Browse our GTPase NRas Proteins (NRAS)

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GTPase NRas Proteins (NRAS)
On www.antibodies-online.com are 17 GTPase NRas (NRAS) Proteins from 6 different suppliers available. Additionally we are shipping GTPase NRas Antibodies (95) and GTPase NRas Kits (6) and many more products for this protein. A total of 123 GTPase NRas products are currently listed.
Synonyms:
ALPS4, AV095280, fj99a10, H-RAS, HRAS, N-RAS, NRAS, NRAS1, NS6, wu:fj99a10, zgc:100761, zras-b1
list all proteins Gene Name GeneID UniProt
Rat NRAS NRAS 24605 Q04970
NRAS 18176  
NRAS 4893 P01111

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GTPase NRas Proteins (NRAS) by Origin

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Top referenced GTPase NRas Proteins

  1. Human GTPase NRas Protein expressed in Escherichia coli (E. coli) - ABIN667768 : Brown, Marshall, Pennie, Hall: Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. in The EMBO journal 1984 (PubMed)
    Show all 2 references for 667768

More Proteins for GTPase NRas Interaction Partners

Mouse (Murine) GTPase NRas (NRAS) interaction partners

  1. loss of one allele of Hras (show HRAS Proteins) increased the sensitivity of mice to this carcinogen, and this effect was further exacerbated by the loss of the second Hras (show HRAS Proteins) allele. However, loss of one or both alleles of Nras failed to alter tumor burden, either in the absence or presence of Hras (show HRAS Proteins), after exposure to urethane.

  2. Genetic inactivation of Ezh2 (show EZH2 Proteins) or Eed (show EED Proteins) cooperates with NRASQ61K in leukemogenesis.

  3. Data indicate that S-phase kinase-associated protein 2 (SKP2) cooperates with N-Ras and AKT proto-oncogenes to promote hepatocarcinogenesis in vivo.

  4. Activated NRAS and aberrant Wnt (show WNT2 Proteins) signaling conspire to drive congenital melanocytic nevus syndrome.

  5. a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN

  6. This work explains the curious predominance in human melanoma of mutations of codon 61 of NRAS over other oncogenic NRAS mutations. we show that physiologic expression of NRASQ61R, but not NRASG12D, drives melanoma formation.

  7. These data reveal the L. major-enhanced CD40-induced N-Ras activation as a novel immune evasion strategy and the potential for Ras isoform-targeted antileishmanial immunotherapy and immunoprophylaxis.

  8. NRAS expression is required for the proliferative advantage of human AML (show RUNX1 Proteins) cell lines in vitro and for the maintenance of mouse Nras-mutant AML (show RUNX1 Proteins) in vivo

  9. There was a nearly complete correspondence between the signaling pathways that were regulated by N-ras in immune cell types.

  10. Cbfbeta (show CBFB Proteins)-SMMHC (show MYH11 Proteins) and Nras(G12D) promote the survival of preleukemic myeloid progenitors primed for leukemia by activation of the MEK (show MDK Proteins)/ERK (show EPHB2 Proteins)/Bim (show BCL2L11 Proteins) axis, and define Nras(LSL-G12D); Cbfb (show CBFB Proteins)(56M) mice as a valuable genetic model for the study of AML (show RUNX1 Proteins) therapies.

Human GTPase NRas (NRAS) interaction partners

  1. Data suggest that isoform-specific sequences in the allosteric lobes of HRAS (show HRAS Proteins), KRAS, and NRAS have an impact on biocatalysis (kinetics of GTP (show AK3 Proteins) hydrolysis) and interaction with c-Raf (show RAF1 Proteins) kinase, which must be due to allosteric effects on dynamics and conformational states, given the identical active sites of these isoenzymes.

  2. NRAS(Q61R) immunohistochemistry is a highly sensitive and specific tool that is useful for differentiating follicular-patterned thyroid tumors.

  3. NRAS variants were identified in 2 cases with a lethal presentation of Noonan syndrome.

  4. Mutation in NRAS gene is associated with chronic myelomonocytic leukemia.

  5. Compared with newly diagnosed multiple myeloma, an increased prevalence of mutations in the Ras pathway genes KRAS, NRAS, and/or BRAF (show BRAF Proteins) (72%), as well as TP53 (show TP53 Proteins) (26%), CRBN (show CRBN Proteins) (12%), and CRBN (show CRBN Proteins) pathway genes (10%) was observed.

  6. Our data suggest that testing for any RAS mutation is unlikely to change the clinical management of thyroid nodules that have indeterminate cytology

  7. Examination of clinical parameters of these tumors found those with APA (show ENPEP Proteins) of NRAS and c-JUN (show JUN Proteins) to be smaller and less proliferative

  8. Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS and RRAS2 to the RAS binding (RB) domain of binding proteins.

  9. Studies indicate that RAS proteins were among the first oncogenes identified and are mutationally activated in 30% of all cancer types.

  10. Studies indicate that the control of spatiotemporal RAS protein signalling show that activation kinetics and subcellular compartmentalisation are tightly coupled to the generation of specific biological outcomes.

Zebrafish GTPase NRas (NRAS) interaction partners

  1. Although oncogenic NRAS expression alone was found to be insufficient to promote tumor formation, loss of functional p53 (show TP53 Proteins) was found to collaborate with NRAS expression in the genesis of melanoma.

GTPase NRas (NRAS) Protein Profile

Protein Summary

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Alternative names and synonyms associated with GTPase NRas (NRAS)

  • GTPase NRas (Tsp_01117)
  • African clawed frog N-ras (n-ras)
  • neuroblastoma ras oncogene (Nras)
  • neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS)
  • neuroblastoma RAS viral (v-ras) oncogene homolog (nras)
  • ALPS4 protein
  • AV095280 protein
  • fj99a10 protein
  • H-RAS protein
  • HRAS protein
  • N-RAS protein
  • NRAS protein
  • NRAS1 protein
  • NS6 protein
  • wu:fj99a10 protein
  • zgc:100761 protein
  • zras-b1 protein

Protein level used designations for GTPase NRas Proteins (NRAS)

GTPase NRas , transforming protein N-Ras , neuroblastoma RAS viral (v-ras) oncogene homolog , N-ras oncogene , p21 protein , N-ras protein part 4 , v-ras neuroblastoma RAS viral oncogene homolog , ras p21 , N-ras oncogene p21 , etID18709.8 , neuroblastoma RAS viral oncogene-like protein , neuroblastoma ras oncogene , v-Ha-ras Harvey rat sarcoma viral oncogene homolog

GENE ID SPECIES
10905151 Trichinella spiralis
399446 Xenopus laevis
24605 Rattus norvegicus
18176 Mus musculus
100135584 Cavia porcellus
4893 Homo sapiens
403872 Canis lupus familiaris
30380 Danio rerio
419885 Gallus gallus
100739349 Sus scrofa
506322 Bos taurus
100174317 Pongo abelii
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