Browse our anti-CD74 (CD74) Antibodies

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anti-CD74 Antigen (Invariant Polypeptide of Major Histocompatibility Complex, Class II Antigen-Associated) Antibodies (CD74)
On are 73 CD74 Antigen (Invariant Polypeptide of Major Histocompatibility Complex, Class II Antigen-Associated) (CD74) Antibodies from 3 different suppliers available. Additionally we are shipping CD74 Kits (12) and and many more products for this protein. A total of 86 CD74 products are currently listed.
list all antibodies Gene Name GeneID UniProt
CD74 16149 P04441
CD74 25599 P10247

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anti-Mouse (Murine) CD74 Antibodies:

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Mouse (Murine) CD74 Antigen (Invariant Polypeptide of Major Histocompatibility Complex, Class II Antigen-Associated) (CD74) interaction partners

  1. We demonstrate that MHCII is dispensable for the B cell phenotype of (signal peptide peptidase-like 2a) SPPL2a (show SPPL2A Antibodies)(-/-) mice, further supporting a CD74-intrinsic effect.

  2. MIF (show MIF Antibodies)-CD74 signaling inhibits interferon (IFN)-gamma (show IFNA Antibodies) secretion in microglia through phosphorylation of microglial ERK1/2 (show MAPK1/3 Antibodies) (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (show MIF Antibodies) signaling or its receptor CD74 promotes IFN-gamma (show IFNG Antibodies) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.

  3. CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction.

  4. explored CD74 expression, which can form a complex with CD44 (show CD44 Antibodies), in glomerular parietal epithelial cells during the progression of a model of focal segmental glomerulosclerosis

  5. Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Antibodies) chemokine (show CCL1 Antibodies) expression by modulation of CD74 antigen processing.

  6. Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis.

  7. CD74 plays a critical role in the MIF (show MIF Antibodies) inhibition of osteoclastogenesis.

  8. Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II.

  9. SPPL2a (show SPPL2A Antibodies)-mediated processing of CD74 NTF (show TNF Antibodies) is indispensable to maintain appropriate levels of tonic BCR (show BCR Antibodies) signaling to promote B cell maturation (show TNFRSF17 Antibodies).

  10. Results support the hypothesis that neurodegeneration following traumatic brain injury is dependent upon antigen processing and presentation that requires CD74

CD74 Antigen Profile

Antigen Summary

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

Alternative names and synonyms associated with CD74

  • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74) antibody
  • Cd74 molecule, major histocompatibility complex, class II invariant chain (Cd74) antibody
  • CLIP antibody
  • DHLAG antibody
  • HLADG antibody
  • Ia-GAMMA antibody
  • Ii antibody
  • INVG34 antibody

Protein level used designations for CD74

H-2 class II histocompatibility antigen gamma chain , HLA-DR-GAMMA , Ia-associated invariant chain , MHC class II-associated invariant chain , class II-associated invariant chain peptide , dinucleotide microsatellite , histocompatibility: class II antigens, gamma chain of , ia antigen-associated invariant chain , invariant polypeptide of major histocompatibility complex, class II antigen-associated , ii

16149 Mus musculus
25599 Rattus norvegicus
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