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Human KLF4 Protein expressed in Wheat germ - ABIN1308754
Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012
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Human KLF4 Protein expressed in HEK-293 Cells - ABIN2724292
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
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zebrafih Klf4a is essential for the repression of intestinal cell proliferation
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (show PKD2 Proteins)-histone deacetylase 5 (show HDAC5 Proteins)-Kruppel-like factor signaling.
CSF (show CSF2 Proteins) and plasma expression of KLF4 mRNA was significantly decreased around 1-3 days after subarachnoid hemorrhage and remained lower than in controls.
PARP1 (show PARP1 Proteins) recruits KLF4 to activate telomerase expression and stem cell pluripotency, indicating a positive regulatory role of the PARP1 (show PARP1 Proteins)-KLF4 complex in telomerase expression in cancer and stem cells.
KLF2 (show KLF2 Proteins) and KLF4 serve as important regulators that promote hemoglobin alpha (show HBA1 Proteins) expression in the endothelium.
Loss of KLF4 expression is associated with T-cell acute lymphoblastic leukemia.
IRF4 (show IRF4 Proteins) protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter.
High KLF4 expression is associated with breast cancer tumorigenesis.
High KLF4 expression is associated with melanoma.
KLF4 transactivates Ch25h and LXR, thereby promoting the synergistic effects between ECs and macrophages to protect against atherosclerosis susceptibility.
findings evidence a positive correlation between SIRT1 (show SIRT1 Proteins) and BCL6 (show BCL6 Proteins) expression increase in follicular lymphomas (FL) . SIRT1 (show SIRT1 Proteins) methylation decreases in FL and diffuse large-B cell lymphomas (DLBCL)and this parallels the increase of KLF4, DAPK1 (show DAPK1 Proteins) and SPG20 (show SPG20 Proteins) methylation
the use of KLF4 as a diagnostic and therapeutic target in cancer requires careful consideration of context.
Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation
overexpression of KLF4 promoted oligomeric Abeta42-induced neuroinflammation by exacerbating the release of pro-inflammatory factors
A long-range enhancer cluster controls Klf4 gene expression in mESCs
we revealed that one of the key functions of KLF4-induced TCL1 (show TCL1A Proteins) during reprogramming is to promote the metabolic shift from oxidative phosphorylation to glycolysis.
KLF4 modulates development of BMI1 (show BMI1 Proteins)-expressing intestinal stem cell-derived lineage following gamma-radiation-induced gut (show GUSB Proteins) injury in mice.
dysregulation of Elovl6-driven long-chain fatty acid metabolism induces phenotypic switching of VSMC via ROS (show ROS1 Proteins) production and AMPK (show PRKAA1 Proteins)/KLF4 signaling that leads to growth arrest and downregulation of VSMC marker expression.
KLF2 (show KLF2 Proteins) and KLF4 serve as important regulators that promote hemoglobin alpha (show HBA-A1 Proteins) expression in the endothelium.
Together, our results suggest that KLF4 regulates asthma development in a TSLP (show TSLP Proteins)- and fibrocyte-dependent manner.
Functional studies indicated that Klf4 mediates the self-renewal-promoting effects of Gbx2 (show GBX2 Proteins), because knockdown of Klf4 expression abrogated the ability of Gbx2 (show GBX2 Proteins) to maintain the undifferentiated state of mESCs.
miR (show MYLIP Proteins)-92a coregulates KLF4 and KLF2 (show KLF2 Proteins) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.
a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene
Krueppel-like factor 4
, Kruppel-like transcription factor 4a
, Kruppel-like factor 4 (gut)
, Kruppel-like factor 4
, endothelial Kruppel-like zinc finger protein
, epithelial zinc finger protein EZF
, gut-enriched krueppel-like factor
, Kruppel-like transcription factor
, blood island enriched kruppel like factor
, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)