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Browse our Cyclin D1 Proteins (CCND1)

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Cyclin D1 Proteins (CCND1)
On are 25 Cyclin D1 (CCND1) Proteins from 10 different suppliers available. Additionally we are shipping Cyclin D1 Antibodies (410) and Cyclin D1 Kits (64) and many more products for this protein. A total of 528 Cyclin D1 products are currently listed.
AI327039, bcl-1, BCL1, cb161, CCND1, ccnd1a, ccnd1b, ccndbp1, cD1, cycd1, Cyl-1, D11S287E, etID37810.7, fb52e01, fc45c08, fc83a12, id:ibd1198, PRAD1, U21B31, wu:fb52e01, wu:fc45c08, wu:fc83a12, ZHM
list all proteins Gene Name GeneID UniProt
CCND1 595 P24385
CCND1 12443 P25322
CCND1 58919 P39948

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Cyclin D1 Proteins (CCND1) by Origin

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Top referenced Cyclin D1 Proteins

  1. Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445 : Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014 (PubMed)

More Proteins for Cyclin D1 Interaction Partners

Xenopus laevis Cyclin D1 (CCND1) interaction partners

  1. Results suggest that the TCF (show HNF4A Proteins)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.

Zebrafish Cyclin D1 (CCND1) interaction partners

  1. Maid (show CCNDBP1 Proteins) is important regulator of hepatocarcinogenesis and aging

  2. show that the knockdown of smc1a (show SMC1A Proteins) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels

  3. Reduction of cyclin D1 expression compromises zebrafish eye and head development.

  4. Role in cell cycle control is mediated by meis1 (show MEIS1 Proteins) regulating cyclin D1 and c-myc (show MYC Proteins) transcription in the embryonic eye.

Human Cyclin D1 (CCND1) interaction partners

  1. Data show that the fusion gene cyclin D1/myotonic dystrophy kinase-related CDC42-binding protein kinase alpha (show CDC42BPA Proteins) (CCND1/MRCK (show CDC42BPA Proteins)) mRNA is resistant to CCND1-targeted miRNA regulation.

  2. Data indicated that HOXA1 (show HOXA1 Proteins) and CCND1 mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC.

  3. Results confirm that CEACAM6 promoted cell proliferation mediated by cyclin D1/CDK4 (show CDK4 Proteins).

  4. Analysis of ctal carcinoma in situ (DCIS) by grade suggested that two independent SNPs near CCND1 were specific to low/intermediate grade DCIS . These associations with grade remained after adjusting for ER status and were also found in IDC (show LMNA Proteins)

  5. CCND1 amplification was seen in 28 of 133 (21.05 %) informative breast cancer patients. A discordant Cyclin D1 amplification status was detected in 6 out of 28 (21.43 %) amplified tumors.

  6. DNA methylation (show HELLS Proteins) changes in neuroblastoma (show ARHGEF16 Proteins) affect not only promoters but also intragenic regions of the genome and target functional chromatin domains of development and cancer-related genes such as CCND1.

  7. FH535 suppressed the proliferation of HCC (show FAM126A Proteins) cells by downregulating the expression of cyclin D1 and by inducing apoptosis

  8. Study suggests that cyclin D1 may be an independent prognostic factor for recurrence-free survival in stage II-IIIA adenocarcinoma of lung.

  9. Cyclin D1 loss identifies prostate tumors with small-cell differentiation and may identify a small subset of adenocarcinomas with poor prognosis.

  10. There is a significant upregulation of cyclin D1 in Ewing's sarcoma as compared to normal tissues.

Mouse (Murine) Cyclin D1 (CCND1) interaction partners

  1. Novel RNA-binding activity of MYF5 (show MYF5 Proteins) enhances Ccnd1 mRNA translation during myogenesis.

  2. The robust increase in the expression of cyclin D1 and CDK4 (show CDK4 Proteins) at day 2 suggests that Muller glia may be in G1 phase of the cell cycle at this stage.

  3. Btg1 (show BTG1 Proteins) regulates the proliferation of cerebellar granule precursors selectively through cyclin D1.

  4. show that the knockdown of smc1a (show SMC1A Proteins) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels

  5. Data show that nonlinear responses were observed in lenses for EdU (5-ethynyl-2'-deoxy-uridine) incorporation, cyclin D1 staining and cell density after 24 h at 100 and 250 mGy.

  6. Cyclin D has a role in activating the Rb tumor suppressor by mono-phosphorylation

  7. Cyclin D1 is capable of transcriptionally upregulating Pax6 (show PAX6 Proteins), which promoted reprogramming cells to commit to a neural progenitor fate rather than a pluripotent cell fate

  8. Cyclin D1 binds to STAT3 (show STAT3 Proteins), a transcription factor downstream of astrogliogenic cytokines, and suppresses its transcriptional activity on the glial fibrillary acidic protein (Gfap (show GFAP Proteins)) gene.

  9. These results reveal that GCNF (show NR6A1 Proteins) plays a key role in regulating activation of cyclin D1 expression via inhibition of Mir302a.

  10. binds to the promoter region of the cell growth regulatory genes Cyclin D1 and COX-2

Cow (Bovine) Cyclin D1 (CCND1) interaction partners

  1. cyclin D1, CDK2 (show CDK2 Proteins) and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation

  2. 17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (show MAPK3 Proteins) kinase) pathway.

Cyclin D1 (CCND1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Alternative names and synonyms associated with Cyclin D1 (CCND1)

  • cyclin D1 (ccnd1-b)
  • cyclin D1 (ccnd1)
  • Cyclin-D1-binding protein 1 homolog (ccndbp1)
  • cyclin Dx (ccndx)
  • zgc:162082 (zgc:162082)
  • cyclin D1 (CCND1)
  • G1/S-specific cyclin-D1 (ccnd1)
  • cyclin D1 (Ccnd1)
  • cyclin D1 (ccnd1-a)
  • AI327039 protein
  • bcl-1 protein
  • BCL1 protein
  • cb161 protein
  • CCND1 protein
  • ccnd1a protein
  • ccnd1b protein
  • ccndbp1 protein
  • cD1 protein
  • cycd1 protein
  • Cyl-1 protein
  • D11S287E protein
  • etID37810.7 protein
  • fb52e01 protein
  • fc45c08 protein
  • fc83a12 protein
  • id:ibd1198 protein
  • PRAD1 protein
  • U21B31 protein
  • wu:fb52e01 protein
  • wu:fc45c08 protein
  • wu:fc83a12 protein
  • ZHM protein

Protein level used designations for Cyclin D1 Proteins (CCND1)

G1/S-specific cyclin-D1 b , cyclin D1 b , parathyroid adenomatosis 1 , cyclin D1 (PRAD1: parathyroid adenomatosis 1) , Cyclin-D1-binding protein 1 homolog , cyclin Dx , cyclin-D1-binding protein 1 homolog , zebrafish homolog of Maid , cyclin D1 , G1/S-specific cyclin-D1 , B-cell CLL/lymphoma 1 , B-cell lymphoma 1 protein , BCL-1 oncogene , PRAD1 oncogene , G1/S-specific cyclin-D1 a , cyclin D1 a (PRAD1: parathyroid adenomatosis 1)

379161 Xenopus laevis
448045 Xenopus (Silurana) tropicalis
495493 Xenopus laevis
548862 Xenopus (Silurana) tropicalis
553373 Danio rerio
574320 Macaca mulatta
747688 Pan troglodytes
100037407 Felis catus
100306852 Salmo salar
595 Homo sapiens
449028 Canis lupus familiaris
100009036 Oryctolagus cuniculus
12443 Mus musculus
58919 Rattus norvegicus
100729808 Cavia porcellus
100171625 Pongo abelii
379937 Xenopus laevis
396341 Gallus gallus
524530 Bos taurus
30222 Danio rerio
100144763 Ovis aries
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