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anti-Mouse (Murine) CD74 Antibodies:
anti-Rat (Rattus) CD74 Antibodies:
anti-Human CD74 Antibodies:
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Data highlight the complexity of the MIF (show MIF Antibodies)/CD74 signaling pathway in the development of mesothelioma.
We demonstrate that MHCII is dispensable for the B cell phenotype of (signal peptide peptidase-like 2a) SPPL2a (show SPPL2A Antibodies)(-/-) mice, further supporting a CD74-intrinsic effect.
MIF (show MIF Antibodies)-CD74 signaling inhibits interferon (IFN)-gamma (show IFNA Antibodies) secretion in microglia through phosphorylation of microglial ERK1/2 (show MAPK1/3 Antibodies) (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF (show MIF Antibodies) signaling or its receptor CD74 promotes IFN-gamma (show IFNG Antibodies) release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown.
CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction.
explored CD74 expression, which can form a complex with CD44 (show CD44 Antibodies), in glomerular parietal epithelial cells during the progression of a model of focal segmental glomerulosclerosis
Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 Antibodies) chemokine (show CCL1 Antibodies) expression by modulation of CD74 antigen processing.
Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis.
CD74 plays a critical role in the MIF (show MIF Antibodies) inhibition of osteoclastogenesis.
Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II.
SPPL2a (show SPPL2A Antibodies)-mediated processing of CD74 NTF (show TNF Antibodies) is indispensable to maintain appropriate levels of tonic BCR (show BCR Antibodies) signaling to promote B cell maturation (show TNFRSF17 Antibodies).
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.
H-2 class II histocompatibility antigen gamma chain
, Ia-associated invariant chain
, MHC class II-associated invariant chain
, class II-associated invariant chain peptide
, dinucleotide microsatellite
, histocompatibility: class II antigens, gamma chain of
, ia antigen-associated invariant chain
, invariant polypeptide of major histocompatibility complex, class II antigen-associated