Browse our TNFSF15 Proteins (TNFSF15)

Full name:
Tumor Necrosis Factor (Ligand) Superfamily, Member 15 Proteins (TNFSF15)
On are 37 Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15) Proteins from 15 different suppliers available. Additionally we are shipping TNFSF15 Antibodies (171) and TNFSF15 Kits (13) and many more products for this protein. A total of 232 TNFSF15 products are currently listed.
Tl1, Tl1a, TTPAL, Vegi, VEGI192A
list all proteins Gene Name GeneID UniProt
TNFSF15 9966 O95150
TNFSF15 326623 Q5UBV8
TNFSF15 252878 Q8K3Y7

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TNFSF15 Proteins (TNFSF15) by Origin

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Top referenced TNFSF15 Proteins

  1. Human TNFSF15 Protein expressed in Escherichia coli (E. coli) - ABIN2666725 : Aiba, Nakamura: The role of TL1A and DR3 in autoimmune and inflammatory diseases. in Mediators of inflammation 2014 (PubMed)
    Show all 6 references for 2666725

  2. Human TNFSF15 Protein expressed in Escherichia coli (E. coli) - ABIN666796 : Zhai, Ni, Jiang, Lu, Xing, Lincoln, Carter, Janat, Kozak, Xu, Rojas, Aggarwal, Ruben, Li, Gentz, Yu: VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999 (PubMed)
    Show all 2 references for 666796

  3. Rat (Rattus) TNFSF15 Protein expressed in Human Cells - ABIN3216410 : Prehn, Thomas, Landers, Yu, Michelsen, Targan: The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)

More Proteins for TNFSF15 Interaction Partners

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15) interaction partners

  1. These results raise the possibility for involvement of TL1A/DR3/DR3 (show TNFRSF25 Proteins)-mediated mechanisms in epithelial-mesenchymal interactions and the development of inflammation-induced intestinal fibrosis in Crohn's disease.

  2. rs1250569 (ZMIZ1) and rs10114470 (TL1A) are two novel loci that indicate susceptibility to Inflammatory Bowel Disease in Han-Chinese patients.

  3. results support an idea that the genetic susceptibility of TNFSF15 to CD may be confounded, in part, by the increase of Prevotella

  4. (188)Re-NGR (show RTN4R Proteins)-VEGI has the potential as a theranostic agent.

  5. miRNA-31 can directly bind to the 3-UTR of TNFSF15, thereafter negatively regulating its expression in Caco2 cells.

  6. Patients with mild traumatic brain injury (TBI (show TBPL1 Proteins)) exhibited higher VEGI levels than those with moderate and severe TBI (show TBPL1 Proteins).

  7. Biologics beyond TNF-alpha (show TNF Proteins) inhibitors and the effect of targeting the homologues TL1A-DR3 (show TNFRSF25 Proteins) pathway in chronic inflammatory disorders.

  8. Rs3810936 of TNFSF15 were related to the risk of ankylosing spondylitis

  9. Higher TL1A levels were associated with early stage chronic lymphocytic leukemia.

  10. TL1A-induced cell death is directly mediated through DR3 (show TNFRSF25 Proteins).

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15) interaction partners

  1. These data demonstrated a direct role for TL1A-DR3 (show TNFRSF25 Proteins) signaling in tissue fibrosis and that modulation of TL1A-DR3 (show TNFRSF25 Proteins) signaling could inhibit gut (show GUSB Proteins) fibrosis.

  2. these data identify TL1A-DR3 (show TNFRSF25 Proteins) interactions as a novel pathway that promotes Th9 differentiation and pathogenicity. TL1A may be a potential therapeutic target in diseases dependent on IL-9 (show IL9 Proteins).

  3. TL1A induces NF-kappaB (show NFKB1 Proteins) activation in EC in renal and cardiac tissue from wild type but not DR3 (show TNFRSF25 Proteins) knock-out mice.

  4. TL1A deficiency impacts on the gut (show GUSB Proteins) microbial composition and the mucosal immune system, especially the intraepithelial TCRgammadelta(+) T-cell subset, and that TL1A is involved in the establishment of adipose tissue.

  5. Our data demonstrate a key role for TL1A in promoting ILC2s at mucosal barriers.

  6. TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor (show FLT1 Proteins) 1.

  7. Both in supernatant and as purified fusion protein, TL1A-Ig binds to TNFRSF25 (show TNFRSF25 Proteins) transfected--but not untransfected--P815 tumor cells as determined by flow cytometry.

  8. These results establish a novel link between tumor necrosis factor (TNF (show TNF Proteins))-family cytokine TL1A (TNFSF15) and interleukin 13 (IL-13 (show IL13 Proteins)) responses that results in small intestinal inflammation.

  9. role of TL1A in mucosal T cells and antigen presenting cells function and showed that up-regulation of TL1A expression can promote mucosal inflammation and gut (show GUSB Proteins) fibrosis.

  10. findings suggest that the transcription factor NF-kappaB (show NFKB1 Proteins) plays an important role in the regulation of VEGI expression

TNFSF15 Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TNFSF15

  • tumor necrosis factor (ligand) superfamily, member 15 (TNFSF15)
  • tumor necrosis factor (ligand) superfamily, member 15 (Tnfsf15)
  • Tl1 protein
  • Tl1a protein
  • TTPAL protein
  • Vegi protein
  • VEGI192A protein

Protein level used designations for TNFSF15

tumor necrosis factor ligand superfamily member 15 , vascular endothelial growth inhibitor , tocopherol (alpha) transfer protein-like , TNF ligand-related molecule 1 , TNF superfamily ligand TL1A , vascular endothelial cell growth inhibitor , vascular endothelial growth inhibitor-192A , bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15)

417247 Gallus gallus
473468 Pan troglodytes
9966 Homo sapiens
326623 Mus musculus
252878 Rattus norvegicus
481688 Canis lupus familiaris
100624969 Sus scrofa
514239 Bos taurus
100725797 Cavia porcellus
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