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Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Ticagrelor reduced TNF-alpha (show TNF Proteins)-induced TF expression via proteasomal degradation.
Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 (show ARF6 Proteins) trafficking.
Evening primrose oil and forskolin decreased the prothrombotic effect of celecoxib initiated by a LPS (show TLR4 Proteins) challenge in mice, and this effect was, at least partly, mediated by mitigating TF expression and activity.
Thrombin (show F2 Proteins)-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
These findings reveal a novel biological function and mechanism of the protein C (show PROC Proteins) pathway in which protein S and the aPC (show APC Proteins)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Proteins) in the context of endotoxemia and infection
Lung epithelial tissue factor regulates alveolar procoagulant activity and permeability in acute lung injury.
PGE2 increases both TF expression and activity through the regulation of the EP1 (show PTGER1 Proteins)/SIRT1 (show SIRT1 Proteins) pathway.
Fas (show FAS Proteins)-initiated, caspase-3 (show CASP3 Proteins)-dependent hepatocyte apoptosis increases tissue factor procoagulant activity through a mechanism involving phosphatidylserine externalization.
Heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo.
TF is essential for the development of pericyte coverage of tumor microvessels and aPL (show FASL Proteins)-induced tumor cell expression of chemokine ligand 2 (show CXCL2 Proteins), a mediator of pericyte recruitment
Tissue Factor was highly expressed in 73.6 % of osteosarcoma biopsies, and expression associated significantly with disease-free survival.
Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin.
the identification of platelet TF and TLR4 (show TLR4 Proteins) as regulators of the effect of E. coli O111 might represent a novel therapeutic target to reduce the devastating consequences of the hemostatic disorder during sepsis.
A coagulation initiating pathway is revealed in which the TF-FVIIa-nascent FXa (show F10 Proteins) complex activates FVIII (show F8 Proteins) apart from thrombin (show F2 Proteins) feedback.
TF-induced microvessel stabilization is regulated via PAR2 (show F2RL1 Proteins)-SMAD3 (show SMAD3 Proteins) that is indispensable for the maintenance of vascular integrity.
The aim of this study was to evaluate the concentration of TF and its inhibitor TFPI (show TFPI Proteins) in blood plasma, the impact of traditional and non-traditional cardiovascular risk factors on their concentration and the impact of both markers of haemostasis on the severity of subclinical atherosclerosis.
Inhibition of the inflammatory signaling intermediate p38 MAPK (show MAPK14 Proteins) reduced tissue factor (TF) mRNA by one third but increased tumor necrosis factor (TNF (show TNF Proteins)) and interleukin-1 beta (IL-1beta (show IL1B Proteins)) mRNA.
TF levels were significantly elevated in type 2 diabetes mellitus (both with and without cardiovascular complications) when compared to the controls. We suggest that pathologic plasma TF activity, as marker of increased propensity of clot (show TXNDC17 Proteins) pathology, should be investigated.
Arterial (18)F-fluorodeoxyglucose uptake reflects balloon catheter-induced thrombus formation and tissue factor expression via nuclear factor-kappaB in rabbit atherosclerotic lesions.
Polycations could present a new class of anticoagulants with such unique upstream downregulation of blood coagulation, selectively blocking tissue factor-dependent factor VII (show TH Proteins) activation.
Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 (show TFPI Proteins) level during reperfusion period.
lectin-like oxidized LDL receptor (show OLR1 Proteins) Oxidized low-density lipoprotein receptor (show LDLR Proteins) 1expression appears to be closely associated with tissue factor expression, apoptotic events and morphological vulnerability in atherosclerotic lesions
Tissue factor expression on porcine neonatal islet cell clusters is an important initiator of instant blood-mediated inflammatory reaction in islet xenotransplantation.
Prolonged clopidogrel treatment reduced coronary tissue factor (TF) expression and tended to reduce the blood TF level post-PCI (show SERPINA5 Proteins), thus possibly modulating the risk of late thrombosis.
Procoagulant porcine tissue factor is induced in primary pig aortic endothelial cells only by fresh human plasma, and not by heat-inactivated plasma.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 (show CCL2 Proteins) and CRP (show CRP Proteins)
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
, coagulation factor III
, tissue factor
, brain tissue factor
, coagulation factor 3