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Browse our Transportin 1 Proteins (TNPO1)

Full name:
Transportin 1 Proteins (TNPO1)
On www.antibodies-online.com are 9 Transportin 1 (TNPO1) Proteins from 4 different suppliers available. Additionally we are shipping Transportin 1 Antibodies (95) and Transportin 1 Kits (33) and many more products for this protein. A total of 138 Transportin 1 products are currently listed.
Synonyms:
ATTRN1, AU021749, D13Ertd688e, DKFZp469O204, F12A24.13, F12A24_13, IPO2, JC310, Kpnb2, MIP, Mip1, SIN1, SIN1b, SIN1g, TNPO1, transportin 1, TRN, zgc:100858, Znf667
list all proteins Gene Name GeneID UniProt
TNPO1 79109 Q9BPZ7
TNPO1 238799 Q8BFY9
Rat TNPO1 TNPO1 309126  

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Transportin 1 Proteins (TNPO1) by Origin

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More Proteins for Transportin 1 Interaction Partners

Xenopus laevis Transportin 1 (TNPO1) interaction partners

  1. Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.

Zebrafish Transportin 1 (TNPO1) interaction partners

  1. These results suggest that Aqp0a is the primary water channel (show AQP4 Proteins) of the lens and that Aqp0b, though possibly a secondary water channel (show AQP4 Proteins), has an unidentified function in the lens.

Human Transportin 1 (TNPO1) interaction partners

  1. FGF2 (show FGF2 Proteins) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase (show RAN Proteins) in human glioblastoma cells

  2. Akt (show AKT1 Proteins) phosphorylates SIN1 (show MAPKAP1 Proteins) at T86, enhancing mTORC2 (show CRTC2 Proteins) kinase activity, which leads to phosphorylation of Akt (show AKT1 Proteins) S473 by mTORC2 (show CRTC2 Proteins), thereby catalyzing full activation of Akt (show AKT1 Proteins).

  3. Kapbeta2 interacts with ULK2 (show ULK2 Proteins) through ULK2 (show ULK2 Proteins)'s putative PY-NLS (show ALDH1A2 Proteins) motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity.

  4. MAPKAP1 (show MAPKAP1 Proteins) may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica.

  5. mitogen-activated protein kinase associated protein 1 (show MAPKAP1 Proteins) rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.

  6. Studies indicate potential roles of Tranportin-1 and Transportin-2 (show TNPO2 Proteins) beyond protein nuclear import.

  7. DNA-PKcs (show PRKDC Proteins)-mTORC2 (show CRTC2 Proteins)(SIN1 (show MAPKAP1 Proteins)) association is required for UVB-induced Akt (show AKT1 Proteins) Ser (show SIGLEC1 Proteins)-473 phosphorylation and cell survival.

  8. ADAR1 (show ADAR Proteins) carries a unique nuclear localization signal (NLS (show ALDH1A2 Proteins)) that overlaps one of its double-stranded RNA-binding domains (dsRBDs). This dsRBD-NLS (show ALDH1A2 Proteins) is recognized by nuclear import receptor transportin 1 (also called karyopherin-beta2) in an RNA-sensitive manner.

  9. Data suggest the C-terminal nuclear localization domain (QYP) is critical for RAM (RNMT-activating mini protein (show FAM103A1 Proteins)) to enter the cell nucleus where RAM (show RAB27A Proteins) activates RNMT resulting in mRNA cap methylation; TNPO1/TNPO2 (show TNPO2 Proteins) mediate RAM (show RAB27A Proteins) nuclear entry.

  10. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient lymphangioleiomyomatosis cells.

Mouse (Murine) Transportin 1 (TNPO1) interaction partners

  1. Co-immunoprecipitation and affinity-binding studies revealed that Rab23 (show RAB23 Proteins) exists in a complex with Kif17 (show KIF17 Proteins) and importin (show KPNA4 Proteins) b2 implying that Kif17 (show KIF17 Proteins) needs to bind to regulatory proteins like Rab23 (show RAB23 Proteins) for its ciliary transport

  2. Association with Tnpo1 is necessary for Oxtr (show OXTR Proteins) nuclear localization. This is required for Oxt (show OXT Proteins)-induced osteoblast differentiation. osteoblast differentiation.

  3. DJ-1 (show PARK7 Proteins) import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.

  4. Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (show HTT Proteins) protein.

  5. Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.

Transportin 1 (TNPO1) Protein Profile

Protein Summary

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.

Alternative names and synonyms associated with Transportin 1 (TNPO1)

  • transportin 1 (TNPO1)
  • transportin 1 (tnpo1)
  • transportin 1 (TRN1)
  • major intrinsic protein of lens fiber a (mipa)
  • mitogen-activated protein kinase associated protein 1 (MAPKAP1)
  • transportin 1 (Tnpo1)
  • zinc finger protein 667 (Zfp667)
  • ATTRN1 protein
  • AU021749 protein
  • D13Ertd688e protein
  • DKFZp469O204 protein
  • F12A24.13 protein
  • F12A24_13 protein
  • IPO2 protein
  • JC310 protein
  • Kpnb2 protein
  • MIP protein
  • Mip1 protein
  • SIN1 protein
  • SIN1b protein
  • SIN1g protein
  • TNPO1 protein
  • transportin 1 protein
  • TRN protein
  • zgc:100858 protein
  • Znf667 protein

Protein level used designations for Transportin 1 Proteins (TNPO1)

transportin 1 , aqp0a , aquaporin-0a , major intrinsic protein of lens fiber 1 , MEKK2-interacting protein 1 , SAPK-interacting protein 1 , TORC2 subunit MAPKAP1 , mSIN1 , mitogen-activated protein kinase 2-associated protein 1 , ras inhibitor MGC2745 , stress-activated map kinase interacting protein 1 , stress-activated map kinase-interacting protein 1 , stress-activated protein kinase-interacting 1 , target of rapamycin complex 2 subunit MAPKAP1 , M9 region interaction protein , importin 2 , importin beta 2 , importin beta-2 , karyopherin (importin) beta 2 , karyopherin beta-2 , transportin-1 , myocardial ischemic preconditioning up-regulated protein 1 , myocardial ischemic preconditioning upregulated 1

GENE ID SPECIES
738932 Pan troglodytes
461817 Pan troglodytes
100073294 Equus caballus
100101656 Xenopus (Silurana) tropicalis
495494 Xenopus laevis
816198 Arabidopsis thaliana
100171937 Pongo abelii
445140 Danio rerio
79109 Homo sapiens
3842 Homo sapiens
100343169 Oryctolagus cuniculus
478093 Canis lupus familiaris
767620 Bos taurus
238799 Mus musculus
309126 Rattus norvegicus
100735321 Cavia porcellus
100627484 Sus scrofa
427218 Gallus gallus
308326 Rattus norvegicus
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