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anti-Human CDK2AP2 Antibodies:
anti-Mouse (Murine) CDK2AP2 Antibodies:
anti-Rat (Rattus) CDK2AP2 Antibodies:
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Human Polyclonal CDK2AP2 Primary Antibody for WB - ABIN1881193
Buajeeb, Zhang, Ohyama, Han, Surarit, Kim, Wong: Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). in Biochemical and biophysical research communications 2004
Show all 2 Pubmed References
Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (show CDK2AP1 Antibodies)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 (show MBD3 Antibodies) to the promoter region of Wnt (show WNT2 Antibodies) signaling genes
Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity.
identified a mitogen-activated protein kinase (show MAPK1 Antibodies) partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption
The upregulation of miR (show MLXIP Antibodies)-302b reduced the expression of CDK2 (show CDK2 Antibodies), and inhibited ERK (show EPHB2 Antibodies) signaling pathway, thereby inhibiting cell proliferation and G1/S phase conversion rate.
High CDK2 (show CDK2 Antibodies) expression is associated with breast cancer.
Here, we introduce a transcriptional signature to specifically track CDK2 (show CDK2 Antibodies) activity. It responds to genetic and chemical perturbations in the CDK (show CDK4 Antibodies)-RB-E2F (show E2F1 Antibodies) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (show CDK2 Antibodies) activity during cell cycle progression
Here, we found that centrosomal protein of 76 kDa (Cep76 (show Cep76 Antibodies)), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2 (show CDK2 Antibodies)) and is a bona fide substrate of this kinase. Cep76 (show Cep76 Antibodies) is preferentially phosphorylated by cyclin A (show CCNA2 Antibodies)/CDK2 (show CDK2 Antibodies) at a single site S83, and this event is crucial to suppress centriole amplification in S phase
The authors find that Spy1 (show SPDYA Antibodies) confers structural changes to Cdk2 (show CDK2 Antibodies) that obviate the requirement of Cdk (show CDK4 Antibodies) activation loop phosphorylation.
CDK2 (show CDK2 Antibodies) serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
Date show that when Wee1 (show WEE1 Antibodies) alone is inhibited, Chk1 (show CHEK1 Antibodies) suppresses CDC45 (show CDC45 Antibodies) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (show CDK4 Antibodies)-activity.
Results show that cyclin E1 (show CCNE1 Antibodies) and CDK2 (show CDK2 Antibodies) participate in STC1 (show STC1 Antibodies) promoting cell proliferation of prostate neoplasm cells.
The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 (show CDK2 Antibodies) disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 (show CDK1 Antibodies) inhibition.
periodic phosphorylation of Ku70 (show XRCC6 Antibodies) by cyclin-cyclin (show PCNA Antibodies) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.
This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene.
CDK2-associated protein 2
, DOC-1-related protein
, cyclin-dependent kinase 2-associated protein 2
, tumor suppressor deleted in oral cancer related 1
, tumor suppressor deleted in oral cancer-related 1
, DOC-1 related protein