Browse our Transportin 1 Proteins (TNPO1)

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Transportin 1 Proteins (TNPO1)
On are 9 Transportin 1 (TNPO1) Proteins from 4 different suppliers available. Additionally we are shipping Transportin 1 Antibodies (100) and Transportin 1 Kits (28) and many more products for this protein. A total of 138 Transportin 1 products are currently listed.
ATTRN1, AU021749, D13Ertd688e, DKFZp469O204, F12A24.13, F12A24_13, IPO2, JC310, Kpnb2, MIP, Mip1, SIN1, SIN1b, SIN1g, TNPO1, transportin 1, TRN, zgc:100858, Znf667
list all proteins Gene Name GeneID UniProt
TNPO1 79109 Q9BPZ7
TNPO1 238799 Q8BFY9
Rat TNPO1 TNPO1 309126  

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Transportin 1 Proteins (TNPO1) by Origin

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More Proteins for Transportin 1 Interaction Partners

Xenopus laevis Transportin 1 (TNPO1) interaction partners

  1. Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.

Arabidopsis thaliana Transportin 1 (TNPO1) interaction partners

  1. Results show that tranportin 1 (AtTRN1) recognizes a broad spectrum of proteins having diverse functions, which will potentially be the cargoes of AtTRN1.

Zebrafish Transportin 1 (TNPO1) interaction partners

  1. These results suggest that Aqp0a is the primary water channel (show AQP4 Proteins) of the lens and that Aqp0b, though possibly a secondary water channel (show AQP4 Proteins), has an unidentified function in the lens.

Human Transportin 1 (TNPO1) interaction partners

  1. the TNPO1-Rab8 (show RAB8A Proteins)-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia.

  2. SIN1 (show MAPKAP1 Proteins) plays an important role in non-small cell lung cancer; SIN1 (show MAPKAP1 Proteins) is a potential biomarker and a promising target in the treatment of NSCLC

  3. This study provides evidence that Sin1 (show MAPKAP1 Proteins), a known element of the mammalian target of rapamycin (show FRAP1 Proteins) complex 2 (mTORC2 (show CRTC2 Proteins)), is required for Interferon-gamma (show IFNG Proteins)-induced phosphorylation and activation of AKT (show AKT1 Proteins) and that such activation mediates downstream regulation of mTORC1 and its effectors.

  4. Together, these results indicate that transportin-1 mediates YB-1 (show YBX1 Proteins) nuclear translocation.

  5. findings suggest that a new player, i.e., O-GlcNAcylation, regulates hnRNP A1 translocation and interaction with Trn1, possibly affecting its function

  6. Intracellular localization of mTORC2 (show CRTC2 Proteins) component, mSin1, contributes to regulation of Akt (show AKT1 Proteins) phosphorylation.

  7. Importins, Impbeta, Kapbeta2, Imp4 (show SPPL2B Proteins), Imp5 (show IPO5 Proteins), Imp7 (show IPO7 Proteins), Imp9 (show IPO9 Proteins), and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 (show IPO5 Proteins) with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.

  8. Results show that Karyopherin-b2 binds to the N-terminal tail of histone H3 (show HIST3H3 Proteins) with high affinity even though H3 lacks a recognizable proline-tyrosine nuclear localization signal (PY-NLS (show ALDH1A2 Proteins)).

  9. FGF2 (show FGF2 Proteins) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase (show RAN Proteins) in human glioblastoma cells

  10. Akt (show AKT1 Proteins) phosphorylates SIN1 (show MAPKAP1 Proteins) at T86, enhancing mTORC2 (show CRTC2 Proteins) kinase activity, which leads to phosphorylation of Akt (show AKT1 Proteins) S473 by mTORC2 (show CRTC2 Proteins), thereby catalyzing full activation of Akt (show AKT1 Proteins).

Mouse (Murine) Transportin 1 (TNPO1) interaction partners

  1. Co-immunoprecipitation and affinity-binding studies revealed that Rab23 (show RAB23 Proteins) exists in a complex with Kif17 (show KIF17 Proteins) and importin (show KPNA4 Proteins) b2 implying that Kif17 (show KIF17 Proteins) needs to bind to regulatory proteins like Rab23 (show RAB23 Proteins) for its ciliary transport

  2. Association with Tnpo1 is necessary for Oxtr (show OXTR Proteins) nuclear localization. This is required for Oxt (show OXT Proteins)-induced osteoblast differentiation. osteoblast differentiation.

  3. DJ-1 (show PARK7 Proteins) import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.

  4. Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (show HTT Proteins) protein.

  5. Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.

Transportin 1 (TNPO1) Protein Profile

Protein Summary

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.

Alternative names and synonyms associated with Transportin 1 (TNPO1)

  • transportin 1 (TNPO1)
  • transportin 1 (tnpo1)
  • transportin 1 (TRN1)
  • major intrinsic protein of lens fiber a (mipa)
  • mitogen-activated protein kinase associated protein 1 (MAPKAP1)
  • transportin 1 (Tnpo1)
  • zinc finger protein 667 (Zfp667)
  • ATTRN1 protein
  • AU021749 protein
  • D13Ertd688e protein
  • DKFZp469O204 protein
  • F12A24.13 protein
  • F12A24_13 protein
  • IPO2 protein
  • JC310 protein
  • Kpnb2 protein
  • MIP protein
  • Mip1 protein
  • SIN1 protein
  • SIN1b protein
  • SIN1g protein
  • TNPO1 protein
  • transportin 1 protein
  • TRN protein
  • zgc:100858 protein
  • Znf667 protein

Protein level used designations for Transportin 1 Proteins (TNPO1)

transportin 1 , aqp0a , aquaporin-0a , major intrinsic protein of lens fiber 1 , MEKK2-interacting protein 1 , SAPK-interacting protein 1 , TORC2 subunit MAPKAP1 , mSIN1 , mitogen-activated protein kinase 2-associated protein 1 , ras inhibitor MGC2745 , stress-activated map kinase interacting protein 1 , stress-activated map kinase-interacting protein 1 , stress-activated protein kinase-interacting 1 , target of rapamycin complex 2 subunit MAPKAP1 , M9 region interaction protein , importin 2 , importin beta 2 , importin beta-2 , karyopherin (importin) beta 2 , karyopherin beta-2 , transportin-1 , myocardial ischemic preconditioning up-regulated protein 1 , myocardial ischemic preconditioning upregulated 1

738932 Pan troglodytes
461817 Pan troglodytes
100073294 Equus caballus
100101656 Xenopus (Silurana) tropicalis
495494 Xenopus laevis
816198 Arabidopsis thaliana
100171937 Pongo abelii
445140 Danio rerio
79109 Homo sapiens
3842 Homo sapiens
100343169 Oryctolagus cuniculus
478093 Canis lupus familiaris
767620 Bos taurus
238799 Mus musculus
309126 Rattus norvegicus
100735321 Cavia porcellus
100627484 Sus scrofa
427218 Gallus gallus
308326 Rattus norvegicus
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