Browse our anti-PDPK1 (PDPK1) Antibodies

Full name:
anti-3-phosphoinositide Dependent Protein Kinase-1 Antibodies (PDPK1)
On www.antibodies-online.com are 467 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antibodies from 32 different suppliers available. Additionally we are shipping PDPK1 Proteins (28) and PDPK1 Kits (25) and many more products for this protein. A total of 551 PDPK1 products are currently listed.
Synonyms:
1210, BG02759, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787
list all antibodies Gene Name GeneID UniProt
PDPK1 81745 O55173
PDPK1 5170 O15530
PDPK1 18607 Q9Z2A0

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Top referenced anti-PDPK1 Antibodies

  1. Human Polyclonal PDPK1 Primary Antibody for EIA - ABIN358390 : Nilsen, Slagsvold, Skjerpen, Brech, Stenmark, Olsnes: Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358390

  2. Human Polyclonal PDPK1 Primary Antibody for IF, IHC (p) - ABIN196616 : Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for 196616

  3. Human Polyclonal PDPK1 Primary Antibody for ICC, IF - ABIN250776 : Tsoi, Li, Chen, Lau, Tsui, Chan: The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. in The Biochemical journal 2014 (PubMed)
    Show all 3 references for 250776

  4. Human Polyclonal PDPK1 Primary Antibody for EIA, WB - ABIN359095 : Frödin, Antal, Dümmler, Jensen, Deak, Gammeltoft, Biondi: A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. in The EMBO journal 2002 (PubMed)
    Show all 3 references for 359095

  5. Human Polyclonal PDPK1 Primary Antibody for ELISA, WB - ABIN185505 : Sarbassov, Guertin, Ali, Sabatini: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. in Science (New York, N.Y.) 2005 (PubMed)

  6. Human Polyclonal PDPK1 Primary Antibody for IHC, ELISA - ABIN1532025 : Stephens, Anderson, Stokoe, Erdjument-Bromage, Painter, Holmes, Gaffney, Reese, McCormick, Tempst, Coadwell, Hawkins: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. in Science (New York, N.Y.) 1998 (PubMed)

  7. Cow (Bovine) Polyclonal PDPK1 Primary Antibody for WB - ABIN2779320 : Lin, Hsieh, Song, Lin: Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. in British journal of cancer 2005 (PubMed)

  8. Human Polyclonal PDPK1 Primary Antibody for IF (p), IHC (p) - ABIN744668 : Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy. in Epilepsy research 2015 (PubMed)

  9. Cow (Bovine) Polyclonal PDPK1 Primary Antibody for WB - ABIN2777432 : Ohba, Watanabe, Murakami, Radovanovic, Iino, Ishida, Tosa, Ono, Ito: Amlodipine inhibits cell proliferation via PKD1-related pathway. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against PDPK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (show CDK7 Antibodies) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.

  2. PDK1 was highly expressed in synovia of collagen-induced-arthritis mice com (show IL1B Antibodies)pared to (show IL6 Antibodies)control. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up- (show RPS6KA3 Antibodies)regulated in CIA compared with normal. This indicated that PDK1/RSK2 may participate in inflammatory pro (show TNF Antibodies)gress of RA.

  3. PDK1 is required for Ca(2 (show CA2 Antibodies)+)-dependent platelet activation on stimulation of collagen receptor (show ITGA2 Antibodies) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.

  4. In conclusion, we have identified that ARL15 acts as an insulin (show INS Antibodies)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Antibodies)/PDPK1/AKT (show AKT1 Antibodies) insulin (show INS Antibodies) pathway by interacting with its GAP ASAP2 (show ASAP2 Antibodies) and activating PDPK1. This research may provide new insights into GTPase (show RACGAP1 Antibodies)-mediated insulin (show INS Antibodies) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Antibodies) sensitizati

  5. Only when suboptimal doses of Akt (show AKT1 Antibodies)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (show NOTCH1 Antibodies) inhibition was seen. We conclude that the Akt (show AKT1 Antibodies) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (show AKT1 Antibodies) signaling.

  6. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (show NFKB1 Antibodies).

  7. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  8. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  9. PDK1 is an important regulator in arterial thrombosis formation.

  10. PDK1 is essential for BCR (show BCR Antibodies)-induced signal transduction to Foxo (show FOXO3 Antibodies) and NF-kappaB (show NFKB1 Antibodies) and is indispensable for both resting and activated B cell survival.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Highly expressed PDK1 (show PDK1 Antibodies) could promote cell invasion and secretion of IL-1beta (show IL1B Antibodies) and IL-6 (show IL6 Antibodies) in human rheumatoid arthritis synovial MH7A cells. Inhibition of RSK2 (show RPS6KA3 Antibodies) reduced the PDK1 (show PDK1 Antibodies)-induced cell invasion and cytokines secretion in MH7A cells. In response to TNF-alpha (show TNF Antibodies), PDK1 (show PDK1 Antibodies) could phosphorylate RSK2 (show RPS6KA3 Antibodies) and activated RSK2 (show RPS6KA3 Antibodies), then promoting the activation of NF-kappaB (show NFKB1 Antibodies).

  2. In cancer cells resistant to PI3Kalpha (show PIK3CA Antibodies) inhibition, PDK1 (show PDK1 Antibodies) blockade restores sensitivity to these therapies. SGK1 (show SGK1 Antibodies), which is activated by PDK1 (show PDK1 Antibodies), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (show TSC2 Antibodies).

  3. Results suggest that Ser (show SIGLEC1 Antibodies)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (show PDK1 Antibodies)-PKCtheta (show PRKCQ Antibodies);-mediated T cell activation.

  4. Elevated expression of PDK1 (show PDK1 Antibodies) was an independent negative prognostic factor of gastric carcinoma.

  5. miR (show MLXIP Antibodies)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (show PDK1 Antibodies).

  6. miR (show MLXIP Antibodies)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (show PDK1 Antibodies) expression.

  7. Decreased PDK1 (show PDK1 Antibodies) level is closely associated with reduced Akt (show AKT1 Antibodies)/cyclin D1 (show CCND1 Antibodies) activity.

  8. MiR (show MLXIP Antibodies)-138 regulation of PI3K (show PIK3CA Antibodies) signaling in ASMCs by altering the expression of PDK1 (show PDK1 Antibodies).

  9. Dephosphorylation of PDK-1 (show PDK1 Antibodies) and the resulting changes to Akt (show AKT1 Antibodies) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  10. Data suggest that claudin-18 (show CLDN18 Antibodies) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (show CDK7 Antibodies)-1 and proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-akt (Akt (show AKT1 Antibodies)).

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. miR (show MYLIP Antibodies)-375 directly targeted PDK1 (show PDK1 Antibodies) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (show PIK3C3 Antibodies) (PI3K)

PDPK1 Antigen Profile

Antigen Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • 3-phosphoinositide dependent protein kinase-1 (PDPK1) antibody
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1) antibody
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1) antibody
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1) antibody
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a) antibody
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1) antibody
  • Phosphoinositide-dependent kinase 1 (Pdk1) antibody
  • Protein PDK-1 (pdk-1) antibody
  • 1210 antibody
  • BG02759 antibody
  • CG1201 antibody
  • CG1210 antibody
  • Dmel\\CG1210 antibody
  • dPDK-1 antibody
  • dPDK1 antibody
  • dSTPK61 antibody
  • MGC82080 antibody
  • PDK antibody
  • PDK-1 antibody
  • Pdk1 antibody
  • PDK1/Pk61C antibody
  • pdpk1 antibody
  • PDPK2 antibody
  • pk61c antibody
  • Pk61C/PDK1 antibody
  • PRO0461 antibody
  • zgc:153787 antibody

Protein level used designations for PDPK1

3-phosphoinositide-dependent protein kinase 1 , 3-phosphoinositide dependent protein kinase-1 , pkB kinase , protein kinase B kinase , PkB kinase like gene 1 , Pkb kinase , mPDK1 , CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase

GENE ID SPECIES
416588 Gallus gallus
444529 Xenopus laevis
479875 Canis lupus familiaris
100138102 Bos taurus
100192445 Sus scrofa
779524 Xenopus (Silurana) tropicalis
81745 Rattus norvegicus
5170 Homo sapiens
18607 Mus musculus
768202 Danio rerio
100380750 Salmo salar
38017 Drosophila melanogaster
180475 Caenorhabditis elegans
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