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Browse our KLF4 Proteins (KLF4)

Full name:
Kruppel-Like Factor 4 (Gut) Proteins (KLF4)
On are 15 Kruppel-Like Factor 4 (Gut) (KLF4) Proteins from 9 different suppliers available. Additionally we are shipping KLF4 Antibodies (282) and KLF4 Kits (8) and many more products for this protein. A total of 321 KLF4 products are currently listed.
biklf, biklf-A, EZF, Gklf, KLF4, Zie
list all proteins Gene Name GeneID UniProt
KLF4 9314 O43474
KLF4 16600 Q60793
Rat KLF4 KLF4 114505  

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KLF4 Proteins (KLF4) by Origin

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Top referenced KLF4 Proteins

  1. Human KLF4 Protein expressed in Escherichia coli (E. coli) - ABIN667940 : Geiman, Ton-That, Johnson, Yang: Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. in Nucleic acids research 2000 (PubMed)
    Show all 2 references for ABIN667940

  2. Human KLF4 Protein expressed in Human - ABIN2724292 : Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014 (PubMed)
    Show all 2 references for ABIN2724292

  3. Human KLF4 Protein expressed in Wheat germ - ABIN1308754 : Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012 (PubMed)
    Show all 2 references for ABIN1308754

More Proteins for KLF4 Interaction Partners

Zebrafish Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. zebrafih Klf4a is essential for the repression of intestinal cell proliferation

  2. Proper heart valve formation in zebrafish critically depends on protein kinase D2 (show PKD2 Proteins)-histone deacetylase 5 (show HDAC5 Proteins)-Kruppel-like factor signaling.

Human Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. KLF4 has been gaining a lot of attention, particularly after it was shown in 2006 as one of four factors involved in the induced pluripotent stem cells (iPSCs).

  2. High KLF5 (show KLF5 Proteins) expression is associated with glioma.

  3. Klf4 directly regulates miR31 in hepatocellular carcinoma.

  4. KLF4 inhibits the ability of invasion and the escape from response to chemotherapy by repressing the EMT (show ITK Proteins) process, and overexpression of KLF4 may be a potential strategy for lung cancer treatment, especially for cisplatin-resistant cases.

  5. Increased miR (show MLXIP Proteins)-92a level plays a positive role in colorectal carcinogenesis by promoting the proliferation and migration of CRC (show CALR Proteins) cells through targeting downstream KLF4 and p21 (show CDKN1A Proteins).

  6. MiR (show MLXIP Proteins)-375 is possibly a tumor suppressor in LSCC by regulating KLF4.

  7. Positive BIRC7 (show BIRC7 Proteins) expression and negative KLF4 expression are associated with the progression of PDAC and poor prognosis in patients with PDAC.

  8. KLF4 expression is a prognostic biomarkers for triple-negative breast cancer

  9. findings demonstrate that KLF4 acts as a tumor suppressor in PDAC cells that restricts metastatic behaviors through direct negative regulation of CD44 (show CD44 Proteins), providing support for the clinical investigation of therapeutic approaches focusing on targeted KLF4 activation in advanced tumors

  10. Results showed that lower KLF-4 expression was correlated with malignant colorectal cancer (CRC (show CALR Proteins)) status and poor prognosis in CRC (show CALR Proteins) patients. Moreover, KLF-4 suppression promoted the proliferation of CRC (show CALR Proteins) cells in vitro providing novel insights into the tumor suppressive role of KLF-4 in CRC (show CALR Proteins).

Xenopus laevis Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation

Mouse (Murine) Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. Data show that the reprogramming factors OCT4 (show POU5F1 Proteins), SOX2 (show SOX2 Proteins), KLF4, and MYC (show MYC Proteins) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.

  2. Study demonstrates that KLF4 plays a significant role in the pathogenesis of colorectal neoplasia.

  3. our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), Klf4, and Myc (show MYC Proteins)) and cofactors and molecular mechanisms for the functional importance of Set1a in ESCs (show NR2E3 Proteins) and early development

  4. Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).

  5. Results suggest that Kruppel-like factor 4 is not required for retinal cell differentiation or survival. Data support a hypothesis that KLF4 suppresses axon growth during development.

  6. KLF4 is a master regulator of EndMT in CCM pathology; thus, the inhibition of Klf4 expression may have a therapeutic role in limiting CCM appearance and progression.

  7. Authors show that absence of Klf4 accelerates carcinogenesis and correlates with the absence of cytokeratin 1 (show KRT1 Proteins) expression. Results suggest a potential role for KLF4 as a tumor suppressor gene for the tongue epithelium.

  8. KLF-4 was downregulated in the TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) model in LA-4 cells. KLF-4 overexpression markedly reduced the PAI-1 (show SERPINE1 Proteins) expression and inhibited the TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) .

  9. Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4) expression and increasing the levels of histone demethylase (show MBD2 Proteins) Lsd1 (show KDM1A Proteins) and transcription factor Brd4 (show BRD4 Proteins) in B cell.

  10. Angiotensin II can modulate epigenetic regulation in podocytes and renin (show REN Proteins)-angiotensin blockade inhibits these actions in part via KLF4 in proteinuric kidney diseases.

Pig (Porcine) Kruppel-Like Factor 4 (Gut) (KLF4) interaction partners

  1. miR (show MYLIP Proteins)-92a coregulates KLF4 and KLF2 (show KLF2 Proteins) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.

KLF4 Protein Profile

Protein Summary

a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene

Alternative names and synonyms associated with KLF4

  • Kruppel-like factor 4 (gut) (KLF4)
  • Kruppel-like factor 4a (klf4a)
  • Kruppel-like factor 4 (klf4)
  • Kruppel-like factor 4 (gut) (klf4)
  • Kruppel-like factor 4 (gut) (Klf4)
  • biklf protein
  • biklf-A protein
  • EZF protein
  • Gklf protein
  • KLF4 protein
  • Zie protein

Protein level used designations for KLF4

Krueppel-like factor 4 , Kruppel-like transcription factor 4a , Kruppel-like factor 4 (gut) , Kruppel-like factor 4 , endothelial Kruppel-like zinc finger protein , epithelial zinc finger protein EZF , gut-enriched krueppel-like factor , Kruppel-like transcription factor , blood island enriched kruppel like factor , Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)

100302636 Ovis aries
100054047 Equus caballus
562155 Danio rerio
711169 Macaca mulatta
100217346 Salmo salar
100379626 Felis catus
9314 Homo sapiens
379518 Xenopus laevis
770254 Gallus gallus
16600 Mus musculus
114505 Rattus norvegicus
520842 Bos taurus
595111 Sus scrofa
100735339 Cavia porcellus
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