You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our Cyclin D1 Proteins (CCND1)

Full name:
Cyclin D1 Proteins (CCND1)
On are 27 Cyclin D1 (CCND1) Proteins from 9 different suppliers available. Additionally we are shipping Cyclin D1 Antibodies (523) and Cyclin D1 Kits (54) and many more products for this protein. A total of 631 Cyclin D1 products are currently listed.
AI327039, bcl-1, BCL1, cb161, CCND1, ccnd1a, ccnd1b, ccndbp1, cD1, cycd1, Cyl-1, D11S287E, etID37810.7, fb52e01, fc45c08, fc83a12, id:ibd1198, PRAD1, U21B31, wu:fb52e01, wu:fc45c08, wu:fc83a12, ZHM
list all proteins Gene Name GeneID UniProt
CCND1 595 P24385
CCND1 12443 P25322
CCND1 58919 P39948

Show all synonyms

Cyclin D1 Proteins (CCND1) by Origin

Select your origin of interest

Top referenced Cyclin D1 Proteins

  1. Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445 : Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014 (PubMed)

More Proteins for Cyclin D1 Interaction Partners

Xenopus laevis Cyclin D1 (CCND1) interaction partners

  1. Results suggest that the TCF (show HNF4A Proteins)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.

Zebrafish Cyclin D1 (CCND1) interaction partners

  1. while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of

  2. Maid (show CCNDBP1 Proteins) is important regulator of hepatocarcinogenesis and aging

  3. show that the knockdown of smc1a (show SMC1A Proteins) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels

  4. Reduction of cyclin D1 expression compromises zebrafish eye and head development.

  5. Role in cell cycle control is mediated by meis1 (show MEIS1 Proteins) regulating cyclin D1 and c-myc (show MYC Proteins) transcription in the embryonic eye.

Human Cyclin D1 (CCND1) interaction partners

  1. Data suggest that CDK4 (cyclin-dependent kinase 4 (show CDK4 Proteins)) is degraded by anaphase-promoting complex/cyclosome (APC (show APC Proteins)/C) during metaphase-anaphase transition while its main regulator, cyclin D1, remains intact but is sequestered in cytoplasm; CDK4 (show CDK4 Proteins) protein reaccumulates in the following G1 phase and shuttles between nucleus and cytoplasm to facilitate nuclear import of cyclin D1; without CDK4 (show CDK4 Proteins), cyclin D1 cannot enter nucleus.

  2. The positive rates of MAPK (show MAPK1 Proteins) and cyclin D1 in osteosarcoma were increased (P<0.05), and the expression of cyclin D1 and pMAPK were positively correlated. The phosphorylation of MAPK (show MAPK1 Proteins) may be important in the development of osteosarcoma, and the overactivation of MAPK (show MAPK1 Proteins) may induce high expression of cyclin D1 and induce tumor cells to proliferate continuously.

  3. Varying degrees of immunoreactivity to Cyclin D1, VEGF (show VEGFA Proteins), and EZH2 (show EZH2 Proteins) were noted in the majority of the AT/RTs (show RECQL4 Proteins), and detection of these markers may be of value in the development of novel therapeutic agents and in determining which patients can benefit from them

  4. results demonstrated the upregulation of miR-18a promoted cell proliferation by increasing cylin D1 via regulating PTEN-PI3K-AKT-mTOR signaling axis, suggesting that small molecule inhibitors of AKT-mTOR signaling are potential agents for the treatment of ESCC patients with upregulation of miR-17-92 cluster

  5. Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 (show USP2 Proteins) Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.

  6. a novel mechanism by which ZBTB33 (show ZBTB33 Proteins) mediates the cyclin D1/cyclin E1 (show CCNE1 Proteins)/RB1 (show RB1 Proteins)/E2F (show E2F1 Proteins) pathway, controlling passage through the G1 restriction point and accelerating cancer cell proliferation.

  7. Low-dose irradiation of human cells induces mitochondrial reactive oxygen species-mediated genomic instability through nuclear retention of cyclin D1. (Review)

  8. High CCND1 expression is associated with glioblastoma multiforme.

  9. High CCND1 expression is associated with Chronic myelogenous leukemia.

  10. CCND1 is downregulated, whereas CCND2 (show CCND2 Proteins) is not, following ionizing radiation (IR) . Both CCND1- and CCND2 (show CCND2 Proteins)-expressing MM cells arrested in S/G2 (show STRN3 Proteins)/M, and did not differ in other cell-cycle proteins or sensitivity to IR. Differential expression of D-cyclin (show PCNA Proteins) does not appear to affect cell-cycle response to IR, and is unlikely to underlie differential sensitivity to DNA damage.

Mouse (Murine) Cyclin D1 (CCND1) interaction partners

  1. Data show that expression of the Oct-4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), Klf4 (show KLF4 Proteins), and c-Myc (show MYC Proteins) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.

  2. study shows that PLCgamma1 (show PLCG1 Proteins) controls osteoclast numbers via a CSF-1 (show CSF1 Proteins)-dependent DAG/beta-catenin (show CTNNB1 Proteins)/cyclinD1 pathway.

  3. Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (show MYC Proteins), Cyc (show CYCS Proteins)-D1 and TERT (show TERT Proteins), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.

  4. Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (show DND1 Proteins) susceptible mice without being necessary for normal germ cell or testis development.

  5. Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (show IL33 Proteins).

  6. Novel RNA-binding activity of MYF5 (show MYF5 Proteins) enhances Ccnd1 mRNA translation during myogenesis.

  7. The robust increase in the expression of cyclin D1 and CDK4 (show CDK4 Proteins) at day 2 suggests that Muller glia may be in G1 phase of the cell cycle at this stage.

  8. Btg1 (show BTG1 Proteins) regulates the proliferation of cerebellar granule precursors selectively through cyclin D1.

  9. show that the knockdown of smc1a (show SMC1A Proteins) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels

  10. Data show that nonlinear responses were observed in lenses for EdU (5-ethynyl-2'-deoxy-uridine) incorporation, cyclin D1 staining and cell density after 24 h at 100 and 250 mGy.

Cow (Bovine) Cyclin D1 (CCND1) interaction partners

  1. cyclin D1, CDK2 (show CDK2 Proteins) and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation

  2. 17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (show MAPK3 Proteins) kinase) pathway.

Cyclin D1 (CCND1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Alternative names and synonyms associated with Cyclin D1 (CCND1)

  • cyclin D1 (ccnd1-b)
  • cyclin D1 (ccnd1)
  • Cyclin-D1-binding protein 1 homolog (ccndbp1)
  • cyclin Dx (ccndx)
  • zgc:162082 (zgc:162082)
  • cyclin D1 (CCND1)
  • G1/S-specific cyclin-D1 (ccnd1)
  • cyclin D1 (Ccnd1)
  • cyclin D1 (ccnd1-a)
  • AI327039 protein
  • bcl-1 protein
  • BCL1 protein
  • cb161 protein
  • CCND1 protein
  • ccnd1a protein
  • ccnd1b protein
  • ccndbp1 protein
  • cD1 protein
  • cycd1 protein
  • Cyl-1 protein
  • D11S287E protein
  • etID37810.7 protein
  • fb52e01 protein
  • fc45c08 protein
  • fc83a12 protein
  • id:ibd1198 protein
  • PRAD1 protein
  • U21B31 protein
  • wu:fb52e01 protein
  • wu:fc45c08 protein
  • wu:fc83a12 protein
  • ZHM protein

Protein level used designations for Cyclin D1 Proteins (CCND1)

G1/S-specific cyclin-D1 b , cyclin D1 b , parathyroid adenomatosis 1 , cyclin D1 (PRAD1: parathyroid adenomatosis 1) , Cyclin-D1-binding protein 1 homolog , cyclin Dx , cyclin-D1-binding protein 1 homolog , zebrafish homolog of Maid , cyclin D1 , G1/S-specific cyclin-D1 , B-cell CLL/lymphoma 1 , B-cell lymphoma 1 protein , BCL-1 oncogene , PRAD1 oncogene , G1/S-specific cyclin-D1 a , cyclin D1 a (PRAD1: parathyroid adenomatosis 1)

379161 Xenopus laevis
448045 Xenopus (Silurana) tropicalis
495493 Xenopus laevis
548862 Xenopus (Silurana) tropicalis
553373 Danio rerio
574320 Macaca mulatta
747688 Pan troglodytes
100037407 Felis catus
100306852 Salmo salar
595 Homo sapiens
449028 Canis lupus familiaris
100009036 Oryctolagus cuniculus
12443 Mus musculus
58919 Rattus norvegicus
100729808 Cavia porcellus
100171625 Pongo abelii
379937 Xenopus laevis
396341 Gallus gallus
524530 Bos taurus
30222 Danio rerio
100144763 Ovis aries
Selected quality suppliers for Cyclin D1 Proteins (CCND1)
Did you look for something else?