Cyclin D1 Protein (CCND1) (AA 16-271) (His tag)
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- Target See all Cyclin D1 (CCND1) Proteins
- Cyclin D1 (CCND1)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 16-271
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Cyclin D1 protein is labelled with His tag.
- Sequence
- Ala 16-Ala 271
- Characteristics
- A DNA sequence encoding the Human Cyclin D1 protein (P24385) (Ala 16-Ala 271) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CCND1 Protein
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Cyclin D1 (CCND1) (AA 1-295) protein (GST tag)
CCND1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cyclin D1 (CCND1) (AA 11-285) protein (His-IF2DI Tag)CCND1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- Cyclin D1 (CCND1)
- Alternative Name
- Cyclin D1 (CCND1 Products)
- Synonyms
- BCL1 Protein, D11S287E Protein, PRAD1 Protein, U21B31 Protein, AI327039 Protein, CycD1 Protein, Cyl-1 Protein, bcl-1 Protein, cD1 Protein, cb161 Protein, cycd1 Protein, etID37810.7 Protein, fb52e01 Protein, fc45c08 Protein, fc83a12 Protein, id:ibd1198 Protein, wu:fb52e01 Protein, wu:fc45c08 Protein, wu:fc83a12 Protein, ccnd1b Protein, prad1 Protein, ccnd1 Protein, ccnd1a Protein, bcl1 Protein, d11s287e Protein, u21b31 Protein, CCND1 Protein, cyclin D1 Protein, cyclin D1 S homeolog Protein, cyclin D1 L homeolog Protein, CCND1 Protein, Ccnd1 Protein, ccnd1 Protein, ccnd1.S Protein, ccnd1.L Protein
- Background
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Abbreviation: Cyclin D1
Target Synonym: B cell leukemia 1,BCL 1,ccnd1,Cd1,Cyl 1,G1/S specific cyclin D1,PRAD1
Background: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
- Molecular Weight
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Calculated MW: 28.05 kDa
Observed MW: 35 kDa
- UniProt
- P24385
- Pathways
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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