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GTPase NRas Products

(GTPase NRas (NRAS))
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011].

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Featured GTPase NRas Categories

GTPase NRas Antibodies

High quality antibodies with extensive validation data.

GTPase NRas ELISA Kits

Reliable ELISA kits for a wide range of species.

GTPase NRas Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GTPase NRas Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (7)
Cat. No. ABIN302138
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN7267532
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS, IF
Validations
  • (7)
Cat. No. ABIN3031130
Quantity 0.4 mL
Datasheet Datasheet

Recommended GTPase NRas ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951188
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1135773
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1135775
Quantity 96 tests
Datasheet Datasheet

Recommended GTPase NRas Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313000
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313002
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3087058
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our GTPase NRas products

Potu, Peterson, Kandarpa, Pal, Sun, Durham, Harms, Hollenhorst, Eskiocak, Talpaz, Donato: "Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma." in: Nature communications, Vol. 8, pp. 14449, (2018) (PubMed).

Oishi, Kondo, Vuong, Nakazawa, Mochizuki, Kasai, Inoue, Tahara, Hirokawa, Miyauchi, Katoh: "Immunohistochemical detection of NRAS(Q61R) protein in follicular-patterned thyroid tumors." in: Human pathology, Vol. 53, pp. 51-7, (2016) (PubMed).

Banerji, Affolter, Judson, Marais, Workman: "BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors." in: Molecular cancer therapeutics, Vol. 7, Issue 4, pp. 737-9, (2008) (PubMed).

Smalley, Contractor, Nguyen, Xiao, Edwards, Muthusamy, King, Flaherty, Bosenberg, Herlyn, Nathanson: "Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression." in: Cancer research, Vol. 68, Issue 14, pp. 5743-52, (2008) (PubMed).

Thomas, Edmiston, Alexander, Millikan, Groben, Hao, Tolbert, Berwick, Busam, Begg, Mattingly, Ollila, Tse, Hummer, Lee-Taylor, Conway: "Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 16, Issue 5, pp. 991-7, (2007) (PubMed).

Hall, Brown: "Human N-ras: cDNA cloning and gene structure." in: Nucleic acids research, Vol. 13, Issue 14, pp. 5255-68, (1985) (PubMed).

Synonyms and alternative names related to GTPase NRas

GTPase NRas (Tsp_01117), neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog (nras.L), NRAS proto-oncogene, GTPase (Nras), neuroblastoma ras oncogene (Nras), NRAS proto-oncogene, GTPase (NRAS), NRAS proto-oncogene, GTPase (nras), neuroblastoma RAS viral oncogene homolog (NRAS), ALPS4, AV095280, fj99a10, H-RAS, HRAS, N-ras, N-RAS, NRAS, NRAS1, NS6, wu:fj99a10, zgc:100761, zras-b1

Protein level used designations for GTPase NRas

  • GTPase NRas
  • transforming protein N-Ras
  • neuroblastoma RAS viral (v-ras) oncogene homolog
  • N-ras oncogene
  • p21 protein
  • N-ras protein part 4
  • v-ras neuroblastoma RAS viral oncogene homolog
  • ras p21
  • N-ras oncogene p21
  • etID18709.8
  • neuroblastoma RAS viral oncogene-like protein
  • neuroblastoma ras oncogene
  • v-Ha-ras Harvey rat sarcoma viral oncogene homolog
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