Browse our RPS6KB1 Proteins (RPS6KB1)

Full name:
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 Proteins (RPS6KB1)
On www.antibodies-online.com are 14 Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) Proteins from 10 different suppliers available. Additionally we are shipping RPS6KB1 Antibodies (674) and RPS6KB1 Kits (33) and many more products for this protein. A total of 768 RPS6KB1 products are currently listed.
Synonyms:
70kDa, 2610318I15Rik, 4732464A07Rik, AA959758, AI256796, AI314060, p70 S6KA, p70(S6K)-alpha, p70-alpha, p70-S6K, p70/85s6k, p70s6k, PS6K, S6K, S6K-beta-1, S6K1, STK14A
list all proteins Gene Name GeneID UniProt
RPS6KB1 6198 P23443
RPS6KB1 72508 Q8BSK8
RPS6KB1 83840 P67999

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RPS6KB1 Proteins (RPS6KB1) by Origin

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Top referenced RPS6KB1 Proteins

  1. Human RPS6KB1 Protein expressed in Baculovirus infected Insect Cells - ABIN593522 : Lustig, Ruas, Estall, Lo, Devarakonda, Laznik, Choi, Ono, Olsen, Spiegelman: Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. in Genes & development 2011 (PubMed)

More Proteins for RPS6KB1 Interaction Partners

Human Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) interaction partners

  1. Data show that acquired immunodeficiency syndrome (AIDS) related diffuse large B-cell lymphoma (AR-DLBCL) frequently contain phosphorylated 70 ribosomal S6 protein-kinase (p70S6K), a main downstream effector of the mTOR serine-threonine kinases (mTOR) pathway, and the presence of p70S6K is positively correlated with phosphorylated phosphatase and tensin homolog (pPTEN).

  2. S6K1 is a promising tumor-specific target for the enhancement of NSCLC radiosensitivity and its effects may be mediated by increased expression of PDCD4 (show PDCD4 Proteins).

  3. Spheroids showed relative lower activities in the AKT (show AKT1 Proteins), mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) and S6K (also known as RPS6KB1) signaling pathway compared to cells cultured in two dimensions.

  4. S6K1 phosphorylation of H2B mediates EZH2 (show EZH2 Proteins) trimethylation of H3 early in adipogenesis, contributing to the promotion of obesity.

  5. Findings indicate that similar to overall cell size growth, Golgi growth is modulated by the "cell growth checkpoint" at late G1 phase through the activities of S6 kinase 1 (S6K1).

  6. the results identify the JNK (show MAPK8 Proteins)/S6K1 axis as a key molecular mechanism whereby a high fat/sucrose diet impairs insulin (show INS Proteins) action in retina.

  7. these findings suggest that activation of S6K1 in an adjuvant trastuzumab setting may represent a reliable early tumor marker predicting patient response to trastuzumab, allowing clinicians to further stratify patients for personalized and effective therapy.

  8. Data indicate YAP1 (show YAP1 Proteins) as a candidate marker to predict cell lines that were most sensitive to MSC2363318A, suggesting clinical development of a dual AKT (show AKT1 Proteins)/P70S6K inhibitor.

  9. RPS6KB1 single nucleotide polymorphism association with colorectal cancer patients survival

  10. These data suggest that S6K1-mediated PIPKIgamma90 phosphorylation regulates cell migration and invasion by controlling PIPKIgamma90 degradation.

Cow (Bovine) Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) interaction partners

  1. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  2. Lys (show LYZ Proteins), His, and Thr (show TRH Proteins) inhibited S6K1 phosphorylation in bovine mammary cells

Pig (Porcine) Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) interaction partners

  1. This study found that, early in rotavirus enteritis, arginine has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation.

  2. There was no correlation of infarct size with expression or phosphorylation of p70S6K or GSK3beta in ischemic postconditioning.

Mouse (Murine) Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) interaction partners

  1. We provide mechanistic evidence that S6K1's negative feedback to PI3K signaling is involved in axon growth inhibition, and show that phosphorylation of S6K1 is a more appropriate regeneration indicator than is S6 phosphorylation.

  2. S6K1 phosphorylation of H2B mediates EZH2 (show EZH2 Proteins) trimethylation of H3 early in adipogenesis, contributing to the promotion of obesity.

  3. the p70S6K isoforms have unique and redundant functions in mediating fibrogenic processes, including proliferation, migration.

  4. Rcan2 (show RCAN2 Proteins) and Rps6kb1 mutations both affect growth and body weight of mice, though likely through different mechanisms

  5. Findings indicate that similar to overall cell size growth, Golgi growth is modulated by the "cell growth checkpoint" at late G1 phase through the activities of S6 kinase 1 (S6K1).

  6. the results identify the JNK (show MAPK8 Proteins)/S6K1 axis as a key molecular mechanism whereby a high fat/sucrose diet impairs insulin (show INS Proteins) action in retina.

  7. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1)-STING membrane protein-TANK-binding kinase 1 (TBK1 (show TBK1 Proteins)) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (show IRF3 Proteins)).

  8. Our study suggests that Ab25-35 induces autophagy and the PI3K/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/p70S6K pathway is involved in the process, which improves our understanding of the pathogenesis of Alzheimer's disease and provides an additional model for AD research

  9. Reducing S6K activity prevents accelerated axon growth induced by hyperactive mTOR (show FRAP1 Proteins) in vivo.

  10. targeting the S6K pathway selectively modifies the progression of pulmonary fibrosis in the subpleural compartment of the lung

RPS6KB1 Protein Profile

Protein Summary

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.

Alternative names and synonyms associated with RPS6KB1

  • ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1)
  • ribosomal protein S6 kinase, polypeptide 1 (Rps6kb1)
  • 70kDa protein
  • 2610318I15Rik protein
  • 4732464A07Rik protein
  • AA959758 protein
  • AI256796 protein
  • AI314060 protein
  • p70 S6KA protein
  • p70(S6K)-alpha protein
  • p70-alpha protein
  • p70-S6K protein
  • p70/85s6k protein
  • p70s6k protein
  • PS6K protein
  • S6K protein
  • S6K-beta-1 protein
  • S6K1 protein
  • STK14A protein

Protein level used designations for RPS6KB1

p70 S6 kinase, alpha , ribosomal protein S6 kinase I , ribosomal protein S6 kinase beta-1 , serine/threonine kinase 14 alpha , serine/threonine-protein kinase 14A , 70 kDa ribosomal protein S6 kinase 1 , P70S6K1 , S6K , S6K-beta-1 , p70 S6 kinase alpha , p70(S6K)-alpha , p70-S6K 1 , p70S6K , ribosomal protein S6 kinase polypeptide 1 , G3 serine/threonine kinase , P70S6K , S6K1 , p70 S6K-alpha , p70 S6KA , p70 ribosomal S6 kinase alpha , ribosomal protein S6 kinase, 70kD, polypeptide 1 , S6 kinase , ribosomal protein S6 kinase, 70kDa, polypeptide 1

GENE ID SPECIES
100057481 Equus caballus
6198 Homo sapiens
404181 Bos taurus
417637 Gallus gallus
480580 Canis lupus familiaris
100127158 Sus scrofa
100009260 Oryctolagus cuniculus
72508 Mus musculus
83840 Rattus norvegicus
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