Browse our anti-PDPK1 (PDPK1) Antibodies

Full name:
anti-3-phosphoinositide Dependent Protein Kinase-1 Antibodies (PDPK1)
On www.antibodies-online.com are 449 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antibodies from 31 different suppliers available. Additionally we are shipping PDPK1 Proteins (23) and PDPK1 Kits (22) and many more products for this protein. A total of 525 PDPK1 products are currently listed.
Synonyms:
1210, BG02759, CD79B, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, LOC100304995, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787
list all antibodies Gene Name GeneID UniProt
PDPK1 18607 Q9Z2A0
PDPK1 5170 O15530
PDPK1 81745 O55173

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Top referenced anti-PDPK1 Antibodies

  1. Human Polyclonal PDPK1 Primary Antibody for WB - ABIN116939 : Noppert, Mayer: In search for the troponin of the kidney. in Current medicinal chemistry 2009 (PubMed)
    Show all 6 references for 116939

  2. Human Polyclonal PDPK1 Primary Antibody for EIA - ABIN358390 : Nilsen, Slagsvold, Skjerpen, Brech, Stenmark, Olsnes: Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358390

  3. Human Polyclonal PDPK1 Primary Antibody for IF, IHC (p) - ABIN196616 : Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for 196616

  4. Human Polyclonal PDPK1 Primary Antibody for EIA, WB - ABIN359095 : Frödin, Antal, Dümmler, Jensen, Deak, Gammeltoft, Biondi: A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. in The EMBO journal 2002 (PubMed)
    Show all 3 references for 359095

  5. Dog (Canine) Polyclonal PDPK1 Primary Antibody for WB - ABIN374625 : Sarbassov, Guertin, Ali, Sabatini: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. in Science (New York, N.Y.) 2005 (PubMed)

  6. Human Polyclonal PDPK1 Primary Antibody for ELISA, WB - ABIN1533064 : Stephens, Anderson, Stokoe, Erdjument-Bromage, Painter, Holmes, Gaffney, Reese, McCormick, Tempst, Coadwell, Hawkins: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. in Science (New York, N.Y.) 1998 (PubMed)

  7. Cow (Bovine) Polyclonal PDPK1 Primary Antibody for WB - ABIN2777432 : Ohba, Watanabe, Murakami, Radovanovic, Iino, Ishida, Tosa, Ono, Ito: Amlodipine inhibits cell proliferation via PKD1-related pathway. in Biochemical and biophysical research communications 2008 (PubMed)

  8. Cow (Bovine) Polyclonal PDPK1 Primary Antibody for WB - ABIN2779320 : Lin, Hsieh, Song, Lin: Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. in British journal of cancer 2005 (PubMed)

More Antibodies against PDPK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (show CDK7 Antibodies) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is required for Ca(2 (show CA2 Antibodies)+)-dependent platelet activation on stimulation of collagen receptor (show ITGA2 Antibodies) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.

  2. In conclusion, we have identified that ARL15 acts as an insulin (show INS Antibodies)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Antibodies)/PDPK1/AKT (show AKT1 Antibodies) insulin (show INS Antibodies) pathway by interacting with its GAP ASAP2 (show ASAP2 Antibodies) and activating PDPK1. This research may provide new insights into GTPase (show RACGAP1 Antibodies)-mediated insulin (show INS Antibodies) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Antibodies) sensitizati

  3. Only when suboptimal doses of Akt (show AKT1 Antibodies)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (show NOTCH1 Antibodies) inhibition was seen. We conclude that the Akt (show AKT1 Antibodies) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (show AKT1 Antibodies) signaling.

  4. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (show NFKB1 Antibodies).

  5. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  6. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  7. PDK1 is an important regulator in arterial thrombosis formation.

  8. PDK1 is essential for BCR (show BCR Antibodies)-induced signal transduction to Foxo (show FOXO3 Antibodies) and NF-kappaB (show NFKB1 Antibodies) and is indispensable for both resting and activated B cell survival.

  9. Results suggest that heat shock protein 90 (show HSP90 Antibodies) inhibitor radicicol inhibited 3T3-L1 preadipocyte differentiation through affecting the PDK1/Akt (show AKT1 Antibodies) pathway.

  10. Inhibition of PDK1 promotes localization of TACE (show ADAM17 Antibodies) to the plasma membrane, restores TACE (show ADAM17 Antibodies)-dependent alpha-secretase activity and cleavage of APP (show APP Antibodies), PrP(C (show PRNP Antibodies)) and TNFR1 (show TNFRSF1A Antibodies), and attenuates PrP(Sc)- and Abeta (show APP Antibodies)-induced neurotoxicity.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. In cancer cells resistant to PI3Kalpha (show PIK3CA Antibodies) inhibition, PDK1 (show PDK1 Antibodies) blockade restores sensitivity to these therapies. SGK1 (show SGK1 Antibodies), which is activated by PDK1 (show PDK1 Antibodies), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (show TSC2 Antibodies).

  2. Results suggest that Ser (show SIGLEC1 Antibodies)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (show PDK1 Antibodies)-PKCtheta (show PRKCQ Antibodies);-mediated T cell activation.

  3. Elevated expression of PDK1 (show PDK1 Antibodies) was an independent negative prognostic factor of gastric carcinoma.

  4. miR (show MLXIP Antibodies)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (show PDK1 Antibodies).

  5. miR (show MLXIP Antibodies)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (show PDK1 Antibodies) expression.

  6. Decreased PDK1 (show PDK1 Antibodies) level is closely associated with reduced Akt (show AKT1 Antibodies)/cyclin D1 (show CCND1 Antibodies) activity.

  7. MiR (show MLXIP Antibodies)-138 regulation of PI3K (show PIK3CA Antibodies) signaling in ASMCs by altering the expression of PDK1 (show PDK1 Antibodies).

  8. Dephosphorylation of PDK-1 (show PDK1 Antibodies) and the resulting changes to Akt (show AKT1 Antibodies) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  9. Data suggest that claudin-18 (show CLDN18 Antibodies) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (show CDK7 Antibodies)-1 and proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-akt (Akt (show AKT1 Antibodies)).

  10. DK1 (show DOLK Antibodies) inhibits the formation of the TAK1 (show MAP3K7 Antibodies)-TAB2 (show TAB2 Antibodies)-TRAF6 (show TRAF6 Antibodies) complex and leads to the inhibition of TRAF6 (show TRAF6 Antibodies) ubiquitination.

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. miR (show MYLIP Antibodies)-375 directly targeted PDK1 (show PDK1 Antibodies) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (show PIK3C3 Antibodies) (PI3K)

PDPK1 Antigen Profile

Antigen Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • Phosphoinositide-dependent kinase 1 (Pdk1) antibody
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1) antibody
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a) antibody
  • CD79b molecule, immunoglobulin-associated beta (CD79B) antibody
  • CD79b molecule, immunoglobulin-associated beta (CD79b) antibody
  • CD79b (LOC100304995) antibody
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1) antibody
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1) antibody
  • 3-phosphoinositide dependent protein kinase-1 (PDPK1) antibody
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1) antibody
  • Protein PDK-1 (pdk-1) antibody
  • 1210 antibody
  • BG02759 antibody
  • CD79B antibody
  • CG1201 antibody
  • CG1210 antibody
  • Dmel\\CG1210 antibody
  • dPDK-1 antibody
  • dPDK1 antibody
  • dSTPK61 antibody
  • LOC100304995 antibody
  • MGC82080 antibody
  • PDK antibody
  • PDK-1 antibody
  • Pdk1 antibody
  • PDK1/Pk61C antibody
  • pdpk1 antibody
  • PDPK2 antibody
  • pk61c antibody
  • Pk61C/PDK1 antibody
  • PRO0461 antibody
  • zgc:153787 antibody

Protein level used designations for PDPK1

CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase , 3-phosphoinositide dependent protein kinase-1 , 3-phosphoinositide-dependent protein kinase 1 , B-cell antigen receptor complex-associated protein beta chain , CD79b molecule, immunoglobulin-associated beta , CD79b , Pkb kinase , mPDK1 , PkB kinase like gene 1 , pkB kinase , protein kinase B kinase

GENE ID SPECIES
38017 Drosophila melanogaster
444529 Xenopus laevis
779524 Xenopus (Silurana) tropicalis
768202 Danio rerio
419940 Gallus gallus
454773 Pan troglodytes
100026330 Monodelphis domestica
100304995 Ictalurus punctatus
100471131 Ailuropoda melanoleuca
100380750 Salmo salar
18607 Mus musculus
5170 Homo sapiens
81745 Rattus norvegicus
100192445 Sus scrofa
416588 Gallus gallus
479875 Canis lupus familiaris
100138102 Bos taurus
180475 Caenorhabditis elegans
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