABIN1349305 : Troncale, Barbet, Coulibaly, Henry, He, Barillot, Dubois, Hupé, de Koning: NormaCurve: a SuperCurve-based method that simultaneously quantifies and normalizes reverse phase protein array data. in PLoS ONE 2012 (PubMed)
    Show all 2 references for 1349305

More Proteins for Checkpoint Kinase 2 Interaction Partners

Human Checkpoint Kinase 2 (CHEK2) interaction partners

  1. SIAH2 (show SIAH2 Proteins) regulates CHK2 basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.

  2. MCM2 (show MCM2 Proteins)-MCM6 (show MCM6 Proteins) complex is required for CHK2 chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.

  3. On the basis of analyses of approximately 87,000 controls and patients with breast cancer from population- and hospital-based studies, our best estimate for the relative risk of invasive breast cancer for carriers of the 1100delC mutation in CHEK2, compared with noncarriers, was 2.26 (95% CI, 1.90 to 2.69).

  4. the G2 damage checkpoint prevents stable recruitment of the chromosome-packaging-machinery components condensin complex (show SMC4 Proteins) I and II onto the chromatin even in the presence of an active Cdk1 (show CDK1 Proteins).

  5. data suggest that cancer risks reported for founder mutations may be generalizable to all CHEK2 + s, particularly for breast cancer

  6. K373E mutation of CHK2 in tumorigenesis

  7. Checkpoint kinase 1 (show CHEK1 Proteins) and 2 signaling is important for apoptin regulation.

  8. High CHEK2 expression is associated with Lung Adenocarcinoma.

  9. Our study reports the first case of Li-Fraumeni syndrome (show TP53 Proteins)-like in Chinese patients and demonstrates the important contribution of de novo mutations in this type of rare disease.

  10. hese findings confirmed that 53BP1 (show TP53BP1 Proteins) loss might be a negative factor for chemotherapy efficacy, promoting cell proliferation and inhibiting apoptosis by suppressing ATM (show ATM Proteins)-CHK2-P53 (show TP53 Proteins) signaling, and finally inducing 5-FU resistance.

Mouse (Murine) Checkpoint Kinase 2 (CHEK2) interaction partners

  1. Together, this study described the regulation of Chk2 expression through promoter methylation by Dnmt3b (show DNMT3B Proteins) and also presented a novel role of Chk2 during neuronal differentiation, which is independent of its previously known function in DNA damage response.

  2. We conclude that Chk2 regulates renal 25-hydroxyvitamin D 1alpha-hydroxylase expression thereby impacting on calcium and phosphate metabolism.

  3. TRIP13 (show TRIP13 Proteins)-deficient spermatocytes also progress to an H1t (show HIST1H1T Proteins)-positive stage if ATM (show ATM Proteins) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A Proteins) or Nbs1 (show NBN Proteins) or by elimination of the ATM (show ATM Proteins)-effector kinase CHK2

  4. Results represent the first demonstration of a role for CHK2 in the in vivo signaling of dysfunctional telomeres.

  5. DNA-PK/Chk2 signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

  6. Results demonstrate that Chk2 plays important roles in regulating cell cycle progression during female meiosis and early embryo development.

  7. These data establish CHK2 as essential for DNA damage surveillance in female meiosis and indicate that the oocyte DNA double-strand breaks damage response primarily involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, which then activates p53 and p63.

  8. Findings indicate that PIRH2 (show RCHY1 Proteins) has central roles in the ubiquitylation of Chk2 and its turnover and in the regulation of its function.

  9. Chk2 deficiency in Myc (show MYC Proteins) overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP (show PARP1 Proteins) inhibition.

  10. Point mutation at the Nbs1 (show NBN Proteins) Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 (show SMC1A Proteins) phosphorylation after DNA damage.

Checkpoint Kinase 2 (CHEK2) Protein Profile

Protein Summary

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Checkpoint Kinase 2 (CHEK2)

  • serine/threonine-protein kinase chk2 (MCYG_07308)
  • blue sensitive cone opsin (LOC396525)
  • checkpoint kinase 2 (CHEK2)
  • checkpoint kinase 2 (Chek2)
  • CHK2 checkpoint homolog (S. pombe) (chek2)
  • Cds1 protein
  • CHK-2 protein
  • Chk2 protein
  • fa66f08 protein
  • hCds1 protein
  • HUCDS1 protein
  • LFS2 protein
  • PP1425 protein
  • Rad53 protein
  • wu:fa66f08 protein
  • zgc:55865 protein

Protein level used designations for Checkpoint Kinase 2 Proteins (CHEK2)

serine/threonine-protein kinase chk2 , blue cone photoreceptor pigment , blue-sensitive opsin , opsin CHK-2 , CHK2 checkpoint homolog , cds1 homolog , checkpoint-like protein CHK2 , serine/threonine-protein kinase Chk2 , Cds1 homolog , Rad53 homolog , protein kinase Chk2

9226831 Arthroderma otae CBS 113480
396525 Gallus gallus
11200 Homo sapiens
50883 Mus musculus
114212 Rattus norvegicus
486338 Canis lupus familiaris
336998 Danio rerio
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