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Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445
Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014
Results suggest that the TCF (show HNF4A Proteins)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
Maid (show CCNDBP1 Proteins) is important regulator of hepatocarcinogenesis and aging
show that the knockdown of smc1a (show SMC1A Proteins) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (show MEIS1 Proteins) regulating cyclin D1 and c-myc (show MYC Proteins) transcription in the embryonic eye.
High CCND1 expression is associated with Myelodysplastic syndromes.
Correlating beta-catenin (show CTNNB1 Proteins) nuclear dynamics to cyclin D1 transcriptional activation showed that the nuclear accumulation rate of change of the signaling factor, and not actual protein levels, correlated with the transcriptional output of the pathway.
Taken together, these findings enabled us to identify a novel mechanism by which eEF1A1 (show EEF1A1 Proteins) regulates the cell cycle's G1 phase to promote tumor proliferation by regulating cyclin D1 expression through STAT1 (show STAT1 Proteins) signaling in HCC (show FAM126A Proteins).
This meta-analysis suggests that the CCND1 G870A polymorphism is associated with an increased risk of colorectal cancer, especially that A carriers may be a major risk factor for colorectal cancer.
results showed that fascaplysin inhibited ovarian cancer cell proliferation, invasion and migration, as well as inducing S arrest and cell apoptosis. Treatment with fascaplysin also suppressed CDK4 (show CDK4 Proteins), cyclin D1, Bcl-2 (show BCL2 Proteins), and VEGFA (show VEGFA Proteins) expression at protein levels
Mutation in the CCND1 gene is associated with acute myeloid leukemia (show BCL11A Proteins).
The first preclinical study evaluates the response to CDK4/6 (show CDK4 Proteins) inhibition in endometrial malignancies driven by PTEN deficiency, and it reveals an important role of cyclin D-CDK4/6 (show CDK4 Proteins) activity in their development.
High CCND1 expression is associated with oropharyngeal squamous cell carcinoma.
Describe a regulatory loop miR (show MLXIP Proteins)-218-CDK6 (show CDK6 Proteins)/CyclinD1-E2F1 (show E2F1 Proteins) whose disruption may contribute to cell cycle progression in gastric cancer.
EGF induces hair follicle-derived mesenchymal stem cell proliferation through the EGFR/ERK and AKT pathways, but not through STAT-3. The G1/S transition was stimulated by upregulation of cyclinD1 and inhibition of p16 expression.
NMB or NMBR silencing inhibited M-CSF (show CSF1R Proteins)/c-Fms (show CSF1R Proteins)-mediated downstream signaling pathways like activation of ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (show CTNNB1 Proteins)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (show PAX5 Proteins) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), Klf4 (show KLF4 Proteins), and c-Myc (show MYC Proteins) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (show PLCG1 Proteins) controls osteoclast numbers via a CSF-1 (show CSF1 Proteins)-dependent DAG/beta-catenin (show CTNNB1 Proteins)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (show MYC Proteins), Cyc (show CYCS Proteins)-D1 and TERT (show TERT Proteins), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (show DND1 Proteins) susceptible mice without being necessary for normal germ cell or testis development.
Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (show IL33 Proteins).
Novel RNA-binding activity of MYF5 (show MYF5 Proteins) enhances Ccnd1 mRNA translation during myogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (show CDK2 Proteins) and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (show MAPK3 Proteins) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, Cyclin-D1-binding protein 1 homolog
, cyclin Dx
, cyclin-D1-binding protein 1 homolog
, zebrafish homolog of Maid
, cyclin D1
, G1/S-specific cyclin-D1
, B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, PRAD1 oncogene
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)